H Roger Lijnen


Affiliation: Katholieke Universiteit Leuven
Country: Belgium


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    Lijnen H, Van Hoef B, Collen D. Inactivation of the serpin alpha(2)-antiplasmin by stromelysin-1. Biochim Biophys Acta. 2001;1547:206-13 pubmed
    ..Cleavage and inactivation of alpha(2)-AP by MMP-3 may constitute a mechanism favoring local plasmin-mediated proteolysis. ..
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    Lijnen H, Van Hoef B, Dewerchin M, Collen D. Alpha(2)-antiplasmin gene deficiency in mice does not affect neointima formation after vascular injury. Arterioscler Thromb Vasc Biol. 2000;20:1488-92 pubmed
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    Lijnen H, Maquoi E, Morange P, Voros G, Van Hoef B, Kopp F, et al. Nutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol. 2003;23:78-84 pubmed
    ..High circulating PAI-1 levels attenuate nutritionally induced obesity. This may be related to modifications in adipose tissue cellularity affecting weight and plasma metabolic parameters. ..
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    Lijnen H, Van Hoef B, Collen D. Characterization of the murine plasminogen/urokinase-type plasminogen-activator system. Eur J Biochem. 1996;241:840-8 pubmed
    ..However, quantitative differences were observed both in the presence of cells and in plasma which may contribute to a reduced u-PA-mediated fibrinolytic activity in the murine systems. ..
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    Lijnen H, Van Hoef B, Vanlinthout I, Verstreken M, Rio M, Collen D. Accelerated neointima formation after vascular injury in mice with stromelysin-3 (MMP-11) gene inactivation. Arterioscler Thromb Vasc Biol. 1999;19:2863-70 pubmed
    ..8% at 3 weeks, P<0. 005). The mechanisms by which MMP-11 could impair elastin degradation and cellular migration in this model remain, however, unknown. ..
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    Lijnen H, Arza B, Van Hoef B, Collen D, Declerck P. Inactivation of plasminogen activator inhibitor-1 by specific proteolysis with stromelysin-1 (MMP-3). J Biol Chem. 2000;275:37645-50 pubmed
    ..Cleavage and inactivation of PAI-1 by MMP-3 may thus constitute a mechanism decreasing the antiproteolytic activity of PAI-1 and impairing the potential inhibitory effect of vitronectin-bound PAI-1 on cell adhesion and/or migration. ..
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    Lijnen H. Matrix metalloproteinases and cellular fibrinolytic activity. Biochemistry (Mosc). 2002;67:92-8 pubmed
    ..Furthermore, the temporal and topographic expression pattern of MMP components, as well as studies in gene-deficient mice, suggest a functional role in neointima formation after vascular injury. ..
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    Lijnen H, Demeulemeester D, Van Hoef B, Collen D, Maquoi E. Deficiency of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) impairs nutritionally induced obesity in mice. Thromb Haemost. 2003;89:249-55 pubmed
    ..Thus, in a murine model of nutritionally induced obesity, TIMP-1 promotes adipose tissue development. ..
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    Lijnen H. Effect of plasminogen activator inhibitor-1 deficiency on nutritionally-induced obesity in mice. Thromb Haemost. 2005;93:816-9 pubmed
    ..Thus, this study in littermate mice on high fat diet did not reveal an effect of PAI-1 deficiency on body weight, and a differential effect on SC and GON adipose tissue. ..

More Information


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    Lijnen H, Alessi M, Van Hoef B, Collen D, Juhan Vague I. On the role of plasminogen activator inhibitor-1 in adipose tissue development and insulin resistance in mice. J Thromb Haemost. 2005;3:1174-9 pubmed
    ..Administration of a synthetic PAI-1 inhibitor for 4 weeks did not affect adipose tissue development in WT or PAI-1 transgenic mice, but induced a higher insulin sensitivity in WT mice. ..