Greet Hermans

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Intensive insulin therapy in the medical ICU
    Greet Van den Berghe
    Department of Intensive Care Medicine, Catholic University of Leuven, Leuven, Belgium
    N Engl J Med 354:449-61. 2006
  2. ncbi request reprint Intensive insulin therapy in mixed medical/surgical intensive care units: benefit versus harm
    Greet Van den Berghe
    Department of Intensive Care Medicine, University Hospital Gasthuisberg, University of Leuven, B 3000 Leuven, Belgium
    Diabetes 55:3151-9. 2006
  3. doi request reprint Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: a post hoc analysis
    Michael P Casaer
    Laboratory and Department of Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium
    Am J Respir Crit Care Med 187:247-55. 2013
  4. ncbi request reprint Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit
    Greet Hermans
    Medical Intensive Care Unit, Department of Internal Medicine, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 175:480-9. 2007
  5. doi request reprint Metabolic aspects of critical illness polyneuromyopathy
    Greet Hermans
    Department of General Internal Medicine, Medical Intensive Care Unit, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 37:S391-7. 2009
  6. doi request reprint Early versus late parenteral nutrition in critically ill adults
    Michael P Casaer
    Department of Intensive Care Medicine, University Hospitals of the Catholic University of Leuven, Leuven, Belgium
    N Engl J Med 365:506-17. 2011
  7. doi request reprint Greater diaphragm fatigability in individuals with recurrent low back pain
    Lotte Janssens
    Department of Rehabilitation Sciences, University of Leuven, Tervuursevest 101 bus 1501, 3000 Leuven, Belgium
    Respir Physiol Neurobiol 188:119-23. 2013
  8. pmc Impact of early parenteral nutrition on metabolism and kidney injury
    Jan Gunst
    Clinical Department, KU Leuven, Leuven, Belgium
    J Am Soc Nephrol 24:995-1005. 2013
  9. doi request reprint Clinical review: Intensive insulin therapy in critically ill patients: NICE-SUGAR or Leuven blood glucose target?
    Greet Van den Berghe
    Laboratory and Department of Intensive Care Medicine, Catholic University of Leuven K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 94:3163-70. 2009
  10. doi request reprint Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial
    Greet Hermans
    Medical Intensive Care Unit, Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium Laboratory of Intensive Care Medicine, Division of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
    Lancet Respir Med 1:621-9. 2013

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Intensive insulin therapy in the medical ICU
    Greet Van den Berghe
    Department of Intensive Care Medicine, Catholic University of Leuven, Leuven, Belgium
    N Engl J Med 354:449-61. 2006
    ..Intensive insulin therapy reduces morbidity and mortality in patients in surgical intensive care units (ICUs), but its role in patients in medical ICUs is unknown...
  2. ncbi request reprint Intensive insulin therapy in mixed medical/surgical intensive care units: benefit versus harm
    Greet Van den Berghe
    Department of Intensive Care Medicine, University Hospital Gasthuisberg, University of Leuven, B 3000 Leuven, Belgium
    Diabetes 55:3151-9. 2006
    ..A blood glucose target <110 mg/day was most effective but also carried the highest risk of hypoglycemia...
  3. doi request reprint Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: a post hoc analysis
    Michael P Casaer
    Laboratory and Department of Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium
    Am J Respir Crit Care Med 187:247-55. 2013
    ..Early parenteral nutrition to supplement insufficient enteral feeding during intensive care (early PN) delays recovery as compared with withholding parenteral nutrition for 1 week (late PN)...
  4. ncbi request reprint Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit
    Greet Hermans
    Medical Intensive Care Unit, Department of Internal Medicine, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 175:480-9. 2007
    ..Besides controlling risk factors, no specific prevention or treatment exists. Recently, intensive insulin therapy prevented critical illness polyneuropathy in a surgical intensive care unit...
  5. doi request reprint Metabolic aspects of critical illness polyneuromyopathy
    Greet Hermans
    Department of General Internal Medicine, Medical Intensive Care Unit, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 37:S391-7. 2009
    ..Potential underlying mechanisms derived from experimental studies and from the analysis of biopsy samples harvested from critically ill patients or patients suffering from other catabolic states are discussed...
  6. doi request reprint Early versus late parenteral nutrition in critically ill adults
    Michael P Casaer
    Department of Intensive Care Medicine, University Hospitals of the Catholic University of Leuven, Leuven, Belgium
    N Engl J Med 365:506-17. 2011
    ..Controversy exists about the timing of the initiation of parenteral nutrition in critically ill adults in whom caloric targets cannot be met by enteral nutrition alone...
  7. doi request reprint Greater diaphragm fatigability in individuals with recurrent low back pain
    Lotte Janssens
    Department of Rehabilitation Sciences, University of Leuven, Tervuursevest 101 bus 1501, 3000 Leuven, Belgium
    Respir Physiol Neurobiol 188:119-23. 2013
    ..010) and 30% (p=0.005) of the controls, respectively. Individuals with LBP exhibit propensity for diaphragm fatigue, which was not observed in controls. An association with reduced spinal control warrants further study...
  8. pmc Impact of early parenteral nutrition on metabolism and kidney injury
    Jan Gunst
    Clinical Department, KU Leuven, Leuven, Belgium
    J Am Soc Nephrol 24:995-1005. 2013
    ..Substantial catabolism of the extra amino acids, which leads to higher levels of plasma urea, might explain the prolonged duration of renal replacement therapy observed with early parenteral nutrition...
  9. doi request reprint Clinical review: Intensive insulin therapy in critically ill patients: NICE-SUGAR or Leuven blood glucose target?
    Greet Van den Berghe
    Laboratory and Department of Intensive Care Medicine, Catholic University of Leuven K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 94:3163-70. 2009
    ..A recent large multicenter study, NICE-SUGAR, compared a similar age-normal with an intermediate glucose target and found the intermediate target superior. These results require explanation...
  10. doi request reprint Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial
    Greet Hermans
    Medical Intensive Care Unit, Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium Laboratory of Intensive Care Medicine, Division of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
    Lancet Respir Med 1:621-9. 2013
    ..The role of weakness was unclear. Our aim was to assess whether late PN and early PN differentially affect muscle weakness and autophagic quality control of myofibres...
  11. doi request reprint Muscle atrophy and preferential loss of myosin in prolonged critically ill patients
    Sarah Derde
    Departments of Intensive Care Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 40:79-89. 2012
    ....
  12. doi request reprint Invasive pulmonary aspergillosis is a frequent complication of critically ill H1N1 patients: a retrospective study
    Joost Wauters
    Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
    Intensive Care Med 38:1761-8. 2012
    ..We hypothesized that invasive pulmonary aspergillosis (IPA) is a frequent complication in critically ill patients with H1N1 virus infection and that CS may contribute to this complication...
  13. pmc Impact of early parenteral nutrition completing enteral nutrition in adult critically ill patients (EPaNIC trial): a study protocol and statistical analysis plan for a randomized controlled trial
    Michael P Casaer
    Department of Intensive Care Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Belgium
    Trials 12:21. 2011
    ..These guidelines differ particularly in the timing of initiating parenteral nutrition (PN) in patients for whom enteral nutrition (EN) does not reach caloric targets...
  14. doi request reprint Effect of insulin therapy on coagulation and fibrinolysis in medical intensive care patients
    Lies Langouche
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 36:1475-80. 2008
    ..We hypothesize that intensive insulin therapy also prevents severe coagulation abnormalities thereby contributing to less organ failure and better survival...
  15. ncbi request reprint Galactomannan in bronchoalveolar lavage fluid: a tool for diagnosing aspergillosis in intensive care unit patients
    Wouter Meersseman
    Medical Intensive Care Unit, University Hospital Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 177:27-34. 2008
    ..The diagnosis of IA remains difficult and is often established too late. Galactomannan (GM) is an exo-antigen released from Aspergillus hyphae while they invade host tissue...
  16. pmc Benefits of intensive insulin therapy on neuromuscular complications in routine daily critical care practice: a retrospective study
    Greet Hermans
    Department of Internal Medicine, Medical Intensive Care Unit, University Hospitals Leuven, Catholic University Leuven, Leuven, Belgium
    Crit Care 13:R5. 2009
    ..In the present study, we investigated whether these effects are also present in daily clinical practice when IIT is implemented outside of a study protocol...
  17. doi request reprint Lectin pathway of complement activation and relation with clinical complications in critically ill children
    Catherine Ingels
    Clinical Department and Laboratory of Intensive Care Medicine, Division of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
    Pediatr Res 75:99-108. 2014
    ..Conclusion:Low on-admission MASP-3 levels in critically ill children were independently associated with subsequent acquisition of infection and prolonged ICU stay. The biological explanation needs further investigation. ..
  18. doi request reprint The interobserver agreement of handheld dynamometry for muscle strength assessment in critically ill patients
    Goele Vanpee
    Department of Rehabilitation Sciences, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 39:1929-34. 2011
    ..Secondary objectives are to quantify muscle weakness, to evaluate distribution of muscle weakness, and to evaluate gender-related differences in muscle strength...
  19. pmc Clinical review: Critical illness polyneuropathy and myopathy
    Greet Hermans
    Medical Intensive Care Unit, Department of General Internal Medicine, University Hospitals, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Crit Care 12:238. 2008
    ..Also, conflicting evidence concerning the neuromuscular effects of corticosteroids exists. A systematic review of the available literature on the optimal approach for preventing CIP/CIM seems warranted...
  20. pmc Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational study
    Greet Hermans
    Medical Intensive Care Unit, General Internal Medicine, University Hospitals Leuven, Herestraat 49, B3000 Leuven, Belgium
    Crit Care 14:R127. 2010
    ..We aimed to evaluate the repeatability of TwPdi BAMPS in critically ill, mechanically ventilated patients and to describe the relation between TwPdi and the duration of mechanical ventilation...
  21. doi request reprint Pharmacokinetics of caspofungin and voriconazole in critically ill patients during extracorporeal membrane oxygenation
    Isabel Spriet
    Department of Pharmacy, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Antimicrob Chemother 63:767-70. 2009
    ..Treating patients during the ECMO period with antifungals is difficult. Loss in the ECMO circuit can potentially result in sub-therapeutic levels...
  22. doi request reprint Alterations in adipose tissue during critical illness: An adaptive and protective response?
    Lies Langouche
    Department and Laboratory of Intensive Care Medicine, Katholieke Universiteit Leuven, Belgium
    Am J Respir Crit Care Med 182:507-16. 2010
    ..Overweight and obese critically ill patients may have a lower risk of death than lean patients, suggestive of a protective role for adipose tissue during illness...
  23. doi request reprint Assessment of limb muscle strength in critically ill patients: a systematic review
    Goele Vanpee
    1Department Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Leuven, Belgium 2Department of Intensive Care, University Hospitals Leuven, Leuven, Belgium 3Medical Intensive Care Unit of the Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium
    Crit Care Med 42:701-11. 2014
    ..To determine the reliability of volitional and nonvolitional limb muscle strength assessment in critically ill patients and to provide guidelines for the implementation of limb muscle strength assessment this population...
  24. doi request reprint Interventions for preventing critical illness polyneuropathy and critical illness myopathy
    Greet Hermans
    Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Leuven, Belgium
    Cochrane Database Syst Rev 1:CD006832. 2014
    ..This is an interim update of a review first published in 2009 (Hermans 2009). It has been updated to October 2011, with further potentially eligible studies from a December 2013 search characterised as awaiting assessment...
  25. ncbi request reprint ICU-based rehabilitation and its appropriate metrics
    Rik Gosselink
    Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium
    Curr Opin Crit Care 18:533-9. 2012
    ..The scope of the review is to discuss recent developments in application of assessment tools and rehabilitation in critically ill patients within an interdisciplinary approach...
  26. ncbi request reprint Neurocognitive development of children 4 years after critical illness and treatment with tight glucose control: a randomized controlled trial
    Dieter Mesotten
    Department of Intensive Care Medicine, Catholic University of Leuven, Leuven, Belgium
    JAMA 308:1641-50. 2012
    ....
  27. doi request reprint The assessment of inspiratory muscle fatigue in healthy individuals: a systematic review
    Lotte Janssens
    Department of Rehabilitation Sciences, University of Leuven, 3000 Leuven, Belgium
    Respir Med 107:331-46. 2013
    ..The specific outcome measures employed to detect IMF, the magnitude of their change, as well as their functional significance, are ultimately dependent upon the research question being addressed...
  28. doi request reprint Endogenous carbon monoxide production: a rare and detrimental complication of extracorporeal membrane oxygenation
    Greet Hermans
    Department of General Internal Medicine, Medical Intensive Care Unit, University Hospitals, Leuven, Belgium
    ASAIO J 54:633-5. 2008
    ..This may have had detrimental effects by further complicating tissue oxygenation. We recommend that COHb should routinely be checked in ECMO patients...
  29. ncbi request reprint pH 48 h after onset of extracorporeal membrane oxygenation is an independent predictor of survival in patients with respiratory failure
    Filip R Rega
    Department of Cardiac Surgery, University Hospital Gasthuisberg, Leuven, Belgium
    Artif Organs 31:384-9. 2007
    ..Although there was no difference in pH at onset of ECMO, blood gas analysis at 48 h revealed pH as an independent predictor of survival...
  30. pmc Relationship between Abdominal Pressure, Pulmonary Compliance, and Cardiac Preload in a Porcine Model
    Joost Wauters
    Medical Intensive Care Unit, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Crit Care Res Pract 2012:763181. 2012
    ..Volumetric filling parameters and transmural filling pressures are clearly superior to classical cardiac filling pressures in the assessment of cardiac preload during elevated IAP...
  31. ncbi request reprint Subacute trismus in a kidney transplant recipient
    Britt Van Aken
    Department of General Internal Medicine, Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
    J Orofac Pain 24:412-6. 2010
    ..The primary tumor was not found on autopsy. The patient was at increased risk for malignancy due to his renal transplantation 16 years before...
  32. doi request reprint Early exercise in critically ill patients enhances short-term functional recovery
    Chris Burtin
    Faculty of Kinesiology and Rehabilitation Sciences CB, BC, CR, DL, TT, RG, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 37:2499-505. 2009
    ..No evidence is available concerning the effectiveness of an early exercise training intervention to prevent these detrimental complications...
  33. ncbi request reprint The Molecular Adsorbent Recirculating System in patients with severe liver failure: clinical results at the K.U. Leuven
    Alexander Wilmer
    Medical Intensive Care Unit, UZ Gasthuisberg, Catholic University of Leuven, Belgium
    Liver 22:52-5. 2002
    ..The Molecular Adsorbent Recirculating System (MARS) is a novel extracorporeal technique for liver support. We report the clinical results in the first 13 patients with severe liver failure treated at our institution...