Johan Fevery

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Incidence, diagnosis, and therapy of cholangiocarcinoma in patients with primary sclerosing cholangitis
    Johan Fevery
    Division of Hepatobiliary, University Hospital Gasthuisberg, Catholic University of Leuven, B3000 Leuven, Belgium
    Dig Dis Sci 52:3123-35. 2007
  2. doi request reprint Giant liver hemangioma: the role of female sex hormones and treatment
    Hannah van Malenstein
    Department of Hepatology, University Hospital Gasthuisberg, KU Leuven, Belgium
    Eur J Gastroenterol Hepatol 23:438-43. 2011
  3. doi request reprint Malignancies and mortality in 200 patients with primary sclerosering cholangitis: a long-term single-centre study
    Johan Fevery
    Department of Hepatology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Liver Int 32:214-22. 2012
  4. doi request reprint Bilirubin in clinical practice: a review
    Johan Fevery
    Laboratory of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    Liver Int 28:592-605. 2008
  5. doi request reprint An update on cholangiocarcinoma associated with primary sclerosing cholangitis
    Johan Fevery
    Division of Hepatobiliary and Pancreas Diseases, University Hospital Gasthuisberg, Catholic University of Leuven, B3000 Leuven, Belgium
    Curr Opin Gastroenterol 26:236-45. 2010
  6. ncbi request reprint Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats
    Wim Laleman
    Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    Gastroenterology 132:709-19. 2007
  7. ncbi request reprint HBx or HCV core gene expression in HepG2 human liver cells results in a survival benefit against oxidative stress with possible implications for HCC development
    Tamara Severi
    Laboratory of Hepatology, University Hospital Gasthuisberg, O and N Building Bus 703, Herestraat 49, Leuven, Belgium
    Chem Biol Interact 168:128-34. 2007
  8. ncbi request reprint Quantitation of replication of the HCV genome in human livers with end-stage cirrhosis by strand-specific real-time RT-PCR assays: methods and clinical relevance
    Lan Lin
    Department of Hepatology, University Hospitals, Leuven, Belgium
    J Med Virol 81:1569-75. 2009
  9. ncbi request reprint Both Ca2+ -dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine
    Wim Laleman
    Dept of Hepatology, Univ Hospital Gasthuisberg, K U Leuven, Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 292:G556-64. 2007
  10. ncbi request reprint CC-type chemokine receptor 5-Delta32 mutation protects against primary sclerosing cholangitis
    Liesbet Henckaerts
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Inflamm Bowel Dis 12:272-7. 2006

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Incidence, diagnosis, and therapy of cholangiocarcinoma in patients with primary sclerosing cholangitis
    Johan Fevery
    Division of Hepatobiliary, University Hospital Gasthuisberg, Catholic University of Leuven, B3000 Leuven, Belgium
    Dig Dis Sci 52:3123-35. 2007
    ..Pretransplant radiotherapy with 5-FU chemosensitization followed by endoscopic brachytherapy with iridium-192 seems to greatly improve the outcome of transplantation. Treatment with ursodeoxycholic acid may prevent development of CCA...
  2. doi request reprint Giant liver hemangioma: the role of female sex hormones and treatment
    Hannah van Malenstein
    Department of Hepatology, University Hospital Gasthuisberg, KU Leuven, Belgium
    Eur J Gastroenterol Hepatol 23:438-43. 2011
    ..In patients with important symptoms, disease control can be obtained by transcatheter arterial embolization. In selected patients, especially in case of Kasabach-Merritt syndrome, there is a good indication for liver transplantation...
  3. doi request reprint Malignancies and mortality in 200 patients with primary sclerosering cholangitis: a long-term single-centre study
    Johan Fevery
    Department of Hepatology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Liver Int 32:214-22. 2012
    ..The outcome of primary sclerosing cholangitis (PSC) has improved by liver transplantation (LT), but patients often develop malignancies. We analysed morbidity and mortality patterns to define strategies to prevent complications...
  4. doi request reprint Bilirubin in clinical practice: a review
    Johan Fevery
    Laboratory of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    Liver Int 28:592-605. 2008
    ..Serum bilirubin levels are often enhanced under a variety of clinical conditions. These are discussed and the mechanisms are outlined...
  5. doi request reprint An update on cholangiocarcinoma associated with primary sclerosing cholangitis
    Johan Fevery
    Division of Hepatobiliary and Pancreas Diseases, University Hospital Gasthuisberg, Catholic University of Leuven, B3000 Leuven, Belgium
    Curr Opin Gastroenterol 26:236-45. 2010
    ..The most feared complication is the presence or development of cholangiocarcinoma (CCA). The present review summarizes recent data with regards to diagnosis, pathobiology and treatment...
  6. ncbi request reprint Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats
    Wim Laleman
    Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    Gastroenterology 132:709-19. 2007
    ..We studied whether administration of nitroflurbiprofen (HCT-1026), a cyclooxygenase inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats...
  7. ncbi request reprint HBx or HCV core gene expression in HepG2 human liver cells results in a survival benefit against oxidative stress with possible implications for HCC development
    Tamara Severi
    Laboratory of Hepatology, University Hospital Gasthuisberg, O and N Building Bus 703, Herestraat 49, Leuven, Belgium
    Chem Biol Interact 168:128-34. 2007
    ..In conclusion, HBx and HCV core expression in HepG2 cells leads to a survival benefit under oxidative stress which in vivo can be induced during inflammation...
  8. ncbi request reprint Quantitation of replication of the HCV genome in human livers with end-stage cirrhosis by strand-specific real-time RT-PCR assays: methods and clinical relevance
    Lan Lin
    Department of Hepatology, University Hospitals, Leuven, Belgium
    J Med Virol 81:1569-75. 2009
    ..This suggests the existence of an extra-hepatic location of HCV with comparable viral replication rate being responsible for the infection of the newly transplanted liver...
  9. ncbi request reprint Both Ca2+ -dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine
    Wim Laleman
    Dept of Hepatology, Univ Hospital Gasthuisberg, K U Leuven, Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 292:G556-64. 2007
    ....
  10. ncbi request reprint CC-type chemokine receptor 5-Delta32 mutation protects against primary sclerosing cholangitis
    Liesbet Henckaerts
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Inflamm Bowel Dis 12:272-7. 2006
    ..We therefore investigated the role of the functional 32-bp deletion in this gene (CCR5-Delta32) with regard to susceptibility to PSC...
  11. doi request reprint Cystic fibrosis transmembrane conductance regulator gene polymorphisms in patients with primary sclerosing cholangitis
    Liesbet Henckaerts
    Department of Gastroenterology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Hepatol 50:150-7. 2009
    ..The histological features in the liver of PSC patients are similar to those observed in cystic fibrosis (CF). Our aim was to study whether variants in the CFTR gene are associated with the occurrence and/or evolution of PSC...
  12. ncbi request reprint MELD score to predict outcome in adult patients with non-acetaminophen-induced acute liver failure
    Aezam Katoonizadeh
    Department of Hepatology, University Hospital Gasthuisberg, KU Leuven, Belgium
    Liver Int 27:329-34. 2007
    ..We analyzed the prognostic value of MELD score in our patients with ALF who were prospectively registered in our database since 1990...
  13. pmc Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure
    Wim Laleman
    Department of Hepatology, University Hospital Gasthuisberg, KU Leuven, Belgium
    Crit Care 10:R108. 2006
    ....
  14. ncbi request reprint Porphyria cutanea tarda and liver disease. A retrospective analysis of 17 cases from a single centre and review of the literature
    David Cassiman
    Department of Hepatology, University Hospital Gasthuisberg, University of Leuven, Belgium
    Acta Gastroenterol Belg 71:237-42. 2008
    ..g. HCV infection, haemochromatosis and especially alcoholic liver disease. We conducted a retrospective analysis on the prevalence of liver disorders in association with Porphyria Cutanea Tarda (PCT), in a university referral centre...
  15. ncbi request reprint Hepatitis B virus replication causes oxidative stress in HepAD38 liver cells
    Tamara Severi
    Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    Mol Cell Biochem 290:79-85. 2006
    ..In this HepAD38 model early events (0-4 days) in the host cell after induction of HBV replication can be studied under strictly defined conditions...
  16. ncbi request reprint Primary graft nonfunction and Kupffer cell activation after liver transplantation from non-heart-beating donors in pigs
    Diethard Monbaliu
    Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    Liver Transpl 13:239-47. 2007
    ..A no-flow phenomenon is eventually observed in these failing grafts...
  17. doi request reprint Cholestasis-induced pruritus treated with ultraviolet B phototherapy: an observational case series study
    Sofie Decock
    Department of Hepatology, University Hospital Gasthuisberg, KU Leuven, Belgium
    J Hepatol 57:637-41. 2012
    ..Pruritus is a disabling complication of cholestatic liver disorders. Its management remains challenging. Ultraviolet B (UVB) phototherapy has been successfully used to treat pruritus in other indications...
  18. ncbi request reprint Orlistat treatment is safe in overweight and obese liver transplant recipients: a prospective, open label trial
    David Cassiman
    Department of Hepatology, University Hospital Gasthuisberg, University of Leuven, Belgium
    Transpl Int 19:1000-5. 2006
    ..Orlistat treatment is well tolerated in liver transplant recipients and can be started safely, provided immunosuppressive drug levels and dietary adherence are closely monitored...
  19. doi request reprint Wilson's disease: long-term follow-up of a cohort of 24 patients treated with D-penicillamine
    Klaartje F Lowette
    Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Eur J Gastroenterol Hepatol 22:564-71. 2010
    ..Detailed data on long-term effectiveness of various drug therapies in Wilson's disease (WD) are lacking. Therefore, we retrospectively reviewed our patient cohort treated with D-penicillamine...
  20. ncbi request reprint TT virus infection in acute and chronic liver diseases and in patients regularly receiving blood products in Belgium
    Soegianto Ali
    Department of Hepatobiliary and Pancreas Diseases, University Hospital Gasthuisberg, B 3000, Leuven, Belgium
    Acta Gastroenterol Belg 67:161-5. 2004
    ..We studied the prevalence of TTV infection in acute or chronic hepatitis in Belgium in comparison with that in blood donors and in patients regularly receiving blood products...
  21. ncbi request reprint A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis
    Wim Laleman
    Laboratories of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    Hepatology 42:1382-90. 2005
    ..2%). In conclusion, in rats with TAA-induced cirrhosis, decreased eNOS enzyme levels seem to be responsible for impaired NOS activity; in rats with biliary cirrhosis, an endogenous NOS inhibitor, ADMA, may mediate decreased NOS activity...
  22. doi request reprint Primary sclerosing cholangitis complicated by amyloid A amyloidosis: complete regression of the nephrotic syndrome by liver transplantation
    Werner Van Steenbergen
    Department of Internal Medicine, Liver Unit, University Hospital Gasthuisberg, Catholic University of Leuven, Turnhout, Belgium
    Eur J Gastroenterol Hepatol 22:1265-70. 2010
    ..This is the first report describing the occurrence of amyloid A amyloidosis in primary sclerosing cholangitis, and the reversal of a secondary amyloidosis-induced nephrotic syndrome as a result of liver transplantation...
  23. ncbi request reprint Hepatic immunohistochemical staining with a monoclonal antibody against HCV-E2 to evaluate antiviral therapy and reinfection of liver grafts in hepatitis C viral infection
    Chris Verslype
    Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    J Hepatol 38:208-14. 2003
    ..A simple and reproducible hepatic immunohistochemical staining (IHS) for hepatitis C virus (HCV) is not available. We aimed to validate hepatic IHS with monoclonal antibody (Mab) IG222, directed against the HCV-envelope 2 (E2) protein...
  24. ncbi request reprint Steroid-free immunosuppression during and after liver transplantation--a 3-yr follow-up report
    Jacques Pirenne
    Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    Clin Transplant 17:177-82. 2003
    ..We report the long-term (median = 40 months) follow-up data of a prospective pilot study designed to determine whether liver transplantation could be performed with no steroids at all (neither during nor after surgery)...
  25. ncbi request reprint Livers from non-heart-beating donors tolerate short periods of warm ischemia
    Diethard Monbaliu
    Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    Transplantation 79:1226-30. 2005
    ..This study aims to develop a reproducible large animal model of liver transplantation using non-heart-beating donors and, in this model, to define the tolerance of the liver to warm ischemia...
  26. ncbi request reprint Detoxifying capacity and kinetics of the molecular adsorbent recycling system. Contribution of the different inbuilt filters
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Blood Purif 21:244-52. 2003
    ..Our data suggest that the rate and efficacy of removal of albumin-bound toxins are related to both the strength of the albumin binding and the saturation of the adsorption columns...
  27. ncbi request reprint Viral interaction and clinical implications of coinfection of hepatitis C virus with other hepatitis viruses
    Lan Lin
    Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Gastroenterol Hepatol 18:1311-9. 2006
    ....
  28. ncbi request reprint Portal hypertension: from pathophysiology to clinical practice
    Wim Laleman
    Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    Liver Int 25:1079-90. 2005
    ..The focus of this review is to give an update on the pathophysiology of PHT in order to elucidate these potential novel strategies subsequently...
  29. ncbi request reprint Congenital veno-venous malformations of the liver: widely variable clinical presentations
    Peter Witters
    Laboratory of Hepatology, Catholic University of Leuven, Leuven, Belgium
    J Gastroenterol Hepatol 23:e390-4. 2008
    ..However, their clinical presentation is less dependent on the anatomical type...
  30. ncbi request reprint Expression of hepatitis C virus core protein impairs DNA repair in human hepatoma cells
    Jos F van Pelt
    Department of Liver and Pancreatic Diseases, University Hospital Gasthuisberg, Herestraat 49, Leuven B 3000, Belgium
    Cancer Lett 209:197-205. 2004
    ..Interestingly, expression of the full-length HCV core did increase the cell doubling time in one of the cell lines we had developed that could not be attributed to an increase in apoptosis or change in telomerase activity in these cells...
  31. ncbi request reprint Halofuginone can worsen liver fibrosis in bile duct obstructed rats
    Marc Van de Casteele
    Deparment of Hepatology, University Hospital Gasthuisbergs, Catholic University of Leuven, B 3000 Leuven, Belgium
    Liver Int 24:502-9. 2004
    ..Halofuginone (HF) is an antifibrotic agent in rat models of liver fibrosis caused by repetitive intoxications. A beneficial effect of HF on a biliary type of liver fibrosis has not been proven yet...
  32. ncbi request reprint Improvement of autoimmune hepatitis during pregnancy followed by flare-up after delivery
    Elwin Buchel
    Divison of Hepatobiliary and Pancreas Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Gastroenterol 97:3160-5. 2002
    ..Pregnancy in autoimmune hepatitis has been a rare event, but it has become more frequent with improved therapy. The present study aimed to analyze the consequences for mother and child in patients with autoimmune hepatitis...
  33. ncbi request reprint Ultrastructural visualization of hepatitis C virus components in human and primate liver biopsies
    Rita De Vos
    Department of Morphology and Molecular Pathology, U Z K U Leuven, Minderbroedersstraat 12, Leuven, Belgium
    J Hepatol 37:370-9. 2002
    ..No conclusive studies were conducted yet on human liver biopsies. This paper describes the ultrastructural findings of hepatitis C virus components in liver biopsies...
  34. ncbi request reprint Identification of HepG2 variant cell lines by short tandem repeat (STR) analysis
    Jos F van Pelt
    Department of Liver and Pancreatic Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    Mol Cell Biochem 243:49-54. 2003
    ..Therefore, STR typing should be applied as a rapid and sensitive technique to determine and monitor the origin of cell lines and to safeguard against contamination...
  35. ncbi request reprint Primary human hepatocytes are protected against prolonged and repeated exposure to ethanol by silibinin-dihemisuccinate
    Jos F van Pelt
    Department of Liver and Pancreatic Diseases, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Alcohol Alcohol 38:411-4. 2003
    ..At regular intervals, the medium was refreshed and liver enzymes and secreted protein in the medium were determined...
  36. ncbi request reprint Primary sclerosing cholangitis in two brothers: report of a family with special emphasis on molecular HLA and MICA genotyping
    Werner Van Steenbergen
    Unit for Liver Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, Belgium
    Eur J Gastroenterol Hepatol 17:767-71. 2005
    ..Their unaffected father and sister both carried the protective DR4 allele. The presence of PSC in two brothers, and the distribution of HLA haplotypes and MICA alleles, adds supportive evidence for an immunogenetic origin of PSC...
  37. pmc Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells
    Philip Roelandt
    Interdepartmental Stem Cell Institute Leuven, Catholic University Leuven, and Hepatology Department, University Hospitals Leuven, Leuven, Belgium
    PLoS ONE 5:e12101. 2010
    ..This differentiation protocol will be useful for generating hepatocyte-like cells from rodent and human stem cells, and to gain insight into the early stages of liver development...
  38. ncbi request reprint The Molecular Adsorbent Recirculating System in patients with severe liver failure: clinical results at the K.U. Leuven
    Alexander Wilmer
    Medical Intensive Care Unit, UZ Gasthuisberg, Catholic University of Leuven, Belgium
    Liver 22:52-5. 2002
    ..The Molecular Adsorbent Recirculating System (MARS) is a novel extracorporeal technique for liver support. We report the clinical results in the first 13 patients with severe liver failure treated at our institution...
  39. ncbi request reprint Statins in hepatobiliary diseases: effects, indications and risks
    Ine Lowyck
    Department of Hepatology, UZ Gasthuisberg, Leuven
    Acta Gastroenterol Belg 70:381-8. 2007
    ..Statins are among the most frequently used medications. Our aim was to study their indications or contraindications in hepatobiliary diseases...
  40. ncbi request reprint TTV infection and its relation to serum transaminases in apparently healthy blood donors and in patients with clotting disorders who have been investigated previously for hepatitis C virus and GBV-C/HGV infection in Belgium
    Soegianto Ali
    Division of Liver and Pancreatic Diseases, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    J Med Virol 66:561-6. 2002
    ..TTV does not cause liver disease or contribute to the severity of liver disease...
  41. ncbi request reprint Hereditary hyperferritinaemia-cataract syndrome: a challenging diagnosis for the hepatogastroenterologist
    Marc Ferrante
    Department of Hepatology, University Hospital, Gasthuisberg, Leuven, Belgium
    Eur J Gastroenterol Hepatol 17:1247-53. 2005
    ..In current clinical practice, gastroenterologists should remember that elevated ferritin levels in the absence of documented iron overload is not haemochromatosis...
  42. ncbi request reprint A novel strand-specific RT-PCR for detection of hepatitis C virus negative-strand RNA (replicative intermediate): evidence of absence or very low level of HCV replication in peripheral blood mononuclear cells
    Lan Lin
    Department of Medicine, Division of Liver and Pancreatic Diseases, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    J Virol Methods 100:97-105. 2002
    ..In addition, HCV replicative intermediates were not detected in PBMCs of patients using immunosuppressive agents. It is concluded that the replication of HCV in PBMCs is very unusual...
  43. ncbi request reprint Positron emission tomography is not a reliable method for the early diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis
    Johan Fevery
    J Hepatol 43:358-60. 2005
  44. pmc Investigating the origin and spread of hepatitis C virus genotype 5a
    Jannick Verbeeck
    Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, BE 3000 Leuven, Belgium
    J Virol 80:4220-6. 2006
    ..These findings have major implications for tracing the origin of HCV genotype 5a. Here, we speculate about the possible origins of these clusters...
  45. ncbi request reprint Hepatic osteodystrophy
    Hans Orlent
    Department of Hepatology, Gasthuisberg University Hospital, Herestraat 49, 3000 Leuven, Belgium
    J Hepatol 38:243. 2003
  46. ncbi request reprint Combined 'en bloc' liver and pancreas transplantation in patients with liver disease and type 1 diabetes mellitus
    Jacques Pirenne
    Department of Abdominal Transplant Surgery Transplant Coordination, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Am J Transplant 4:1921-7. 2004
    ..Surgical, medical and immunological aspects of combined liver-pancreas transplantation are discussed in the light of the existing relevant literature...
  47. ncbi request reprint Breast cancer resistance protein (BCRP/ABCG2) is expressed by progenitor cells/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: possible functional consequences
    Sara Vander Borght
    Laboratory of Morphology and Molecular Pathology, University Hospitals Leuven, Belgium
    J Histochem Cytochem 54:1051-9. 2006
    ..Strong differences between human and rat liver must be taken into account in future studies with animal models...
  48. ncbi request reprint Aplastic anemia after transplantation for non-A, non-B, non-C fulminant hepatic failure: case report and review of the literature
    Patrick Itterbeek
    Abdominal Transplant Surgery Department, University Hospitals Leuven, Belgium
    Transpl Int 15:117-23. 2002
    ..In unresponsive patients, six-HLA-identical bone marrow transplantation has been successful...
  49. pmc The RANTES -28 g polymorphism is associated with primary sclerosing cholangitis
    Liesbet Henckaerts
    Gut 56:891-2. 2007