R H Fagard

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi Exercise characteristics and the blood pressure response to dynamic physical training
    R H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven KULeuven, Leuven, Belgium
    Med Sci Sports Exerc 33:S484-92; discussion S493-4. 2001
  2. ncbi Exercise is good for your blood pressure: effects of endurance training and resistance training
    R H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, Faculty of Medicine, University of Leuven, KU Leuven, Leuven, Belgium
    Clin Exp Pharmacol Physiol 33:853-6. 2006
  3. ncbi Effects of aerobic training intensity on resting, exercise and post-exercise blood pressure, heart rate and heart-rate variability
    V A Cornelissen
    Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, KU Leuven, Leuven, Belgium
    J Hum Hypertens 24:175-82. 2010
  4. ncbi Orthostatic hypotension is a more robust predictor of cardiovascular events than nighttime reverse dipping in elderly
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, Faculty of Medicine, KU Leuven University, Leuven, Belgium
    Hypertension 56:56-61. 2010
  5. ncbi ESC Study Group of Sports Cardiology recommendations for participation in leisure-time physical activities and competitive sports for patients with hypertension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, KULeuven, Leuven, Belgium
    Eur J Cardiovasc Prev Rehabil 12:326-31. 2005
  6. ncbi Prognostic significance of blood pressure measured in the office, at home and during ambulatory monitoring in older patients in general practice
    R H Fagard
    Department of Molecular and Cardiovascular Research, Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, UZ Gasthuisberg, Leuven, Belgium
    J Hum Hypertens 19:801-7. 2005
  7. ncbi Prognostic significance of electrocardiographic voltages and their serial changes in elderly with systolic hypertension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven, Leuven, Belgium
    Hypertension 44:459-64. 2004
  8. ncbi Relationship between ambulatory blood pressure and follow-up clinic blood pressure in elderly patients with systolic hypertension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Catholic University of Leuven, Leuven, Belgium
    J Hypertens 22:81-7. 2004
  9. ncbi Do we need drug therapy to manage mild hypertension in the elderly?
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven K U Leuven, Leuven, Belgium
    Drugs Aging 21:1-6. 2004
  10. ncbi Athlete's heart
    Robert Fagard
    U.Z. Gasthuisberg-Hypertensie, Herestraat 49, B-3000 Leuven, Belgium
    Heart 89:1455-61. 2003

Detail Information

Publications97

  1. ncbi Exercise characteristics and the blood pressure response to dynamic physical training
    R H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven KULeuven, Leuven, Belgium
    Med Sci Sports Exerc 33:S484-92; discussion S493-4. 2001
    ....
  2. ncbi Exercise is good for your blood pressure: effects of endurance training and resistance training
    R H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, Faculty of Medicine, University of Leuven, KU Leuven, Leuven, Belgium
    Clin Exp Pharmacol Physiol 33:853-6. 2006
    ..In addition, the few available data suggest that resistance training is able to reduce blood pressure...
  3. ncbi Effects of aerobic training intensity on resting, exercise and post-exercise blood pressure, heart rate and heart-rate variability
    V A Cornelissen
    Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, KU Leuven, Leuven, Belgium
    J Hum Hypertens 24:175-82. 2010
    ....
  4. ncbi Orthostatic hypotension is a more robust predictor of cardiovascular events than nighttime reverse dipping in elderly
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, Faculty of Medicine, KU Leuven University, Leuven, Belgium
    Hypertension 56:56-61. 2010
    ..We conclude that orthostatic hypotension contributes to the phenomenon of reverse dipping but is a more robust predictor of cardiovascular events than reverse dipping in the elderly of the current study...
  5. ncbi ESC Study Group of Sports Cardiology recommendations for participation in leisure-time physical activities and competitive sports for patients with hypertension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, KULeuven, Leuven, Belgium
    Eur J Cardiovasc Prev Rehabil 12:326-31. 2005
  6. ncbi Prognostic significance of blood pressure measured in the office, at home and during ambulatory monitoring in older patients in general practice
    R H Fagard
    Department of Molecular and Cardiovascular Research, Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, UZ Gasthuisberg, Leuven, Belgium
    J Hum Hypertens 19:801-7. 2005
    ..The prognosis of patients with white-coat hypertension is similar to that of true normotensives...
  7. ncbi Prognostic significance of electrocardiographic voltages and their serial changes in elderly with systolic hypertension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven, Leuven, Belgium
    Hypertension 44:459-64. 2004
    ..86; P< or =0.05), but not of stroke or mortality. In conclusion, electrocardiographic voltages at baseline and their serial changes during follow-up predict subsequent events in older patients with systolic hypertension...
  8. ncbi Relationship between ambulatory blood pressure and follow-up clinic blood pressure in elderly patients with systolic hypertension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Catholic University of Leuven, Leuven, Belgium
    J Hypertens 22:81-7. 2004
    ..On the contrary, current guidelines emphasize repeated clinic blood pressure measurements for the initiation of antihypertensive therapy...
  9. ncbi Do we need drug therapy to manage mild hypertension in the elderly?
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven K U Leuven, Leuven, Belgium
    Drugs Aging 21:1-6. 2004
    ....
  10. ncbi Athlete's heart
    Robert Fagard
    U.Z. Gasthuisberg-Hypertensie, Herestraat 49, B-3000 Leuven, Belgium
    Heart 89:1455-61. 2003
  11. ncbi Treatment and blood pressure control in isolated systolic hypertension vs diastolic hypertension in primary care
    R H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven KU Leuven, Leuven, Belgium
    J Hum Hypertens 17:681-7. 2003
    ..In conclusion, isolated systolic hypertension is less frequently treated than diastolic hypertension, overall BP control is poor and actual drug therapy diverges from recommendations based on placebo-controlled intervention trials...
  12. ncbi Influence of chorionicity on the heritability estimates of blood pressure: a study in twins
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, KU Leuven, Belgium
    J Hypertens 21:1313-8. 2003
    ..However, the intra-uterine environment may differ according to the chorionicity of the monozygotic twins, which may have biased previous heritability estimates of blood pressure...
  13. ncbi Benefits and safety of long-acting calcium antagonists in coronary artery disease: the Action Trial
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven KU Leuven, Leuven, Belgium
    J Hypertens 23:489-91. 2005
  14. ncbi Survey on treatment of hypertension and implementation of World Health Organization/International Society of Hypertension risk stratification in primary care in Belgium
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven, Leuven, Belgium
    J Hypertens 20:1297-302. 2002
    ....
  15. ncbi Characteristics of conventional blood pressure in studies on the predictive power of ambulatory blood pressure
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven K U Leuven, Leuven, Belgium
    Blood Press Monit 7:33-6. 2002
    ..It is commonly believed that the associations of left ventricular mass and cardiovascular morbidity/mortality with blood pressure are stronger for 24-h ambulatory pressure than for conventional clinic or casual pressure...
  16. ncbi Effect of exercise on blood pressure control in hypertensive patients
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, Faculty of Medicine, University of Leuven, K U Leuven, Leuven, Belgium
    Eur J Cardiovasc Prev Rehabil 14:12-7. 2007
    ..The few available data suggest that resistance training can reduce blood pressure. Exercise is a cornerstone therapy for the prevention, treatment and control of hypertension...
  17. ncbi Is the predictive power of a low-pulse pressure independent of peak oxygen uptake in advanced chronic heart failure?
    R H Fagard
    Faculty of Medicine, Department of Cardiovascular Diseases, Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven, Leuven, Belgium
    J Hum Hypertens 22:57-9. 2008
  18. ncbi Reappraisal of the European guidelines on hypertension management: the European Society of Hypertension Task Force document: a short review
    Robert Fagard
    Department of Cardiovascular Diseases, KU Leuven University, Leuven, Belgium
    Pol Arch Med Wewn 120:31-5. 2010
    ..The document ends with a number of issues in urgent need to be approached by new trials...
  19. ncbi Smoking and diabetes--the double health hazard!
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven K U Leuven, Leuven, Belgium
    Prim Care Diabetes 3:205-9. 2009
    ..Smoking cessation programs are of great importance for primary care specialists dealing with diabetes...
  20. ncbi Hypertension in the elderly: new and old evidence that treatment may benefit the old
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, Leuven, Belgium
    J Nephrol 22:580-6. 2009
    ..Finally, blood pressure lowering therapy also improves prognosis in hypertensive patients with type 2 diabetes...
  21. ncbi Regression of left ventricular mass by antihypertensive treatment: a meta-analysis of randomized comparative studies
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven KU Leuven, Leuven, Belgium
    Hypertension 54:1084-91. 2009
    ..The inferiority of beta-blockers appears to be more convincing than the superiority of angiotensin receptor blockers...
  22. ncbi Dipping pattern of nocturnal blood pressure in patients with hypertension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven, U Z Gasthuisberg, Herestraat 49, Leuven B 3000, Belgium
    Expert Rev Cardiovasc Ther 7:599-605. 2009
    ..Some studies suggest that prognosis is similar in nondippers and extreme dippers in comparison with dippers, but other studies suggest a somewhat worse prognosis in nondippers, or a better or worse prognosis in extreme dippers...
  23. ncbi Night-day blood pressure ratio and dipping pattern as predictors of death and cardiovascular events in hypertension
    R H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, Leuven, Belgium
    J Hum Hypertens 23:645-53. 2009
    ....
  24. ncbi Prognostic significance of ambulatory blood pressure in hypertensive patients with history of cardiovascular disease
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, KU Leuven, Belgium
    Blood Press Monit 13:325-32. 2008
    ..To assess the prognostic significance of nighttime and daytime blood pressure (BP), their ratio and the nighttime dipping pattern for mortality and recurrent cardiovascular (CV) events in patients with CV disease at baseline...
  25. ncbi Daytime and nighttime blood pressure as predictors of death and cause-specific cardiovascular events in hypertension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, Belgium
    Hypertension 51:55-61. 2008
    ....
  26. ncbi Athletes with systemic hypertension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, University of Leuven, KU Leuven, B 3000 Leuven, Belgium
    Cardiol Clin 25:441-8, vii. 2007
    ..When antihypertensive treatment is required, calcium channel blockers and blockers of the renin-angiotensin system are currently the drugs of choice...
  27. ncbi Sympathetic activity, assessed by power spectral analysis of heart rate variability, in white-coat, masked and sustained hypertension versus true normotension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven K U Leuven, Leuven, Belgium
    J Hypertens 25:2280-5. 2007
    ..To assess, in a population-based approach, sympathetic nervous system activity by the use of power spectral analysis of heart rate variability, in normotension, white-coat hypertension, masked hypertension and sustained hypertension...
  28. ncbi Incidence of cardiovascular events in white-coat, masked and sustained hypertension versus true normotension: a meta-analysis
    Robert H Fagard
    Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Faculty of Medicine, University of Leuven KU Leuven, Leuven, Belgium
    J Hypertens 25:2193-8. 2007
    ..To perform a meta-analysis on the incidence of cardiovascular events in white-coat hypertension (WCHT), masked and sustained hypertension in comparison with true normotension...
  29. ncbi On-treatment diastolic blood pressure and prognosis in systolic hypertension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven, B 3000 Leuven, Belgium
    Arch Intern Med 167:1884-91. 2007
    ..We examined the association between on-treatment diastolic BP, mortality, and cardiovascular events in the prospective placebo-controlled Systolic Hypertension in Europe Trial...
  30. ncbi Physical exercise and coronary artery disease
    Robert H Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven K.U. Leuven, Belgium
    Acta Cardiol 57:91-100. 2002
  31. ncbi The pulse pressure-to-stroke index ratio predicts cardiovascular events and death in uncomplicated hypertension
    R H Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, KU Leuven, Belgium
    J Am Coll Cardiol 38:227-31. 2001
    ..The goal of this study was to assess the prognostic power of the pulse pressure-to-stroke index (PP-to-SVi) ratio for cardiovascular events and mortality in patients with uncomplicated hypertension...
  32. ncbi Left ventricular diastolic function predicts outcome in uncomplicated hypertension
    R Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven KU Leuven, Belgium
    Am J Hypertens 14:504-8. 2001
    ....
  33. ncbi A randomised, placebo-controlled, double-blind, crossover study of losartan and enalapril in patients with essential hypertension
    R Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven KU Leuven, Leuven, Belgium
    J Hum Hypertens 15:161-7. 2001
    ..The current study does not provide convincing evidence that addition of losartan to enalapril in the doses used further reduces BP...
  34. ncbi Relationships of heart rate and heart rate variability with conventional and ambulatory blood pressure in the population
    R H Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Belgium
    J Hypertens 19:389-97. 2001
    ....
  35. ncbi Response to antihypertensive therapy in older patients with sustained and nonsustained systolic hypertension. Systolic Hypertension in Europe (Syst-Eur) Trial Investigators
    R H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Catholic University of Leuven, Leuven, Belgium
    Circulation 102:1139-44. 2000
    ....
  36. ncbi Prognostic significance of exercise versus resting blood pressure in patients with chronic heart failure
    R Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven KULeuven, Belgium
    J Hypertens 17:1977-81. 1999
    ..Results on the prognostic value of exercise blood pressure differ among studies; this may be related to the characteristics of the studied population...
  37. ncbi Influence of demographic, anthropometric and lifestyle characteristics on heart rate and its variability in the population
    R H Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven K U, Belgium
    J Hypertens 17:1589-99. 1999
    ....
  38. ncbi Epidemiology of hypertension in the elderly
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, U Z Gasthuisberg Hypertensie, Herestraat 49, B 3000 Leuven, Belgium
    Am J Geriatr Cardiol 11:23-8. 2002
    ..In addition, pulse pressure has been shown to be an important predictor of cardiovascular events and death, above and beyond the predictive power of mean blood pressure...
  39. ncbi Physical activity in the prevention and treatment of hypertension in the obese
    R H Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Belgium
    Med Sci Sports Exerc 31:S624-30. 1999
    ..Physical activity in the prevention and treatment of hypertension in the obese...
  40. ncbi Power spectral analysis of heart rate variability by autoregressive modelling and fast Fourier transform: a comparative study
    R H Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Belgium
    Acta Cardiol 53:211-8. 1998
    ..To compare the results from autoregressive modelling (ARM) and from fast Fourier transform (FFT), the most commonly used methods for the analysis of short-term heart rate variability in the frequency domain...
  41. ncbi Calcium channel blockade and cardiovascular prognosis in the European trial on isolated systolic hypertension
    J A Staessen
    Klinisch Laboratorium Hypertensie, Inwendige Geneeskunde Cardiologie, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Hypertension 32:410-6. 1998
    ....
  42. ncbi Risk and benefit of treatment of isolated systolic hypertension in the elderly: evidence from the Systolic Hypertension in Europe Trial
    H Celis
    Studiecoördinatiecentrum, Laboratorium Hypertensie, Campus Gasthuisbrg, Leuven, Belgium
    Curr Opin Cardiol 16:342-8. 2001
    ..Finally, a meta-analysis partly based on Syst-Eur data showed that in older hypertensive patients pulse pressure and not mean pressure is the major determinant of cardiovascular risk...
  43. ncbi Should pulse pressure become part of the Framingham risk score?
    T S Nawrot
    Studiecoördinatiecentrum, Laboratorium Hypertensie, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    J Hum Hypertens 18:279-86. 2004
    ..37 (CI: 1.16-1.69). These prospective data suggest that pulse pressure may improve the Framingham risk prediction among middle-aged and older individuals. Further studies, especially in the Framingham cohort, are warranted...
  44. ncbi Long-term treatment with enalapril or losartan does not show antiproliferative effects in peripheral blood mononuclear cells
    V V Petrov
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven (K.U. Leuven, Belgium
    Methods Find Exp Clin Pharmacol 23:149-52. 2001
    ..Our data show that proliferation was not affected during angiotensin-converting enzyme inhibition with enalapril and angiotensin receptor type 1 antagonism with losartan...
  45. ncbi Induction of cardiac fibrosis by angiotensin II
    P J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Leuven, Belgium
    Methods Find Exp Clin Pharmacol 22:709-23. 2000
    ..The ability of ANG II to induce collagen synthesis in cardiac fibroblasts may be mediated by increased TGF-beta 1 production...
  46. ncbi Dihydropyridine calcium-channel blockers for antihypertensive treatment in older patients--evidence from the Systolic Hypertension in Europe Trial
    J A Staessen
    , Laboratorium Hypertensie, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
    S Afr Med J 91:1060-8. 2001
    ..CONCLUSION: Stepwise antihypertensive drug treatment, starting with the dihydropiridine calcium-channel blocker nitrendipine, improves prognosis in elderly patients with isolated systolic hypertension...
  47. ncbi Effect of telmisartan on angiotensin II-mediated collagen gel contraction by adult rat cardiac fibroblasts
    P J Lijnen
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven Katholieke Universiteit Leuven, Belgium
    J Cardiovasc Pharmacol 38:39-48. 2001
    ....
  48. ncbi Pulsatile blood pressure component as predictor of mortality in hypertension: a meta-analysis of clinical trial control groups
    Jerzy Gasowski
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Herestraat 49, B-3000 Leuven, Belgium
    J Hypertens 20:145-51. 2002
    ..01). CONCLUSIONS: In hypertensive patients pulse pressure, not mean pressure, is associated with an increased risk of fatal events. This appears to be true in a broad range of patients with hypertension...
  49. ncbi Effect of endurance training on blood pressure regulation, biomarkers and the heart in subjects at a higher age
    V A Cornelissen
    Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular, Diseases, Faculty of Medicine, University of Leuven, KU Leuven, Leuven, Belgium
    Scand J Med Sci Sports 21:526-34. 2011
    ..Our results suggest that the BP reduction observed appears to be due to a decrease in systemic vascular resistance; training intensity does not significantly affect the results on mechanisms, biomarkers and the heart...
  50. ncbi Effect of bisoprolol and atenolol on endurance exercise capacity in healthy men
    L Vanhees
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, KU Leuven University of Leuven, Belgium
    J Hypertens 18:35-43. 2000
    ..To compare the effects of a highly beta1-selective adrenoceptor antagonist bisoprolol with those of atenolol and placebo on endurance exercise capacity in young, healthy male volunteers...
  51. ncbi Menopause and the characteristics of the large arteries in a population study
    J A Staessen
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Campus Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Hum Hypertens 15:511-8. 2001
    ..We hypothesise that this phenomenon may contribute to the rise in systolic pressure and pulse pressure in women beyond age 50 and, in turn, may lead to a slight dilatation of the common carotid artery...
  52. ncbi The impact of genetic and environmental influences on blood pressure variance across age-groups
    W J Vinck
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Belgium
    J Hypertens 19:1007-13. 2001
    ..The purpose of the present investigation was to examine the age-dependency of blood pressure heritability by use of the twin method in different age groups...
  53. ncbi T-lymphocyte and plasma angiotensin-converting enzyme activity during enalapril and losartan administration in humans
    V V Petrov
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven (K.U. Leuven, Leuven, Belgium
    J Cardiovasc Pharmacol 38:578-83. 2001
    ..Angiotensin II receptor type 1 antagonism with losartan had no effect on plasma or lymphocytic angiotensin-converting enzyme...
  54. ncbi Interaction between nonsteroidal anti-inflammatory drug intake and calcium-channel blocker-based antihypertensive treatment in the Syst-Eur trial
    H Celis
    The Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    J Hum Hypertens 15:613-8. 2001
    ....
  55. ncbi A population-based study on the determinants of heart rate and heart rate variability in the frequency domain
    R H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculteit Geneeskunde, K.U.Leuven, U.Z. Gasthuisberg-Hypertensie, Herestraat 49-B 3000 Leuven
    Verh K Acad Geneeskd Belg 63:57-89; discussion 90-1. 2001
    ..In conclusion, the employed methodology and several demographic, anthropometric and/or lifestyle characteristics should be taken into account for the interpretation of HRV in cardiovascular disease...
  56. ncbi Effect of creatine supplementation as a potential adjuvant therapy to exercise training in cardiac patients: a randomized controlled trial
    V A Cornelissen
    Cardiovascular Rehabilitation Unit, Department of Rehabilitation Sciences, K U Leuven, Leuven, Belgium
    Clin Rehabil 24:988-99. 2010
    ..To investigate the effect of oral creatine supplementation in conjunction with an exercise programme on physical fitness in patients with coronary artery disease or chronic heart failure...
  57. ncbi Prediction of peak exercise oxygen uptake by cardiopulmonary measurements at rest in heart transplant candidates
    K Pardaens
    Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, Belgium
    Acta Cardiol 54:345-54. 1999
    ..It is unknown whether it is possible to predict peak VO2 from a comprehensive dataset with parameters of heart and lung function at rest...
  58. ncbi Blood pressure and blood selenium: a cross-sectional and longitudinal population study
    Tim S Nawrot
    Studies Coordinating Centre, Laboratory of Hypertension, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Campus Gasthuisberg, University of Leuven, Leuven, Belgium
    Eur Heart J 28:628-33. 2007
    ..Western Europeans have low blood levels of selenium (BSe), an antioxidant trace element. In a Flemish population, we investigated the cross-sectional and longitudinal association of blood pressure (BP) with BSe...
  59. ncbi Prognostic value of ambulatory blood-pressure recordings in patients with treated hypertension
    Denis L Clement
    Department of Cardiovascular Diseases, Ghent University, Ghent, Belgium
    N Engl J Med 348:2407-15. 2003
    ....
  60. ncbi Effects of exercise, diet and their combination on blood pressure
    R H Fagard
    Department of Molecular and Cardiovascular Research, Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, KU Leuven, Leuven, Belgium
    J Hum Hypertens 19:S20-4. 2005
    ..However, exercise appears to be less effective than diet in lowering blood pressure (P < 0.02), and adding exercise to diet does not seem to further reduce blood pressure...
  61. ncbi Influence of exercise at lower and higher intensity on blood pressure and cardiovascular risk factors at older age
    Véronique A Cornelissen
    Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Faculty of Medicine, University of Leuven, KU Leuven, Leuven, Belgium
    J Hypertens 27:753-62. 2009
    ..We therefore compared the effect of training at lower and higher intensity on blood pressure, and, in addition on other cardiovascular risk factors, in at least 55-year-old sedentary men and women...
  62. ncbi Progression to hypertension in the non-hypertensive participants in the Flemish Study on Environment, Genes and Health Outcomes
    Haifeng Zhang
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Hypertens 24:1719-27. 2006
    ..The Framingham findings, which have informed several guidelines, can be extrapolated to a Western European population...
  63. ncbi Prevalence of left ventricular diastolic dysfunction in a general population
    Tatiana Kuznetsova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Circ Heart Fail 2:105-12. 2009
    ....
  64. ncbi Modern approaches to blood pressure measurement
    J A Staessen
    Studiecoördinatie Centrum, Laboratorium Hypertensie, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Occup Environ Med 57:510-20. 2000
    ..Although apparently simple, this procedure is fraught with many potential sources of error. This review focuses on two alternative techniques of BP measurement: ambulatory monitoring and self measurement...
  65. ncbi Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials
    J A Staessen
    Department of Molecular and Cardiovasuclar Research, Univeristy of Leuven, Belgium
    Lancet 355:865-72. 2000
    ..We therefore undertook a quantitative overview of the trials to further evaluate the risks associated with systolic blood pressure in treated and untreated older patients with isolated systolic hypertension..
  66. ncbi Arginine-aminopeptidase in rat cardiac fibroblastic cells participates in angiotensin peptide turnover
    V V Petrov
    Hypertension and Cardiovascular Rehabilitation Unit, Campus Gasthuisberg, Department of Molecular and Cardiovascular Research, University of Leuven KULeuven, Herestraat 49, Louvain 3000, Belgium
    Cardiovasc Res 61:724-35. 2004
    ..The aim of the present study was to elucidate the presence in rat cardiac fibroblastic cells of arginine-aminopeptidase and its involvement in the hydrolysis of angiotensin peptides...
  67. ncbi Endothelial function and outdoor temperature
    Tim S Nawrot
    Study Coordinating Centre, Laboratory of Hypertension, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Eur J Epidemiol 20:407-10. 2005
    ..Our findings suggest that endothelial dysfunction might contribute to the increase in cardiovascular morbidity and mortality associated with hot weather...
  68. ncbi Ambulatory pulse pressure as predictor of outcome in older patients with systolic hypertension
    Jan A Staessen
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    Am J Hypertens 15:835-43. 2002
    ....
  69. ncbi Stimulation of collagen production by transforming growth factor-beta1 during differentiation of cardiac fibroblasts to myofibroblasts
    Victor V Petrov
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Leuven, Belgium
    Hypertension 39:258-63. 2002
    ..Instead, TGF-beta(1) induces the differentiation of fibroblasts to myofibroblasts, which have a higher activity for collagen production than fibroblasts...
  70. ncbi Cardiovascular risk in white-coat and sustained hypertensive patients
    Hilde Celis
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Blood Press 11:352-6. 2002
    ..Although white-coat hypertension was less frequently associated with antihypertensive drug treatment during follow-up, it carried a significantly better prognosis than sustained hypertension...
  71. ncbi Association between transforming growth factor-beta and hypertension
    Paul J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Am J Hypertens 16:604-11. 2003
    ..A higher plasma TGF-beta(1) concentration is found in hypertensive patients with microalbuminuria and left ventricle hypertrophy. In these patients, AT(1)R antagonism and ACEI reduced these plasma TGF-beta(1) levels significantly...
  72. ncbi Host and environmental determinants of heart rate and heart rate variability in four European populations
    Katarzyna Stolarz
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Campus Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Hypertens 21:525-35. 2003
    ....
  73. ncbi TGF-beta1-induced cardiac myofibroblasts are nonproliferating functional cells carrying DNA damages
    Victor V Petrov
    Department of Heart Diseases, University of Leuven KULeuven, Leuven, Belgium
    Exp Cell Res 314:1480-94. 2008
    ..Despite carrying of the DNA damages TGF-beta1-activated MyoFbs are highly functional cells producing lysyl oxidase and contracting the collagen matrix...
  74. ncbi Collagen production in cardiac fibroblasts during inhibition of aminopeptidase B
    Paul J Lijnen
    Department of Cardiovascular Diseases, Katholoke Universiteit Leuven K U Leuven Belgium
    J Renin Angiotensin Aldosterone Syst 6:69-77. 2005
    ..To determine whether the aminopeptidase B inhibitor, arphamenine A, could affect collagen production and expression in control and TGF-ss1-treated cardiac fibroblasts...
  75. ncbi Reversal of angiotensin II-stimulated collagen gel contraction in cardiac fibroblasts by aminopeptidase inhibition
    Paul J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Katholieke Universiteit Leuven, Leuven, Belgium
    J Cardiovasc Pharmacol 45:68-73. 2005
    ..Our data suggest that both alanine and arginine aminopeptidases are involved in the reversal of the angiotensin II-stimulated collagen gel contraction in control and TGF-beta1-treated cardiac fibroblasts or myofibroblasts...
  76. ncbi Prevalence of hypertension, hypercholesterolemia, smoking and overweight in older Belgian adolescents
    Tim S Nawrot
    Studiecoördinatiecentrum, Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Faculteit Geneeskunde, Leuven, Belgium
    Eur J Public Health 14:361-5. 2004
    ..The purpose of this study was to describe the prevalence of hypertension and other established CV risk factors in older adolescents...
  77. ncbi Collagen production in cardiac fibroblasts during inhibition of angiotensin-converting enzyme and aminopeptidases
    Paul J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Catholic University of Leuven K U Leuven, Belgium
    J Hypertens 22:209-16. 2004
    ....
  78. ncbi Blood pressure, serum total cholesterol and contraceptive pill use in 17-year-old girls
    Tim S Nawrot
    Studiecoördinatiecentrum, Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Cardiovasc Prev Rehabil 10:438-42. 2003
    ..Many studies have analysed the relation between cardiovascular risk factors and oral contraceptive use in adult women, whereas information on the possible health effects of oral contraceptive use during adolescence is lacking...
  79. ncbi Heritability of plasma renin activity and plasma concentration of angiotensinogen and angiotensin-converting enzyme
    W J Vinck
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    J Hum Hypertens 16:417-22. 2002
    ..For PRA, we are the first to show significant heritability. Our results regarding ACE confirm the findings in other populations...
  80. ncbi Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors
    P J Lijnen
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Leuven, Belgium
    J Renin Angiotensin Aldosterone Syst 2:117-22. 2001
    ....
  81. ncbi Influencing the natural history of hypertension: it is the blood pressure achieved more than the drug
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, University of Leuven KU Leuven, Leuven, Belgium
    J Hypertens 26:1533-5. 2008
  82. ncbi Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population
    Tatiana Kuznetsova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Hypertens 26:1229-36. 2008
    ..We investigated the possible association between left ventricular diastolic function and the ADD1 Gly460Trp and ADD3 IVS11 +386A>G polymorphisms alone and in combination...
  83. ncbi Serum collagen-derived peptides are unaffected by physical training in older sedentary subjects
    Véronique A Cornelissen
    Department of Cardiovascular Diseases, Katholieke Universiteit Leuven KU Leuven, Belgium
    J Sci Med Sport 13:424-8. 2010
    ..Our results showed that 10 weeks of endurance training at lower or higher intensity did not significantly alter serum markers of collagen synthesis and degradation in healthy older men and women...
  84. ncbi Telomere length and its associations with oxidized-LDL, carotid artery distensibility and smoking
    Tim S Nawrot
    Department of Molecular and Cardiovascular Research, Laboratory of Hypertension, University of Leuven, Study Coordinating Centre, Leuven, Belgium
    Front Biosci (Elite Ed) 2:1164-8. 2010
    ..03) than in non-smokers. Higher level of oxidized-LDL, is associated with shorter WBC telomeres and increased stiffness of the carotid artery. Smoking is marked by increased oxidative stress in concert with shortened WBC telomere length...
  85. ncbi Left ventricular geometry and endogenous ouabain in a Flemish population
    Tatiana Kuznetsova
    Studies Coordinating Centre, Department of Cardiovascular Diseases, University of Leuven, Belgium
    J Hypertens 27:1884-91. 2009
    ..Endogenous ouabain, an endogenous digitalis-like steroid, is synthesized in the adrenal glands and possibly in the hypothalamus. In vitro and in vivo, endogenous ouabain triggers growth and proliferation of cardiomyocytes...
  86. ncbi Withdrawal from treatment in the Syst-Eur Trial
    Christopher J Bulpitt
    Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
    J Hypertens 20:339-46. 2002
    ..To investigate the reasons for withdrawal from double-blind randomized trials, and the reasons for changing treatment within a randomized therapeutic group...
  87. ncbi The drive to identify genetic factors influencing left ventricular mass responses to antihypertensive treatment
    Robert H Fagard
    J Hypertens 20:583-5. 2002
  88. ncbi Physical activity, physical fitness and the incidence of hypertension
    Robert H Fagard
    J Hypertens 23:265-7. 2005
  89. ncbi Prognostic significance of renal function in elderly patients with isolated systolic hypertension: results from the Syst-Eur trial
    Peter W de Leeuw
    Department of Internal Medicine, University of Maastricht, Maastricht, The Netherlands
    J Am Soc Nephrol 13:2213-22. 2002
    ..It is concluded that higher levels of serum creatinine and trace or overt proteinuria are associated with an increased number of cardiovascular events and with a higher mortality in patients with isolated systolic hypertension...
  90. ncbi Influence of the endothelial nitric oxide synthase gene on conventional and ambulatory blood pressure: sib-pair analysis and haplotype study
    Alexandre Persu
    Nephrology Unit, Universite Catholique de Louvain, Brussels, Belgium
    J Hypertens 23:759-65. 2005
    ..Nitric oxide is involved in the regulation of vascular basal tone and blood pressure. Polymorphisms of NOS3, the gene that codes for endothelial nitric oxide synthase, have been associated with essential hypertension...
  91. ncbi Prognostic significance of various characteristics of out-of-the-office blood pressure
    Robert H Fagard
    J Hypertens 22:1663-6. 2004
  92. ncbi Systolic blood pressure variability as a risk factor for stroke and cardiovascular mortality in the elderly hypertensive population
    Edward Pringle
    Royal Sussex County Hospital, Brighton, UK
    J Hypertens 21:2251-7. 2003
    ..CONCLUSION: In the placebo group, but not the active treatment group, increased night-time systolic blood pressure variability on admission to the Syst-Eur trial was an independent risk factor for stroke during the trial...
  93. ncbi Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension
    Paolo Palatini
    Clinica Medica 4, University of Padova, Via Giustiniani 2, 35128 Padua, Italy
    Arch Intern Med 162:2313-21. 2002
    ..To examine the association of clinic and ambulatory heart rate with total, cardiovascular, and noncardiovascular death in a cohort of elderly subjects with isolated systolic hypertension from the Systolic Hypertension in Europe Trial...
  94. ncbi The ALLHAT trial: strengths and limitations
    Robert H Fagard
    J Hypertens 21:229-32. 2003