Paul Holvoet

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplasty
    Gregor Theilmeier
    Center for Molecular and Vascular Biology, Campus Gasthuisberg, O and N, Herestraat 49, B 3000, Leuven, Belgium
    Cardiovasc Res 55:385-95. 2002
  2. ncbi request reprint Analytical performance and diagnostic accuracy of immunometric assays for the measurement of circulating oxidized LDL
    Paul Holvoet
    Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Chem 52:760-4. 2006
  3. ncbi request reprint Obesity, the metabolic syndrome, and oxidized LDL
    Paul Holvoet
    Am J Clin Nutr 83:1438; author reply 1438-9. 2006
  4. pmc Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS ONE 7:e30414. 2012
  5. pmc PPAR agonist-induced reduction of Mcp1 in atherosclerotic plaques of obese, insulin-resistant mice depends on adiponectin-induced Irak3 expression
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
    PLoS ONE 8:e62253. 2013
  6. pmc Decrease of miR-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
    PLoS ONE 7:e32794. 2012
  7. ncbi request reprint Oxidized low-density lipoprotein correlates positively with toll-like receptor 2 and interferon regulatory factor-1 and inversely with superoxide dismutase-1 expression: studies in hypercholesterolemic swine and THP-1 cells
    Paul Holvoet
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, PB 705, B 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 26:1558-65. 2006
  8. ncbi request reprint The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Paul Holvoet
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Atherosclerosis 194:245-52. 2007
  9. ncbi request reprint Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice
    Wim Verreth
    Cardiovascular Research Unit of the Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Belgium
    Circulation 110:3259-69. 2004
  10. ncbi request reprint Dietary cholesterol withdrawal reduces vascular inflammation and induces coronary plaque stabilization in miniature pigs
    Peter Verhamme
    Cardiovascular Research Unit, Center for Experimental Surgery and Anesthesiology, KU Leuven, Campus Gasthuisberg, O and N, Herestraat 49, Leuven, Belgium
    Cardiovasc Res 56:135-44. 2002

Detail Information

Publications44

  1. ncbi request reprint Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplasty
    Gregor Theilmeier
    Center for Molecular and Vascular Biology, Campus Gasthuisberg, O and N, Herestraat 49, B 3000, Leuven, Belgium
    Cardiovasc Res 55:385-95. 2002
    ..To assess the effect of hypercholesterolemia on neointima formation and vascular remodelling after porcine coronary angioplasty...
  2. ncbi request reprint Analytical performance and diagnostic accuracy of immunometric assays for the measurement of circulating oxidized LDL
    Paul Holvoet
    Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Chem 52:760-4. 2006
    ....
  3. ncbi request reprint Obesity, the metabolic syndrome, and oxidized LDL
    Paul Holvoet
    Am J Clin Nutr 83:1438; author reply 1438-9. 2006
  4. pmc Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS ONE 7:e30414. 2012
    ..Visceral obesity is associated with the rising incidence of type 2 diabetes and metabolic syndrome. Low-grade chronic inflammation and oxidative stress synergize in obesity and obesity-induced disorders...
  5. pmc PPAR agonist-induced reduction of Mcp1 in atherosclerotic plaques of obese, insulin-resistant mice depends on adiponectin-induced Irak3 expression
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
    PLoS ONE 8:e62253. 2013
    ..In aggregate, our results emphasize an interaction between PPAR agonist-mediated increase in adiponectin and macrophage-associated Irak3 in the protection against atherosclerosis by PPAR agonists...
  6. pmc Decrease of miR-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
    PLoS ONE 7:e32794. 2012
    ..Because it was low we determined the involvement of this miR in the anti-inflammatory, antioxidative and insulin signaling action of globular adiponectin...
  7. ncbi request reprint Oxidized low-density lipoprotein correlates positively with toll-like receptor 2 and interferon regulatory factor-1 and inversely with superoxide dismutase-1 expression: studies in hypercholesterolemic swine and THP-1 cells
    Paul Holvoet
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, PB 705, B 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 26:1558-65. 2006
    ..We searched for the strongest gene correlates of oxLDL in macrophages in coronary plaques and studied the effect of oxLDL on their expression in THP-1 cells...
  8. ncbi request reprint The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Paul Holvoet
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Atherosclerosis 194:245-52. 2007
    ..95 mg/dl; P=0.0002). Adjustment for risk factor correlates attenuated associations with subclinical CVD (P=0.026). In conclusion, oxLDL is associated with subclinical CVD by its relationship with many cardiovascular risk factors...
  9. ncbi request reprint Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice
    Wim Verreth
    Cardiovascular Research Unit of the Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Belgium
    Circulation 110:3259-69. 2004
    ..Weight loss in obese insulin-resistant but not in insulin-sensitive persons reduces coronary heart disease risk. To what extent changes in gene expression are related to atherosclerosis and cardiovascular function is unknown...
  10. ncbi request reprint Dietary cholesterol withdrawal reduces vascular inflammation and induces coronary plaque stabilization in miniature pigs
    Peter Verhamme
    Cardiovascular Research Unit, Center for Experimental Surgery and Anesthesiology, KU Leuven, Campus Gasthuisberg, O and N, Herestraat 49, Leuven, Belgium
    Cardiovasc Res 56:135-44. 2002
    ..To study the effect of dietary cholesterol withdrawal on size and composition of LDL-hypercholesterolemia-induced coronary plaques in miniature pigs...
  11. doi request reprint Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve
    An Van den Bergh
    Department of Cardiovascular Diseases, Division of Experimental Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Heart Fail 11:1118-25. 2009
    ..However, their effect on contractile dysfunction and impaired cardiac functional reserve is unknown...
  12. doi request reprint Increased PAFAH and oxidized lipids are associated with inflammation and atherosclerosis in hypercholesterolemic pigs
    Dieuwke De Keyzer
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Belgium
    Arterioscler Thromb Vasc Biol 29:2041-6. 2009
    ..To study the association of PAF-acetyl hydrolase (PAFAH) activity with inflammation, oxidative stress, and atherosclerosis in hypercholesterolemic swine...
  13. ncbi request reprint The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohort
    Paul Holvoet
    Center for Experimental Surgery and Anesthesiology, Catholic University, Leuven, Belgium
    Diabetes 53:1068-73. 2004
    ..22-4.15). We concluded that the metabolic syndrome, a risk factor for CHD, is associated with higher levels of circulating oxLDL that are associated with a greater disposition to atherothrombotic coronary disease...
  14. doi request reprint Decreased miR-181a expression in monocytes of obese patients is associated with the occurrence of metabolic syndrome and coronary artery disease
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Katholieke Universiteit Leuven, Herestraat 49, PB 705, 3000 Leuven, Belgium
    J Clin Endocrinol Metab 97:E1213-8. 2012
    ..Weight loss after bariatric surgery leads to significant improvement of obesity-related comorbidities. MicroRNA (miR), a class of small noncoding RNA, have been implicated as negative regulators of inflammatory processes...
  15. ncbi request reprint Peroxisome proliferator-activated receptor-alpha,gamma-agonist improves insulin sensitivity and prevents loss of left ventricular function in obese dyslipidemic mice
    Wim Verreth
    Department of Molecular and Cardiovascular Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 26:922-8. 2006
    ..In these mice, obesity, diabetes, and hyperlipidemia are associated with accelerated atherosclerosis and loss of cardiac function...
  16. ncbi request reprint Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis
    Ann Mertens
    Cardiovascular Research Unit at the Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Campus Gasthuisberg, O and N, Herestraat 49, B 3000 Leuven, Belgium
    Circulation 107:1640-6. 2003
    ..We investigated the association between oxidation of apolipoprotein B-containing lipoproteins, high-density lipoprotein (HDL) antioxidant defense, and atherosclerosis in these mice...
  17. ncbi request reprint Dyslipidaemia in type II diabetic mice does not aggravate contractile impairment but increases ventricular stiffness
    An Van den Bergh
    Laboratory of Experimental Cardiac Surgery, Department of Cardiovascular Disease, Katholieke Universiteit Leuven, Provisorium I, Minderbroedersstraat 19, K U Leuven postbus 01033 FEHA, 3000 Leuven, Belgium
    Cardiovasc Res 77:371-9. 2008
    ..The differential impact of type II diabetes and the metabolic syndrome on left ventricular function, however, remains incompletely defined...
  18. ncbi request reprint Hypercholesterolemia in minipigs impairs left ventricular response to stress: association with decreased coronary flow reserve and reduced capillary density
    Gregor Theilmeier
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    Circulation 106:1140-6. 2002
    ..Our objective was therefore to assess the effect of hypercholesterolemia and cholesterol withdrawal on LV function in the presence of advanced coronary plaques that do not cause stenosis...
  19. doi request reprint MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, O and N1, PB 705, B 3000 Leuven, Belgium
    FASEB J 25:2515-27. 2011
    ....
  20. ncbi request reprint Chlamydia pneumoniae induces neointima formation in coronary arteries of normal pigs
    Sorin V Pislaru
    University of Leuven, Leuven, Belgium
    Cardiovasc Res 57:834-42. 2003
    ..We evaluated the role of intracoronary, intrapulmonary and macrophage-mediated delivery of C. pneumoniae (Cp) on coronary lesion formation...
  21. doi request reprint The vicious circle between oxidative stress and inflammation in atherosclerosis
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Belgium
    J Cell Mol Med 14:70-8. 2010
    ..The latter is associated with increased infiltration of inflammatory cells, loss of anti-oxidant protection and cell death in the arterial wall...
  22. ncbi request reprint MicroRNAs as early biomarkers in obesity and related metabolic and cardiovascular diseases
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, PB 705, B 3000 Leuven, Belgium
    Curr Pharm Des 19:5704-17. 2013
    ....
  23. ncbi request reprint MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, PB 705, Leuven B 3000, Belgium
    Cardiovasc Res 100:7-18. 2013
    ..These data warrant further investigation of the potential of microvesicles as putative biomarkers and as novel carriers for the cell-specific transfer of microRNAs and other therapeutic agents. ..
  24. doi request reprint Influence of exercise at lower and higher intensity on blood pressure and cardiovascular risk factors at older age
    Véronique A Cornelissen
    Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Faculty of Medicine, University of Leuven, KU Leuven, Leuven, Belgium
    J Hypertens 27:753-62. 2009
    ..We therefore compared the effect of training at lower and higher intensity on blood pressure, and, in addition on other cardiovascular risk factors, in at least 55-year-old sedentary men and women...
  25. pmc Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome
    Paul Holvoet
    Atherosclerosis and Metabolism Unit, Katholieke Universiteit Leuven, Belgium
    JAMA 299:2287-93. 2008
    ..Experimental data support the hypothesis that oxidized low-density lipoprotein (LDL) is associated with the metabolic syndrome. However, this hypothesis has not been tested in humans...
  26. ncbi request reprint Association of high coronary heart disease risk status with circulating oxidized LDL in the well-functioning elderly: findings from the Health, Aging, and Body Composition study
    Paul Holvoet
    Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 23:1444-8. 2003
    ..Therefore, we studied the association between high, predicted CHD risk and oxLDL in the Health ABC cohort...
  27. ncbi request reprint Beta-actin cannot be used as a control for gene expression in ovine interstitial cells derived from heart valves
    Jessa Yperman
    Cardiovascular Research Laboratory, Centrum voor Experimentele Heelkunde en Anaesthesiologie, Katholieke Universiteit Leuven, Leuven, Belgium
    J Heart Valve Dis 13:848-53. 2004
    ..In the present study, a frequently used control gene, beta-actin, was examined in ovine heart valves to evaluate its applicability as a housekeeping gene for this tissue...
  28. pmc Hematopoietic stem/progenitor cell proliferation and differentiation is differentially regulated by high-density and low-density lipoproteins in mice
    Yingmei Feng
    Interdepartementaal Stem Cell Institute, Katholieke Universiteit Leuven, Belgium
    PLoS ONE 7:e47286. 2012
    ..Recently, studies have suggested that HDL cholesterol may inhibit and impaired cholesterol efflux may increase HSPC proliferation and differentiation...
  29. doi request reprint Mitochondrial reactive oxygen species and risk of atherosclerosis
    Maarten Hulsmans
    Department of Cardiovascular Sciences, KU Leuven, Atherosclerosis and Metabolism Unit, Belgium
    Curr Atheroscler Rep 14:264-76. 2012
    ..However, wide-spread use in humans requires the development of specific and sensitive assays to evaluate mitochondrial oxidative stress and the development of orally active compounds...
  30. ncbi request reprint Application of NIRS in mice: a study comparing the oxygenation of cerebral blood and main tissue oxygenation of mice and rat
    Geofrey De Visscher
    Laboratory of Cardiovascular Research, CEHA, Catholic University of Leuven, Leuven, Belgium
    Adv Exp Med Biol 578:197-202. 2006
  31. ncbi request reprint Telomere length and its associations with oxidized-LDL, carotid artery distensibility and smoking
    Tim S Nawrot
    Department of Molecular and Cardiovascular Research, Laboratory of Hypertension, University of Leuven, Study Coordinating Centre, Leuven, Belgium
    Front Biosci (Elite Ed) 2:1164-8. 2010
    ..03) than in non-smokers. Higher level of oxidized-LDL, is associated with shorter WBC telomeres and increased stiffness of the carotid artery. Smoking is marked by increased oxidative stress in concert with shortened WBC telomere length...
  32. doi request reprint Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- mice
    Rute Moura
    Center for Molecular and Vascular Biology, Department of Cardiovascular Diseases, University of Leuven, Belgium
    Circ Res 103:1181-9. 2008
    ....
  33. ncbi request reprint Gene therapy approaches for cardiovascular diseases
    Rozenn Quarck
    Cardiovascular Research Unit, Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Belgium
    Curr Gene Ther 4:207-23. 2004
    ....
  34. ncbi request reprint The complex link between oxidised low-density lipoprotein and unstable angina
    Giampaolo Niccoli
    Institute of Cardiology, Catholic University, Rome, Italy
    J Cardiovasc Med (Hagerstown) 8:387-91. 2007
    ..We also assessed the correlation between plaque or plasma ox-LDL and angiographic complex stenosis morphology...
  35. ncbi request reprint CREB activation induced by mitochondrial dysfunction triggers triglyceride accumulation in 3T3-L1 preadipocytes
    Sebastien Vankoningsloo
    Laboratory of Biochemistry and Cellular Biology, University of Namur F U N D P, rue de Bruxelles, 61, 5000 Namur, Belgium
    J Cell Sci 119:1266-82. 2006
    ..These results highlight a new role for CREB in the control of triglyceride metabolism during the adaptative response of preadipocytes to mitochondrial dysfunction...
  36. ncbi request reprint Oxidized LDL and coronary heart disease
    Paul Holvoet
    Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Belgium
    Acta Cardiol 59:479-84. 2004
    ..Finally, elevated oxidized LDL predicted myocardial infarction in the Health ABC cohort consisting of well-functioning elderly people, even after adjusting for age, gender, race, smoking, and the metabolic syndrome...
  37. ncbi request reprint Increased levels of low-density lipoprotein oxidation in patients with familial hypercholesterolemia and in end-stage renal disease patients on hemodialysis
    Lambertus Van Tits
    Department of Medicine, Division of General Internal Medicine, UMC Nijmegen, Nijmegen, The Netherlands
    Lab Invest 83:13-21. 2003
    ..We conclude that cholesterol-lowering therapy does not normalize elevated LDL oxidation levels in FH patients and elevated LDL oxidation level in FH and in ESRD might mirror atherosclerosis...
  38. ncbi request reprint Obesity, regional body fat distribution, and the metabolic syndrome in older men and women
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:777-83. 2005
    ..We determined whether patterns of regional fat deposition are associated with metabolic syndrome in older adults...
  39. ncbi request reprint Lipoprotein peroxidation and mobility limitation: results from the Health, Aging, and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville 32608, USA
    Arch Intern Med 165:2148-54. 2005
    ..The aim of this study was to assess the predictive value of a lipoprotein peroxidation marker, oxidized low-density lipoprotein (oxLDL) for incident mobility limitation (ML)...
  40. ncbi request reprint Oxidized LDL and the metabolic syndrome
    Paul Holvoet
    Arterioscler Thromb Vasc Biol 26:e31; author reply e31-2. 2006
  41. ncbi request reprint Human paraoxonase-1 overexpression inhibits atherosclerosis in a mouse model of metabolic syndrome
    Bharti Mackness
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Arterioscler Thromb Vasc Biol 26:1545-50. 2006
    ..Paraoxonase1 (PON1), a high-density lipoprotein (HDL)-associated antioxidant enzyme that prevents the oxidation of low-density lipoprotein (LDL), is low in the metabolic syndrome...
  42. ncbi request reprint The importance of catch-up growth after early malnutrition for the programming of obesity in male rat
    Florence Bieswal
    Laboratory of Cell Biology, University of Louvain, Louvain la Neuve, Belgium
    Obesity (Silver Spring) 14:1330-43. 2006
    ..To investigate whether catch-up growth after maternal malnutrition would favor the development of obesity in adulthood...
  43. ncbi request reprint Metabolic syndrome and the risk of cardiovascular disease in older adults
    Javed Butler
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Am Coll Cardiol 47:1595-602. 2006
    ..The purpose of this study was to assess whether metabolic syndrome (MetSyn) predicts a higher risk for cardiovascular events in older adults...