Lies Langouche

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. doi request reprint Anterior pituitary morphology and hormone production during sustained critical illness in a rabbit model
    L Langouche
    Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
    Horm Metab Res 45:277-82. 2013
  2. ncbi request reprint Impact of early nutrient restriction during critical illness on the nonthyroidal illness syndrome and its relation with outcome: a randomized, controlled clinical study
    Lies Langouche
    Clinical Department and Laboratory of Intensive Care Medicine, Division Cellular and Molecular Medicine, University of Leuven KU Leuven, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 98:1006-13. 2013
  3. pmc Critical illness induces alternative activation of M2 macrophages in adipose tissue
    Lies Langouche
    Laboratory and Department of Intensive Care Medicine, K U Leuven, Herestraat 49, 3000 Leuven, Belgium
    Crit Care 15:R245. 2011
  4. pmc Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin
    Lies Langouche
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Crit Care 13:R112. 2009
  5. doi request reprint Alterations in adipose tissue during critical illness: An adaptive and protective response?
    Lies Langouche
    Department and Laboratory of Intensive Care Medicine, Katholieke Universiteit Leuven, Belgium
    Am J Respir Crit Care Med 182:507-16. 2010
  6. ncbi request reprint Impact of parenteral nutrition versus fasting on hepatic bile acid production and transport in a rabbit model of prolonged critical illness
    Yoo Mee Vanwijngaerden
    Laboratory and Department of Intensive Care Medicine, University Hospitals KU Leuven, Leuven, Belgium and Storr Liver Unit, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia
    Shock 41:48-54. 2014
  7. ncbi request reprint Contribution of nutritional deficit to the pathogenesis of the nonthyroidal illness syndrome in critical illness: a rabbit model study
    Liese Mebis
    Laboratory of Intensive Care Medicine, University of Leuven, Herestraat 49, bus 503, B 3000 Leuven, Belgium
    Endocrinology 153:973-84. 2012
  8. pmc Effect of tight glucose control with insulin on the thyroid axis of critically ill children and its relation with outcome
    Marijke Gielen
    Clinical Department and Laboratory of Intensive Care Medicine, Catholic University of Leuven, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 97:3569-76. 2012
  9. doi request reprint Expression of thyroid hormone transporters during critical illness
    Liese Mebis
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Eur J Endocrinol 161:243-50. 2009
  10. pmc Changes in the central component of the hypothalamus-pituitary-thyroid axis in a rabbit model of prolonged critical illness
    Liese Mebis
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Herestraat 49, Leuven B 3000, Belgium
    Crit Care 13:R147. 2009

Detail Information

Publications37

  1. doi request reprint Anterior pituitary morphology and hormone production during sustained critical illness in a rabbit model
    L Langouche
    Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
    Horm Metab Res 45:277-82. 2013
    ....
  2. ncbi request reprint Impact of early nutrient restriction during critical illness on the nonthyroidal illness syndrome and its relation with outcome: a randomized, controlled clinical study
    Lies Langouche
    Clinical Department and Laboratory of Intensive Care Medicine, Division Cellular and Molecular Medicine, University of Leuven KU Leuven, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 98:1006-13. 2013
    ..The contribution of restricted nutrition during critical illness in the pathophysiology of NTI remains unclear...
  3. pmc Critical illness induces alternative activation of M2 macrophages in adipose tissue
    Lies Langouche
    Laboratory and Department of Intensive Care Medicine, K U Leuven, Herestraat 49, 3000 Leuven, Belgium
    Crit Care 15:R245. 2011
    ..However, the characteristics of adipose tissue macrophage accumulation in critical illness remain unknown...
  4. pmc Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin
    Lies Langouche
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Crit Care 13:R112. 2009
    ..Recently, several hormones secreted by adipose tissue have been identified to be involved in overall insulin sensitivity in metabolic syndrome-related conditions. However, little is known about these adipokines in critical illness...
  5. doi request reprint Alterations in adipose tissue during critical illness: An adaptive and protective response?
    Lies Langouche
    Department and Laboratory of Intensive Care Medicine, Katholieke Universiteit Leuven, Belgium
    Am J Respir Crit Care Med 182:507-16. 2010
    ..Overweight and obese critically ill patients may have a lower risk of death than lean patients, suggestive of a protective role for adipose tissue during illness...
  6. ncbi request reprint Impact of parenteral nutrition versus fasting on hepatic bile acid production and transport in a rabbit model of prolonged critical illness
    Yoo Mee Vanwijngaerden
    Laboratory and Department of Intensive Care Medicine, University Hospitals KU Leuven, Leuven, Belgium and Storr Liver Unit, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia
    Shock 41:48-54. 2014
    ..Cholestatic liver dysfunction frequently occurs during critical illness. Administration of parenteral nutrition (PN) is thought to aggravate this. Underlying mechanisms are not clear...
  7. ncbi request reprint Contribution of nutritional deficit to the pathogenesis of the nonthyroidal illness syndrome in critical illness: a rabbit model study
    Liese Mebis
    Laboratory of Intensive Care Medicine, University of Leuven, Herestraat 49, bus 503, B 3000 Leuven, Belgium
    Endocrinology 153:973-84. 2012
    ..In conclusion, in this rabbit model of sustained critical illness, reduced circulating T(3), but not T(4), levels could be prevented by parenteral nutrition, which may be mediated by leptin and its actions on tissue deiodinase activity...
  8. pmc Effect of tight glucose control with insulin on the thyroid axis of critically ill children and its relation with outcome
    Marijke Gielen
    Clinical Department and Laboratory of Intensive Care Medicine, Catholic University of Leuven, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 97:3569-76. 2012
    ..In adults, TGC did not affect the illness-induced alterations in thyroid hormones. With better feeding in children than in adult patients, we hypothesized that TGC in pediatric ICU patients reactivates the thyroid axis...
  9. doi request reprint Expression of thyroid hormone transporters during critical illness
    Liese Mebis
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Eur J Endocrinol 161:243-50. 2009
    ..We examined the role of TH transporters monocarboxylate transporter 8 (MCT8, also known as SLC16A2) and MCT10 in the pathogenesis of the low T(3) syndrome in prolonged critical illness...
  10. pmc Changes in the central component of the hypothalamus-pituitary-thyroid axis in a rabbit model of prolonged critical illness
    Liese Mebis
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Herestraat 49, Leuven B 3000, Belgium
    Crit Care 13:R147. 2009
    ....
  11. doi request reprint Modulation of regional nitric oxide metabolism: blood glucose control or insulin?
    Bjorn Ellger
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, 3000, Leuven, Belgium
    Intensive Care Med 34:1525-33. 2008
    ....
  12. ncbi request reprint Effect of intensive insulin therapy on insulin sensitivity in the critically ill
    Lies Langouche
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, B 3000, Leuven, Belgium
    J Clin Endocrinol Metab 92:3890-7. 2007
    ..Blood glucose control explains this benefit because a high insulin dose is associated with adverse outcome. Mitogenic insulin effects could theoretically explain this link...
  13. ncbi request reprint Tight blood glucose control: what is the evidence?
    Ilse Vanhorebeek
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 35:S496-502. 2007
    ..In conclusion, demonstration of the clinical benefits of intensive insulin therapy depends on the quality of blood glucose control and the statistical power of the studies...
  14. doi request reprint Glycemic control modulates arginine and asymmetrical-dimethylarginine levels during critical illness by preserving dimethylarginine-dimethylaminohydrolase activity
    Bjorn Ellger
    Department of Intensive Care Medicine, Catholic University of Leuven, 3000 Leuven, Belgium
    Endocrinology 149:3148-57. 2008
    ..Conclusively, maintenance of normoglycemia and not glycemia-independent actions of insulin maintained physiological ADMA plasma and tissue levels by preserving physiological DDAH activity...
  15. ncbi request reprint Therapy insight: the effect of tight glycemic control in acute illness
    Lies Langouche
    Katholieke Universiteit Leuven, Belgium
    Nat Clin Pract Endocrinol Metab 3:270-8. 2007
    ..Prevention of glucose toxicity by strict glycemic control (but also other metabolic and nonmetabolic effects of insulin) contribute to these clinical benefits...
  16. ncbi request reprint Tight blood glucose control with insulin in the ICU: facts and controversies
    Ilse Vanhorebeek
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Chest 132:268-78. 2007
    ..The risk of hypoglycemia increases with this therapy, but it remains unclear whether this is truly harmful in the setting of critical care...
  17. doi request reprint Tight glycemic control protects the myocardium and reduces inflammation in neonatal heart surgery
    Dirk Vlasselaers
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Belgium
    Ann Thorac Surg 90:22-9. 2010
    ..We hypothesized that insulin-titrated TGC, initiated prior to myocardial ischemia and reperfusion, protects the myocardium and attenuates the inflammatory response after neonatal cardiac surgery...
  18. ncbi request reprint Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin
    Bjorn Ellger
    Department of Intensive Care Medicine, Catholic University of Leuven, B 3000 Leuven, Belgium
    Diabetes 55:1096-105. 2006
    ..The results suggest that the observed benefits of intensive insulin therapy required mainly maintenance of normoglycemia; whereas glycemia-independent actions of insulin exerted only minor, organ-specific impact...
  19. ncbi request reprint Impact of early parenteral nutrition on muscle and adipose tissue compartments during critical illness
    Michael P Casaer
    1Department and Laboratory of Intensive Care Medicine, University Hospitals Leuven, KU Leuven, Leuven, Belgium 2Department of Radiology, University Hospitals Leuven, KU Leuven, Leuven, Belgium
    Crit Care Med 41:2298-309. 2013
    ..However, such effect has not been proven. This study aimed to assess the effect of early administration of parenteral nutrition on muscle volume and composition by repeated quantitative CT...
  20. ncbi request reprint Indication and practical use of intensive insulin therapy in the critically ill
    Liese Mebis
    Department of Intensive Care Medicine, Catholic University of Leuven, Leuven, Belgium
    Curr Opin Crit Care 13:392-8. 2007
    ..This review gives an overview of the benefits associated with this therapy and highlights the importance of achieving optimal blood glucose levels. It discusses the indications for this therapy and the fear for potential harm...
  21. ncbi request reprint Molecular mechanisms behind clinical benefits of intensive insulin therapy during critical illness: glucose versus insulin
    Ilse Vanhorebeek
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Best Pract Res Clin Anaesthesiol 23:449-59. 2009
    ..Next, the molecular basis of glucose toxicity in critical illness and the impact of intensive insulin therapy hereon are described, as well as other non-glucose-toxicity-related metabolic effects of intensive insulin therapy...
  22. ncbi request reprint Withholding parenteral nutrition during critical illness increases plasma bilirubin but lowers the incidence of biliary sludge
    Yoo Mee Vanwijngaerden
    University Hospitals of the KU Leuven, Intensive Care Medicine and Department of Molecular and Cellular Medicine, Leuven, Belgium
    Hepatology 60:202-10. 2014
    ..01). Glycine/taurine-conjugated primary BAs increased over time in ICU (P < 0.01), similarly for the two groups. Fewer patients in the late PN than in the early PN group developed biliary sludge on day 5 (37% versus 45%; P = 0.04)...
  23. doi request reprint Endocrine, metabolic, and morphologic alterations of adipose tissue during critical illness
    Mirna B Marques
    Department and Laboratory of Intensive Care Medicine, KU Leuven, Belgium
    Crit Care Med 41:317-25. 2013
    ..Observational studies report lower mortality in obese than in lean critically ill patients, an association referred to as the "obesity paradox." This may suggest a possible protective role for adipose tissue during severe illness...
  24. pmc Intensive insulin therapy protects the endothelium of critically ill patients
    Lies Langouche
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 115:2277-86. 2005
    ....
  25. ncbi request reprint Intensive insulin therapy in the intensive care unit: update on clinical impact and mechanisms of action
    Ilse Vanhorebeek
    Department of Intensive Care Medicine, Katholieke Universiteit, Leuven, Leuven, Belgium
    Endocr Pract 12:14-22. 2006
    ....
  26. doi request reprint Critical illness evokes elevated circulating bile acids related to altered hepatic transporter and nuclear receptor expression
    Yoo Mee Vanwijngaerden
    Laboratory and Department of Intensive Care Medicine, University Hospitals KU Leuven, Belgium
    Hepatology 54:1741-52. 2011
    ..Immunostaining showed marked down-regulation of nuclear farnesoid X receptor, retinoid X receptor alpha, constitutive androstane receptor, and pregnane X receptor nuclear protein levels...
  27. doi request reprint Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit
    Liesbet Henckaerts
    Department of Medicine, Catholic University of Leuven, Leuven, Belgium
    Crit Care Med 37:192-201, e1-3. 2009
    ..Our aim was to study the influence of single nucleotide polymorphisms in selected genes involved in innate immunity on the development of bacteremia or risk of death in patients admitted to a medical intensive care unit...
  28. ncbi request reprint Effect of insulin therapy on coagulation and fibrinolysis in medical intensive care patients
    Lies Langouche
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 36:1475-80. 2008
    ..We hypothesize that intensive insulin therapy also prevents severe coagulation abnormalities thereby contributing to less organ failure and better survival...
  29. ncbi request reprint Modulating the endocrine response in sepsis: insulin and blood glucose control
    Ilse Vanhorebeek
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Novartis Found Symp 280:204-15; discussion 215-22. 2007
    ..Prevention of cellular glucose toxicity by strict glycaemic control appears to play a predominant role, but also other metabolic and non-metabolic effects of insulin appear to contribute to the clinical benefits...
  30. ncbi request reprint Glucose metabolism and insulin therapy
    Lies Langouche
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Crit Care Clin 22:119-29, vii. 2006
    ..Prevention of glucose toxicity by strict glycemic control but also other metabolic and non-metabolic effects of insulin contribute to these clinical benefits...
  31. doi request reprint Reduced cortisol metabolism during critical illness
    Eva Boonen
    Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
    N Engl J Med 368:1477-88. 2013
    ..However, low corticotropin levels have also been reported in critically ill patients, which may be due to reduced cortisol metabolism...
  32. ncbi request reprint The role of insulin therapy in critically ill patients
    Lies Langouche
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Treat Endocrinol 4:353-60. 2005
    ..In addition to its metabolic effects, intensive insulin therapy also prevented excessive inflammation and improved immune function...
  33. ncbi request reprint The dynamic neuroendocrine response to critical illness
    Lies Langouche
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Herestraat 49, B 300 Leuven, Belgium
    Endocrinol Metab Clin North Am 35:777-91, ix. 2006
    ..In contrast, in prolonged critical illness, uniform suppression of the neuroendocrine axes, predominantly of hypothalamic origin, contributes to low serum levels of the respective target-organ hormones...
  34. ncbi request reprint The type II iodothyronine deiodinase is up-regulated in skeletal muscle during prolonged critical illness
    Liese Mebis
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 92:3330-3. 2007
    ..Critical illness is associated with the low T(3) syndrome. It remains unclear whether altered type II deiodinase activity (D2) in skeletal muscle contributes to this syndrome...
  35. ncbi request reprint Endocrine aspects of acute and prolonged critical illness
    Ilse Vanhorebeek
    University of Leuven, Belgium
    Nat Clin Pract Endocrinol Metab 2:20-31. 2006
    ....
  36. doi request reprint Molecular analysis of sepsis-induced changes in the liver: microarray study in a porcine model of acute fecal peritonitis with fluid resuscitation
    Hannah van Malenstein
    Liver Research Facility and Labo Hepatology, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Shock 34:427-36. 2010
    ..Induction of inflammatory mediators by sepsis was supported by the detection of corresponding cytokines (interleukin 6 and interleukin 8) in the blood...
  37. ncbi request reprint Glycemic and nonglycemic effects of insulin: how do they contribute to a better outcome of critical illness?
    Ilse Vanhorebeek
    Department of Intensive Care Medicine, Catholic University of Leuven, Leuven, Belgium
    Curr Opin Crit Care 11:304-11. 2005
    ..This review gives an overview of the clinical outcome benefits associated with intensive insulin therapy administered to critically ill patients and of the progress in the unraveling of the mechanisms underlying these positive effects...