Genomes and Genes
Affiliation: Katholieke Universiteit Leuven
- Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplastyGregor Theilmeier
Center for Molecular and Vascular Biology, Campus Gasthuisberg, O and N, Herestraat 49, B-3000, Leuven, Belgium
Cardiovasc Res 55:385-95. 2002..Our in vitro data suggest that this decrease can be due to macrophage-induced matrix degradation and reduced VSMC adhesion and to impaired VSMC migration. Oxidised LDL mimics the inhibitory effect of hypercholesterolemic serum...
- Analytical performance and diagnostic accuracy of immunometric assays for the measurement of circulating oxidized LDLPaul Holvoet
Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
Clin Chem 52:760-4. 2006....
- Obesity, the metabolic syndrome, and oxidized LDLPaul Holvoet
Am J Clin Nutr 83:1438; author reply 1438-9. 2006
- Oxidized low-density lipoprotein correlates positively with toll-like receptor 2 and interferon regulatory factor-1 and inversely with superoxide dismutase-1 expression: studies in hypercholesterolemic swine and THP-1 cellsPaul Holvoet
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, PB 705, B 3000 Leuven, Belgium
Arterioscler Thromb Vasc Biol 26:1558-65. 2006..We searched for the strongest gene correlates of oxLDL in macrophages in coronary plaques and studied the effect of oxLDL on their expression in THP-1 cells...
- The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA)Paul Holvoet
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
Atherosclerosis 194:245-52. 2007..95 mg/dl; P=0.0002). Adjustment for risk factor correlates attenuated associations with subclinical CVD (P=0.026). In conclusion, oxLDL is associated with subclinical CVD by its relationship with many cardiovascular risk factors...
- Dietary cholesterol withdrawal reduces vascular inflammation and induces coronary plaque stabilization in miniature pigsPeter Verhamme
Cardiovascular Research Unit, Center for Experimental Surgery and Anesthesiology, KU Leuven, Campus Gasthuisberg, O and N, Herestraat 49, Leuven, Belgium
Cardiovasc Res 56:135-44. 2002..Increased migration and decreased apoptosis of SMC may contribute to the disappearance of the a-cellular core after lipid lowering...
- Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserveAn Van den Bergh
Department of Cardiovascular Diseases, Division of Experimental Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
Eur J Heart Fail 11:1118-25. 2009..However, their effect on contractile dysfunction and impaired cardiac functional reserve is unknown...
- Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant miceWim Verreth
Cardiovascular Research Unit of the Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Belgium
Circulation 110:3259-69. 2004..Improved lipid metabolism and insulin signaling is associated with decreased tissue deposition of oxidized LDL that increases cardiovascular risk in persons with the metabolic syndrome...
- Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndromeMaarten Hulsmans
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
PLoS ONE 7:e30414. 2012..Visceral obesity is associated with the rising incidence of type 2 diabetes and metabolic syndrome. Low-grade chronic inflammation and oxidative stress synergize in obesity and obesity-induced disorders...
- Increased PAFAH and oxidized lipids are associated with inflammation and atherosclerosis in hypercholesterolemic pigsDieuwke De Keyzer
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Belgium
Arterioscler Thromb Vasc Biol 29:2041-6. 2009..To study the association of PAF-acetyl hydrolase (PAFAH) activity with inflammation, oxidative stress, and atherosclerosis in hypercholesterolemic swine...
- Decreased miR-181a expression in monocytes of obese patients is associated with the occurrence of metabolic syndrome and coronary artery diseaseMaarten Hulsmans
Atherosclerosis and Metabolism Unit, Katholieke Universiteit Leuven, Herestraat 49, PB 705, 3000 Leuven, Belgium
J Clin Endocrinol Metab 97:E1213-8. 2012..Weight loss after bariatric surgery leads to significant improvement of obesity-related comorbidities. MicroRNA (miR), a class of small noncoding RNA, have been implicated as negative regulators of inflammatory processes...
- Peroxisome proliferator-activated receptor-alpha,gamma-agonist improves insulin sensitivity and prevents loss of left ventricular function in obese dyslipidemic miceWim Verreth
Department of Molecular and Cardiovascular Research, Katholieke Universiteit Leuven, Leuven, Belgium
Arterioscler Thromb Vasc Biol 26:922-8. 2006..CONCLUSIONS: The dual PPARalpha,gamma-agonist improved insulin sensitivity without affecting cholesterol and triglycerides. This was associated with induction of PPARgamma in the heart and prevention of loss of left ventricle function...
- Decrease of miR-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectinMaarten Hulsmans
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
PLoS ONE 7:e32794. 2012..Because it was low we determined the involvement of this miR in the anti-inflammatory, antioxidative and insulin signaling action of globular adiponectin...
- The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohortPaul Holvoet
Center for Experimental Surgery and Anesthesiology, Catholic University, Leuven, Belgium
Diabetes 53:1068-73. 2004..22-4.15). We concluded that the metabolic syndrome, a risk factor for CHD, is associated with higher levels of circulating oxLDL that are associated with a greater disposition to atherothrombotic coronary disease...
- Dyslipidaemia in type II diabetic mice does not aggravate contractile impairment but increases ventricular stiffnessAn Van den Bergh
Laboratory of Experimental Cardiac Surgery, Department of Cardiovascular Disease, Katholieke Universiteit Leuven, Provisorium I, Minderbroedersstraat 19, K U Leuven postbus 01033 FEHA, 3000 Leuven, Belgium
Cardiovasc Res 77:371-9. 2008..The differential impact of type II diabetes and the metabolic syndrome on left ventricular function, however, remains incompletely defined...
- Chlamydia pneumoniae induces neointima formation in coronary arteries of normal pigsSorin V Pislaru
University of Leuven, Leuven, Belgium
Cardiovasc Res 57:834-42. 2003..Pre-existing coronary lesions seem a prerequisite for Cp-induced proliferation...
- Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosisAnn Mertens
Cardiovascular Research Unit at the Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Campus Gasthuisberg, O and N, Herestraat 49, B-3000 Leuven, Belgium
Circulation 107:1640-6. 2003..Transient LCAT overexpression was associated with a reduction of oxidative stress and atherosclerosis...
- Hypercholesterolemia in minipigs impairs left ventricular response to stress: association with decreased coronary flow reserve and reduced capillary densityGregor Theilmeier
Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
Circulation 106:1140-6. 2002..CONCLUSION: LDL hypercholesterolemia in minipigs impaired LV response to dobutamine stress in the absence of coronary stenosis...
- Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndromePaul Holvoet
Atherosclerosis and Metabolism Unit, Katholieke Universiteit Leuven, Belgium
JAMA 299:2287-93. 2008..Experimental data support the hypothesis that oxidized low-density lipoprotein (LDL) is associated with the metabolic syndrome. However, this hypothesis has not been tested in humans...
- Association of high coronary heart disease risk status with circulating oxidized LDL in the well-functioning elderly: findings from the Health, Aging, and Body Composition studyPaul Holvoet
Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit, Leuven, Belgium
Arterioscler Thromb Vasc Biol 23:1444-8. 2003..Therefore, we studied the association between high, predicted CHD risk and oxLDL in the Health ABC cohort...
- MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosisMaarten Hulsmans
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, O and N1, PB 705, B 3000 Leuven, Belgium
FASEB J 25:2515-27. 2011....
- Influence of exercise at lower and higher intensity on blood pressure and cardiovascular risk factors at older ageVéronique A Cornelissen
Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Faculty of Medicine, University of Leuven, KU Leuven, Leuven, Belgium
J Hypertens 27:753-62. 2009..We therefore compared the effect of training at lower and higher intensity on blood pressure, and, in addition on other cardiovascular risk factors, in at least 55-year-old sedentary men and women...
- Mitochondrial reactive oxygen species and risk of atherosclerosisMaarten Hulsmans
Department of Cardiovascular Sciences, KU Leuven, Atherosclerosis and Metabolism Unit, Belgium
Curr Atheroscler Rep 14:264-76. 2012..However, wide-spread use in humans requires the development of specific and sensitive assays to evaluate mitochondrial oxidative stress and the development of orally active compounds...
- The vicious circle between oxidative stress and inflammation in atherosclerosisMaarten Hulsmans
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Belgium
J Cell Mol Med 14:70-8. 2010..The latter is associated with increased infiltration of inflammatory cells, loss of anti-oxidant protection and cell death in the arterial wall...
- Beta-actin cannot be used as a control for gene expression in ovine interstitial cells derived from heart valvesJessa Yperman
Cardiovascular Research Laboratory, Centrum voor Experimentele Heelkunde en Anaesthesiologie, Katholieke Universiteit Leuven, Leuven, Belgium
J Heart Valve Dis 13:848-53. 2004..Different serum conditions did not lead to different beta-actin levels. CONCLUSION: Due to the variation in expression, beta-actin cannot be used as a reference for gene expression of ovine-derived heart valve IC in culture...
- Application of NIRS in mice: a study comparing the oxygenation of cerebral blood and main tissue oxygenation of mice and ratGeofrey De Visscher
Laboratory of Cardiovascular Research, CEHA, Catholic University of Leuven, Leuven, Belgium
Adv Exp Med Biol 578:197-202. 2006
- Telomere length and its associations with oxidized-LDL, carotid artery distensibility and smokingTim S Nawrot
Department of Molecular and Cardiovascular Research, Laboratory of Hypertension, University of Leuven, Study Coordinating Centre, Leuven, Belgium
Front Biosci (Elite Ed) 2:1164-8. 2010..03) than in non-smokers. Higher level of oxidized-LDL, is associated with shorter WBC telomeres and increased stiffness of the carotid artery. Smoking is marked by increased oxidative stress in concert with shortened WBC telomere length...
- Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- miceRute Moura
Center for Molecular and Vascular Biology, Department of Cardiovascular Diseases, University of Leuven, Belgium
Circ Res 103:1181-9. 2008....
- Hematopoietic stem/progenitor cell proliferation and differentiation is differentially regulated by high-density and low-density lipoproteins in miceYingmei Feng
Interdepartementaal Stem Cell Institute, Katholieke Universiteit Leuven, Belgium
PLoS ONE 7:e47286. 2012..Recently, studies have suggested that HDL cholesterol may inhibit and impaired cholesterol efflux may increase HSPC proliferation and differentiation...
- Gene therapy approaches for cardiovascular diseasesRozenn Quarck
Cardiovascular Research Unit, Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Belgium
Curr Gene Ther 4:207-23. 2004....
- CREB activation induced by mitochondrial dysfunction triggers triglyceride accumulation in 3T3-L1 preadipocytesSebastien Vankoningsloo
Laboratory of Biochemistry and Cellular Biology, University of Namur F U N D P, rue de Bruxelles, 61, 5000 Namur, Belgium
J Cell Sci 119:1266-82. 2006..These results highlight a new role for CREB in the control of triglyceride metabolism during the adaptative response of preadipocytes to mitochondrial dysfunction...
- The complex link between oxidised low-density lipoprotein and unstable anginaGiampaolo Niccoli
Institute of Cardiology, Catholic University, Rome, Italy
J Cardiovasc Med (Hagerstown) 8:387-91. 2007..We also assessed the correlation between plaque or plasma ox-LDL and angiographic complex stenosis morphology...
- Oxidized LDL and coronary heart diseasePaul Holvoet
Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Belgium
Acta Cardiol 59:479-84. 2004..Finally, elevated oxidized LDL predicted myocardial infarction in the Health ABC cohort consisting of well-functioning elderly people, even after adjusting for age, gender, race, smoking, and the metabolic syndrome...
- Increased levels of low-density lipoprotein oxidation in patients with familial hypercholesterolemia and in end-stage renal disease patients on hemodialysisLambertus Van Tits
Department of Medicine, Division of General Internal Medicine, UMC Nijmegen, Nijmegen, The Netherlands
Lab Invest 83:13-21. 2003..We conclude that cholesterol-lowering therapy does not normalize elevated LDL oxidation levels in FH patients and elevated LDL oxidation level in FH and in ESRD might mirror atherosclerosis...
- Human paraoxonase-1 overexpression inhibits atherosclerosis in a mouse model of metabolic syndromeBharti Mackness
University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
Arterioscler Thromb Vasc Biol 26:1545-50. 2006..Paraoxonase1 (PON1), a high-density lipoprotein (HDL)-associated antioxidant enzyme that prevents the oxidation of low-density lipoprotein (LDL), is low in the metabolic syndrome...
- Metabolic syndrome and the risk of cardiovascular disease in older adultsJaved Butler
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee, USA
J Am Coll Cardiol 47:1595-602. 2006..The purpose of this study was to assess whether metabolic syndrome (MetSyn) predicts a higher risk for cardiovascular events in older adults...
- Obesity, regional body fat distribution, and the metabolic syndrome in older men and womenBret H Goodpaster
Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Arch Intern Med 165:777-83. 2005..We determined whether patterns of regional fat deposition are associated with metabolic syndrome in older adults...
- Lipoprotein peroxidation and mobility limitation: results from the Health, Aging, and Body Composition StudyMatteo Cesari
Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville 32608, USA
Arch Intern Med 165:2148-54. 2005..The aim of this study was to assess the predictive value of a lipoprotein peroxidation marker, oxidized low-density lipoprotein (oxLDL) for incident mobility limitation (ML)...
- The importance of catch-up growth after early malnutrition for the programming of obesity in male ratFlorence Bieswal
Laboratory of Cell Biology, University of Louvain, Louvain-la-Neuve, Belgium
Obesity (Silver Spring) 14:1330-43. 2006..DISCUSSION: Catch-up growth immediately after early malnutrition should be a key point for the programming of obesity...
- Oxidized LDL and the metabolic syndromePaul Holvoet
Arterioscler Thromb Vasc Biol 26:e31; author reply e31-2. 2006