K Geboes

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Is histology useful for the assessment of the efficacy of immunosuppressive agents in IBD and if so, how should it be applied ?
    K Geboes
    Department of Pathology, University Hospital, KUL, Leuven, Belgium
    Acta Gastroenterol Belg 67:285-9. 2004
  2. ncbi request reprint Indeterminate colitis
    Karel Geboes
    Department of Pathology, University Hospital KU Leuven, Leuven, Belgium
    Inflamm Bowel Dis 9:324-31. 2003
  3. ncbi request reprint Endoscopic and histologic evidence of persistent mucosal healing and correlation with clinical improvement following sustained infliximab treatment for Crohn's disease
    Karel Geboes
    Universitair Ziekenhuis St Rafael, Afdeling Pathologie, Leuven, Belgium
    Curr Med Res Opin 21:1741-54. 2005
  4. ncbi request reprint Appendiceal function and dysfunction: what are the implications for inflammatory bowel disease?
    Karel Geboes
    Gastrointestinal Pathology Unit, KU Leuven University Hospital, Leuven, Belgium
    Nat Clin Pract Gastroenterol Hepatol 2:338-9. 2005
  5. ncbi request reprint Long-term lansoprazole treatment for gastro-oesophageal reflux disease: clinical efficacy and influence on gastric mucosa
    K Geboes
    Department of Pathology, University Hospital St Rafael, Leuven, Belgium
    Aliment Pharmacol Ther 15:1819-26. 2001
  6. doi request reprint Lymphocytic, collagenous and other microscopic colitides: pathology and the relationship with idiopathic inflammatory bowel diseases
    K Geboes
    Department of Pathology, University Hospital, KU Leuven, Leuven, Belgium
    Gastroenterol Clin Biol 32:689-94. 2008
  7. doi request reprint Inflammatory bowel disease unclassified and indeterminate colitis: the role of the pathologist
    K Geboes
    Department of Pathology, University Hospital KU Leuven, Leuven, Belgium
    J Clin Pathol 62:201-5. 2009
  8. pmc Influence of treatment on morphological features of mucosal inflammation
    K Geboes
    Department of Pathology, University of Leuven, Belgium
    Gut 50:III37-42. 2002
  9. ncbi request reprint Pathology of early lower GI cancer
    Karel Geboes
    Department of Pathology, University Hospital, KULeuven, Minderbroedersstraat 12, 3000 Leuven, Belgium
    Best Pract Res Clin Gastroenterol 19:963-78. 2005
  10. doi request reprint Indeterminate colitis: a review of the concept--what's in a name?
    Karel Geboes
    Department of Pathology, University Hospital Leuven, Belgium
    Inflamm Bowel Dis 14:850-7. 2008

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Is histology useful for the assessment of the efficacy of immunosuppressive agents in IBD and if so, how should it be applied ?
    K Geboes
    Department of Pathology, University Hospital, KUL, Leuven, Belgium
    Acta Gastroenterol Belg 67:285-9. 2004
    ..This allows comparisons between different studies. Different scoring systems have been designed for ulcerative colitis and Crohn's disease. For the latter, multiple biopsies should be analysed. Most scoring systems still need validation...
  2. ncbi request reprint Indeterminate colitis
    Karel Geboes
    Department of Pathology, University Hospital KU Leuven, Leuven, Belgium
    Inflamm Bowel Dis 9:324-31. 2003
    ..Therefore, the possibility that IC could be a separate entity must be investigated...
  3. ncbi request reprint Endoscopic and histologic evidence of persistent mucosal healing and correlation with clinical improvement following sustained infliximab treatment for Crohn's disease
    Karel Geboes
    Universitair Ziekenhuis St Rafael, Afdeling Pathologie, Leuven, Belgium
    Curr Med Res Opin 21:1741-54. 2005
    ....
  4. ncbi request reprint Appendiceal function and dysfunction: what are the implications for inflammatory bowel disease?
    Karel Geboes
    Gastrointestinal Pathology Unit, KU Leuven University Hospital, Leuven, Belgium
    Nat Clin Pract Gastroenterol Hepatol 2:338-9. 2005
  5. ncbi request reprint Long-term lansoprazole treatment for gastro-oesophageal reflux disease: clinical efficacy and influence on gastric mucosa
    K Geboes
    Department of Pathology, University Hospital St Rafael, Leuven, Belgium
    Aliment Pharmacol Ther 15:1819-26. 2001
    ..Long-term acid suppression is believed to accelerate atrophic gastritis in Helicobacter pylori-positive patients. The influence of long-term therapy with lansoprazole has not been examined...
  6. doi request reprint Lymphocytic, collagenous and other microscopic colitides: pathology and the relationship with idiopathic inflammatory bowel diseases
    K Geboes
    Department of Pathology, University Hospital, KU Leuven, Leuven, Belgium
    Gastroenterol Clin Biol 32:689-94. 2008
    ..In rare cases, however, a double diagnosis was made. Certain patients, usually of older age, presented first with a microscopic, usually collagenous colitis and developed subsequently genuine ulcerative colitis...
  7. doi request reprint Inflammatory bowel disease unclassified and indeterminate colitis: the role of the pathologist
    K Geboes
    Department of Pathology, University Hospital KU Leuven, Leuven, Belgium
    J Clin Pathol 62:201-5. 2009
    ..This paper describes an algorithm for a diagnosis of colitis with a focus on indeterminate colitis...
  8. pmc Influence of treatment on morphological features of mucosal inflammation
    K Geboes
    Department of Pathology, University of Leuven, Belgium
    Gut 50:III37-42. 2002
    ..Diagnostic microscopic features and the features characteristic for disease activity vary with time and treatment. The more recently developed drugs used for Crohn's disease can induce mucosal healing...
  9. ncbi request reprint Pathology of early lower GI cancer
    Karel Geboes
    Department of Pathology, University Hospital, KULeuven, Minderbroedersstraat 12, 3000 Leuven, Belgium
    Best Pract Res Clin Gastroenterol 19:963-78. 2005
    ..Whenever a favourable tumour grade is found, without vascular invasion and tumour budding, there seems to be a low risk for adverse outcome and laparotomy may thus be avoided...
  10. doi request reprint Indeterminate colitis: a review of the concept--what's in a name?
    Karel Geboes
    Department of Pathology, University Hospital Leuven, Belgium
    Inflamm Bowel Dis 14:850-7. 2008
    ..The vast majority of these have severe colitis. For those that cannot bear to abandon the highly ambiguous term IC, if it is used at all, this is where it can be used parenthetically...
  11. pmc A reproducible grading scale for histological assessment of inflammation in ulcerative colitis
    K Geboes
    GI Pathology Unit, KU Leuven, Belgium
    Gut 47:404-9. 2000
    ..Evaluation of histological activity in ulcerative colitis needs to be reproducible but has rarely been tested. This could be useful both clinically and in clinical trials...
  12. ncbi request reprint Dysplasia in inflammatory bowel diseases: definition and clinical impact
    K Geboes
    University Hospital KU Leuven, Leuven, Belgium
    Can J Gastroenterol 13:671-8. 1999
    ..In practice, treatment means surgery because dysplasia can be a precursor and/or a marker of malignancy, except for sporadic adenomas, which can be removed locally...
  13. ncbi request reprint Review article: what are the important endoscopic lesions for detection of dysplasia in inflammatory bowel disease?
    K Geboes
    Department of Pathology, University Hospital KU, Leuven, Belgium
    Aliment Pharmacol Ther 24:50-5. 2006
    ..Ultimately, the combination of chromoendoscopy, or more advanced endoscopic techniques, and targeted biopsies may become the standard approach, rather than random biopsy sampling...
  14. doi request reprint [Chronic inflammatory bowel disease]
    Karel Geboes
    Departement de Pathologie, hôpital universitaire Saint Rafaël, KU Leuven, 12 Minderbroedersstraat, Leuven, Belgium
    Ann Pathol 28:187-90. 2008
  15. ncbi request reprint Role of interleukin-12 in the induction of mucosal inflammation and abrogation of regulatory T cell function in chronic experimental colitis
    Z Liu
    Laboratory of Experimental Immunology, University of Leuven, Belgium
    Eur J Immunol 31:1550-60. 2001
    ..These findings indicate that IL-12 is important for the induction of experimental colitis through effects on proinflammatory cytokine production and on regulatory T cell function...
  16. pmc Involvement of 4-1BB (CD137)-4-1BBligand interaction in the modulation of CD4 T cell-mediated inflammatory colitis
    P Maerten
    Laboratory of Experimental Immunology, University Hospital, Katholieke Universiteit Leuven, Belgium
    Clin Exp Immunol 143:228-36. 2006
    ..In conclusion, our data provide evidence that 4-1BB-4-1BBL interaction modulates the effector CD4+ T cell-driven immune response and cytokine production in experimental colitis without affecting regulatory T cell function...
  17. doi request reprint Characterization of myenteric neuropathy in the jejunum of spontaneously diabetic BB-rats
    M Zandecki
    Center for Gastroenterological Research, Catholic University Leuven, Leuven, Belgium
    Neurogastroenterol Motil 20:818-28. 2008
    ..These findings indicate that nitrergic enteric neuropathy may be a primary dysfunction in diabetes, independent from vagal dysfunction...
  18. ncbi request reprint Tenascin and strictures in inflammatory bowel disease: an immunohistochemical study
    K Geboes
    Department of Pathology, University Hospital, K. U. Leuven, Belgium
    Int J Surg Pathol 9:281-6. 2001
    ..We conclude that tenascin is involved in stricture formation in Crohn's disease and that it is a marker of phenotypic change in smooth muscle cells...
  19. ncbi request reprint Contractile effects and intracellular Ca2+ signalling induced by motilin and erythromycin in the circular smooth muscle of human colon
    G Van Assche
    Center for Gastroenterological Research, University of Leuven, B-3000 Leuven, Belgium
    Neurogastroenterol Motil 13:27-35. 2001
    ..These findings suggest that motilin may regulate colonic motility and that motilides may have therapeutic potential for the treatment of colonic hypomotility...
  20. ncbi request reprint Effect of repeated cycles of acute esophagitis and healing on esophageal peristalsis, tone, and length
    X Zhang
    Faculty of Medicine KU Leuven, Lab G I Physiopathology, O and N Gasthuisberg, 7th Floor, Herestraat 49, 3000 Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 288:G1339-46. 2005
    ..Acute experimental esophagitis provokes severe but reversible hypomotility. Spaced repeated acute injuries provoke milder motor effects, suggesting an adaptive response...
  21. ncbi request reprint Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial
    G D'Haens
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Gastroenterology 116:1029-34. 1999
    ..Tumor necrosis factor (TNF) is a pivotal cytokine in intestinal inflammation. Controlled trials using a chimeric anti-TNF antibody (infliximab) have shown its efficacy in refractory Crohn's disease...
  22. doi request reprint Intestinal immune activation in presumed post-infectious functional dyspepsia
    S Kindt
    Center for Gastroenterological Research, University Hospital Gasthuisberg, Leuven, Belgium
    Neurogastroenterol Motil 21:832-e56. 2009
    ..This may indicate impaired ability of the immune system to terminate the inflammatory response after acute insult...
  23. doi request reprint Pouchitis, similar to active ulcerative colitis, is associated with impaired butyrate oxidation by intestinal mucosa
    Vicky De Preter
    Department of Gastrointestinal Research and Leuven Food Science and Nutrition Research Centre LFoRCe, University Hospital Leuven, KU Leuven, Leuven, Belgium
    Inflamm Bowel Dis 15:335-40. 2009
    ..The aim of this study was to measure mucosal butyrate oxidation in UC (involved and noninvolved colon) and in pouchitis and to study the relationship with endoscopic as well as histological disease activity...
  24. ncbi request reprint Chronic intestinal pseudo-obstruction caused by an intestinal inflammatory myopathy: case report and review of the literature
    S DeWit
    Divisions of Gastroenterology and Pathology, University Hospital Gasthuisberg, Leuven, Belgium
    Neurogastroenterol Motil 20:343-8. 2008
    ..This case illustrates another form of CIP, characterized by an inflammatory myopathy, which is histologically distinct from other known visceral myopathies and neuropathies...
  25. ncbi request reprint Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitis
    G D'Haens
    Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Gastroenterology 120:1323-9. 2001
    ..We investigated the effects of intravenous (IV) cyclosporine as single IV therapy (without glucocorticosteroids) for severe UC and compared these with the response to glucocorticosteroids...
  26. ncbi request reprint In vivo evaluation of a colonic delivery system using isotope techniques
    K Verbeke
    Department of Gastrointestinal Research, University Hospital Gasthuisberg, Leuven, Belgium
    Aliment Pharmacol Ther 21:187-94. 2005
    ..This study was repeated after a 2-week lactulose intake period...
  27. ncbi request reprint Review article: the nature of oesophageal injury in gastro-oesophageal reflux disease
    G De Hertogh
    Department of Morphology and Molecular Pathology, University Hospitals KUL, Leuven, Belgium
    Aliment Pharmacol Ther 24:17-26. 2006
    ..Activated pepsin, trypsin and conjugated bile acids at an acidic pH have been identified as probable causes of reflux-induced damage...
  28. ncbi request reprint The value of myenteric plexitis to predict early postoperative Crohn's disease recurrence
    Marc Ferrante
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Gastroenterology 130:1595-606. 2006
    ..Unequivocal histologic markers predicting recurrence have not been identified. We assessed the predictive value of neural lesions for early endoscopic CD recurrence and long-term reintervention risk...
  29. ncbi request reprint Crohn's-like changes in the colon due to mycophenolate?
    I J Dalle
    University Hospitals Leuven, Leuven, Belgium
    Colorectal Dis 7:27-34. 2005
    ..A subset of patients suffers from chronic diarrhoea of unknown origin. The aim of the study was to investigate the effect of MMF on the colonic mucosa...
  30. ncbi request reprint Adalimumab induces apoptosis of human monocytes: a comparative study with infliximab and etanercept
    C Shen
    Laboratory of Experimental Immunology, Catholic University, Leuven, Belgium
    Aliment Pharmacol Ther 21:251-8. 2005
    ..Adalimumab, a fully human monoclonal antibody to tumour necrosis factor, was recently introduced for therapy of Crohn's disease...
  31. ncbi request reprint Miliary tuberculosis following infliximab therapy for Crohn disease: A case report and review of the literature
    P Stas
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Acta Gastroenterol Belg 69:217-20. 2006
    ..Even though tuberculosis is usually not rapidly fatal, the disease may show a fulminant course in immunocompromised patients...
  32. pmc Epithelioid granulomas, pattern recognition receptors, and phenotypes of Crohn's disease
    M Pierik
    Department of Gasteroenterology, University Hospitals, Katholieke Universiteit, Leuven, Belgium
    Gut 54:223-7. 2005
    ..This may lead to specific histological lesions. The epithelioid granuloma is particularly interesting in this regard as it is also observed in several bacterial infections of the gut...
  33. ncbi request reprint Etanercept in the treatment of active refractory Crohn's disease: a single-center pilot trial
    C Swijsen
    Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Gastroenterol 96:2564-8. 2001
    ..No moderate or severe adverse events were observed. CONCLUSIONS: Etanercept may be effective in Crohn's disease refractory to standard therapy...
  34. ncbi request reprint The value of serologic markers in indeterminate colitis: a prospective follow-up study
    Sofie Joossens
    Gastroenterology Unit, Department of Pathology, U Z Gasthuisberg, Leuven, Belgium
    Gastroenterology 122:1242-7. 2002
    ..We evaluated the value of anti-Saccharomyces cerevisiae antibodies (ASCA) and perinuclear antineutrophil cytoplasmic antibodies (pANCA) to increase diagnostic accuracy in categorizing IC...
  35. pmc On the existence and location of cardiac mucosa: an autopsy study in embryos, fetuses, and infants
    G De Hertogh
    Department of Pathology, University Hospitals, Catholic University Leuven, Belgium
    Gut 52:791-6. 2003
    ..Gaining insight into the pathogenesis of this lesion is hampered by the limited knowledge of the origin and histology of cardiac mucosa (CM). Currently, the location, extent, and even the existence of CM are controversial...
  36. ncbi request reprint Crohn's disease, ulcerative colitis or indeterminate colitis--how important is it to differentiate?
    K Geboes
    Department of Pathology, University Hospital Leuven, Belgium
    Acta Gastroenterol Belg 64:197-200. 2001
    ..Medical treatment can influence the microscopic features and induce a discontinuous inflammation in UC, reminiscent of CD. In cases of doubt, the original biopsies should be reviewed to ascertain the diagnosis, and orient treatment...
  37. ncbi request reprint Effects of anti-tumour necrosis factor, interleukin-10 and antibiotic therapy in the indometacin-induced bowel inflammation rat model
    S Colpaert
    Laboratory of Experimental Immunology, University Hospital and Catholic University of Leuven, Belgium
    Aliment Pharmacol Ther 15:1827-36. 2001
    ..The administration of indometacin to rats increases intestinal permeability and induces inflammatory pathology of the small bowel. This represents a potential model for Crohn's disease...
  38. ncbi request reprint Validation of 16S rDNA sequencing in microdissected bowel biopsies from Crohn's disease patients to assess bacterial flora diversity
    G De Hertogh
    Department of Morphology and Molecular Pathology, University Hospitals KULeuven, Belgium
    J Pathol 209:532-9. 2006
    ..Further study is needed to confirm these preliminary findings...
  39. doi request reprint Oesophageal tracheobronchial remnants
    S Nemolato
    Dipartimento di Citomorfologia, Divisione di Anatomia Patologica, Universita degli Studi di Cagliari, Cagliari, Italy
    Gastroenterol Clin Biol 32:779-81. 2008
    ..The treatment of this condition requires surgical resection of the stenosis with little morbidity or mortality. The presence of tracheobronchial remnants is confirmed upon histopathological examination of the resected bowel segment...
  40. ncbi request reprint Chemo-radiotherapy versus radiotherapy alone in the pre-operative treatment of resectable rectal cancer
    L Goethals
    Department of Radiation Oncology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Surg Oncol 31:969-76. 2005
    ....
  41. ncbi request reprint Is adenocarcinoma of the esophagogastric junction or cardia different from Barrett adenocarcinoma?
    Nadine Ectors
    Department of Pathology, University Hospitals Leuven, KULeuven, Belgium
    Arch Pathol Lab Med 129:183-5. 2005
    ..Unfortunately, this confusion is also apparent in the classification systems available for staging of cancer, thus closing the "vicious" circle...
  42. doi request reprint Comparative expressed sequence hybridization studies of t(11;18)(q21;q21)-positive and -negative gastric MALT lymphomas reveal both unique and overlapping gene programs
    Xavier Sagaert
    Section of Morphology and Molecular Pathology, Department of Pathology, Katholieke Universiteit Leuven, Leuven, Belgium
    Mod Pathol 23:458-69. 2010
    ....
  43. doi request reprint Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development
    Xavier Sagaert
    Department of Pathology, University Hospitals of K U Leuven, Minderbroederstraat 12, B 3000 Leuven, Belgium
    Nat Rev Gastroenterol Hepatol 7:336-46. 2010
    ....
  44. ncbi request reprint Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial
    Paul Rutgeerts
    Department of Gastroenterology, University Hospital Gasthuisberg, 3000 Leuven, Belgium
    Gastroenterology 128:856-61. 2005
    ..We investigated the efficacy and safety of ornidazole, a nitroimidazole antibiotic, for the prevention of clinical recurrence of Crohn's disease after curative ileocolonic resection in a placebo-controlled double-blind clinical trial...
  45. ncbi request reprint On the origin of cardiac mucosa: a histological and immunohistochemical study of cytokeratin expression patterns in the developing esophagogastric junction region and stomach
    Gert De Hertogh
    Department of Morphology and Molecular Pathology, University Hospitals, KU Leuven, Leuven Belgium
    World J Gastroenterol 11:4490-6. 2005
    ....
  46. ncbi request reprint Surgical therapy and histological abnormalities in functional isolated small bowel obstruction and idiopathic gastrointestinal perforation in the very low birth weight infant
    Marc Miserez
    Department of Abdominal Surgery, University Hospital Gasthuisberg, Catholic University Leuven, Herestraat 49, B 3000, Leuven, Belgium
    World J Surg 27:350-5. 2003
    ..Survival and long-term gastrointestinal function is excellent. IGIP should be distinguished from NEC...
  47. ncbi request reprint Medical therapy for Crohn's disease strictures
    Gert Van Assche
    Division of Gastroenterology, Leuven University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Inflamm Bowel Dis 10:55-60. 2004
    ..Specific medical therapy aimed at preventing or reversing intestinal fibrosis is not yet available, but candidate molecules are emerging from research in the liver and in other organs...
  48. ncbi request reprint In vitro analysis of interferon gamma (IFN-gamma) and interleukin-12 (IL-12) production and their effects in ileal Crohn's disease
    Stefaan Colpaert
    Laboratory of Experimental Immunology, University Hospital Gasthuisberg and Catholic University of Leuven, Belgium
    Eur Cytokine Netw 13:431-7. 2002
    ..Therapies aiming at neutralisation of IFN-gamma or IL-12 are therefore unlikely to replace anti-TNF, but they might provide an additive or synergistic effect...
  49. ncbi request reprint Serrated lesions of the colorectum, a new entity: what should a clinician/ endoscopist know about it ?
    A Jouret-Mourin
    Department of Pathology, St Luc Hospital, UCL, Brussels, Belgium
    Acta Gastroenterol Belg 75:197-202. 2012
    ..The aim of this article is to summarize the present data concerning the morphological and molecular characteristics of these serrated lesions and to give some recommendations for the management of such lesions...
  50. pmc Terminology for the diagnosis of colitis
    K Geboes
    Department of Pathology, Catholic University, Leuven 3000, Belgium
    J Clin Pathol 58:1133-4. 2005
  51. ncbi request reprint EGFR-immunohistochemistry in colorectal cancer and non-small cell lung cancer: comparison of 3 commercially available EGFR-antibodies
    W Buffet
    Department of Pathology, University Hospital Gasthuisberg, Leuven
    Acta Gastroenterol Belg 71:213-8. 2008
    ..The rising amount of commercially available EGFR-antibodies makes standardisation of EGFR-IHC necessary. The goal of this study was to analyse possible discrepancies between 3 antibodies against EGFR...
  52. ncbi request reprint Neural mechanisms of early postinflammatory dysmotility in rat small intestine
    I Demedts
    Center for Gastroenterological Research, Catholic University Leuven, Leuven, Belgium
    Neurogastroenterol Motil 18:1102-11. 2006
    ..These observations may provide a model for early postinflammatory dysmotility syndromes...
  53. pmc Immune cells in a case of postherpetic marginal trophic ulcer
    K Geboes
    Department of Ophthalmology, , Leuven, Belgium
    Br J Ophthalmol 73:191-6. 1989
    ..The composition of the infiltrate points towards the involvement of cell mediated immunity as well as humoral immunity. No immunoglobulins were bound to the conjunctival epithelium...
  54. ncbi request reprint Vascular anatomy of the gastrointestinal tract
    K Geboes
    Department of Pathology, University Hospital, KULeuven, Minderbroedersstraat 12, Leuven, 3000, Belgium
    Best Pract Res Clin Gastroenterol 15:1-14. 2001
    ..Interrelations and weak points are of significant clinical importance. As well as this, there is a great individual variability in the anatomy of the gastrointestinal vasculature...
  55. ncbi request reprint B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis
    Z Liu
    Laboratory of Experimental Immunology, Department of Pathology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Immunol 167:1830-8. 2001
    ..CTLA-4 signaling plays a key role in maintaining mucosal lymphocyte tolerance, most likely by activating the regulatory T cells...
  56. pmc Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment
    Ingrid Arijs
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    PLoS ONE 4:e7984. 2009
    ..We investigated the impact of anti-inflammatory therapy with infliximab on the mucosal gene expression of AMPs in IBD...
  57. ncbi request reprint A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis
    Geert D'Haens
    University Hospital Gasthuisberg, Leuven, Belgium
    Gastroenterology 132:763-86. 2007
  58. ncbi request reprint Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease
    Peter Suenaert
    Department of Gastroenterology, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium
    Am J Gastroenterol 97:2000-4. 2002
    ....
  59. pmc Crohn's disease and infections: a complex relationship
    Gert De Hertogh
    Department of Morphology and Molecular Pathology, University Hospital KU Leuven, Leuven, Belgium
    MedGenMed 6:14. 2004
  60. ncbi request reprint Anthranoids and the mucosal immune system of the colon
    K Geboes
    Department of Medical Research, KU Leuven, Belgium
    Pharmacology 47:49-57. 1993
    ..This finding indicates that rhein anthrone is activating cellular components of the intestinal immune system and may by this pathway induce secretion and motility...
  61. ncbi request reprint Histopathological reporting of resected carcinomas of the oesophagus and gastro-oesophageal junction
    N Ectors
    Department of Pathology, University Hospitals Leuven, Catholic University Leuven, Minderbroedersstraat, 12, B 3000 Leuven, Belgium
    Acta Gastroenterol Belg 67:28-33. 2004
  62. ncbi request reprint Chemokines in gastrointestinal disorders
    K Gijsbers
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Curr Drug Targets 7:47-64. 2006
    ..However, chemokines can passively favor escape of tumor cells by stimulating the release of tissue degrading matrix metalloproteinases and can actively promote metastasis of chemokine receptor-expressing tumor cells...
  63. ncbi request reprint Microscopic colitis with giant cells
    L Libbrecht
    Department of Pathology, Leuven University Hospitals, Leuven, Belgium
    Histopathology 40:335-8. 2002
    ..Collagenous colitis and lymphocytic colitis are the two types of microscopic colitis with specific morphological features. In this report we describe a new histopathological subtype of microscopic colitis...
  64. doi request reprint Interphotoreceptor retinoid-binding protein as biomarker in systemic autoimmunity with eye inflictions
    F J Descamps
    Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    J Cell Mol Med 12:2449-56. 2008
    ..The analysis of IRBP proteolysis is useful as a biomarker for uveitis and suggests that inhibition of proteinases might become a therapeutic strategy in an inflammatory context of a damaged blood-ocular barrier...
  65. ncbi request reprint The in vivo use of the stable isotope-labelled biomarkers lactose-[15N]ureide and [2H4]tyrosine to assess the effects of pro- and prebiotics on the intestinal flora of healthy human volunteers
    V De Preter
    Department of Gastrointestinal Research, University Hospital Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Br J Nutr 92:439-46. 2004
    ..The present results demonstrate that suppression of the generation and accumulation of potentially toxic fermentation metabolites by pro- and prebiotics can reliably be monitored in vivo by the use of stable isotope-labelled biomarkers...
  66. ncbi request reprint Do cell kinetics have prognostic and/or predictive value in oesophageal cancer treated by surgery?
    K Haustermans
    Department of Radiotherapy, University Hospital, Leuven, Belgium
    Eur J Surg Oncol 23:293-7. 1997
    ....
  67. ncbi request reprint Hypoxia in human colorectal adenocarcinoma: comparison between extrinsic and potential intrinsic hypoxia markers
    Laurence Goethals
    Department of Radiation Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Int J Radiat Oncol Biol Phys 65:246-54. 2006
    ....
  68. ncbi request reprint Decreased lamina propria effector cell responsiveness to interleukin-10 in ileal Crohn's disease
    Stefaan Colpaert
    Laboratory of Experimental Immunology, University Hospital and Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Immunol 102:68-76. 2002
    ..We conclude that IL-10 exhibits poor anti- and even potential proinflammatory effects on ileal Crohn's disease lamina propria. These data might explain the lack of therapeutic efficacy when IL-10 is given to Crohn's disease patients...
  69. pmc Atonal homolog 1 is a tumor suppressor gene
    Wouter Bossuyt
    Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium
    PLoS Biol 7:e39. 2009
    ..Our data indicate that ATOH1 may be an early target for oncogenic mutations in tissues where it instructs cellular differentiation...
  70. doi request reprint Effects of T cell-induced colonic inflammation on epithelial barrier function
    Peter Suenaert
    Division of Gastroenterology, University Hospital, Leuven, Belgium
    Inflamm Bowel Dis 16:1322-31. 2010
    ....
  71. doi request reprint Expression of angiostatic platelet factor-4var/CXCL4L1 counterbalances angiogenic impulses of vascular endothelial growth factor, interleukin-8/CXCL8, and stromal cell-derived factor 1/CXCL12 in esophageal and colorectal cancer
    Hannelien Verbeke
    Rega Institute for Medical Research, Laboratory of Molecular Immunology, K U Leuven, 3000 Leuven, Belgium
    Hum Pathol 41:990-1001. 2010
    ....
  72. ncbi request reprint Studies on the relationship between esophageal acid exposure, mucosal lesions and heartburn using an acid exposure sensor
    G Vantrappen
    Center for Gastroenterological Research and Dept of Pathology, University Hospital Gasthuisberg and Interuniversity Micro Electronics Centre, University of Leuven, Leuven, Belgium
    Scand J Gastroenterol 37:1253-8. 2002
    ..The aim was to determine whether SR correlates with the severity of acid-induced esophageal mucosal lesions and acid-induced heartburn...
  73. ncbi request reprint Vasculitis and the gastrointestinal tract
    K Geboes
    Department of Pathology, K U Leuven, Minderbroederstraat 12, 3000 Leuven, Belgium
    Acta Gastroenterol Belg 65:204-12. 2002
    ..Establishing a precise diagnosis can be difficult but is important because treatment and prognosis can be highly variable...
  74. ncbi request reprint Actinomycosis, a rare and unsuspected cause of anal fistulous abscess: report of three cases and review of the literature
    G Coremans
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Dis Colon Rectum 48:575-81. 2005
    ..The indication for extended antibiotherapy combined with sphincter damaging surgery may need to be revised in the presence of early detection...
  75. ncbi request reprint Vascular lesions of the gastrointestinal tract
    I Dalle
    Department of Pathology, K U Leuven, Minderbroederstraat 12, 3000 Leuven, Belgium
    Acta Gastroenterol Belg 65:213-9. 2002
    ..Good results have been reported with different drugs, albeit most of them have not been tested in large trials...
  76. ncbi request reprint A pilot study on the use of the humanized anti-interleukin-2 receptor antibody daclizumab in active ulcerative colitis
    Gert Van Assche
    Department of Gastroenterology, University of Leuven, Belgium
    Am J Gastroenterol 98:369-76. 2003
    ..Because cyclosporine acts by inhibiting interleukin-2 (IL-2) production, we studied the efficacy and safety of humanized anti-IL2 receptor (CD25) antibodies daclizumab for refractory UC in an open label pilot study...
  77. pmc Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease
    Gert De Hertogh
    Department of Pathology, University Hospitals KULeuven, Minderbroedersstraat 12, Leuven 3000, Belgium
    World J Gastroenterol 14:845-52. 2008
    ..At present, one cannot exclude with certainty any of these three proposed hypotheses; they may all apply to CD to a certain extent...
  78. ncbi request reprint Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease
    Gert Van Assche
    Division of Gastroenterology, University of Leuven Hospitals, Leuven, Belgium
    N Engl J Med 353:362-8. 2005
    ..There was staining of the brain lesion for polyomavirus. This case report, along with two others, suggests that anti-alpha4-integrin therapy can result in JC virus-induced PML...
  79. ncbi request reprint Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's disease
    Philippe Maerten
    Clinical Immunology, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Immunol 112:239-46. 2004
    ..Taken together, our data suggest that 4-1BB/4-1BBL interactions contribute to the persistence of gut inflammation in CD...
  80. doi request reprint Efficacy of infliximab in refractory pouchitis and Crohn's disease-related complications of the pouch: a Belgian case series
    Marc Ferrante
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Inflamm Bowel Dis 16:243-9. 2010
    ..In case reports, thiopurine analogs and infliximab (IFX) have been proposed as effective therapy in this setting. We analyzed the long-term efficacy of IFX in Belgian patients with refractory pouch complications...
  81. doi request reprint Diagnostic performance of IgG anti-deamidated gliadin peptide antibody assays is comparable to IgA anti-tTG in celiac disease
    Pieter Vermeersch
    Laboratory Medicine, Immunology, University Hospitals Leuven, Catholic University of Leuven, Leuven, Belgium
    Clin Chim Acta 411:931-5. 2010
    ..Our aim was to evaluate the technical performance and diagnostic accuracy of four commercial IgG anti-DGP assays...
  82. ncbi request reprint Topical cidofovir (HPMPC) is an effective adjuvant to surgical treatment of anogenital condylomata acuminata
    G Coremans
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Dis Colon Rectum 46:1103-8; discussion 1108-9. 2003
    ..This study was aimed at determining the efficacy of topical application of the antiviral agent cidofovir at 1 percent...
  83. ncbi request reprint Histological and immunohistochemical study of the lymphoid tissue in the normal stomach of the gnotobiotic pig
    Ann Driessen
    Department of Pathology, University Hospitals K U Leuven, U Z St Rafael, Minderbroedersstraat 12, Belgium
    Virchows Arch 441:589-98. 2002
    ..In conclusion, MALT is present in normal foetal gnotobiotic pig gastric mucosa, and in this model the stomach is no exception to the rest of the gastrointestinal tract...
  84. ncbi request reprint CXCR1-binding chemokines in inflammatory bowel diseases: down-regulated IL-8/CXCL8 production by leukocytes in Crohn's disease and selective GCP-2/CXCL6 expression in inflamed intestinal tissue
    Klara Gijsbers
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Eur J Immunol 34:1992-2000. 2004
    ..Thus, the chemokine network shows complementarity rather than redundancy...
  85. pmc Molecular and clinico-pathological markers in rectal cancer: a tissue micro-array study
    Annelies Debucquoy
    Department of Radiation Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
    Int J Colorectal Dis 24:129-38. 2009
    ..The aims of the study were to study the effect of pre-operative treatment on the expression of tumour-related proteins and to correlate the expression of these proteins with response and survival of patients with advanced rectal cancer...
  86. ncbi request reprint Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4
    Sofie Struyf
    Rega Institute for Medical Research, Laboratory of Molecular Immunology, University of Leuven, Leuven, Belgium
    J Immunol 182:666-74. 2009
    ..Therefore, PAD is a potent physiologic down-regulator of CXCL12 function...
  87. ncbi request reprint Outcome after proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis
    Marc Ferrante
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Inflamm Bowel Dis 14:20-8. 2008
    ..During the course of their disease, about 30% of patients with ulcerative colitis (UC) will undergo proctocolectomy with ileal pouch-anal anastomosis (IPAA). We evaluated the outcome of IPAA in a Belgian referral center...
  88. ncbi request reprint Protein-losing enteropathy in Crohn's disease
    Marc Ferrante
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Acta Gastroenterol Belg 69:384-9. 2006
    ..Histology showed severe mesenteric granulomatosis, dilated lymph vessels and granulomatous vasculitis. After the resection our patient improved without further albumin infusions and the oedema resolved...
  89. doi request reprint Double blind randomized phase II study with radiation+5-fluorouracil+/-celecoxib for resectable rectal cancer
    Annelies Debucquoy
    Department of Radiation Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium
    Radiother Oncol 93:273-8. 2009
    ..To assess the feasibility and efficacy of the COX-2 inhibitor celecoxib in conjunction with preoperative chemoradiation for patients with locally advanced rectal cancer in a double blind randomized phase II study...
  90. ncbi request reprint Contribution of genetic and environmental factors in the pathogenesis of Crohn's disease in a large family with multiple cases
    Marie Joossens
    Department of Gastroenterology, University Hospital, Leuven, Belgium
    Inflamm Bowel Dis 13:580-4. 2007
    ..In this family the father developed Crohn's disease (CD) after moving from Morocco to Belgium and successively 4 of his 8 children subsequently developed CD. There was no previous history of familial CD...
  91. ncbi request reprint Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin
    Francis J Descamps
    Rega Institute for Medical Research, Laboratory of Molecular Immunology, University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    FASEB J 17:887-9. 2003
    ..Consequently, diabetes may be worsened by enzymatic degradation of insulin by gelatinase B and by the consequent enhancement of the autoimmune process. Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin...
  92. ncbi request reprint The CXC chemokine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma: comparison with interleukin-8/CXCL8
    Anja Wuyts
    Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Leuven, Belgium
    Lab Invest 83:23-34. 2003
    ..The patterns of producer cell types, inducers and kinetics and the quantities of GCP-2 produced, suggest a unique role for GCP-2 in physiologic and pathologic processes...
  93. ncbi request reprint Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease
    Anna Maria Wolf
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Internal Medicine, Innsbruck, Austria
    Clin Immunol 113:47-55. 2004
    ..In summary, high local expression of IDO may represent an anti-inflammatory mechanism tempting to counterbalance the tissue-damaging effects of activated T-cells infiltrating the colonic mucosa in IBD...
  94. ncbi request reprint Remission-inducing effect of anti-TNF monoclonal antibody in TNBS colitis: mechanisms beyond neutralization?
    Chong Shen
    Laboratory of Experimental Immunology, Katholike Universiteit Leuven, Belgium
    Inflamm Bowel Dis 13:308-16. 2007
    ..The aim was to investigate the pathogenic role of TNF in hapten-induced colitis models and to study the relationship between apoptosis induction and disease remission...
  95. ncbi request reprint Chronic urticaria is associated with mast cell infiltration in the gastroduodenal mucosa
    Francesca Minnei
    Dipartimento di Citomorfologia, Divisione di Anatomia Patologica, Universita degli Studi di Cagliari, Via Ospedale 46, Cagliari, Italy
    Virchows Arch 448:262-8. 2006
    ..Mast cell counting in gastroduodenal biopsies of CU patients can be useful in selecting patients who may respond to a therapy with intestinal mast-cell-stabilizing agents...
  96. ncbi request reprint Budesonide in collagenous colitis: a double-blind placebo-controlled trial with histologic follow-up
    Filip Baert
    Imelda Hospital Bonheiden, Belgium
    Gastroenterology 122:20-5. 2002
    ..Several treatment options have been suggested, but no controlled data are available. We conducted a placebo-controlled trial to show the clinical and histologic effects of budesonide in CC...
  97. ncbi request reprint The strategy for biopsies of the terminal ileum should be evidence based
    Karel Geboes
    Am J Gastroenterol 102:1090-2. 2007
    ..The data suggest that biopsies of the terminal ileum are mainly helpful in patients with inflammatory diarrhea and/or suspected inflammatory bowel disease...
  98. ncbi request reprint Raman spectroscopy, a potential tool for the objective identification and classification of neoplasia in Barrett's oesophagus
    Catherine Kendall
    Cranfield Postgraduate Medical School, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK
    J Pathol 200:602-9. 2003
    ..76). Raman spectroscopy appears to provide a highly sensitive and specific technique for the identification and classification of neoplasia in Barrett's oesophagus...
  99. ncbi request reprint Expression of apoptosis markers in the retinas of human subjects with diabetes
    Ahmed M Abu-El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Invest Ophthalmol Vis Sci 45:2760-6. 2004
    ..To investigate the expression of the apoptotic mediators in the retinas from human subjects with diabetes mellitus...
  100. ncbi request reprint Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis
    Chong Shen
    Laboratory of Experimental Immunology, Catholic University of Leuven, Campus Gasthuisberg O and N, Herestraat 49, B 3000 Leuven, Belgium
    Int Immunopharmacol 4:939-51. 2004
    ..The data also provide evidence that glycolipid biosynthesis is involved in the inflammatory cascade in these inflammatory bowel disease (IBD) models...
  101. ncbi request reprint Infliximab induces apoptosis of monocytes and T lymphocytes in a human-mouse chimeric model
    Chong Shen
    Laboratory of Experimental Immunology, Campus Gasthuisberg O and N, Herestraat 49, B 3000 Leuven, Belgium
    Clin Immunol 115:250-9. 2005
    ..These data provide support for caspase-dependent apoptosis induction being the mechanism of action of infliximab in vivo...