Research Topics
Genomes and Genes | Mieke GouwySummaryAffiliation: Katholieke Universiteit Leuven Country: Belgium Publications
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Publications
CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infectionMieke Gouwy
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
Eur J Immunol 41:963-73. 2011..Our data demonstrate the cooperation between CCL5 and CXCL12, which has implications in migration of monocytes/lymphocytes during inflammation and in HIV-1 infection...
Synergy in cytokine and chemokine networks amplifies the inflammatory responseMieke Gouwy
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
Cytokine Growth Factor Rev 16:561-80. 2005....
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammationPaul Proost
Laboratory of Molecular Immunology, Rega Institute, K U Leuven, Leuven, Belgium
J Exp Med 205:2085-97. 2008..This study shows that PAD citrullinates the chemokine CXCL8, and thus may dampen neutrophil extravasation during acute or chronic inflammation...- Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cellsJo Vandercappellen
Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
J Leukoc Biol 82:1519-30. 2007..Application of angiostatic CXCL4L1/PF-4var without attraction of protumoral phagocytes may be beneficial in cancer therapy... - Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4Sofie Struyf
Rega Institute for Medical Research, Laboratory of Molecular Immunology, University of Leuven, Leuven, Belgium
J Immunol 182:666-74. 2009..Therefore, PAD is a potent physiologic down-regulator of CXCL12 function... - Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated eventsMieke Gouwy
Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
Mol Pharmacol 74:485-95. 2008..These data indicate that for synergistic interaction between chemokines binding and signaling of the two chemokines via their proper receptors is necessary... - Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migrationPaul Proost
Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Leuven, Belgium
Blood 110:37-44. 2007..Taken together, during inflammation or cancer, CXCL11 processing by CD13 may lead to a reduced number of tumor-infiltrating lymphocytes and in a more angiogenic environment... - TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritisTamara Loos
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
Lab Invest 86:902-16. 2006..Thus, CXCL9 is an important chemokine in autoimmune arthritis... - Posttranslational modification of the NH2-terminal region of CXCL5 by proteases or peptidylarginine Deiminases (PAD) differently affects its biological activityAnneleen Mortier
Laboratory of Molecular Immunology, Rega Institute, KU Leuven, B 3000 Leuven, Belgium
J Biol Chem 285:29750-9. 2010..The highly divergent effects of modifications of CXCL5 on neutrophil influx underline the potential importance of tissue-specific interactions between chemokines and PAD or proteases... - Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulationTamara Loos
Laboratory of Molecular Immunology, Rega Institute, KU Katholieke Universiteit Leuven, Leuven, Belgium
Blood 112:2648-56. 2008..Additionally because citrullination has severe consequences for chemokine biology, this invites to reassess the involvement and impact of PAD and citrullinated peptides in inflammation, autoimmunity, and hematologic disorders... - Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathiesPaul Proost
Laboratory of Molecular Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium
Arthritis Res Ther 8:R107. 2006..Synovial concentrations of the neutrophil chemoattractant CXCL8 may therefore be useful to discriminate between autoimmune arthritis types... - GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumorsKlara Gijsbers
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
Exp Cell Res 303:331-42. 2005.... - Rabbit neutrophil chemotactic protein (NCP) activates both CXCR1 and CXCR2 and is the functional homologue for human CXCL6Julie Catusse
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium
Biochem Pharmacol 68:1947-55. 2004..It is concluded that the rabbit is a better model to study human neutrophil activation compared to mice, which lack CXCL8/IL-8... - Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3Sofie Struyf
Rega Institute, K U Leuven, Leuven, Belgium
Blood 117:480-8. 2011..However, the in vivo data indicate that the angiostatic property of CXCL4L1 is equally important in retarding tumor growth. Thus, both CXCR3A and CXCR3B are implicated in the chemotactic and vascular effects of CXCL4L1... - Synergy between proinflammatory ligands of G protein-coupled receptors in neutrophil activation and migrationMieke Gouwy
Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium
J Leukoc Biol 76:185-94. 2004..Thus, proinflammatory chemokines (IL-8, MCP-1), coinduced during infection in the tissue, synergize with each other or with constitutive chemokines (regakine-1, SDF-1alpha) to enhance the inflammatory response... - Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effectsSofie Struyf
Laboratory of Molecular Immunology, Rega Institute for Medical Research, K U Leuven, Leuven, Belgium
Eur J Immunol 39:843-57. 2009..These data indicate that optimal induction and delivery of MCP-2/CCL8 is counteracted by converting this chemokine into a receptor antagonist, thereby losing its anti-tumoral potential... - CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8Mieke Gouwy
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, B 3000 Leuven, Belgium
J Leukoc Biol 86:671-80. 2009.... - Hypoxia enhances CXCR4 expression in human microvascular endothelial cells and human melanoma cellsEvemie Schutyser
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Belgium
Eur Cytokine Netw 18:59-70. 2007..These results demonstrate that the tumor microenvironment regulates chemokine receptor expression through both cytokine and oxygen levels... - Chemokines synergize in the recruitment of circulating neutrophils into inflamed tissueSofie Struyf
Laboratory of Molecular Immunology, Rega Institute for Medical Research, Leuven, Belgium
Eur J Immunol 35:1583-91. 2005..These data demonstrate that inducible and constitutive GPCR ligands synergize to enhance inflammation and facilitate a more effective immune response... - Possible mechanisms involved in chemokine synergy fine tuning the inflammatory responseMieke Gouwy
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
Immunol Lett 145:10-4. 2012..The cellular mechanisms involved in chemokine synergy are still debated, but probably include chemokine and/or receptor heterodimerization and subsequent cooperation in signal transduction... - Myeloid cells are tunable by a polyanionic polysaccharide derivative and co-determine host rescue from lethal virus infectionSandra Li
Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, Minderbroedersstraat 10, Leuven, Belgium
J Leukoc Biol 88:1017-29. 2010..These findings reinforce the role of neutrophils and macrophages as critical cells that can be manipulated toward antiviral defense... - PARC/CCL18 is a plasma CC chemokine with increased levels in childhood acute lymphoblastic leukemiaSofie Struyf
Laboratories of Molecular Immunology, Rega Institute, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
Am J Pathol 163:2065-75. 2003..Serum PARC levels thus constitute a novel leukemia marker, possibly reflecting tumor/host cell interactions in the circulation... - The unique property of the CC chemokine regakine-1 to synergize with other plasma-derived inflammatory mediators in neutrophil chemotaxis does not reside in its NH2-terminal structureMieke Gouwy
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
Mol Pharmacol 62:173-80. 2002..These findings indicate that the constitutive plasma chemokine regakine-1 is a stable enhancer of the inflammatory response and that its blockade might be beneficial in acute and systemic inflammatory disorders... - Effect of posttranslational processing on the in vitro and in vivo activity of chemokinesAnneleen Mortier
Laboratory of Molecular Immunology, Rega Institute, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
Exp Cell Res 317:642-54. 2011..This goes along with other positive and negative regulatory mechanisms for leukocyte migration, such as chemokine synergy and scavenging by decoy receptors...