S Liekens

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint The sulfonic acid polymers PAMPS [poly(2-acrylamido-2-methyl-1-propanesulfonic acid)] and related analogues are highly potent inhibitors of angiogenesis
    S Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Oncol Res 9:173-81. 1997
  2. ncbi request reprint Inhibition of fibroblast growth factor-2-induced vascular tumor formation by the acyclic nucleoside phosphonate cidofovir
    S Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Cancer Res 61:5057-64. 2001
  3. ncbi request reprint The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action
    Sandra Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Biol Chem 279:29598-605. 2004
  4. ncbi request reprint Potent inhibition of hemangiosarcoma development in mice by cidofovir
    S Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroederstraat 10, B 3000 Leuven, Belgium
    Int J Cancer 92:161-7. 2001
  5. ncbi request reprint Angiogenesis: regulators and clinical applications
    S Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000, Leuven, Belgium
    Biochem Pharmacol 61:253-70. 2001
  6. ncbi request reprint A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470
    S Liekens
    Rega Institute for Medical Research, University Hospitals, Leuven, Belgium
    Cancer Res 59:2376-83. 1999
  7. ncbi request reprint Potent inhibition of hemangioma formation in rats by the acyclic nucleoside phosphonate analogue cidofovir
    S Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Cancer Res 58:2562-7. 1998
  8. ncbi request reprint The role of growth factors, angiogenic enzymes and apoptosis in neovascularization and tumor growth-collected publications
    S Liekens
    Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research, Minderbroedersstraat 10, B 3000 Leuven
    Verh K Acad Geneeskd Belg 64:197-224. 2002
  9. doi request reprint Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59)
    A Bronckaers
    Rega Institute for Medical Research, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Biochem Pharmacol 78:231-40. 2009
  10. ncbi request reprint Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds
    S Liekens
    Rega Institute for Medical Research, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
    Mol Pharmacol 56:204-13. 1999

Detail Information

Publications17

  1. ncbi request reprint The sulfonic acid polymers PAMPS [poly(2-acrylamido-2-methyl-1-propanesulfonic acid)] and related analogues are highly potent inhibitors of angiogenesis
    S Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Oncol Res 9:173-81. 1997
    ..These results suggest that sulfonic acid polymers, and in particular PAMPS, may be considered as specific, nontoxic angiogenesis inhibitors...
  2. ncbi request reprint Inhibition of fibroblast growth factor-2-induced vascular tumor formation by the acyclic nucleoside phosphonate cidofovir
    S Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Cancer Res 61:5057-64. 2001
    ..In conclusion, cidofovir appears to inhibit the growth of endothelium-derived tumors via induction of apoptosis without exerting a direct antiangiogenic activity...
  3. ncbi request reprint The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action
    Sandra Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Biol Chem 279:29598-605. 2004
    ..Identification of these site(s) is important to obtain a better insight into the molecular role of TPase in the progression of cancer and angiogenic diseases...
  4. ncbi request reprint Potent inhibition of hemangiosarcoma development in mice by cidofovir
    S Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroederstraat 10, B 3000 Leuven, Belgium
    Int J Cancer 92:161-7. 2001
    ..Cidofovir should be further explored for its potential in the treatment of fast-growing vascular tumors, like hemangiomas and hemangiosarcomas...
  5. ncbi request reprint Angiogenesis: regulators and clinical applications
    S Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000, Leuven, Belgium
    Biochem Pharmacol 61:253-70. 2001
    ....
  6. ncbi request reprint A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470
    S Liekens
    Rega Institute for Medical Research, University Hospitals, Leuven, Belgium
    Cancer Res 59:2376-83. 1999
    ..i. The model described here may be useful for investigating (a) the angiogenic mechanism(s) underlying hemangioma progression; and (b) the effect of anti-angiogenic compounds on vascular tumor growth...
  7. ncbi request reprint Potent inhibition of hemangioma formation in rats by the acyclic nucleoside phosphonate analogue cidofovir
    S Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Cancer Res 58:2562-7. 1998
    ..Cidofovir may thus be further explored for the treatment of vascular tumors and, in particular, life-threatening juvenile hemangiomas...
  8. ncbi request reprint The role of growth factors, angiogenic enzymes and apoptosis in neovascularization and tumor growth-collected publications
    S Liekens
    Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research, Minderbroedersstraat 10, B 3000 Leuven
    Verh K Acad Geneeskd Belg 64:197-224. 2002
    ..Our findings open new perspectives for the use of cidofovir as an anti-tumor agent in the therapy of hemangiomas and other tumors that are not associated with an oncogenic virus...
  9. doi request reprint Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59)
    A Bronckaers
    Rega Institute for Medical Research, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Biochem Pharmacol 78:231-40. 2009
    ..Our findings reveal the existence of a previously unrecognized site in TP that can be targeted by small molecules to inhibit the catalytic activity of TP...
  10. ncbi request reprint Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds
    S Liekens
    Rega Institute for Medical Research, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
    Mol Pharmacol 56:204-13. 1999
    ..In conclusion, sulfonic acid polymers bind FGF-2 by mimicking heparin interaction. These compounds may provide a tool to inhibit FGF-2-induced endothelial cell proliferation in angiogenesis and tumor growth...
  11. ncbi request reprint Thymidine phosphorylase is noncompetitively inhibited by 5'-O-trityl-inosine (KIN59) and related compounds
    S Liekens
    Rega Institute for Medical Research, KU Leuven, Leuven, Belgium
    Nucleosides Nucleotides Nucleic Acids 25:975-80. 2006
    ..Our observations indicate that allosteric sites in TPase may regulate its biological activity...
  12. ncbi request reprint Effect of TNP-470 (AGM-1470) on the growth of rat rhabdomyosarcoma tumors of different sizes
    W Landuyt
    University Hospital, K U Leuven, Belgium
    Cancer Invest 19:35-40. 2001
    ..The antivasculature therapy might also improve hypoxia/necrosis-related therapeutic approaches...
  13. ncbi request reprint The Pyrimidine Nucleoside Phosphorylase of Mycoplasma hyorhinis and How It May Affect Nucleoside-Based Therapy
    J Vande Voorde
    a Rega Institute for Medical Research, KU Leuven, Leuven, Belgium
    Nucleosides Nucleotides Nucleic Acids 33:394-402. 2014
    ..Due to their close association with human cancers, the presence of mycoplasmas may markedly influence the therapeutic efficiency of nucleoside-based drugs. ..
  14. doi request reprint 2-aminothiophene-3-carboxylic acid ester derivatives as novel highly selective cytostatic agents
    J Balzarini
    Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000, Leuven, Belgium
    Invest New Drugs 32:200-10. 2014
    ..Compound 3 was also shown to induce apoptosis in prostate cancer cells. The 2-aminothiophene-3-carboxylic acid ester derivatives represent novel candidate cytostatic agents to be further explored for their tumor-selective potential...
  15. ncbi request reprint Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties
    P Proost
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, Leuven, Belgium
    Blood 98:3554-61. 2001
    ..These data demonstrate a negative feedback regulation by CD26/DPP IV in CXCR3-mediated chemotaxis without affecting the angiostatic potential of the CXCR3 ligands IP-10 and Mig...
  16. ncbi request reprint Heparin derivatives as angiogenesis inhibitors
    M Presta
    Department of Biomedical Science and Biotechnology, School of Medicine, University of Brescia, 25123 Brescia, Italy
    Curr Pharm Des 9:553-66. 2003
    ....
  17. ncbi request reprint Regulation of cancer progression by inhibition of angiogenesis and induction of apoptosis
    S Liekens
    Laboratory of Virology and Chemotherapy, Rega Institute, KULeuven, Minderbroedersstraat 10 B 3000 Leuven
    Verh K Acad Geneeskd Belg 70:175-91. 2008
    ..These exciting results open new perspectives for the use of cidofovir as an anti-tumor agent in the therapy of tumors that are not associated with an oncogenic virus...