P Lambin

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint The potential therapeutic gain of radiation-associated gene therapy with the suicide gene cytosine deaminase
    P Lambin
    University Hospital Gasthuisberg, Department of Radiation Oncology, Leuven, Belgium
    Int J Radiat Biol 76:285-93. 2000
  2. ncbi request reprint Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum
    J Theys
    Laboratory of Bacteriology, Rega Institute for Medical Research, Leuven, Belgium
    Cancer Gene Ther 8:294-7. 2001
  3. ncbi request reprint Increasing specificity of anti-tumor therapy: cytotoxic protein delivery by non-pathogenic clostridia under regulation of radio-induced promoters
    S Nuyts
    Laboratory of Experimental Radiobiology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Anticancer Res 21:857-61. 2001
  4. ncbi request reprint In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment
    W Landuyt
    Laboratory of Experimental Radiobiology, University Hospital Gasthuisberg, Leuven, Belgium
    Int J Radiat Oncol Biol Phys 49:443-50. 2001
  5. pmc Insertion or deletion of the Cheo box modifies radiation inducibility of Clostridium promoters
    S Nuyts
    Laboratory of Bacteriology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    Appl Environ Microbiol 67:4464-70. 2001
  6. ncbi request reprint Vascular targeting of solid tumours: a major 'inverse' volume-response relationship following combretastatin A-4 phosphate treatment of rat rhabdomyosarcomas
    W Landuyt
    Department of Experimental Radiobiology Radiotherapy, Catholic University of Leuven KULeuven, University Hospital Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Eur J Cancer 36:1833-43. 2000
  7. ncbi request reprint Clostridium as a tumor-specific delivery system of therapeutic proteins
    J Theys
    Laboratory of Bacteriology, Rega Institute for Medical Research, Leuven, Belgium
    Cancer Detect Prev 25:548-57. 2001
  8. pmc Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo
    J Theys
    Department of Radiation Oncology Maastro Lab, GROW Research Institute, University of Maastricht, UNS 50 23, PO Box 616, Maastricht 6200 MD, The Netherlands
    Br J Cancer 95:1212-9. 2006
  9. ncbi request reprint Tumor-specific gene delivery using genetically engineered bacteria
    J Theys
    MAASTRO lab, Maastricht Radiation Oncology, Maastricht, The Netherlands
    Curr Gene Ther 3:207-21. 2003
  10. ncbi request reprint Clostridium spores for tumor-specific drug delivery
    S Nuyts
    Laboratory of Bacteriology, Rega Institute, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    Anticancer Drugs 13:115-25. 2002

Collaborators

  • S Nuyts
  • W Landuyt
  • J F Fowler
  • Hong Zhang
  • J Theys
  • B G Wouters
  • L Dubois
  • L Van Mellaert
  • A Mengesha
  • M C G Pijls-Johannesma
  • P Van Hecke
  • K Paesmans
  • T Dresselaers
  • A L A J Dekker
  • G Anlezark
  • O Pennington
  • T Vaughan
  • P J Burke
  • N P Minton
  • D K M de Ruysscher
  • A Gokana
  • B Wouters
  • S Barbe
  • J Anne
  • R K Chiu
  • M Koritzinsky
  • S A Weppler
  • A W Landuyt
  • A van Oosterom
  • A Ahaded
  • J P Cartron
  • A Ben-Ghanem
  • J J Winchenne

Detail Information

Publications17

  1. ncbi request reprint The potential therapeutic gain of radiation-associated gene therapy with the suicide gene cytosine deaminase
    P Lambin
    University Hospital Gasthuisberg, Department of Radiation Oncology, Leuven, Belgium
    Int J Radiat Biol 76:285-93. 2000
    ..To estimate the concentration of 5-fluorocytosine (5-FC), necessary for conversion to 5-fluorouracil (5-FU) in tumours transduced with the gene cytosine deaminase (CD), to achieve clinically significant radiosensitization to radiotherapy...
  2. ncbi request reprint Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum
    J Theys
    Laboratory of Bacteriology, Rega Institute for Medical Research, Leuven, Belgium
    Cancer Gene Ther 8:294-7. 2001
    ..acetobutylicum. The results provide evidence for the potential application of Clostrisdium-based therapeutic protein transfer to tumors in anticancer therapy...
  3. ncbi request reprint Increasing specificity of anti-tumor therapy: cytotoxic protein delivery by non-pathogenic clostridia under regulation of radio-induced promoters
    S Nuyts
    Laboratory of Experimental Radiobiology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Anticancer Res 21:857-61. 2001
    ..This specificity can be further improved if expression of these genes is controlled by a radio-induced promoter, leading to spatial and temporal control of gene expression...
  4. ncbi request reprint In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment
    W Landuyt
    Laboratory of Experimental Radiobiology, University Hospital Gasthuisberg, Leuven, Belgium
    Int J Radiat Oncol Biol Phys 49:443-50. 2001
    ..We aimed to evaluate the potential (hypothesis-based) benefit from combinations of vascular targeting using combretastatin A-4 phosphate (combreAp) with either ionizing radiation or anti-angiogenesis...
  5. pmc Insertion or deletion of the Cheo box modifies radiation inducibility of Clostridium promoters
    S Nuyts
    Laboratory of Bacteriology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    Appl Environ Microbiol 67:4464-70. 2001
    ..Reverse transcriptase PCR of RNA samples isolated from irradiated and nonirradiated bacterial cultures demonstrated that the increase in secretion was the result of enhanced transcription of the mTNF-alpha gene...
  6. ncbi request reprint Vascular targeting of solid tumours: a major 'inverse' volume-response relationship following combretastatin A-4 phosphate treatment of rat rhabdomyosarcomas
    W Landuyt
    Department of Experimental Radiobiology Radiotherapy, Catholic University of Leuven KULeuven, University Hospital Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Eur J Cancer 36:1833-43. 2000
    ..This significant differential volume-response obtained with 'selective' vascular targeting, stronger in larger tumours than smaller ones, suggests the potential of broadening the therapeutic window...
  7. ncbi request reprint Clostridium as a tumor-specific delivery system of therapeutic proteins
    J Theys
    Laboratory of Bacteriology, Rega Institute for Medical Research, Leuven, Belgium
    Cancer Detect Prev 25:548-57. 2001
    ..Based on these data and supported by its selective colonization pattern and safety, the Clostridium gene transfer system offers a potential application in anti-cancer therapies...
  8. pmc Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo
    J Theys
    Department of Radiation Oncology Maastro Lab, GROW Research Institute, University of Maastricht, UNS 50 23, PO Box 616, Maastricht 6200 MD, The Netherlands
    Br J Cancer 95:1212-9. 2006
    ..Importantly, this regimen demonstrated that intravenously administered spores of NTR-recombinant C. sporogenes produced significant antitumour efficacy when combined with prodrug administration...
  9. ncbi request reprint Tumor-specific gene delivery using genetically engineered bacteria
    J Theys
    MAASTRO lab, Maastricht Radiation Oncology, Maastricht, The Netherlands
    Curr Gene Ther 3:207-21. 2003
    ..We believe that this approach will act in a complementary way to current radiotherapy and chemotherapy treatments of solid tumors...
  10. ncbi request reprint Clostridium spores for tumor-specific drug delivery
    S Nuyts
    Laboratory of Bacteriology, Rega Institute, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    Anticancer Drugs 13:115-25. 2002
    ..This high selectivity offers a major advantage in comparison with the classical gene therapy systems...
  11. pmc Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
    L Dubois
    Department of Radiation Oncology Maastro Lab, GROW Research Institute, University of Maastricht, UNS 50 23, 6200 MD, Maastricht, The Netherlands
    Br J Cancer 96:758-61. 2007
    ....
  12. ncbi request reprint Radio-responsive recA promoter significantly increases TNFalpha production in recombinant clostridia after 2 Gy irradiation
    S Nuyts
    Laboratory of Bacteriology, Rega Institute, Katholieke Universiteit Leuven, Belgium
    Gene Ther 8:1197-201. 2001
    ..Gene targeting by ionising radiation could thus provide a new means of increasing the therapeutic ratio in cancer treatment...
  13. ncbi request reprint The use of radiation-induced bacterial promoters in anaerobic conditions: a means to control gene expression in clostridium-mediated therapy for cancer
    S Nuyts
    Department of Experimental Radiobiology/Bacteriology, Laboratory of Bacteriology, Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    Radiat Res 155:716-23. 2001
    ....
  14. ncbi request reprint Hypoxia as a target for combined modality treatments
    B G Wouters
    Department of Experimental Radiation Oncology, UNS 50 Box 23, azM University of Maastricht, Postbox 616, 6200 MD Maastricht, The Netherlands
    Eur J Cancer 38:240-57. 2002
    ..An overview of the various properties ascribed to tumour hypoxia and the current efforts underway to exploit hypoxia for improving cancer treatment will be discussed...
  15. ncbi request reprint BOLD contrast fMRI of whole rodent tumour during air or carbogen breathing using echo-planar imaging at 1.5 T
    W Landuyt
    Laboratory of Experimental Radiobiology and Department of Radiotherapy/Oncology, KU Leuven, University Hospitals Leuven, 3000 Leuven, Belgium
    Eur Radiol 11:2332-40. 2001
    ..Selection of tumours on the basis of their individual response to carbogen is possible, indicating a role of such non-invasive measurements for using tailor-made treatments...
  16. ncbi request reprint [Protons and ions in the treatment of cancer; a systematic review of the literature]
    M C G Pijls-Johannesma
    Maastro Clinic, Dr Tanslaan 12, 6229 ET Maastricht
    Ned Tijdschr Geneeskd 150:2435-41. 2006
    ..To provide an overview of the present role of proton and ion therapy, also referred to as 'charged particle therapy', in the treatment of cancer...
  17. ncbi request reprint Chromatographic separation of recombinant human erythropoietin isoforms
    A Gokana
    Institut National de la Transfusion Sanguine, Paris, France
    J Chromatogr A 791:109-18. 1997
    ..Seven fractions of decreasing isoelectric point (pI) were obtained. The specific activity of these fractions measured by an immunoradiometric assay was not equally distributed...