H Roger Lijnen
Affiliation: Katholieke Universiteit Leuven
Lijnen H, Van Hoef B, Collen D. Inactivation of the serpin alpha(2)-antiplasmin by stromelysin-1. Biochim Biophys Acta. 2001;1547:206-13 pubmed
..Cleavage and inactivation of alpha(2)-AP by MMP-3 may constitute a mechanism favoring local plasmin-mediated proteolysis. ..
Lijnen H, Van Hoef B, Dewerchin M, Collen D. Alpha(2)-antiplasmin gene deficiency in mice does not affect neointima formation after vascular injury. Arterioscler Thromb Vasc Biol. 2000;20:1488-92 pubmed
Lijnen H, Maquoi E, Morange P, Voros G, Van Hoef B, Kopp F, et al
. Nutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol. 2003;23:78-84 pubmed
..High circulating PAI-1 levels attenuate nutritionally induced obesity. This may be related to modifications in adipose tissue cellularity affecting weight and plasma metabolic parameters. ..
Lijnen H, Van Hoef B, Collen D. Characterization of the murine plasminogen/urokinase-type plasminogen-activator system. Eur J Biochem. 1996;241:840-8 pubmed
..However, quantitative differences were observed both in the presence of cells and in plasma which may contribute to a reduced u-PA-mediated fibrinolytic activity in the murine systems. ..
Lijnen H, Van Hoef B, Vanlinthout I, Verstreken M, Rio M, Collen D. Accelerated neointima formation after vascular injury in mice with stromelysin-3 (MMP-11) gene inactivation. Arterioscler Thromb Vasc Biol. 1999;19:2863-70 pubmed
..8% at 3 weeks, P<0. 005). The mechanisms by which MMP-11 could impair elastin degradation and cellular migration in this model remain, however, unknown. ..
Lijnen H, Arza B, Van Hoef B, Collen D, Declerck P. Inactivation of plasminogen activator inhibitor-1 by specific proteolysis with stromelysin-1 (MMP-3). J Biol Chem. 2000;275:37645-50 pubmed
..Cleavage and inactivation of PAI-1 by MMP-3 may thus constitute a mechanism decreasing the antiproteolytic activity of PAI-1 and impairing the potential inhibitory effect of vitronectin-bound PAI-1 on cell adhesion and/or migration. ..
Lijnen H. Matrix metalloproteinases and cellular fibrinolytic activity. Biochemistry (Mosc). 2002;67:92-8 pubmed
..Furthermore, the temporal and topographic expression pattern of MMP components, as well as studies in gene-deficient mice, suggest a functional role in neointima formation after vascular injury. ..
Lijnen H, Demeulemeester D, Van Hoef B, Collen D, Maquoi E. Deficiency of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) impairs nutritionally induced obesity in mice. Thromb Haemost. 2003;89:249-55 pubmed
..Thus, in a murine model of nutritionally induced obesity, TIMP-1 promotes adipose tissue development. ..
Lijnen H. Effect of plasminogen activator inhibitor-1 deficiency on nutritionally-induced obesity in mice. Thromb Haemost. 2005;93:816-9 pubmed
..Thus, this study in littermate mice on high fat diet did not reveal an effect of PAI-1 deficiency on body weight, and a differential effect on SC and GON adipose tissue. ..