D R J Kuypers

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Drug interaction between mycophenolate mofetil and rifampin: possible induction of uridine diphosphate-glucuronosyltransferase
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, B 3000 Leuven, Belgium
    Clin Pharmacol Ther 78:81-8. 2005
  2. doi request reprint Improved adherence to tacrolimus once-daily formulation in renal recipients: a randomized controlled trial using electronic monitoring
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospital Leuven, Gasthuisberg, Belgium
    Transplantation 95:333-40. 2013
  3. doi request reprint Management of polyomavirus-associated nephropathy in renal transplant recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Nat Rev Nephrol 8:390-402. 2012
  4. doi request reprint Skin problems in chronic kidney disease
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Nat Clin Pract Nephrol 5:157-70. 2009
  5. doi request reprint Early clinical assessment of glucose metabolism in renal allograft recipients: diagnosis and prediction of post-transplant diabetes mellitus (PTDM)
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, Belgium
    Nephrol Dial Transplant 23:2033-42. 2008
  6. ncbi request reprint Kidney transplantation: current issues and future prospects
    D R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, Belgium
    Acta Clin Belg 62:208-17. 2007
  7. ncbi request reprint CYP3A5 and CYP3A4 but not MDR1 single-nucleotide polymorphisms determine long-term tacrolimus disposition and drug-related nephrotoxicity in renal recipients
    D R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals of Leuven, Leuven, Belgium
    Clin Pharmacol Ther 82:711-25. 2007
  8. ncbi request reprint Recurrence of light chain deposit disease after renal allograft transplantation: potential role of rituximab?
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transpl Int 20:381-5. 2007
  9. ncbi request reprint The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, Laboratory of Absorption and Digestion, University Hospitals Leuven, Belgium
    Clin Pharmacol Ther 78:351-61. 2005
  10. doi request reprint Immunosuppressive drug therapy and subclinical acute renal allograft rejection: impact and effect
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals of Leuven, Belgium
    Transplantation 85:S25-30. 2008

Detail Information

Publications56

  1. ncbi request reprint Drug interaction between mycophenolate mofetil and rifampin: possible induction of uridine diphosphate-glucuronosyltransferase
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, B 3000 Leuven, Belgium
    Clin Pharmacol Ther 78:81-8. 2005
    ....
  2. doi request reprint Improved adherence to tacrolimus once-daily formulation in renal recipients: a randomized controlled trial using electronic monitoring
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospital Leuven, Gasthuisberg, Belgium
    Transplantation 95:333-40. 2013
    ..A once-daily, modified-release oral formulation of tacrolimus has been developed to simplify dosing and improve medication adherence...
  3. doi request reprint Management of polyomavirus-associated nephropathy in renal transplant recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Nat Rev Nephrol 8:390-402. 2012
    ..Finally, novel compounds and their in vitro actions against BKV are discussed together with future prospects for specific antiviral drug development...
  4. doi request reprint Skin problems in chronic kidney disease
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Nat Clin Pract Nephrol 5:157-70. 2009
    ..Hemodialysis following gadolinium exposure might offer benefits but evidence is lacking...
  5. doi request reprint Early clinical assessment of glucose metabolism in renal allograft recipients: diagnosis and prediction of post-transplant diabetes mellitus (PTDM)
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, Belgium
    Nephrol Dial Transplant 23:2033-42. 2008
    ..Post-transplant diabetes mellitus (PTDM) has serious consequences for renal allograft survival, cardiovascular risk and patient survival...
  6. ncbi request reprint Kidney transplantation: current issues and future prospects
    D R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, Belgium
    Acta Clin Belg 62:208-17. 2007
  7. ncbi request reprint CYP3A5 and CYP3A4 but not MDR1 single-nucleotide polymorphisms determine long-term tacrolimus disposition and drug-related nephrotoxicity in renal recipients
    D R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals of Leuven, Leuven, Belgium
    Clin Pharmacol Ther 82:711-25. 2007
    ....
  8. ncbi request reprint Recurrence of light chain deposit disease after renal allograft transplantation: potential role of rituximab?
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transpl Int 20:381-5. 2007
    ....
  9. ncbi request reprint The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, Laboratory of Absorption and Digestion, University Hospitals Leuven, Belgium
    Clin Pharmacol Ther 78:351-61. 2005
    ....
  10. doi request reprint Immunosuppressive drug therapy and subclinical acute renal allograft rejection: impact and effect
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals of Leuven, Belgium
    Transplantation 85:S25-30. 2008
    ..The latter would enable clinicians to preemptively make strategic adjustments to immunosuppressive therapy in an attempt to further improve renal allograft survival and clinical care of the transplant patient...
  11. ncbi request reprint Current target ranges of mycophenolic acid exposure and drug-related adverse events: a 5-year, open-label, prospective, clinical follow-up study in renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Ther 30:673-83. 2008
    ..No reduced incidence of MMF-related adverse events (AEs) was observed in either of the 2 trials when MMF concentration-controlled and fixed dosing were compared...
  12. doi request reprint Effects of CYP3A5 and MDR1 single nucleotide polymorphisms on drug interactions between tacrolimus and fluconazole in renal allograft recipients
    Dirk R Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, Leuven, Belgium
    Pharmacogenet Genomics 18:861-8. 2008
    ..The aim of this study was to examine the influence of the CYP3A4, CYP3A5, and MDR1 single nucleotide polymorphisms on changes in tacrolimus exposure and dosing in renal allograft recipients treated with fluconazole...
  13. ncbi request reprint Influence of interactions between immunosuppressive drugs on therapeutic drug monitoring
    Dirk R Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Ann Transplant 13:11-8. 2008
    ....
  14. doi request reprint Mycophenolic acid exposure after administration of mycophenolate mofetil in the presence and absence of cyclosporin in renal transplant recipients
    Dirk R Kuypers
    Department of Nephrology, University Hospitals Leuven, Leuven, Belgium
    Clin Pharmacokinet 48:329-41. 2009
    ..Here we report on the pharmacokinetic and pharmacodynamic behaviour of MPA in renal transplant patients on standard dose, reduced dose and no cyclosporin...
  15. doi request reprint Immunotherapy in elderly transplant recipients: a guide to clinically significant drug interactions
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals of Leuven, Leuven, Belgium
    Drugs Aging 26:715-37. 2009
    ..While these age-related changes are well-known, few specific effects of the latter on immunosuppressant drug metabolism have been reported. Therefore, more clinical data from elderly organ recipients are urgently required...
  16. doi request reprint Tacrolimus dose requirements and CYP3A5 genotype and the development of calcineurin inhibitor-associated nephrotoxicity in renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals of Leuven, Leuven, Belgium
    Ther Drug Monit 32:394-404. 2010
    ..Prolonged calcineurin inhibitor maintenance therapy in kidney allograft recipients is complicated by the development of chronic irreversible drug-induced nephrotoxicity (CNIT)...
  17. doi request reprint A prospective, open-label, observational clinical cohort study of the association between delayed renal allograft function, tacrolimus exposure, and CYP3A5 genotype in adult recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Ther 32:2012-23. 2010
    ..New-onset diabetes after transplantation (NODAT) is a known adverse effect of tacrolimus therapy and has been associated with DGF...
  18. ncbi request reprint Adjuvant low-dose cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Am J Transplant 5:1997-2004. 2005
    ..In this selected group of recipients with BKVIN, the use of adjuvant low-dose cidofovir therapy resulted in prolonged graft survival and stabilized graft function...
  19. ncbi request reprint A simplified strategy for clinical management of late cytomegalovirus infection after oral ganciclovir prophylaxis in renal recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Antimicrob Chemother 55:391-4. 2005
    ..Identifying patients at risk for late infection is clinically difficult; prolonged cytomegalovirus (CMV) monitoring is costly and cumbersome as follow-up intervals lengthen...
  20. ncbi request reprint Time to reach tacrolimus maximum blood concentration,mean residence time, and acute renal allograft rejection: an open-label, prospective, pharmacokinetic study in adult recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Clin Ther 26:1834-44. 2004
    ....
  21. ncbi request reprint Long-term pharmacokinetic study of the novel combination of tacrolimus and sirolimus in de novo renal allograft recipients
    D R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospital Leuven, Leuven, Belgium
    Ther Drug Monit 25:447-51. 2003
    ....
  22. ncbi request reprint The rate of gastric emptying determines the timing but not the extent of oral tacrolimus absorption: simultaneous measurement of drug exposure and gastric emptying by carbon-14-octanoic acid breath test in stable renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Drug Metab Dispos 32:1421-5. 2004
    ....
  23. ncbi request reprint Time-related clinical determinants of long-term tacrolimus pharmacokinetics in combination therapy with mycophenolic acid and corticosteroids: a prospective study in one hundred de novo renal transplant recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Pharmacokinet 43:741-62. 2004
    ..The specific characteristics of the inter-relationship between dose, concentration and clinical (side-)effects for tacrolimus have not yet been identified and extensive long-term pharmacokinetic studies are presently lacking...
  24. ncbi request reprint The use of an anti-CD25 monoclonal antibody and mycophenolate mofetil enables the use of a low-dose tacrolimus and early withdrawal of steroids in renal transplant recipients
    D R J Kuypers
    Department of Nephrology, University Hospitals Leuven, Leuven, Belgium
    Clin Transplant 17:234-41. 2003
    ....
  25. ncbi request reprint A prospective proof of concept study of the efficacy of tacrolimus ointment on uraemic pruritus (UP) in patients on chronic dialysis therapy
    Dirk R Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Nephrol Dial Transplant 19:1895-901. 2004
    ..UP causes skin damage, discomfort, sleeping disorders and diminished quality of life. Since UP is considered to be in part an immune-mediated inflammatory process, immunosuppressive drugs like tacrolimus may be beneficial...
  26. ncbi request reprint Clinical efficacy and toxicity profile of tacrolimus and mycophenolic acid in relation to combined long-term pharmacokinetics in de novo renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Clin Pharmacol Ther 75:434-47. 2004
    ....
  27. ncbi request reprint C3D deposition in peritubular capillaries indicates a variant of acute renal allograft rejection characterized by a worse clinical outcome
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transplantation 76:102-8. 2003
    ....
  28. doi request reprint Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantation
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 5:341-58. 2010
    ..Although this consensus report does not evaluate the final role of MPA TDM in transplantation, it seeks to examine the current scientific evidence for concentration-controlled dosing of MPA...
  29. ncbi request reprint Calcium channel blockade and preservation of renal graft function in cyclosporine-treated recipients: a prospective randomized placebo-controlled 2-year study
    D R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Transplantation 78:1204-11. 2004
    ..Lacidipine is a dihydropyridine CCB that possesses antioxidative, anti-atherosclerotic, and anti-adhesion properties and was shown to prevent cyclosporine-induced nephrotoxicity in a rat model...
  30. ncbi request reprint Immunosuppressive drug monitoring - what to use in clinical practice today to improve renal graft outcome
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, Leuven, Belgium
    Transpl Int 18:140-50. 2005
    ....
  31. ncbi request reprint Benefit-risk assessment of sirolimus in renal transplantation
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, B 3000 Leuven, Belgium
    Drug Saf 28:153-81. 2005
    ....
  32. ncbi request reprint Clinical use of rapamycin in renal allograft recipients identifies its relevant toxicity profile and raises unsolved questions: a single-center experience
    D R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transplant Proc 35:138S-142S. 2003
    ....
  33. ncbi request reprint Role of immunosuppressive drugs in the development of tissue-invasive cytomegalovirus infection in renal transplant recipients
    D R J Kuypers
    Department of Nephrology, University Hospitals, Leuven, Belgium
    Transplant Proc 34:1164-70. 2002
  34. ncbi request reprint Tacrolimus exposure and evolution of renal allograft histology in the first year after transplantation
    M Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Am J Transplant 7:2114-23. 2007
    ..Tacrolimus doses or systemic exposure were not associated with lesions of calcineurin inhibitor nephrotoxicity, suggesting that other factors determine susceptibility to tacrolimus nephrotoxicity...
  35. doi request reprint Chronic histological damage in early indication biopsies is an independent risk factor for late renal allograft failure
    M Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium, EU
    Am J Transplant 13:86-99. 2013
    ..The global burden of early chronic histological damage within the first year after transplantation importantly affects the fate of the allografts...
  36. doi request reprint In vivo CYP3A activity is significantly lower in cyclosporine-treated as compared with tacrolimus-treated renal allograft recipients
    H de Jonge
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Pharmacol Ther 90:414-22. 2011
    ..This observation has important implications in the context of drug-drug interactions in transplant recipients...
  37. ncbi request reprint Rifampin induces alterations in mycophenolic acid glucuronidation and elimination: implications for drug exposure in renal allograft recipients
    Maarten Naesens
    Department of Nephrology, Catholic University Leuven, University Hospitals Leuven, Belgium
    Clin Pharmacol Ther 80:509-21. 2006
    ..It can be hypothesized that drugs interfering with glucuronidation and excretion will alter (Ac)MPA(G) exposure...
  38. doi request reprint Balancing efficacy and toxicity of kidney transplant immunosuppression
    M Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, B 3000 Leuven, Belgium
    Transplant Proc 41:3393-5. 2009
    ..Finally, the interplay between immune and nonimmune phenomena was demonstrated by the association between donor origin (deceased versus living) and local renal complement gene expression, by using whole-genome expression microarrays...
  39. ncbi request reprint Twelve-month evaluation of the clinical pharmacokinetics of total and free mycophenolic acid and its glucuronide metabolites in renal allograft recipients on low dose tacrolimus in combination with mycophenolate mofetil
    D R J Kuypers
    Department of Nephrology and Renal Transplantation, Catholic University of Leuven, Belgium
    Ther Drug Monit 25:609-22. 2003
    ..Furthermore, the pharmacokinetic characteristics of free and total MPA and its glucuronides depend directly or indirectly on graft function and the type of co-administered calcineurin-inhibitor...
  40. ncbi request reprint Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transplantation 82:1074-84. 2006
    ..MPAG is excreted into the bile via the multidrug resistance-associated protein 2 (MRP2/ABCC2), which is essential for enterohepatic (re)circulation (EHC) of MPA(G)...
  41. doi request reprint New insights into the pharmacokinetics and pharmacodynamics of the calcineurin inhibitors and mycophenolic acid: possible consequences for therapeutic drug monitoring in solid organ transplantation
    Hylke de Jonge
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Ther Drug Monit 31:416-35. 2009
    ..For MPA, the differences in pharmacokinetic behavior between the old and the novel formulation will have implications for TDM, whereas for tacrolimus, this probably will not to be the case...
  42. doi request reprint Calcineurin inhibitor nephrotoxicity
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Clin J Am Soc Nephrol 4:481-508. 2009
    ..Better insight into the mechanisms underlying calcineurin inhibitor nephrotoxicity might pave the way toward more targeted therapy or prevention of calcineurin inhibitor nephrotoxicity...
  43. ncbi request reprint Secondary effects of immunosuppressive drugs after simultaneous pancreas-kidney transplantation
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Nephrol Dial Transplant 20:ii33-9, ii62. 2005
    ..This report examines the early and late secondary effects of tacrolimus, cyclosporin microemulsion (ME), mycophenolate mofetil (MMF) and rabbit anti-thymocyte globulin (rATG) in simultaneous pancreas-kidney (SPK) recipients...
  44. ncbi request reprint The impact of renal allograft function on exposure and elimination of mycophenolic acid (MPA) and its metabolite MPA 7-O-glucuronide
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Catholic University of Leuven, Leuven, Belgium
    Transplantation 84:362-73. 2007
    ..In contrast to these studies, other studies have associated renal impairment with higher MPA exposure. The reason for these inconsistencies is not clear...
  45. ncbi request reprint Polyomavirus interstitial nephritis and concurrent post-transplant lymphoma in a renal allograft: coincidence or more?
    Evelyne Lerut
    Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium
    Transpl Int 18:1304-7. 2005
    ..To our knowledge, this is the first report of a simultaneous polyomavirus infection and post-transplant lymphoproliferative disorder...
  46. doi request reprint Pseudoaneurysm complicating protocol renal transplant biopsies: case reports
    L Kubasiewicz
    Department of Nephrology, University Hospitals Leuven, Leuven, Belgium
    Transplant Proc 40:1397-8. 2008
    ..We describe two cases of kidney transplant recipients who were diagnosed with a pseudoaneurysm more than 48 hours after protocol renal allograft biopsy and were successfully treated by selective embolization of the afferent artery...
  47. doi request reprint Pharmacogenetics in solid organ transplantation: current status and future directions
    Hylke de Jonge
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, B 3000 Leuven, Belgium
    Transplant Rev (Orlando) 22:6-20. 2008
    ..Currently, we still are in the early phases of this exciting research, and the question whether pharmacogenetic profiling will eventually become a useful clinical tool remains to be answered...
  48. pmc Donor age and renal P-glycoprotein expression associate with chronic histological damage in renal allografts
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Am Soc Nephrol 20:2468-80. 2009
    ..In addition, ABCB1 genotype and expression of P-glycoprotein in renal tubular epithelial cells determine susceptibility to chronic tubulointerstitial damage of transplanted kidneys...
  49. ncbi request reprint Secondary renal amyloidosis due to long-standing tubulointerstitial nephritis in a patient with Sjögren syndrome
    Vanessa Ooms
    Department of Nephrology, University Hospitals Leuven, Belgium
    Am J Kidney Dis 46:e75-80. 2005
    ..To our knowledge, this is the first report of a patient with primary Sjögren syndrome and secondary (AA) amyloidosis with amyloid deposition in the kidneys causing nephrotic syndrome...
  50. ncbi request reprint Emerging immunosuppressive drugs in kidney transplantation
    Christoph Metalidis
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Curr Clin Pharmacol 6:130-6. 2011
    ..In this review, we report on the mechanism of action, pharmacokinetics and preliminary results of clinical trials of these promising new immunosuppressive drugs...
  51. ncbi request reprint An unusual cause of ureteral obstruction in a renal allograft
    Sven Smets
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Nephrol Dial Transplant 21:3593-4. 2006
  52. ncbi request reprint Tailoring immunosuppressive therapy
    Dirk R J Kuypers
    Nephrol Dial Transplant 17:2051-4. 2002
  53. doi request reprint CYP3A5 genotype is not associated with a higher risk of acute rejection in tacrolimus-treated renal transplant recipients
    Dennis A Hesselink
    Department of Internal Medicine, Renal Transplant Unit, Erasmus MC, Rotterdam, The Netherlands
    Pharmacogenet Genomics 18:339-48. 2008
    ..We studied the influence of the CYP3A5(*)3 allele, which results in the absence of CYP3A5 protein, on tacrolimus dose and exposure, as well as the incidence of biopsy-proven acute rejection (BPAR) after renal transplantation...
  54. ncbi request reprint Monoclonal antibodies in renal transplantation: old and new
    Dirk R J Kuypers
    Nephrol Dial Transplant 19:297-300. 2004
  55. ncbi request reprint Intracerebral haemorrhage caused by cefazoline-induced hypoprothrombinaemia in a renal transplant recipient
    Dirk R J Kuypers
    Nephrol Dial Transplant 17:532-3. 2002
  56. ncbi request reprint A prospective, randomized, double-blind crossover study on the use of 5% citrate lock versus 10% citrate lock in permanent hemodialysis catheters
    Gert Meeus
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, Leuven, Belgium
    Blood Purif 23:101-5. 2005
    ....