Research Topics
| L LibbrechtSummaryAffiliation: Katholieke Universiteit Leuven Country: Belgium Publications
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Detail Information
Publications
Liver pathology and hepatocarcinogenesis in a long-term mouse model of erythropoietic protoporphyriaLouis Libbrecht
Department of Pathology, University Hospitals Leuven, Leuven, Belgium
J Pathol 199:191-200. 2003..The classical stages of hepatocarcinogenesis were observed and hepatic progenitor cells appear to be involved in this process. PP acts as the promoting agent and is probably also the initiating agent...- Glypican-3 expression distinguishes small hepatocellular carcinomas from cirrhosis, dysplastic nodules, and focal nodular hyperplasia-like nodulesLouis Libbrecht
Department and Laboratories of Pathology, University and University Hospitals of Leuven, Leuven, Belgium
Am J Surg Pathol 30:1405-11. 2006..83 and 1, respectively, for needle biopsies. Because the result of the staining was easily interpretable, immunohistochemistry for GPC3 is valuable ancillary tool in the histopathologic diagnosis of small focal lesions in cirrhosis... - Peripheral bile duct paucity and cholestasis in the liver of a patient with Alagille syndrome: further evidence supporting a lack of postnatal bile duct branching and elongationLouis Libbrecht
Department of Pathology, University Hospitals of Leuven, Minderbroedersstraat 12, 3000 Leuven, Belgium
Am J Surg Pathol 29:820-6. 2005..Our findings also suggest that anomalies of the intrahepatic arterial branches may be part of AGS in some patients... - Hepatic progenitor cells in human liver tumor developmentLouis Libbrecht
Laboratory of Morphology and Molecular Pathology, Minderbroedersstraat 12, Leuven 3000, Belgium
World J Gastroenterol 12:6261-5. 2006.... - Hepatic progenitor cells in human liver diseasesLouis Libbrecht
Department of Pathology and the Laboratory of Morphology and Molecular Pathology, University Hospitals, University of Leuven, 3000, Leuven, Belgium
Semin Cell Dev Biol 13:389-96. 2002..Analogous to oval cells in animal liver, there is evidence that human hepatic progenitor cells may be able to give rise to hepatocellular carcinoma and other liver tumors... - Focal lesions in cirrhotic explant livers: pathological evaluation and accuracy of pretransplantation imaging examinationsLouis Libbrecht
Department of Pathology, University Hospitals, University of Leuven, Leuven, Belgium
Liver Transpl 8:749-61. 2002..Regular contrast-enhanced MR examination of cirrhotic patients waiting for liver transplantation is the best tool for the early detection of (pre)malignant lesions... - Preneoplastic lesions in human hepatocarcinogenesisLouis Libbrecht
Liver Research Unit of the Laboratory of Morphology and Molecular Pathology, Department of Pathology, University and University Hospitals of Leuven, 3000 Leuven, Belgium
Liver Int 25:16-27. 2005..We propose three criteria by which good mimickers can be identified... - Microscopic colitis with giant cellsL Libbrecht
Department of Pathology, Leuven University Hospitals, Leuven, Belgium
Histopathology 40:335-8. 2002..Collagenous colitis and lymphocytic colitis are the two types of microscopic colitis with specific morphological features. In this report we describe a new histopathological subtype of microscopic colitis... - Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with non-cirrhotic and cirrhotic chronic viral hepatitisL Libbrecht
Department of Pathology, University Hospitals, University of Leuven, Leuven, Belgium
Histopathology 39:66-73. 2001..If these results are confirmed, the presence of LLCD can be used to identify a subgroup of patients at high risk for HCC requiring more intensive screening... - The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cellsL Libbrecht
Laboratory for Histo and Cytochemistry, University of Leuven, Belgium
J Hepatol 33:76-84. 2000..In view of the known role of rat oval cells in regeneration and hepatocarcinogenesis, we investigated a possible correlation between human putative progenitor cells and different types of dysplastic foci... - Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseasesL Libbrecht
Laboratory of Morphology and Molecular Pathology, University of Leuven, Minderbroedersstraat 12, 3000 Leuven, Belgium
Histochem Cell Biol 116:233-9. 2001..Our results suggest that NCAM may have a function in the development of the intrahepatic bile ducts and that NCAM-positive immature biliary cells can contribute to the repair of damaged bile ducts in chronic liver diseases... - Deep intralobular extension of human hepatic 'progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis: can 'progenitor cells' migrate?L Libbrecht
Laboratory for Histo and Cytochemistry, University of Leuven, Minderbroedersstraat 12, B 3000 Leuven, Belgium
J Pathol 192:373-8. 2000.... - Hepatic progenitor cells in hepatocellular adenomasL Libbrecht
Department of Pathology, University Hospitals, University of Leuven, Leuven, Belgium
Am J Surg Pathol 25:1388-96. 2001..Our study shows that hepatic progenitor cells are present in a considerable proportion of hepatocellular adenomas, supporting the hypothesis that human hepatic progenitor cells can play a role in the development of hepatocellular tumors... - Fas and Fas ligand: strong co-expression in human hepatocytes surrounding hepatocellular carcinoma; can cancer induce suicide in peritumoural cells?T Roskams
Laboratory for Histo and Cytochemistry, University of Leuven, Belgium
J Pathol 191:150-3. 2000..Within the tumour, the Fas-Fas-L apoptosis pathway seems to be little involved... - Alpha B-crystallin expression in human and rat hepatic stellate cellsD Cassiman
Laboratory of Cell Pharmacology, University of Leuven, Belgium
J Hepatol 35:200-7. 2001..We searched for factors implicated in early hepatic stellate cell (HSC) activation in diseased liver, by means of suppression subtractive hybridization (SSH)... - The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell originA Durnez
Department of Morphology and Molecular Pathology, KULeuven University Hospital Gasthuisberg, Belgium
Histopathology 49:138-51. 2006..Therefore, our aim was to study the occurrence and clinicopathological characteristics of HCC expressing CK7 and/or CK19 in 109 Caucasian patients... - Diagnostic and pathogenetic implications of the expression of hepatic transporters in focal lesions occurring in normal liverSara Vander Borght
Laboratory of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
J Pathol 207:471-82. 2005..The finding that each type of focal lesion in non-cirrhotic liver has a specific transporter expression pattern may be useful in the establishment of a correct diagnosis by imaging or on needle biopsy... - Hepatic stellate cells do not derive from the neural crestDavid Cassiman
Department of Hepatology, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
J Hepatol 44:1098-104. 2006..Hepatic stellate cells (HSC) have been hypothesised to derive from the neural crest, based on their expression of multiple neural/neuroendocrine features and their contacts with autonomic nerve endings... - Breast cancer resistance protein (BCRP/ABCG2) is expressed by progenitor cells/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: possible functional consequencesSara Vander Borght
Laboratory of Morphology and Molecular Pathology, University Hospitals Leuven, Belgium
J Histochem Cytochem 54:1051-9. 2006..Strong differences between human and rat liver must be taken into account in future studies with animal models... - HBx or HCV core gene expression in HepG2 human liver cells results in a survival benefit against oxidative stress with possible implications for HCC developmentTamara Severi
Laboratory of Hepatology, University Hospital Gasthuisberg, O and N Building Bus 703, Herestraat 49, Leuven, Belgium
Chem Biol Interact 168:128-34. 2007..In conclusion, HBx and HCV core expression in HepG2 cells leads to a survival benefit under oxidative stress which in vivo can be induced during inflammation... - Neuroregulation of the neuroendocrine compartment of the liverTania Roskams
Department of Pathology, University of Leuven, Belgium
Anat Rec A Discov Mol Cell Evol Biol 280:910-23. 2004..Moreover, since there is a shortage of donor organs, a better understanding of the mechanisms of regeneration could have therapeutic possibilities, which could even obviate the need for orthotopic liver transplantation... - Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutationsAnouk Demunter
Department of Pathology, Laboratory of Morphology and Molecular Pathology, University Hospitals, Katholieke Universiteit Leuven, Belgium
Mod Pathol 15:454-61. 2002..Our results suggest that posttranslational events, rather than CTNNB1 mutations, are responsible for the altered distribution of beta-catenin in cutaneous melanoma... - The correlation between portal myofibroblasts and development of intrahepatic bile ducts and arterial branches in human liverLouis Libbrecht
Laboratory of Morphology and Molecular Pathology, Department of Pathology, University of Leuven, Belgium
Liver 22:252-8. 2002.... 
Expression of multidrug resistance-associated protein 1 in hepatocellular carcinoma is associated with a more aggressive tumour phenotype and may reflect a progenitor cell originSara Vander Borght
Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium
Liver Int 28:1370-80. 2008....- Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat liversDavid Cassiman
Laboratory of Cell Pharmacology, Herestraat 49, B 3000 Leuven, Belgium
J Hepatol 36:200-9. 2002..We studied the distribution and expression profile of mesenchymal (myo)fibroblast-like populations in fibrotic and cirrhotic liver, in an attempt to elucidate their possible interrelationships... - The extent of vacuolation in non-heart-beating porcine donor liver grafts prior to transplantation predicts their viabilityDiethard Monbaliu
Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
Liver Transpl 14:1256-65. 2008..Further studies are now warranted to evaluate whether these anoxic changes that are associated with liver graft viability in pigs also apply to human NHBD liver biopsies... - The multidisciplinary management of gastrointestinal cancer. The diagnostic and therapeutic approach for primary solid liver tumours in adultsChris Verslype
Department of Hepatology and Digestive Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
Best Pract Res Clin Gastroenterol 21:983-96. 2007..Selected patients with primary liver cancer are candidates for liver transplantation, while patients with advanced malignant tumours have a poor outcome... - Progenitor cells in diseased human liverTania A Roskams
Laboratory of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
Semin Liver Dis 23:385-96. 2003..The factors that govern human hepatic progenitor cell activation and differentiation are beginning to be identified... - Forkhead box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation to diffuse large B-cell lymphomaXavier Sagaert
Department of Morphology and Molecular Pathology, and the Centre for Human Genetics, Catholic University Leuven, Leuven, Belgium
J Clin Oncol 24:2490-7. 2006..In this study, we investigated FOXP1 expression in its relationship to morphology, genetic features, and prognosis in a series of 70 MALT lymphomas... - A unique combination of celiac disease, mesenteric lymph node cavitation, splenic atrophy and necrotizing hepatitisT Cornelis
Department of Medicine, Division of Gastroenterology, University Hospitals Leuven, Leuven, Belgium
Acta Gastroenterol Belg 71:267-70. 2008..The causal relationship with celiac disease, if any, remains unproven... - A stable model of cirrhotic portal hypertension in the rat: thioacetamide revisitedW Laleman
Department pf Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
Eur J Clin Invest 36:242-9. 2006.... - Human hepatic progenitor cells express vasoactive intestinal peptide receptor type 2 and receive nerve endingsDavid Cassiman
Department of Hepatology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
Liver Int 27:323-8. 2007..VIP expressing nerves are known to be present in the liver... - Multifactorial biological modulation of warm ischemia reperfusion injury in liver transplantation from non-heart-beating donors eliminates primary nonfunction and reduces bile salt toxicityDiethard Monbaliu
Liver research facility Department of Abdominal Transplant Surgery, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
Ann Surg 250:808-17. 2009..To design a multifactorial biological modulation approach targeting ischemia reperfusion injury to augment viability of porcine liver grafts from non-heart-beating donors (NHBD)... - Clinicopathological features of focal nodular hyperplasia-like nodules in 130 cirrhotic explant liversLouis Libbrecht
Department of Pathology, University Hospitals Leuven, Leuven, Belgium
Am J Gastroenterol 101:2341-6. 2006.... - An adult male patient with multiple adenomas and a hepatocellular carcinoma: mild glycogen storage disease type IaDavid Cassiman
Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
J Hepatol 53:213-7. 2010.... 
The vagal nerve stimulates activation of the hepatic progenitor cell compartment via muscarinic acetylcholine receptor type 3David Cassiman
Laboratory of Cell Pharmacology, University of Leuven, Leuven, Belgium
Am J Pathol 161:521-30. 2002..These findings may be of clinical importance for patients with a transplant liver...- Molecular and clinico-pathological markers in rectal cancer: a tissue micro-array studyAnnelies Debucquoy
Department of Radiation Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
Int J Colorectal Dis 24:129-38. 2009..The aims of the study were to study the effect of pre-operative treatment on the expression of tumour-related proteins and to correlate the expression of these proteins with response and survival of patients with advanced rectal cancer... - Porphyria cutanea tarda and liver disease. A retrospective analysis of 17 cases from a single centre and review of the literatureDavid Cassiman
Department of Hepatology, University Hospital Gasthuisberg, University of Leuven, Belgium
Acta Gastroenterol Belg 71:237-42. 2008..g. HCV infection, haemochromatosis and especially alcoholic liver disease. We conducted a retrospective analysis on the prevalence of liver disorders in association with Porphyria Cutanea Tarda (PCT), in a university referral centre... - Molecular diagnostic approach to liver tissue as an ancillary tool for liver histopathologyLouis Libbrecht
Liver Research Unit of the Laboratory of Morphology and Molecular Pathology and Department of Pathology, University Hospitals of Leuven, Leuven, Belgium
Semin Liver Dis 26:328-36. 2006..It is very likely that ancillary molecular techniques will be applied in routine practice to improve diagnosis and prognostication of liver tumors in the foreseeable future... - Quantitation of replication of the HCV genome in human livers with end-stage cirrhosis by strand-specific real-time RT-PCR assays: methods and clinical relevanceLan Lin
Department of Hepatology, University Hospitals, Leuven, Belgium
J Med Virol 81:1569-75. 2009..This suggests the existence of an extra-hepatic location of HCV with comparable viral replication rate being responsible for the infection of the newly transplanted liver... - CC-type chemokine receptor 5-Delta32 mutation protects against primary sclerosing cholangitisLiesbet Henckaerts
Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
Inflamm Bowel Dis 12:272-7. 2006..We therefore investigated the role of the functional 32-bp deletion in this gene (CCR5-Delta32) with regard to susceptibility to PSC... - Orlistat treatment is safe in overweight and obese liver transplant recipients: a prospective, open label trialDavid Cassiman
Department of Hepatology, University Hospital Gasthuisberg, University of Leuven, Belgium
Transpl Int 19:1000-5. 2006..Orlistat treatment is well tolerated in liver transplant recipients and can be started safely, provided immunosuppressive drug levels and dietary adherence are closely monitored... - Molecular response to cetuximab and efficacy of preoperative cetuximab-based chemoradiation in rectal cancerAnnelies Debucquoy
Lab of Experimental Radiotherapy, Department of Radiation Oncology, CDG Building, Box 815, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
J Clin Oncol 27:2751-7. 2009.... - High expression of MDR1, MRP1, and MRP3 in the hepatic progenitor cell compartment and hepatocytes in severe human liver diseaseJenny E Ros
Center for the Study of Liver, Digestive and Metabolic Diseases, Groningen University Institute for Drug Exploration (GUIDE, University Hospital Groningen, Groningen, The Netherlands
J Pathol 200:553-60. 2003..In conclusion, MDR1, MRP1, and MRP3 are up-regulated in hepatocytes in severe human liver disease. Strong MDR1, MRP1, and MRP3 reactivity is seen in regenerating human bile ductules... - The beta-catenin pathway is activated in focal nodular hyperplasia but not in cirrhotic FNH-like nodulesSandra Rebouissou
INSERM, U674, Génomique fonctionnelle des tumeurs solides, 27 rue Juliette Dodu, Paris F 75010, France
J Hepatol 49:61-71. 2008..In contrast, FNH-like lesions/nodules occur in cirrhotic liver but share similar histopathological features. We conducted a transcriptome analysis to identify biological pathways deregulated in FNH... - Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liverJolanda van Hengel
Molecular Cell Biology Unit, VIB, Ghent, Belgium Department of Molecular Biology, Ghent University, Ghent, Belgium
Gastroenterology 134:781-92. 2008..This implies that Cdc42 might be required for liver function... - Epithelial expression of angiogenic growth factors modulate arterial vasculogenesis in human liver developmentLuca Fabris
CeLiveR, Center for Liver Research, Ospedali Riuniti di Bergamo, Bergamo, Italy
Hepatology 47:719-28. 2008.... - A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cellsJu-Seog Lee
Lab of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 4146, Bethesda, Maryland 20892, USA
Nat Med 12:410-6. 2006..Analyses of gene networks showed that activation of AP-1 transcription factors in this newly identified HCC subtype might have key roles in tumor development... - Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virusPhilip Meuleman
Center for Vaccinology, Ghent University and Hospital, Building A, First Floor, De Pintelaan 185, 9000 Ghent, Belgium
J Virol 80:2797-807. 2006..These lesions show much resemblance to the ones encountered in immunosuppressed chronic HBV patients. Our observations indicate that HBV may be directly cytopathic in conditions of severe immune suppression... - Influence of TIPS on development of hepatocellular carcinoma in cirrhosisLouis Libbrecht
Hepatology 42:236; author reply 236-7. 2005 - Lack of cilia and differentiation defects in the liver of human foetuses with the Meckel syndromeFrederic Clotman
Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
Liver Int 28:377-84. 2008..The aim of the present work was to investigate the formation of the primary cilia and the differentiation of the hepatic cells in foetuses with Meckel syndrome... - Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimeraPhilip Meuleman
Center for Vaccinology, Ghent University and Hospital, Ghent, Belgium
Hepatology 41:847-56. 2005..Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html)... - Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouseThomas Vanwolleghem
Center for Vaccinology, Ghent University and Hospital, Gent, Belgium
Gastroenterology 133:1144-55. 2007.... - Stellate-type scirrhous dysplastic nodules in liver cirrhosis: identical to focal nodular hyperplasia-like nodules?Louis Libbrecht
J Gastroenterol Hepatol 19:944-5. 2004 - Hepatic artery malformations associated with a primary defect in intrahepatic bile duct developmentFrederic Clotman
Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75, box 7529, B 1200 Brussels, Belgium
J Hepatol 39:686-92. 2003..Hepatic artery malformations are found in diseases in which fetal biliary structures persist after birth (ductal plate malformations). Here we investigated how hepatic artery malformations relate to abnormal bile duct development... - Human hepatocytes secrete soluble CD14, a process not directly influenced by HBV and HCV infectionPhilip Meuleman
Center for Vaccinology, Ghent University and Hospital, Building A, 1st Floor, De Pintelaan 185, B-9000 Ghent, Belgium
Clin Chim Acta 366:156-62. 2006..In addition we demonstrate that HBV and HCV infections have no direct influence on the production of sCD14 by human hepatocytes in this chimeric model... - Morphological features and molecular markers in rectal cancer from 95 patients included in the European Organisation for Research and Treatment of Cancer 22921 trial: prognostic value and effects of preoperative radio (chemo) therapyAnnelies Debucquoy
Department of Radiation Oncology, Leuven Cancer Institute, University Hospital Leuven, Belgium
Eur J Cancer 44:791-7. 2008..However, the fibro-inflammatory reaction after preoperative radiochemotherapy correlated with T-downstaging and seems to be an important factor for response... - Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levelsHans Blokzijl
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Inflamm Bowel Dis 13:710-20. 2007..Here we compared intestinal MDR1 mRNA and protein expression in uninflamed and inflamed intestinal epithelium (IE) of patients with gastrointestinal inflammatory disorders to healthy controls...