E Lesaffre

..The calculations are illustrated using data from anti-epileptic trials...

..The proposed method offers an opportunity to refine existing analytical approaches and is relevant to any health outcome study...

..Med. 1998; 17: 1863-1892). Finally, we propose a correction factor for Koch's test statistic that better preserves the type I error...

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..Analytic results will be given to quantify this risk and a simulation study illustrates our findings...

..In our analysis, we show that the dentition type and tooth or surface type affect the quality of caries experience detection...

..To review aspects of methods for assessing caries experience (CE) in epidemiological surveys...

..The second study is a twin study, where the association between the elements of twin pairs is of primary interest. The results show that smoothing on the association level can give a significant improvement to the model fit...

..The influence of perturbing a missing-at-random dropout model in the direction of nonrandom dropout is explored. The method is applied to data from a randomized experiment on the inhibition of testosterone production in rats...

..No significant benefit from restoring primary molars could be demonstrated, possibly because of methodological limitations...

..Finally, the analyses of the motivating problem are presented...

..This study describes the development and validation of a questionnaire to measure the determinants of oral health related behaviour in health care workers, based on the Theory of Planned Behaviour (TPB)...

..We conclude that the increased 7 alpha-dehydroxylation of tauroconjugated cholic acid depends on the reduction of taurine to H2S, which is a necessary growth factor for the 7 alpha-dehydroxylating bacteria...

..Different items are exemplified with articles that deal with the emergence of permanent teeth...

..Therefore, our aim was to study the occurrence and clinicopathological characteristics of HCC expressing CK7 and/or CK19 in 109 Caucasian patients...

..The 95 per cent confidence/credible intervals also possess good coverage properties, given that the point estimates perform good. The performance of the C-indices is evaluated on a real data set...

..Furthermore, it tries to answer some practical questions that may arise during the conduct of interim analyses in longitudinal trials. Simulations have been carried out to obtain insight in these practical considerations...

..To document the prevalence of low back pain (LBP) in Flemish adolescents and to recognize the association between perceived social support and affect and medical consultation and reduction of activities...

..Central to our paper is to provide appropriate statistical models to resolve some dental questions on emergence. The analyses are based on data from the longitudinal Signal-Tandmobiel study...

..Lower nursing unit staffing levels in the general nursing units were associated with high in-hospital mortality in units past the traditional cardiac surgery nursing units...

..A simulation study shows that our approach yields almost unbiased estimates of the regression and the smoothing parameters in small sample settings. Consistency of the estimates is shown in a particular case...

..Using our example, we illustrate how a non-differential misclassification process for each examiner can lead to differential misclassification overall...

..A simulation study evaluates the performance of our method which is also applied to the ECASS-1 stroke study...

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..For computational convenience, the computations are based on Markov chain Monte Carlo techniques. The proposed method is illustrated on the disease-free survival times of early breast cancer patients collected in the EORTC trial 10854...

..These variations 'cover' 84-88% of all sequences. The presentation of emergence sequences solely based on means or medians should thus be regarded as misleading...

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..For reimbursement purposes of pimecrolimus cream 1%, the Belgian authorities asked to document its consumption, its topical corticosteroid-sparing effect and quality of life within the routine clinical practice...

..The aim was to conduct a systematic review of the reported methodology of clinical studies using a split-mouth design published in dental journals over a 1-year period (2004)...

..A simulation study compares the performance of our approach with the two-sample Wilcoxon test and with OP regression. Finally, the different methods are illustrated on two data sets...

..To tackle the problem of the large number of left-censored observations a similar Finnish data set was introduced. Our analysis shows no convincing effect of fluoride-intake on caries development...

..4, p = 0.03)...

..The multiple survival analysis confirmed the major impact of the caries status of the deciduous dentition and self-reported oral hygiene habits on the incidence of cavities in permanent first molars...

..To determine the life span of cryopreserved homografts implanted in the right ventricular outflow tract and the factors influencing it...

..In conclusion, when considering permanent tooth emergence ages, caries experience in the primary dentition should be taken into account...

..The comparison is illustrated with simulations using a randomized clinical trial for toenail fungal infection...

..A flexible AFT model (avoiding parametric assumptions on the distribution of the error term) is described in greater detail and is used to solve a typical dental question in a longitudinal oral health study...

..Most mandibular teeth emerged significantly before their antagonists, in boys as well as in girls. These findings are in agreement with other studies on the emergence of permanent teeth...

..We investigated possible factors, including cardioplegia techniques, influencing hospital mortality in patients undergoing cardiac valve surgery...

..We illustrate our approach using data collected in a study on the prevalence of porcine cysticercosis with verification from external data...

..Caries experience in the primary molars had a more pronounced impact on the timing of emergence of the successors than exposure to any of the four fluoride parameters...

..Special attention is paid to the practical implications when setting up a non-inferiority trial. Illustrations are taken from a clinical trial in osteoarthritis and from thrombolytic research...

..Extensive simulations based on a toenail dermatophyte onychomycosis trial are used to illustrate our results...

..Personal or telephone contact methods are often used to increase attendance for mammography screening. A meta-analysis of the literature was performed to assess the overall effect of direct-contact recruitment on mammography participation...

..CONCLUSIONS: The Contegra conduit's performance was clearly superior to that of the control MH100 conduit when implanted in the pulmonary artery position in juvenile sheep for 5 months...

..Annual follow-up on the data published is intended to reveal the changes in the relative drug efficacy values of ACTs...

..Striking variation exists in the risk-adjusted adverse outcome rates across Belgian acute hospitals, revealing a large potential for quality gains that encourage further action...

..Little is known about their content. This study aimed to define and compare the content of PT and OT for stroke patients between 4 European rehabilitation centers...

..Data from a psychiatric trial, the Fluvoxamine (an antidepressant drug) study, are used to illustrate the methodology...

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..Outcome after first stroke varies significantly across Europe. This study was designed to compare motor and functional recovery after stroke between four European rehabilitation centers...

..The influence of the prior information on the final result may not be ignored. Guidance for the choice of prior information not in conflict with the data can be obtained from a set of statistics and indices (DIC, p(D), Bayes-p)...

..It was developed for the measurement of nursing care in acute hospitals. It is used to support healthcare management & policy decision making such as hospital financing and nurse staffing decisions...

..The aim of the present study was to identify differences in the use of time by stroke patients in 4 rehabilitation centers in 4 European countries...

..We apply our method to a study on caries with a misclassified longitudinal response...

..It will also be shown that the (95%) confidence interval is to be preferred over the p-value as a statistical inference tool...