Tatiana Kuznetsova

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Quality control of the blood pressure phenotype in the European Project on Genes in Hypertension
    Tatiana Kuznetsova
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Blood Press Monit 7:215-24. 2002
  2. ncbi request reprint Maternal and paternal influences on left ventricular mass of offspring
    Tatiana Kuznetsova
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Hypertension 41:69-74. 2003
  3. ncbi request reprint beta-Adducin polymorphisms, blood pressure, and sodium excretion in three European populations
    Valerie Tikhonoff
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Am J Hypertens 16:840-6. 2003
  4. ncbi request reprint Sodium excretion as a modulator of genetic associations with cardiovascular phenotypes in the European Project on Genes in Hypertension
    Tatiana Kuznetsova
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    J Hypertens 24:235-42. 2006
  5. pmc Double product reflects the predictive power of systolic pressure in the general population: evidence from 9,937 participants
    Rudolph Schutte
    Department of Cardiovascular Sciences, Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, University of Leuven, Leuven, Belgium
    Am J Hypertens 26:665-72. 2013
  6. doi request reprint Arterial properties in relation to genetic variations in the adducin subunits in a white population
    Jitka Seidlerova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Am J Hypertens 22:21-6. 2009
  7. doi request reprint Independent relations of left ventricular structure with the 24-hour urinary excretion of sodium and aldosterone
    Yu Jin
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Hypertension 54:489-95. 2009
  8. ncbi request reprint Blood pressure phenotypes in relation to the beta-adducin C1797T polymorphism in the European Project on Genes in Hypertension (EPOGH)
    Valerie Tikhonoff
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Blood Press Monit 8:151-4. 2003
  9. pmc Heritability and intrafamilial aggregation of arterial characteristics
    Jitka Seidlerova
    The Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Hypertens 26:721-8. 2008
  10. ncbi request reprint Left ventricular structure in relation to the human SAH gene in the European Project on Genes in Hypertension
    Yu Jin
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Research, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Hypertens Res 32:145-51. 2009

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Quality control of the blood pressure phenotype in the European Project on Genes in Hypertension
    Tatiana Kuznetsova
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Blood Press Monit 7:215-24. 2002
    ..In this report, we present the quality control of one of the BP phenotypes...
  2. ncbi request reprint Maternal and paternal influences on left ventricular mass of offspring
    Tatiana Kuznetsova
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Hypertension 41:69-74. 2003
    ..Further studies are required to elucidate the genetic, epigenetic, and ecogenetic mechanisms underlying these divergent parent-offspring correlations...
  3. ncbi request reprint beta-Adducin polymorphisms, blood pressure, and sodium excretion in three European populations
    Valerie Tikhonoff
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Am J Hypertens 16:840-6. 2003
    ..Genetic determinants of complex quantitative traits such as BP can only be investigated within their epidemiologic context...
  4. ncbi request reprint Sodium excretion as a modulator of genetic associations with cardiovascular phenotypes in the European Project on Genes in Hypertension
    Tatiana Kuznetsova
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    J Hypertens 24:235-42. 2006
    ..The EPOGH therefore highlights the concept that phenotype-genotype relations can only be studied within a defined ecogenetic context...
  5. pmc Double product reflects the predictive power of systolic pressure in the general population: evidence from 9,937 participants
    Rudolph Schutte
    Department of Cardiovascular Sciences, Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, University of Leuven, Leuven, Belgium
    Am J Hypertens 26:665-72. 2013
    ..The double product (DP), consisting of the systolic blood pressure (SBP) multiplied by the pulse rate (PR), is an index of myocardial oxygen consumption, but its prognostic value in the general population remains unknown...
  6. doi request reprint Arterial properties in relation to genetic variations in the adducin subunits in a white population
    Jitka Seidlerova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Am J Hypertens 22:21-6. 2009
    ..We investigated whether arterial characteristics might be related to the genes encoding ADD1 (Gly460Trp-rs4961), ADD2 (C1797T-rs4984), and ADD3 (IVS11+386A>G-rs3731566)...
  7. doi request reprint Independent relations of left ventricular structure with the 24-hour urinary excretion of sodium and aldosterone
    Yu Jin
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Hypertension 54:489-95. 2009
    ..In conclusion, LVMI independently increased with both urinary sodium and aldosterone excretion. Increased MWT explained the association of LVMI with urinary sodium and increased LVID the association of LVMI with urinary aldosterone...
  8. ncbi request reprint Blood pressure phenotypes in relation to the beta-adducin C1797T polymorphism in the European Project on Genes in Hypertension (EPOGH)
    Valerie Tikhonoff
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Blood Press Monit 8:151-4. 2003
    ..Subjects were genotyped for the beta-adducin C1797 T polymorphism. Both a population-based association study and a family-based analysis were performed...
  9. pmc Heritability and intrafamilial aggregation of arterial characteristics
    Jitka Seidlerova
    The Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Hypertens 26:721-8. 2008
    ..We investigated the heritability and familial aggregation of various indexes of arterial stiffness and wave reflection and we partitioned the phenotypic correlation between these traits into shared genetic and environmental components...
  10. ncbi request reprint Left ventricular structure in relation to the human SAH gene in the European Project on Genes in Hypertension
    Yu Jin
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Research, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Hypertens Res 32:145-51. 2009
    ..007). In conclusion, LVMI and MWT, two phenotypes that are jointly influenced by blood pressure and obesity, might be related to variation in the human SAH gene...
  11. ncbi request reprint Angiotensin-converting enzyme I/D and alpha-adducin Gly460Trp polymorphisms: from angiotensin-converting enzyme activity to cardiovascular outcome
    Yan Li
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Research, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Hypertension 49:1291-7. 2007
    ....
  12. doi request reprint Fatal and nonfatal outcomes, incidence of hypertension, and blood pressure changes in relation to urinary sodium excretion
    Katarzyna Stolarz-Skrzypek
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    JAMA 305:1777-85. 2011
    ..Extrapolations from observational studies and short-term intervention trials suggest that population-wide moderation of salt intake might reduce cardiovascular events...
  13. pmc Outcome-driven thresholds for ambulatory pulse pressure in 9938 participants recruited from 11 populations
    Yu Mei Gu
    Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven, Kapucijnenvoer 35, Block D, Box 7001, BE 3000 Leuven, Belgium
    Hypertension 63:229-37. 2014
    ..Thus, in randomly recruited people, ambulatory PP does not add to risk stratification below age 60; in the elderly, PP is a weak risk factor with levels below 64 mm Hg probably being innocuous...
  14. ncbi request reprint Conventional and 24-h ambulatory blood pressure as independent predictors of elastic arterial properties
    Barbara Wizner
    Department of Cardiovascular Diseases, Division of Hypertension and Cardiovascular Rehabilitation, Studies Coordinating Centre, University of Leuven, Leuven, Belgium
    Blood Press Monit 14:12-9. 2009
    ....
  15. pmc Masked hypertension in diabetes mellitus: treatment implications for clinical practice
    Stanley S Franklin
    Heart Disease Prevention Program, Division of Cardiology, School of Medicine, University of California, Irvine, California, USA
    Hypertension 61:964-71. 2013
    ..Importantly, many hypertensive diabetics when receiving antihypertensive therapy can present with normalized conventional and elevated ambulatory blood pressure that mimics masked hypertension...
  16. pmc Central systolic augmentation indexes and urinary sodium in a white population
    Yan Ping Liu
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Sciences, University of Leuven, Belgium
    Am J Hypertens 26:95-103. 2013
    ..The association between cardiovascular health and salt intake remains controversial. The objective of our study was to assess the association between arterial stiffness and urinary sodium, both cross-sectionally and prospectively...
  17. doi request reprint Prognostic value of the morning blood pressure surge in 5645 subjects from 8 populations
    Yan Li
    Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium
    Hypertension 55:1040-8. 2010
    ..In conclusion, a MS above the 90th percentile significantly and independently predicted cardiovascular outcome and might contribute to risk stratification by ambulatory blood pressure monitoring...
  18. doi request reprint Is blood pressure during the night more predictive of cardiovascular outcome than during the day?
    Yan Li
    Department of Cardiovascular Diseases, Division of Hypertension and Cardiovascular Rehabilitation, Studies Coordinating Centre, University of Leuven, Leuven, Belgium
    Blood Press Monit 13:145-7. 2008
    ..The increased mortality in patients with higher NDR probably indicates reverse causality. Our findings support recording the ambulatory BP during the whole day...
  19. ncbi request reprint -391 C to G substitution in the regulator of G-protein signalling-2 promoter increases susceptibility to the metabolic syndrome in white European men: consistency between molecular and epidemiological studies
    Kathleen Freson
    Center for Molecular and Vascular Biology, University Hospital Gasthuisberg, University of Leuven, Belgium
    J Hypertens 25:117-25. 2007
    ..The regulator of G-protein signalling-2 (RGS2) is a key factor in adipogenesis. We hypothesized that the metabolic syndrome, of which obesity is an important component, might be related to genetic variation in RGS2...
  20. doi request reprint Ambulatory blood pressure monitoring in 9357 subjects from 11 populations highlights missed opportunities for cardiovascular prevention in women
    José Boggia
    Studies Coordinating Centre, Laboratory of Hypertension, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block D, Level 00, Box 7001, B 3000 Leuven, Belgium
    Hypertension 57:397-405. 2011
    ..1 mm Hg). In conclusion, although absolute risks associated with systolic BP were lower in women than men, our results reveal a vast and largely unused potential for cardiovascular prevention by BP-lowering treatment in women...
  21. doi request reprint Left ventricular radial function associated with genetic variation in the cGMP-dependent protein kinase
    Tatiana Kuznetsova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block D, Box 7001, B 3000 Leuven, Belgium
    Hypertension 62:1034-9. 2013
    ..If experimental studies and longitudinal follow-up of LV function confirm the causality of this association, interference with cGMP-dependent protein kinase type I function might be a target for pharmacological intervention...
  22. doi request reprint From pioneering to implementing automated blood pressure measurement in clinical practice: Thomas Pickering's legacy
    Katarzyna Stolarz-Skrzypek
    Studies Coordinating Centre, Division of Hypertension and Cardiac Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Blood Press Monit 15:72-81. 2010
    ..Recent studies validated Pickering's observations in terms of cardiovascular outcome and bridged the path from concept to application in clinical practice...
  23. doi request reprint Blood pressure variability in relation to outcome in the International Database of Ambulatory blood pressure in relation to Cardiovascular Outcome
    Katarzyna Stolarz-Skrzypek
    Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Hypertens Res 33:757-66. 2010
    ..1%. In conclusion, the IDACO observations support the concept that BP variability adds to risk stratification, but above all highlight that 24-h ambulatory BP level remains the main predictor to be considered in clinical practice...
  24. doi request reprint Association of echocardiographic left ventricular structure with the ACE D/I polymorphism: a meta-analysis
    - Yu Jin
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Renin Angiotensin Aldosterone Syst 12:243-53. 2011
    ..We updated this meta-analysis until May 2009 only considering echocardiographic phenotypes...
  25. doi request reprint Morbidity and mortality on combination versus monotherapy: a posthoc analysis of the Systolic Hypertension in Europe trial
    Lutgarde Thijs
    Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Studies Coordinating Centre, Leuven, Belgium
    J Hypertens 28:865-74. 2010
    ....
  26. ncbi request reprint Sympathetic activity, assessed by power spectral analysis of heart rate variability, in white-coat, masked and sustained hypertension versus true normotension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven K U Leuven, Leuven, Belgium
    J Hypertens 25:2280-5. 2007
    ..To assess, in a population-based approach, sympathetic nervous system activity by the use of power spectral analysis of heart rate variability, in normotension, white-coat hypertension, masked hypertension and sustained hypertension...
  27. pmc Within-subject blood pressure level--not variability--predicts fatal and nonfatal outcomes in a general population
    Rudolph Schutte
    Department of Cardiovascular Sciences, Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block D, Box 7001, BE 3000 Leuven, Belgium
    Hypertension 60:1138-47. 2012
    ..In conclusion, in an unbiased population sample, BP variability did not contribute to risk stratification over and beyond mean systolic BP...
  28. ncbi request reprint Genetic variation in CYP11B2 and AT1R influences heart rate variability conditional on sodium excretion
    Katarzyna Stolarz
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    Hypertension 44:156-62. 2004
    ..Thus, CYP11B2 C-344T and AT1R A1166C polymorphisms affect the autonomic modulation of heart rate, but these genetic effects depend on sodium excretion...
  29. doi request reprint Left ventricular geometry and endogenous ouabain in a Flemish population
    Tatiana Kuznetsova
    Studies Coordinating Centre, Department of Cardiovascular Diseases, University of Leuven, Belgium
    J Hypertens 27:1884-91. 2009
    ..Endogenous ouabain, an endogenous digitalis-like steroid, is synthesized in the adrenal glands and possibly in the hypothalamus. In vitro and in vivo, endogenous ouabain triggers growth and proliferation of cardiomyocytes...
  30. ncbi request reprint Prevalence of left ventricular diastolic dysfunction in a general population
    Tatiana Kuznetsova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Circ Heart Fail 2:105-12. 2009
    ....
  31. ncbi request reprint Left ventricular mass in relation to genetic variation in angiotensin II receptors, renin system genes, and sodium excretion
    Tatiana Kuznetsova
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Circulation 110:2644-50. 2004
    ....
  32. ncbi request reprint Relationship between left ventricular mass and the ACE D/I polymorphism varies according to sodium intake
    Tatiana Kuznetsova
    Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    J Hypertens 22:287-95. 2004
    ....
  33. pmc Heritability of the retinal microcirculation in Flemish families
    Yan Ping Liu
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
    Am J Hypertens 26:392-9. 2013
    ..Few population studies have described the heritability and intrafamilial concordance of the retinal microvessels, or the genetic or environmental correlations of the phenotypes of these vessels...
  34. doi request reprint Left ventricular structure and function in relation to steroid biosynthesis genes in a white population
    Yu Jin
    The Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Am J Hypertens 25:986-93. 2012
    ..Cholesterol side-chain cleavage enzyme (CYP11A1) and 3β-hydroxysteroid dehydrogenase (HSD3B1) are two key enzymes in the pathway of steroid biosynthesis...
  35. ncbi request reprint Short-term blood pressure variability in relation to outcome in the International Database of Ambulatory blood pressure in relation to Cardiovascular Outcome (IDACO)
    Katarzyna Stolarz-Skrzypek
    The Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Belgium
    Acta Cardiol 66:701-6. 2011
    ....
  36. doi request reprint Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population
    Tatiana Kuznetsova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Hypertens 26:1229-36. 2008
    ..We investigated the possible association between left ventricular diastolic function and the ADD1 Gly460Trp and ADD3 IVS11 +386A>G polymorphisms alone and in combination...
  37. pmc Heritability of left ventricular structure and function in Caucasian families
    Yu Jin
    The Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Leuven, Belgium
    Eur J Echocardiogr 12:326-32. 2011
    ..The aim of this study was to investigate the heritability as well as genetic and environmental correlations of left ventricular (LV) structural and functional traits in complex pedigrees of a Caucasian population...
  38. ncbi request reprint Cardiovascular risk in relation to alpha-adducin Gly460Trp polymorphism and systolic pressure: a prospective population study
    Yan Li
    Study Coordinating Centre, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    Hypertension 46:527-32. 2005
    ..9% and 44.3%, respectively. In conclusion, the alpha-adducin Gly460Trp polymorphism, in combination with systolic blood pressure, is a strong predictor of cardiovascular mortality and morbidity...
  39. ncbi request reprint The International Database of Ambulatory Blood Pressure in relation to Cardiovascular Outcome (IDACO): protocol and research perspectives
    Lutgarde Thijs
    Studies Coordinating Centre, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Blood Press Monit 12:255-62. 2007
    ..We are constructing a new resource of longitudinal population studies to investigate with great precision to what extent the ambulatory blood pressure improves risk stratification...
  40. doi request reprint Sphygmomanometric and ambulatory blood pressures as forerunners of carotid and femoral intima-media thickness
    Dirk G Dechering
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Hypertens 27:813-21. 2009
    ....
  41. doi request reprint Association of left ventricular mass with the AGTR1 A1166C polymorphism
    Yu Jin
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Belgium
    Am J Hypertens 25:472-8. 2012
    ..We hypothesized that left ventricular (LV) mass is associated with the AGTR1 A1166C polymorphism...
  42. doi request reprint Association between left ventricular mass and telomere length in a population study
    Tatiana Kuznetsova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Biomedical Sciences Group, University of Leuven, Leuven, Belgium
    Am J Epidemiol 172:440-50. 2010
    ..Longer mean leukocyte TL is associated with increased LV mass, particularly in normotensive subjects. This association could have a biologic basis related to the role of TL in determining cardiomyocyte size and replication potential...
  43. ncbi request reprint 'Beyond blood pressure' means multiple risk factor intervention, not pleiotropic antihypertensive drugs
    Jan A Staessen
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Curr Opin Cardiol 22:335-43. 2007
    ..We examined the role of blood pressure-lowering compared with class-specific properties of antihypertensive drugs in cardiovascular prevention...
  44. pmc Association of left ventricular diastolic function with systolic dyssynchrony: a population study
    Tatiana Kuznetsova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Science, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block D, Level 00, Box 7001, B 3000 Leuven, Belgium
    Eur Heart J Cardiovasc Imaging 14:471-9. 2013
    ....
  45. doi request reprint Are retinal microvascular phenotypes associated with the 1675G/A polymorphism in the angiotensin II type-2 receptor gene?
    Yan Ping Liu
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Am J Hypertens 24:1300-5. 2011
    ..AT2R is expressed in the human retina, but no previous study examined the association between retinal microvascular phenotypes and the AT2R 1675G/A polymorphism...
  46. ncbi request reprint Host and environmental determinants of heart rate and heart rate variability in four European populations
    Katarzyna Stolarz
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Campus Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Hypertens 21:525-35. 2003
    ....
  47. pmc Bone resorption and environmental exposure to cadmium in women: a population study
    Rudolph Schutte
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Environ Health Perspect 116:777-83. 2008
    ..Environmental exposure to cadmium decreases bone density indirectly through hypercalciuria resulting from renal tubular dysfunction...
  48. ncbi request reprint Association between arterial properties and renal sodium handling in a general population
    Jitka Seidlerova
    Studies Coordination Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Hypertension 48:609-15. 2006
    ..These findings demonstrate that there might be an influence of renal sodium handling on arterial properties or vice versa or that common mechanisms might influence both arterial and renal function...
  49. pmc Impact of hypertension on ventricular-arterial coupling and regional myocardial work at rest and during isometric exercise
    Tatiana Kuznetsova
    The Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, University of Leuven, Leuven, Belgium
    J Am Soc Echocardiogr 25:882-90. 2012
    ....
  50. ncbi request reprint OASIS-HT: design of a pharmacogenomic dose-finding study
    Jan A Staessen
    Department of Molecular and Cardiovascular Research, Hypertension and Cardiovascular Rehabilitation Unit, Study Coordinating Centre, University of Leuven, Belgium
    Pharmacogenomics 6:755-75. 2005
    ..To our knowledge, OASIS-HT is the first Phase II dose-finding study in which a genetic hypothesis is driving primary and secondary end points...
  51. ncbi request reprint Left ventricular strain and strain rate in a general population
    Tatiana Kuznetsova
    The Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, University of Leuven, Campus Gasthuisberg, Herestraat 49, Box 702, B 3000 Leuven, Belgium
    Eur Heart J 29:2014-23. 2008
    ..We therefore described peak-systolic strain and SR of the LV in the general population and derived diagnostic thresholds for these measurements in a healthy subgroup...
  52. ncbi request reprint Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study
    Kei Kamide
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan and Department of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan and Research Institute, National Cerebro and Cardiovascular Research Center, Osaka, Japan and Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
    Pharmacogenomics 14:1709-21. 2013
    ....
  53. ncbi request reprint Progression to hypertension in the non-hypertensive participants in the Flemish Study on Environment, Genes and Health Outcomes
    Haifeng Zhang
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Hypertens 24:1719-27. 2006
    ..To evaluate the consistency between a randomly recruited Western European population and the participants of the Framingham Heart Study, with respect to the rates and determinants of progression to hypertension...
  54. pmc Cadmium-related mortality and long-term secular trends in the cadmium body burden of an environmentally exposed population
    Tim S Nawrot
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Herestraat 49, Leuven, Belgium
    Environ Health Perspect 116:1620-8. 2008
    ..Few population studies have reported on the long-term changes in the internal cadmium dose and simultaneously occurring mortality...
  55. pmc Urinary proteome analysis in hypertensive patients with left ventricular diastolic dysfunction
    Tatiana Kuznetsova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Sciences, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, B 3000 Leuven, Belgium
    Eur Heart J 33:2342-50. 2012
    ....
  56. ncbi request reprint Arterial characteristics in normotensive offspring of parents with or without a history of hypertension
    Jitka Kucerová
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Am J Hypertens 19:264-9. 2006
    ..In this study we compared the arterial characteristics and blood pressure (BP) of normotensive offspring of two normotensive parents (OFF/NT) and normotensive offspring who had at least one hypertensive parent (OFF/HT)...
  57. doi request reprint Systolic and diastolic left ventricular dysfunction: from risk factors to overt heart failure
    Tatiana Kuznetsova
    Division of Hypertension and Cardiac Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block D, B 3000 Leuven, Belgium
    Expert Rev Cardiovasc Ther 8:251-8. 2010
    ..Future prospective studies will clarify the hitherto unknown prognosis associated with early symptom-free LV dysfunction...
  58. ncbi request reprint Prognostic value of left ventricular diastolic dysfunction in a general population
    Tatiana Kuznetsova
    Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium
    J Am Heart Assoc 3:e000789. 2014
    ..Therefore, we investigated in continuous and categorical analyses whether Doppler diastolic indexes contained any prognostic information over and beyond traditional cardiovascular risk factors in a general population...
  59. ncbi request reprint Association between hypertension and variation in the alpha- and beta-adducin genes in a white population
    Ji Guang Wang
    Studiecoördinatiecentrum, Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement voor Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    Kidney Int 62:2152-9. 2002
    ..In the present study, we investigated in multivariate analyses whether the risk of hypertension was associated with the C1797T polymorphism of the beta-adducin gene...
  60. ncbi request reprint Intrafamilial correlations of carotid intima-media thickness and flow-mediated dilation in a Siberian population
    Andrew Ryabikov
    Laboratory of Internal Medicine and Department of Non invasive Diagnostics, Institute of Internal Medicine, Siberian Branch of the Russian Academy of Medical Science, Novosibirsk, Russia
    Am J Hypertens 20:248-54. 2007
    ..The goal of our study was to assess the sex-specific intrafamilial aggregation of ultrasonographic carotid intima-media thickness (IMT) and brachial flow-mediated vasodilation (FMD) in a Siberian population...
  61. doi request reprint Diagnostic thresholds for ambulatory blood pressure monitoring based on 10-year cardiovascular risk
    Masahiro Kikuya
    The Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Blood Press Monit 12:393-5. 2007
    ..In conclusion, population-based outcome-driven thresholds for optimal and normal ABP are lower than those currently proposed by hypertension guidelines...
  62. ncbi request reprint Hypertension prevalence and stroke mortality across populations
    Jan A Staessen
    JAMA 289:2420-2. 2003
  63. ncbi request reprint Alcohol intake modulates the genetic association between HDL cholesterol and the PPARgamma2 Pro12Ala polymorphism
    Stefan Martin Brand-Herrmann
    Leibniz Institute for Arteriosclerosis Research, Department of Molecular Genetics of Cardiovascular Disease, University of Muenster, Muenster, Germany
    J Lipid Res 46:913-9. 2005
    ..We conclude that alcohol intake modulates the relation between the PPARgamma2 Pro12Ala and HDL cholesterol level and that, therefore, the Pro12Ala polymorphism, pending confirmation of our findings, might affect cardiovascular prognosis...
  64. ncbi request reprint Association of peripheral and central arterial wave reflections with the CYP11B2 -344C allele and sodium excretion
    Wiktoria Wojciechowska
    The First Cardiac Department Medical College, Jagiellonian University, Cracow, Poland
    J Hypertens 22:2311-9. 2004
    ..In the European Project on Genes in Hypertension (EPOGH), we therefore investigated whether the ACE I/D and CYP11B2 C-344T polymorphisms influence early arterial wave reflections, a measure of vascular stiffness...
  65. ncbi request reprint Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans
    Marcin Cwynar
    Department of Internal Medicine and Gerontology, Medical College, Jagiellonian University, Cracow, Poland
    J Hypertens 23:961-9. 2005
    ....
  66. ncbi request reprint The drive to identify genetic factors influencing left ventricular mass responses to antihypertensive treatment
    Robert H Fagard
    J Hypertens 20:583-5. 2002
  67. ncbi request reprint Diagnostic thresholds for ambulatory blood pressure monitoring based on 10-year cardiovascular risk
    Masahiro Kikuya
    Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Circulation 115:2145-52. 2007
    ..Current diagnostic thresholds for ambulatory blood pressure (ABP) mainly rely on statistical parameters derived from reference populations. We determined an outcome-driven reference frame for ABP measurement...
  68. ncbi request reprint Prognostic superiority of daytime ambulatory over conventional blood pressure in four populations: a meta-analysis of 7,030 individuals
    Tine W Hansen
    Research Center for Prevention and Health, Copenhagen, Denmark
    J Hypertens 25:1554-64. 2007
    ..To investigate the multivariate-adjusted predictive value of systolic and diastolic blood pressures on conventional (CBP) and daytime (10-20 h) ambulatory (ABP) measurement...
  69. doi request reprint SAH gene variants revisited in the European Project On Genes in Hypertension
    Valerie Tikhonoff
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    J Hypertens 26:244-50. 2008
    ..We sought independent confirmation of these findings in the European Project On Genes in Hypertension...
  70. doi request reprint Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4
    Jan A Staessen
    Genetic Epidemiology Unit, Department of Epidemiology, University of Maastricht, The Netherlands
    Hypertension 51:1643-50. 2008
    ..In conclusion, renal sodium handling and BP were associated with genetic variation in the DRD1 promoter. The between-family variance component excluded population stratification for BP, but not for the renal phenotypes...
  71. doi request reprint Segmental renal sodium handling in relation to the human SAH gene
    Yu Jin
    Hypertension 52:e12-3. 2008
  72. ncbi request reprint Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study
    José Boggia
    Departamento de Fisiopatologia, Hospital de Clinicas, Universidad de la Republica, Montevideo, Uruguay
    Lancet 370:1219-29. 2007
    ..We investigated the prognostic significance of the ambulatory blood pressure during night and day and of the night-to-day blood pressure ratio...