Wim Janssens

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. doi request reprint Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act
    Wim Janssens
    Division of Respiratory Medicine, University Hospital Gasthuisberg KUL Herestraat 49, 3000 Leuven, Belgium
    Am J Respir Crit Care Med 179:630-6. 2009
  2. doi request reprint Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010
  3. pmc Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial
    Miek Hornikx
    Respiratory Division and Rehabilitation, Laboratory of Pneumology, University Hospital Gasthuisberg, KULeuven, Herestraat 49, Leuven, 3000, Belgium
    Respir Res 13:84. 2012
  4. doi request reprint Chronic obstructive pulmonary disease
    Marc Decramer
    Respiratory Division, University Hospital, University of Leuven, Leuven, Belgium
    Lancet 379:1341-51. 2012
  5. pmc Long-term nose-only cigarette smoke exposure induces emphysema and mild skeletal muscle dysfunction in mice
    Manuela Rinaldi
    Respiratory Muscle Research Unit, Katholieke Universiteit Leuven, Herestraat 49, Onderwijs en Navorsing 1, bus 706, Herestraat 49, 3000 Leuven, Belgium
    Dis Model Mech 5:333-41. 2012
  6. doi request reprint Vitamin D deficiency and chronic obstructive pulmonary disease: a vicious circle
    Wim Janssens
    Respiratory Division, University of Leuven, Leuven, Belgium
    Vitam Horm 86:379-99. 2011
  7. doi request reprint COPD, bone metabolism, and osteoporosis
    An Lehouck
    Respiratory Division, Center of Metabolic Bone Diseases, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Chest 139:648-57. 2011
  8. doi request reprint Repeated invasive lung function measurements in intubated mice: an approach for longitudinal lung research
    Stephanie I De Vleeschauwer
    Research Unit of Lung Transplantation, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Lab Anim 45:81-9. 2011
  9. doi request reprint Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases
    Jeroen A J Vanoirbeek
    Lung Toxicology Research Unit, Katholieke Universiteit Leuven, Herestraat 49 bus 706, Leuven, Belgium
    Am J Respir Cell Mol Biol 42:96-104. 2010
  10. doi request reprint Alveolar and bronchial exhaled nitric oxide in chronic obstructive pulmonary disease
    An Lehouck
    Respiratory Division, University Hospital Gasthuisberg Katholieke Universiteit Leuven, Herestraat 49, bus 706, 3000 Leuven, Belgium
    Respir Med 104:1020-6. 2010

Collaborators

Detail Information

Publications13

  1. doi request reprint Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act
    Wim Janssens
    Division of Respiratory Medicine, University Hospital Gasthuisberg KUL Herestraat 49, 3000 Leuven, Belgium
    Am J Respir Crit Care Med 179:630-6. 2009
    ..A further challenge of such studies is to define optimal serum 25-OHD levels for such noncalcemic endpoints...
  2. doi request reprint Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010
    ..Vitamin D deficiency has been associated with many chronic illnesses, but little is known about its relationship with chronic obstructive pulmonary disease (COPD)...
  3. pmc Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial
    Miek Hornikx
    Respiratory Division and Rehabilitation, Laboratory of Pneumology, University Hospital Gasthuisberg, KULeuven, Herestraat 49, Leuven, 3000, Belgium
    Respir Res 13:84. 2012
    ..As vitamin D status is linked to skeletal muscle function, we aimed to explore if high dose vitamin D supplementation can improve the outcomes of rehabilitation in Chronic Obstructive Pulmonary Disease...
  4. doi request reprint Chronic obstructive pulmonary disease
    Marc Decramer
    Respiratory Division, University Hospital, University of Leuven, Leuven, Belgium
    Lancet 379:1341-51. 2012
    ..Besides improving symptoms, these treatments are also thought to lead to some degree of disease modification. Future research should be directed towards the development of agents that notably affect the course of disease...
  5. pmc Long-term nose-only cigarette smoke exposure induces emphysema and mild skeletal muscle dysfunction in mice
    Manuela Rinaldi
    Respiratory Muscle Research Unit, Katholieke Universiteit Leuven, Herestraat 49, Onderwijs en Navorsing 1, bus 706, Herestraat 49, 3000 Leuven, Belgium
    Dis Model Mech 5:333-41. 2012
    ..In this model, muscular changes became apparent only after 6 months, particularly in muscles with a mixed fiber-type composition...
  6. doi request reprint Vitamin D deficiency and chronic obstructive pulmonary disease: a vicious circle
    Wim Janssens
    Respiratory Division, University of Leuven, Leuven, Belgium
    Vitam Horm 86:379-99. 2011
    ..The burning question in COPD is whether prevention of vitamin D deficiency or adequate supplementation may reverse the natural course of the disease...
  7. doi request reprint COPD, bone metabolism, and osteoporosis
    An Lehouck
    Respiratory Division, Center of Metabolic Bone Diseases, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Chest 139:648-57. 2011
    ..As long as intervention studies focusing on the bone in COPD are lacking, a more rigorous application of existing treatment guidelines of osteoporosis in general is mandatory...
  8. doi request reprint Repeated invasive lung function measurements in intubated mice: an approach for longitudinal lung research
    Stephanie I De Vleeschauwer
    Research Unit of Lung Transplantation, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Lab Anim 45:81-9. 2011
    ..This may open new perspectives for longitudinal research in animal models of respiratory diseases...
  9. doi request reprint Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases
    Jeroen A J Vanoirbeek
    Lung Toxicology Research Unit, Katholieke Universiteit Leuven, Herestraat 49 bus 706, Leuven, Belgium
    Am J Respir Cell Mol Biol 42:96-104. 2010
    ..Invasive pulmonary functions allow distinction between respiratory diseases in mice by clinically relevant variables, and should become standard in the functional evaluation of pathological disease models...
  10. doi request reprint Alveolar and bronchial exhaled nitric oxide in chronic obstructive pulmonary disease
    An Lehouck
    Respiratory Division, University Hospital Gasthuisberg Katholieke Universiteit Leuven, Herestraat 49, bus 706, 3000 Leuven, Belgium
    Respir Med 104:1020-6. 2010
    ..We examined whether the use of Fe,NO, CAlv,NO and J'aw,NO may contribute to the clinical diagnosis of COPD...
  11. doi request reprint Modification of COPD presentation during the last 25 years
    Antoine Fremault
    University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    COPD 7:345-51. 2010
    ..As the length of hospitalization and the overall survival were not different between the two samples, a currently improved management of COPD can be hypothesized...
  12. doi request reprint Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease
    Wim Janssens
    Department of Human Genetics, Katholieke Universiteit Leuven, Gasthuisberg O and N1 602, Herestraat 49, B 3000, Leuven, Belgium
    Am J Respir Crit Care Med 182:163-9. 2010
    ..Objectives: We investigated whether genomic copy number variations of the beta-defensin gene cluster have a functional role in airway epithelial cells and associate with the presence of COPD...
  13. doi request reprint Computer quantification of airway collapse on forced expiration to predict the presence of emphysema
    Marko Topalovic
    Respiratory Division, University Hospital Leuven, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium
    Respir Res 14:131. 2013
    ..We then explored and validated the relationship of airway collapse with computed tomography (CT) diagnosed emphysema in two large independent cohorts...