T Lerut

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Anastomotic complications after esophagectomy
    T Lerut
    Department of Thoracic Surgery, University Hospitals Leuven, Belgium
    Dig Surg 19:92-8. 2002
  2. ncbi request reprint Extracapsular lymph node involvement is a negative prognostic factor in T3 adenocarcinoma of the distal esophagus and gastroesophageal junction
    T Lerut
    Catholic University Leuven, Department of Thoracic Surgery, UZ Gasthuisberg, Herestraat 49, Belgium
    J Thorac Cardiovasc Surg 126:1121-8. 2003
  3. ncbi request reprint Extended surgery for cancer of the esophagus and gastroesophageal junction
    T Lerut
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Herestraat 49, Leuven, Belgium
    J Surg Res 117:58-63. 2004
  4. pmc Three-field lymphadenectomy for carcinoma of the esophagus and gastroesophageal junction in 174 R0 resections: impact on staging, disease-free survival, and outcome: a plea for adaptation of TNM classification in upper-half esophageal carcinoma
    T Lerut
    Department of Thoracic Surgery, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Ann Surg 240:962-72; discussion 972-4. 2004
  5. ncbi request reprint Cancer of the esophagus and gastro-esophageal junction: potentially curative therapies
    T Lerut
    Department Thoracic Surgery, Catholic University Leuven, U Z Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
    Surg Oncol 10:113-22. 2001
  6. ncbi request reprint Optimizing treatment of carcinoma of the esophagus and gastroesophageal junction
    T Lerut
    Department of Thoracic Surgery, Hospital Gasthuisberg, K U Leuven, Belgium
    Surg Oncol Clin N Am 10:863-84, x. 2001
  7. ncbi request reprint Quality in the surgical treatment of cancer of the esophagus and gastroesophageal junction
    T Lerut
    Department Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Surg Oncol 31:587-94. 2005
  8. pmc Histopathologic validation of lymph node staging with FDG-PET scan in cancer of the esophagus and gastroesophageal junction: A prospective study based on primary surgery with extensive lymphadenectomy
    T Lerut
    Departments of Thoracic Surgery, Nuclear Medicine, Pathology, Internal Medicine, and Radiology, University Hospital Gasthuisberg, Leuven, Belgium
    Ann Surg 232:743-52. 2000
  9. ncbi request reprint Surgical techniques
    T Lerut
    Department of Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Surg Oncol 92:218-29. 2005
  10. ncbi request reprint Diagnosis and therapy in advanced cancer of the esophagus and the gastroesophageal junction
    Toni Lerut
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
    Curr Opin Gastroenterol 22:437-41. 2006

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Anastomotic complications after esophagectomy
    T Lerut
    Department of Thoracic Surgery, University Hospitals Leuven, Belgium
    Dig Surg 19:92-8. 2002
    ..As to the management, most leaks can be treated by conservative measures and reintervention surgery today is rather exceptional. Early endoscopy and dilatation seem to decrease the incidence and severity of anastomotic stenosis...
  2. ncbi request reprint Extracapsular lymph node involvement is a negative prognostic factor in T3 adenocarcinoma of the distal esophagus and gastroesophageal junction
    T Lerut
    Catholic University Leuven, Department of Thoracic Surgery, UZ Gasthuisberg, Herestraat 49, Belgium
    J Thorac Cardiovasc Surg 126:1121-8. 2003
    ..All patients underwent primary R0 esophagectomy. The mean number of resected nodes per patient was 36.9. Survival was analyzed according to intracapsular and extracapsular involvement...
  3. ncbi request reprint Extended surgery for cancer of the esophagus and gastroesophageal junction
    T Lerut
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Herestraat 49, Leuven, Belgium
    J Surg Res 117:58-63. 2004
    ..It appears that positive cervical lymph nodes in patients with middle or proximal third carcinoma should no longer be considered as M(1a/b) distant lymph node metastasis but rather as N(1) regional disease...
  4. pmc Three-field lymphadenectomy for carcinoma of the esophagus and gastroesophageal junction in 174 R0 resections: impact on staging, disease-free survival, and outcome: a plea for adaptation of TNM classification in upper-half esophageal carcinoma
    T Lerut
    Department of Thoracic Surgery, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Ann Surg 240:962-72; discussion 972-4. 2004
    ..To determine the impact of esophagectomy with 3-field lymphadenectomy on staging, disease-free survival, and 5-year survival in patients with carcinoma of the esophagus and gastroesophageal junction (GEJ)...
  5. ncbi request reprint Cancer of the esophagus and gastro-esophageal junction: potentially curative therapies
    T Lerut
    Department Thoracic Surgery, Catholic University Leuven, U Z Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
    Surg Oncol 10:113-22. 2001
    ..In early carcinoma T(is)-T(1a) endoluminal ablation technique seem to open promising perspectives provided of discrimination between T(is)-T(1a) and T(1b) can be made by the use of 20mhz EUS probes...
  6. ncbi request reprint Optimizing treatment of carcinoma of the esophagus and gastroesophageal junction
    T Lerut
    Department of Thoracic Surgery, Hospital Gasthuisberg, K U Leuven, Belgium
    Surg Oncol Clin N Am 10:863-84, x. 2001
    ..Future research, therefore, needs to focus on early identification of responders (e.g., through molecular biology) and new chemotherapeutic drugs with higher impact on tumor response and fewer side effects...
  7. ncbi request reprint Quality in the surgical treatment of cancer of the esophagus and gastroesophageal junction
    T Lerut
    Department Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Surg Oncol 31:587-94. 2005
    ..These improvements in outcome should become the gold standard to which all other therapeutic regimens should be compared. Poor surgical quality and related poor results should not be a justification for multimodality regimen...
  8. pmc Histopathologic validation of lymph node staging with FDG-PET scan in cancer of the esophagus and gastroesophageal junction: A prospective study based on primary surgery with extensive lymphadenectomy
    T Lerut
    Departments of Thoracic Surgery, Nuclear Medicine, Pathology, Internal Medicine, and Radiology, University Hospital Gasthuisberg, Leuven, Belgium
    Ann Surg 232:743-52. 2000
    ..To assess the value of positron emission tomography with 18fluorodeoxyglucose (FDG-PET) for preoperative lymph node staging of patients with primary cancer of the esophagus and gastroesophageal junction...
  9. ncbi request reprint Surgical techniques
    T Lerut
    Department of Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Surg Oncol 92:218-29. 2005
    ..With overall 5-year survival currently exceeding 30%-40%, these figures should be the gold standard against which all other therapeutic modalities are compared...
  10. ncbi request reprint Diagnosis and therapy in advanced cancer of the esophagus and the gastroesophageal junction
    Toni Lerut
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
    Curr Opin Gastroenterol 22:437-41. 2006
    ..The aim of this article is to discuss recent developments in the diagnosis and treatment with curative option of advanced cancer of the esophagus and gastroesophageal junction...
  11. ncbi request reprint Induction therapy for clinical T4 oesophageal carcinoma; a plea for continued surgical exploration
    D Van Raemdonck
    Department of Thoracic Surgery, University Hospitals, UZ Gasthuisberg, Leuven, Belgium
    Eur J Cardiothorac Surg 11:828-37. 1997
    ..The use of induction therapy prior to surgical exploration in patients with these clinical T4 tumours is anticipated to improve the resectability rate...
  12. ncbi request reprint Result of induction chemotherapy followed by surgery in patients with stage IIIA N2 NSCLC: importance of pre-treatment mediastinoscopy
    P De Leyn
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Catholic University, Leuven, Belgium
    Eur J Cardiothorac Surg 15:608-14. 1999
    ..The aim of this study was to look at the correlation between downstaging, survival and pre-treatment staging...
  13. ncbi request reprint Morbidity and mortality after induction chemotherapy followed by surgery in IIIa-N2 non small cell lung cancer
    Ph Borreman
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
    Acta Chir Belg 109:333-9. 2009
    ..To evaluate the frequency and risk of postoperative complications and mortality in patients with IIIa-N2 non small cell lung cancer after induction chemotherapy and surgery...
  14. ncbi request reprint Effects of preoperative chemoradiotherapy on postsurgical morbidity and mortality in cT3-4 +/- cM1lymph cancer of the oesophagus and gastro-oesophageal junction
    O Hagry
    Department of Thoracic Surgery, University Hospitals, U Z Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Cardiothorac Surg 24:179-86; discussion 186. 2003
    ..This study assessed the effects of induction chemoradiotherapy on post-operative course after resection of locally advanced oesophageal carcinoma (cT3-4 + cM1lymph)...
  15. ncbi request reprint Present status of induction treatment in stage IIIA-N2 non-small cell lung cancer: a review. The Leuven Lung Cancer Group
    J Vansteenkiste
    Department of Pulmonology, University Hospital Gasthuisberg, Catholic University, Leuven, Belgium
    Eur J Cardiothorac Surg 13:1-12. 1998
    ..Theoretical concepts suggest a beneficial role for preoperative induction treatment. The solidity of the therapeutic results with this approach in the currently available data is examined...
  16. doi request reprint Cervical videomediastinoscopy
    T Lerut
    Department of Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Thorac Surg Clin 20:195-206. 2010
    ..This article discusses the current deployment of videomediastinoscopy in the diagnosis and management of NSCLC...
  17. ncbi request reprint Sleeve lobectomy for non-small cell lung cancer
    P De Leyn
    Department of Thoracic Surgery, University Hospital Leuven, Herestraat 49, 3000 Leuven
    Acta Chir Belg 103:570-6. 2003
    ..It is the aim of this study to describe the technique of sleeve lobectomy and to analyse the early postoperative results and late results (survival-recurrence) after sleeve lobectomy for non-small-cell lung cancer...
  18. ncbi request reprint European trends in preoperative and intraoperative nodal staging: ESTS guidelines
    P De Leyn
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
    J Thorac Oncol 2:357-61. 2007
    ..We hope that the adherence to these guidelines will standardize and improve preoperative and intraoperative LN staging and pathologic evaluation of non-small cell lung cancer...
  19. doi request reprint The lectin-like domain of thrombomodulin protects against ischaemia-reperfusion lung injury
    N Geudens
    Laboratory of Experimental Thoracic Surgery, University of Leuven, Leuven, Belgium
    Eur Respir J 32:862-70. 2008
    ..These novel findings support further evaluation of recombinant lectin-like domain of thrombomodulin to protect the lung against tissue-damaging pro-inflammatory responses following ischaemia-reperfusion...
  20. ncbi request reprint Cyclophosphamide rescue therapy for chronic rejection after lung transplantation
    G M Verleden
    Department of Respiratory Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    J Heart Lung Transplant 18:1139-42. 1999
    ..We therefore conducted an open, uncontrolled study to look at the effect of cyclophosphamide rescue therapy in the treatment of chronic rejection in lung transplant recipients...
  21. ncbi request reprint The role of acid and duodenal gastroesophageal reflux in symptomatic GERD
    G H Koek
    Center for Gastroenterological Research, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Gastroenterol 96:2033-40. 2001
    ..CONCLUSIONS: Symptom episodes in patients with presumed GERD are more related to acid reflux than to DGER. DGER does not play a major role in producing typical esophageal symptoms...
  22. ncbi request reprint Do cell kinetics have prognostic and/or predictive value in oesophageal cancer treated by surgery?
    K Haustermans
    Department of Radiotherapy, University Hospital, Leuven, Belgium
    Eur J Surg Oncol 23:293-7. 1997
    ....
  23. ncbi request reprint Pulmonary sequestration: a comparison between pediatric and adult patients
    D Van Raemdonck
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Cardiothorac Surg 19:388-95. 2001
    ..Modern large single institutional reports on pulmonary sequestration (PS) are extremely rare. We were interested in comparing patients with PS referred by our pediatric versus adult pulmonologists...
  24. ncbi request reprint Role of FDG-PET scan in staging of cancer of the esophagus and gastroesophageal junction
    T Lerut
    Department Thoracic Surgery, Catholic University Hospital Gathuisberg, Leuven, Belgium
    Minerva Chir 57:837-45. 2002
    ..FDG-PET scan has generated in recent years an increasing interest in staging and assessment of response to treatment in cancer patients...
  25. ncbi request reprint Position of positron emission tomography and other imaging diagnostic modalities in esophageal cancer
    P Flamen
    Department of Nuclear Medicine, University Hospital Leuven, Leuven, Belgium
    Q J Nucl Med Mol Imaging 48:96-108. 2004
    ....
  26. doi request reprint Quality indicators of surgery for adenocarcinoma of the esophagus and gastroesophageal junction
    Toni Lerut
    Department of Thoracic and Esophageal Surgery, University Hospitals Leuven, 3000, Leuven, Belgium
    Recent Results Cancer Res 182:127-42. 2010
    ..Improvements in this wide spectrum of aspects is mandatory and will certainly be of great value to further improve both short and long term outcome after surgery for these complex cancers...
  27. ncbi request reprint Is there a role for FGD-PET in radiotherapy planning in esophageal carcinoma?
    Olga Vrieze
    Department of Radiation Oncology, University Hospital Gasthuisberg, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Radiother Oncol 73:269-75. 2004
    ..To determine the additional value of FDG-positron emission tomography (PET) to optimize delineation of the clinical target volume (CTV) in patients with advanced esophageal carcinoma...
  28. doi request reprint Multivariate analysis of the association of acid and duodeno-gastro-oesophageal reflux exposure with the presence of oesophagitis, the severity of oesophagitis and Barrett's oesophagus
    G H Koek
    Center for Gastroenterological Research, University Hospital Gasthuisberg, Leuven, Belgium
    Gut 57:1056-64. 2008
    ..It is unknown whether DGOR exposure is an independent risk factor for oesophageal lesions. A multivariate analysis was performed on the relationship between oesophageal lesions and demographics and acid and DGOR exposure...
  29. ncbi request reprint Is adenocarcinoma of the esophagogastric junction or cardia different from Barrett adenocarcinoma?
    Nadine Ectors
    Department of Pathology, University Hospitals Leuven, KULeuven, Belgium
    Arch Pathol Lab Med 129:183-5. 2005
    ..Unfortunately, this confusion is also apparent in the classification systems available for staging of cancer, thus closing the "vicious" circle...
  30. ncbi request reprint Prospective comparative study of integrated positron emission tomography-computed tomography scan compared with remediastinoscopy in the assessment of residual mediastinal lymph node disease after induction chemotherapy for mediastinoscopy-proven stage II
    Paul De Leyn
    Department of Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Clin Oncol 24:3333-9. 2006
    ....
  31. ncbi request reprint The importance of lymphocytes in lung ischemia-reperfusion injury
    N Geudens
    Department of Laboratory of Experimental Thoracic Surgery, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    Transplant Proc 39:2659-62. 2007
    ..We concluded that lymphocytes invading the lung during ischemia trigger an inflammatory response upon reperfusion. Antilymphocyte therapies in the donor should be further investigated as treatment strategies against IRI...
  32. doi request reprint Outcome after esophagectomy for cancer of the esophagus and GEJ in patients aged over 75 years
    Eveline Internullo
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
    Eur J Cardiothorac Surg 33:1096-104. 2008
    ..This study is a single institution retrospective analysis of outcome after esophagectomy for cancer of the esophagus and GEJ in patients aged over 75 years...
  33. doi request reprint Surgical multimodality treatment for baseline resectable stage IIIA-N2 non-small cell lung cancer. Degree of mediastinal lymph node involvement and impact on survival
    Herbert Decaluwe
    Leuven Lung Cancer Group, Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium
    Eur J Cardiothorac Surg 36:433-9. 2009
    ..Analysis of single centre results and identification of prognostic factors of surgical combined modality treatment in pathological proven stage IIIA-N2 non-small cell lung cancer (NSCLC)...
  34. ncbi request reprint Exhaled nitric oxide after lung transplantation: impact of the native lung
    G M Verleden
    Dept of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    Eur Respir J 21:429-32. 2003
    ..The diseased native lung after single lung transplantation probably does not contribute much to the exhaled nitric oxide values, either in stable lung transplant patients or in lung transplant patients with chronic rejection...
  35. doi request reprint Multidisciplinary treatment of advanced cancer of the esophagus and gastroesophageal junction: a European center's approach
    Toni Lerut
    Department of Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Surg Oncol Clin N Am 17:485-502, vii-viii. 2008
    ..Therefore, further efforts are needed to elaborate more precise algorithms for selecting candidates for induction therapy versus primary surgery...
  36. doi request reprint Postoperative complications after transthoracic esophagectomy for cancer of the esophagus and gastroesophageal junction are correlated with early cancer recurrence: role of systematic grading of complications using the modified Clavien classification
    Toni Lerut
    From the Department of Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Ann Surg 250:798-807. 2009
    ..To assess the impact of postoperative complications after transthoracic esophagectomy, using the modified Clavien classification, on recurrence and on its timing in patients with cancer of the esophagus or gastroesophageal junction...
  37. ncbi request reprint Spontaneous haemopneumothorax
    H Mufty
    Dpt of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium
    Acta Chir Belg 111:323-6. 2011
    ..In haemodynamic stable patients without any contra-indications, VATS is the preferred treatment method. However there's still discussion about the timing of surgery in hemodynamically instable patients...
  38. ncbi request reprint Methemoglobinemia and hemolysis after enteral administration of methylene blue in a preterm infant: relevance for pediatric surgeons
    K Allegaert
    Neonatal Intensive Care Unit, Department of Paediatrics, University Hospitals, Gasthuisberg, Leuven, Belgium
    J Pediatr Surg 39:E35-7. 2004
    ..The dye was administered to exclude a tracheoesophageal fistula. Methylene blue is a noxious product, especially in neonates. It should be considered a potential cause of acquired methemoglobulinemia, even after enteral administration...
  39. ncbi request reprint Pulmonary vascular morphology in a fetal rabbit model for congenital diaphragmatic hernia
    X Roubliova
    Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    J Pediatr Surg 39:1066-72. 2004
    ..For this reason, detailed studies in well-validated animal models could still be of significance in our understanding of the pathogenesis of CDH...
  40. ncbi request reprint A one-year follow-up study of endoluminal gastroplication (Endocinch) in GERD patients refractory to proton pump inhibitor therapy
    J Arts
    Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium
    Dig Dis Sci 50:351-6. 2005
    ..We conclude that EG provides short- and medium-term symptomatic and objective relief to a subset of GERD patients refractory to high-dose PPI...
  41. doi request reprint Minimally invasive esophagectomy for cancer
    Georges Decker
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Cardiothorac Surg 35:13-20; discussion 20-1. 2009
    ..Oncological outcome of MIE remains largely unknown by lack of good quality data and selection bias. MIE remains an investigational and still evolving treatment for invasive cancer...
  42. doi request reprint The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resection
    Christian G Peyre
    Department of Surgery, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA
    Ann Surg 248:549-56. 2008
    ..Surveillance, Epidemiology and End Results (SEER) data indicate that number of lymph nodes removed impacts survival in gastric cancer. Our aim was to study this relationship in esophageal cancer...
  43. pmc Expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein, rather than vascular-endothelial growth factor (VEGF), a pro-angiogenic factor, correlates with an extremely poor prognosis in esophageal and gastric adenocarcinomas
    Ann Driessen
    Department of Pathology, University Hospital Maastricht, Maastricht, The Netherlands
    Ann Surg 243:334-40. 2006
    ..To evaluate the expression of carbonic anhydrase IX (CA IX) and vascular-endothelial growth factor (VEGF) in esophageal and gastric adenocarcinomas and in turn with the histologic subtype...
  44. ncbi request reprint ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer
    Didier Lardinois
    Department of Thoracic Surgery, University Hospital, Zurich, Switzerland
    Eur J Cardiothorac Surg 30:787-92. 2006
    ..The adherence to these guidelines will standardize the intraoperative lymph node staging and pathologic evaluation, and improve pathologic staging, which will help decide on the best adjuvant therapy...
  45. ncbi request reprint Risk factors for airway complications within the first year after lung transplantation
    Caroline van de Wauwer
    Department of Thoracic Surgery, UZ Leuven, Belgium
    Eur J Cardiothorac Surg 31:703-10. 2007
    ..Nevertheless, airway anastomotic complications (AC) are still a potential cause of early morbidity and mortality. In this retrospective cohort study we looked at possible predictors of AC within the first year after LTx...
  46. ncbi request reprint Laparoscopic Nissen fundoplication in infants and children: analysis of 106 consecutive patients with special emphasis in neurologically impaired vs. neurologically normal patients
    Jan Mathei
    Thoracic Surgery, University Hospitals Gasthuisberg, 3000, Leuven, Belgium
    Surg Endosc 22:1054-9. 2008
    ..In this study we describe our 8-year experience with 106 consecutive laparoscopic Nissen fundoplications...