An Goris

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease
    An Goris
    Department of Clinical Neurosciences Neurology Unit, University of Cambridge, Cambridge, United Kingdom
    Ann Neurol 62:145-53. 2007
  2. doi KIR2DL4 (CD158d) polymorphisms and susceptibility to multiple sclerosis
    An Goris
    Katholieke Universiteit Leuven, Belgium
    J Neuroimmunol 210:113-5. 2009
  3. doi A Taqman assay for high-throughput genotyping of the multiple sclerosis-associated HLA-DRB1*1501 allele
    A Goris
    Laboratory of Neuroimmunology, Section of Experimental Neurology, Katholieke Universiteit Leuven, Leuven, Belgium
    Tissue Antigens 72:401-3. 2008
  4. doi Replication of KIF21B as a susceptibility locus for multiple sclerosis
    A Goris
    Laboratory for Neuroimmunology, Section of Experimental Neurology, O and N2, Herestraat 49, Box 1022, 3000 Leuven, Belgium
    J Med Genet 47:775-6. 2010
  5. doi TNFRSF1A coding variants in multiple sclerosis
    An Goris
    Laboratory for Neuroimmunology, Section of Experimental Neurology, Katholieke Universiteit Leuven, Herestraat 49 bus 1022, 3000 Leuven, Belgium
    J Neuroimmunol 235:110-2. 2011
  6. doi The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort
    Caroline H Williams-Gray
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK
    Brain 132:2958-69. 2009
  7. doi Association of the human leucocyte antigen region with susceptibility to Parkinson's disease
    Misuzu Saiki
    Department of Clinical Neurosciences Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    J Neurol Neurosurg Psychiatry 81:890-1. 2010
  8. ncbi Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans
    Maria Ban
    University of Cambridge, Department of Clinical Neurosciences, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    J Neuroimmunol 179:108-16. 2006
  9. doi Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson's disease
    Caroline H Williams-Gray
    Cambridge Centre for Brain Repair, Dept of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    J Neurol 256:493-8. 2009
  10. ncbi New candidate loci for multiple sclerosis susceptibility revealed by a whole genome association screen in a Belgian population
    An Goris
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    J Neuroimmunol 143:65-9. 2003

Detail Information

Publications33

  1. ncbi Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease
    An Goris
    Department of Clinical Neurosciences Neurology Unit, University of Cambridge, Cambridge, United Kingdom
    Ann Neurol 62:145-53. 2007
    ..We investigated the genetic basis of susceptibility to and cognitive heterogeneity of this disease...
  2. doi KIR2DL4 (CD158d) polymorphisms and susceptibility to multiple sclerosis
    An Goris
    Katholieke Universiteit Leuven, Belgium
    J Neuroimmunol 210:113-5. 2009
    ..Whereas 26% of the study population has a genotype corresponding to a lack of any functional membrane-bound form of the molecule, no association of the KIR2DL4 transmembrane alleles with susceptibility to MS was observed...
  3. doi A Taqman assay for high-throughput genotyping of the multiple sclerosis-associated HLA-DRB1*1501 allele
    A Goris
    Laboratory of Neuroimmunology, Section of Experimental Neurology, Katholieke Universiteit Leuven, Leuven, Belgium
    Tissue Antigens 72:401-3. 2008
    ..94. Subsequently, applying the assay to a group of MS patients and controls from Belgium confirmed the association of HLA-DRB1*1501 and MS in this population (P = 5 x 10(-21))...
  4. doi Replication of KIF21B as a susceptibility locus for multiple sclerosis
    A Goris
    Laboratory for Neuroimmunology, Section of Experimental Neurology, O and N2, Herestraat 49, Box 1022, 3000 Leuven, Belgium
    J Med Genet 47:775-6. 2010
    ..KIF21B is a member of the kinesin superfamily and was recently established as a susceptibility locus for inflammatory bowel disease and for multiple sclerosis...
  5. doi TNFRSF1A coding variants in multiple sclerosis
    An Goris
    Laboratory for Neuroimmunology, Section of Experimental Neurology, Katholieke Universiteit Leuven, Herestraat 49 bus 1022, 3000 Leuven, Belgium
    J Neuroimmunol 235:110-2. 2011
    ..26 (95% CI 1.41-3.61)], which appears independent of an established common risk variant in the same gene. No other non-synonymous variants in the same allele frequency range influencing risk of MS were observed...
  6. doi The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort
    Caroline H Williams-Gray
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK
    Brain 132:2958-69. 2009
    ..Our work suggests that the dementing process in Parkinson's disease is predictable and related to tau while frontal-executive dysfunction evolves independently with a more dopaminergic basis and better prognosis...
  7. doi Association of the human leucocyte antigen region with susceptibility to Parkinson's disease
    Misuzu Saiki
    Department of Clinical Neurosciences Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    J Neurol Neurosurg Psychiatry 81:890-1. 2010
    ..The Human Leucocyte Antigen (HLA) region is one of the most important genetic susceptibility factors in many immune-mediated diseases but has not been extensively investigated in PD...
  8. ncbi Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans
    Maria Ban
    University of Cambridge, Department of Clinical Neurosciences, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    J Neuroimmunol 179:108-16. 2006
    ..Association mapping across the candidate genes implicated by these markers in 937 UK trio families revealed modestly associated haplotypes in JAG1 (p=0.019) on chromosome 20p12.2 and POU2AF1 (p=0.003) on chromosome 11q23.1...
  9. doi Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson's disease
    Caroline H Williams-Gray
    Cambridge Centre for Brain Repair, Dept of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    J Neurol 256:493-8. 2009
    ..Large scale longitudinal studies would be best placed to further evaluate any impact of APOE genotype on cognitive decline in PD...
  10. ncbi New candidate loci for multiple sclerosis susceptibility revealed by a whole genome association screen in a Belgian population
    An Goris
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    J Neuroimmunol 143:65-9. 2003
    ..g. the integrin ligand EDIL3, the high-mobility group box protein TOX, neutral sphingomyelinase activating factor (NSMAF) and the B-cell specific transcription factor POU2AF1...
  11. pmc Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor
    Maria Ban
    Department of Clinical Neuroscience, Addenbrooke s, Hospital, University of Cambridge, Cambridge, UK
    Eur J Hum Genet 17:1309-13. 2009
    ....
  12. pmc Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke
    Robin Lemmens
    Department of Neurology, University Hospitals Leuven, Leuven, Belgium
    Eur J Hum Genet 17:1287-93. 2009
    ..The risk variant on chromosome 9, tagged by rs10757278, is associated with coronary heart disease in the Belgian population, but not with isolated CVD. These findings suggest different pathogenic mechanisms in CAD versus CVD...
  13. pmc A second major histocompatibility complex susceptibility locus for multiple sclerosis
    Tai Wai Yeo
    Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Ann Neurol 61:228-36. 2007
    ..The possibility that other genes in the MHC independently influence susceptibility to multiple sclerosis has been suggested but remains unconfirmed...
  14. doi Rare MEFV variants are not associated with risk to develop multiple sclerosis and severity of disease
    Ine Pauwels
    Department of Neurosciences, Laboratory for Neuroimmunology, Section of Experimental Neurology, KU Leuven, Belgium
    Mult Scler 19:1132-6. 2013
    ....
  15. pmc Novel COL4A1 mutations cause cerebral small vessel disease by haploinsufficiency
    Robin Lemmens
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Hum Mol Genet 22:391-7. 2013
    ..These findings suggest haploinsufficiency, a different mechanism from the commonly assumed dominant-negative effect, for COL4A1 mutations as a cause of (antenatal) intracerebral hemorrhage and white matter disease...
  16. ncbi EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans
    Annelies Van Hoecke
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Nat Med 18:1418-22. 2012
    ..This suggests that Epha4 generically modulates the vulnerability of (motor) neurons to axonal degeneration and may represent a new target for therapeutic intervention...
  17. pmc Whole-genome sequencing reveals a coding non-pathogenic variant tagging a non-coding pathogenic hexanucleotide repeat expansion in C9orf72 as cause of amyotrophic lateral sclerosis
    Sarah Herdewyn
    Department of Neurology, University of Leuven, Leuven, Belgium
    Hum Mol Genet 21:2412-9. 2012
    ..It also confirms (GGGGCC)n repeat expansions in C9orf72 as a cause of familial ALS...
  18. pmc Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis
    Elke Bogaert
    Laboratory for Neurobiology, Experimental Neurology, University of Leuven, Leuven, Belgium
    Neurobiol Aging 33:418-20. 2012
    ..We conclude that polymorphisms in the GluR2 gene (GRIA2) are not a major contributory factor in the pathogenesis of ALS...
  19. pmc Progress in multiple sclerosis genetics
    An Goris
    Laboratory for Neuroimmunology, Section of Experimental Neurology, KU Leuven, Leuven, Belgium
    Curr Genomics 13:646-63. 2012
    ..We discuss how these translate into an improved understanding of disease mechanisms, and address current challenges such as genotype-phenotype correlations, functional mechanisms of risk variants and the missing heritability...
  20. ncbi Interleukin-12 p40 polymorphism and susceptibility to multiple sclerosis
    Iraide Alloza
    Ann Neurol 52:524-5. 2002
  21. ncbi Cytokine gene polymorphisms in multifactorial diseases: gateways to novel targets for immunotherapy?
    Koen Vandenbroeck
    Cytokine Biology and Genetics Programme, School of Pharmacy, Queen s University Belfast, Belfast BT9 7BL, UK
    Trends Pharmacol Sci 24:284-9. 2003
    ....
  22. ncbi SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Italy
    Neurosci Lett 394:92-6. 2006
    ..Therefore, none of the SNPs investigated is associated with MS, although this analysis does not conclusively exclude SELPLG and SELP as genetic risk factors for MS as much variation remains untested...
  23. ncbi No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson's disease
    Caroline H Williams-Gray
    Mov Disord 21:731-2. 2006
  24. ncbi CD24 Ala/Val polymorphism and multiple sclerosis
    An Goris
    Department of Clinical Neurosciences, Neurology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neuroimmunol 175:200-2. 2006
    ..Since the CD24 gene is part of a segmental duplication, special care is required for the identification and genotyping of single nucleotide polymorphisms...
  25. ncbi No evidence for association of a European-specific chromosome 17 inversion with multiple sclerosis
    An Goris
    Eur J Hum Genet 14:1064. 2006
  26. ncbi Polymorphisms in the neuromyelitis optica auto-antigen AQP4 and susceptibility to multiple sclerosis
    Maria Ban
    J Neurol 254:398-9. 2007
  27. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  28. ncbi Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis
    Simon G Gregory
    Center for Human Genetics, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Genet 39:1083-91. 2007
    ..The SNP influences the amount of soluble and membrane-bound isoforms of the protein by putatively disrupting an exonic splicing silencer...
  29. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  30. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  31. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  32. ncbi Chromosome 7q21-22 and multiple sclerosis: evidence for a genetic susceptibility effect in vicinity to the protachykinin-1 gene
    Koen Vandenbroeck
    Rega Institute for Medical Research, University of Leuven, B 3000 Louvain, Belgium
    J Neuroimmunol 125:141-8. 2002
    ..e. D7S477, and MS. Overall, the analysis presented here may contribute to the increasingly refined genomic map of MS and underscores the requirement for a further high-resolution screening of chromosome 7q21-22...