S Liekens


Affiliation: Katholieke Universiteit Leuven
Country: Belgium


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    Liekens S, Neyts J, De Clercq E, Verbeken E, Ribatti D, Presta M. Inhibition of fibroblast growth factor-2-induced vascular tumor formation by the acyclic nucleoside phosphonate cidofovir. Cancer Res. 2001;61:5057-64 pubmed
    ..In conclusion, cidofovir appears to inhibit the growth of endothelium-derived tumors via induction of apoptosis without exerting a direct antiangiogenic activity. ..
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    Liekens S, Hernández A, Ribatti D, De Clercq E, Camarasa M, Pérez Pérez M, et al. The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action. J Biol Chem. 2004;279:29598-605 pubmed
    ..Identification of these site(s) is important to obtain a better insight into the molecular role of TPase in the progression of cancer and angiogenic diseases. ..