Mieke Gouwy

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. doi request reprint CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection
    Mieke Gouwy
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Eur J Immunol 41:963-73. 2011
  2. ncbi request reprint Synergy in cytokine and chemokine networks amplifies the inflammatory response
    Mieke Gouwy
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Cytokine Growth Factor Rev 16:561-80. 2005
  3. pmc Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation
    Paul Proost
    Laboratory of Molecular Immunology, Rega Institute, K U Leuven, Leuven, Belgium
    J Exp Med 205:2085-97. 2008
  4. ncbi request reprint Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells
    Jo Vandercappellen
    Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Leukoc Biol 82:1519-30. 2007
  5. ncbi request reprint Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4
    Sofie Struyf
    Rega Institute for Medical Research, Laboratory of Molecular Immunology, University of Leuven, Leuven, Belgium
    J Immunol 182:666-74. 2009
  6. doi request reprint Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events
    Mieke Gouwy
    Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Mol Pharmacol 74:485-95. 2008
  7. ncbi request reprint Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration
    Paul Proost
    Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Leuven, Belgium
    Blood 110:37-44. 2007
  8. pmc Posttranslational modification of the NH2-terminal region of CXCL5 by proteases or peptidylarginine Deiminases (PAD) differently affects its biological activity
    Anneleen Mortier
    Laboratory of Molecular Immunology, Rega Institute, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 285:29750-9. 2010
  9. ncbi request reprint TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis
    Tamara Loos
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Lab Invest 86:902-16. 2006
  10. doi request reprint Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation
    Tamara Loos
    Laboratory of Molecular Immunology, Rega Institute, KU Katholieke Universiteit Leuven, Leuven, Belgium
    Blood 112:2648-56. 2008

Collaborators

Detail Information

Publications27

  1. doi request reprint CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection
    Mieke Gouwy
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Eur J Immunol 41:963-73. 2011
    ..Our data demonstrate the cooperation between CCL5 and CXCL12, which has implications in migration of monocytes/lymphocytes during inflammation and in HIV-1 infection...
  2. ncbi request reprint Synergy in cytokine and chemokine networks amplifies the inflammatory response
    Mieke Gouwy
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Cytokine Growth Factor Rev 16:561-80. 2005
    ....
  3. pmc Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation
    Paul Proost
    Laboratory of Molecular Immunology, Rega Institute, K U Leuven, Leuven, Belgium
    J Exp Med 205:2085-97. 2008
    ..This study shows that PAD citrullinates the chemokine CXCL8, and thus may dampen neutrophil extravasation during acute or chronic inflammation...
  4. ncbi request reprint Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells
    Jo Vandercappellen
    Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Leukoc Biol 82:1519-30. 2007
    ..Application of angiostatic CXCL4L1/PF-4var without attraction of protumoral phagocytes may be beneficial in cancer therapy...
  5. ncbi request reprint Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4
    Sofie Struyf
    Rega Institute for Medical Research, Laboratory of Molecular Immunology, University of Leuven, Leuven, Belgium
    J Immunol 182:666-74. 2009
    ..Therefore, PAD is a potent physiologic down-regulator of CXCL12 function...
  6. doi request reprint Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events
    Mieke Gouwy
    Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Mol Pharmacol 74:485-95. 2008
    ..These data indicate that for synergistic interaction between chemokines binding and signaling of the two chemokines via their proper receptors is necessary...
  7. ncbi request reprint Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration
    Paul Proost
    Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Leuven, Belgium
    Blood 110:37-44. 2007
    ..Taken together, during inflammation or cancer, CXCL11 processing by CD13 may lead to a reduced number of tumor-infiltrating lymphocytes and in a more angiogenic environment...
  8. pmc Posttranslational modification of the NH2-terminal region of CXCL5 by proteases or peptidylarginine Deiminases (PAD) differently affects its biological activity
    Anneleen Mortier
    Laboratory of Molecular Immunology, Rega Institute, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 285:29750-9. 2010
    ..The highly divergent effects of modifications of CXCL5 on neutrophil influx underline the potential importance of tissue-specific interactions between chemokines and PAD or proteases...
  9. ncbi request reprint TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis
    Tamara Loos
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Lab Invest 86:902-16. 2006
    ..Thus, CXCL9 is an important chemokine in autoimmune arthritis...
  10. doi request reprint Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation
    Tamara Loos
    Laboratory of Molecular Immunology, Rega Institute, KU Katholieke Universiteit Leuven, Leuven, Belgium
    Blood 112:2648-56. 2008
    ..Additionally because citrullination has severe consequences for chemokine biology, this invites to reassess the involvement and impact of PAD and citrullinated peptides in inflammation, autoimmunity, and hematologic disorders...
  11. pmc Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies
    Paul Proost
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium
    Arthritis Res Ther 8:R107. 2006
    ..Synovial concentrations of the neutrophil chemoattractant CXCL8 may therefore be useful to discriminate between autoimmune arthritis types...
  12. ncbi request reprint GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors
    Klara Gijsbers
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Exp Cell Res 303:331-42. 2005
    ....
  13. ncbi request reprint Rabbit neutrophil chemotactic protein (NCP) activates both CXCR1 and CXCR2 and is the functional homologue for human CXCL6
    Julie Catusse
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Biochem Pharmacol 68:1947-55. 2004
    ..It is concluded that the rabbit is a better model to study human neutrophil activation compared to mice, which lack CXCL8/IL-8...
  14. doi request reprint Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects
    Sofie Struyf
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, K U Leuven, Leuven, Belgium
    Eur J Immunol 39:843-57. 2009
    ..These data indicate that optimal induction and delivery of MCP-2/CCL8 is counteracted by converting this chemokine into a receptor antagonist, thereby losing its anti-tumoral potential...
  15. doi request reprint CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8
    Mieke Gouwy
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, B 3000 Leuven, Belgium
    J Leukoc Biol 86:671-80. 2009
    ....
  16. pmc Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3
    Sofie Struyf
    Rega Institute, K U Leuven, Leuven, Belgium
    Blood 117:480-8. 2011
    ..However, the in vivo data indicate that the angiostatic property of CXCL4L1 is equally important in retarding tumor growth. Thus, both CXCR3A and CXCR3B are implicated in the chemotactic and vascular effects of CXCL4L1...
  17. ncbi request reprint Synergy between proinflammatory ligands of G protein-coupled receptors in neutrophil activation and migration
    Mieke Gouwy
    Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Leukoc Biol 76:185-94. 2004
    ..Thus, proinflammatory chemokines (IL-8, MCP-1), coinduced during infection in the tissue, synergize with each other or with constitutive chemokines (regakine-1, SDF-1alpha) to enhance the inflammatory response...
  18. ncbi request reprint Chemokines synergize in the recruitment of circulating neutrophils into inflamed tissue
    Sofie Struyf
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, Leuven, Belgium
    Eur J Immunol 35:1583-91. 2005
    ..These data demonstrate that inducible and constitutive GPCR ligands synergize to enhance inflammation and facilitate a more effective immune response...
  19. pmc Hypoxia enhances CXCR4 expression in human microvascular endothelial cells and human melanoma cells
    Evemie Schutyser
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Belgium
    Eur Cytokine Netw 18:59-70. 2007
    ..These results demonstrate that the tumor microenvironment regulates chemokine receptor expression through both cytokine and oxygen levels...
  20. ncbi request reprint Identification and characterization of MIP-1α/CCL3 isoform 2 from bovine serum as a potent monocyte/dendritic cell chemoattractant
    Mieke De Buck
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, Minderbroedersstraat 10, Belgium
    Biochem Pharmacol 85:789-97. 2013
    ..Since it cannot be deduced which is the exact human homolog of boCCL3 isoform 2, further research is required to study the biology of other boCCL3 family members...
  21. doi request reprint Possible mechanisms involved in chemokine synergy fine tuning the inflammatory response
    Mieke Gouwy
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Immunol Lett 145:10-4. 2012
    ..The cellular mechanisms involved in chemokine synergy are still debated, but probably include chemokine and/or receptor heterodimerization and subsequent cooperation in signal transduction...
  22. doi request reprint Myeloid cells are tunable by a polyanionic polysaccharide derivative and co-determine host rescue from lethal virus infection
    Sandra Li
    Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, Minderbroedersstraat 10, Leuven, Belgium
    J Leukoc Biol 88:1017-29. 2010
    ..These findings reinforce the role of neutrophils and macrophages as critical cells that can be manipulated toward antiviral defense...
  23. ncbi request reprint The unique property of the CC chemokine regakine-1 to synergize with other plasma-derived inflammatory mediators in neutrophil chemotaxis does not reside in its NH2-terminal structure
    Mieke Gouwy
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Mol Pharmacol 62:173-80. 2002
    ..These findings indicate that the constitutive plasma chemokine regakine-1 is a stable enhancer of the inflammatory response and that its blockade might be beneficial in acute and systemic inflammatory disorders...
  24. pmc PARC/CCL18 is a plasma CC chemokine with increased levels in childhood acute lymphoblastic leukemia
    Sofie Struyf
    Laboratories of Molecular Immunology, Rega Institute, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Am J Pathol 163:2065-75. 2003
    ..Serum PARC levels thus constitute a novel leukemia marker, possibly reflecting tumor/host cell interactions in the circulation...
  25. doi request reprint Effect of posttranslational processing on the in vitro and in vivo activity of chemokines
    Anneleen Mortier
    Laboratory of Molecular Immunology, Rega Institute, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Exp Cell Res 317:642-54. 2011
    ..This goes along with other positive and negative regulatory mechanisms for leukocyte migration, such as chemokine synergy and scavenging by decoy receptors...
  26. doi request reprint Chemokines and other GPCR ligands synergize in receptor-mediated migration of monocyte-derived immature and mature dendritic cells
    Mieke Gouwy
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium
    Immunobiology 219:218-29. 2014
    ..Thus, chemokine synergy in immature and mature MDDC migration is dose-dependently regulated by chemokines via alterations in their chemokine receptor expression pattern according to their role in immune responses...
  27. ncbi request reprint CXCL4L1 and CXCL4 signaling in human lymphatic and microvascular endothelial cells and activated lymphocytes: involvement of mitogen-activated protein (MAP) kinases, Src and p70S6 kinase
    Katrien Van Raemdonck
    Laboratory of Molecular Immunology, KU Leuven University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, 3000, Leuven, Belgium
    Angiogenesis 17:631-40. 2014
    ..Our findings confirm that the angiostatic chemokines CXCL4L1 and CXCL4 activate both CXCR3A and CXCR3B and bring new insights into the complexity of their signaling cascades. ..