P Evenepoel

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. doi request reprint Recovery versus persistence of disordered mineral metabolism in kidney transplant recipients
    Pieter Evenepoel
    Department of Immunology and Microbiology, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
    Semin Nephrol 33:191-203. 2013
  2. doi request reprint Mineral metabolism in renal transplant recipients discontinuing cinacalcet at the time of transplantation: a prospective observational study
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospitals Leuven, Leuven, Belgium
    Clin Transplant 26:393-402. 2012
  3. doi request reprint Calcium balance in chronic kidney disease: walking the tightrope
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Kidney Int 81:1057-9. 2012
  4. doi request reprint Residual renal function is an independent determinant of serum FGF-23 levels in dialysis patients
    Liesbeth Viaene
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Nephrol Dial Transplant 27:2017-22. 2012
  5. doi request reprint Dietary fiber and protein: nutritional therapy in chronic kidney disease and beyond
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Kidney Int 81:227-9. 2012
  6. pmc Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure
    Wim Laleman
    Department of Hepatology, University Hospital Gasthuisberg, KU Leuven, Belgium
    Crit Care 10:R108. 2006
  7. ncbi request reprint Heparin-coated polyacrylonitrile membrane versus regional citrate anticoagulation: a prospective randomized study of 2 anticoagulation strategies in patients at risk of bleeding
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Am J Kidney Dis 49:642-9. 2007
  8. ncbi request reprint Natural history of parathyroid function and calcium metabolism after kidney transplantation: a single-centre study
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Belgium
    Nephrol Dial Transplant 19:1281-7. 2004
  9. ncbi request reprint Acute toxic renal failure
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospital Leuven, B 3000 Leuven, Belgium
    Best Pract Res Clin Anaesthesiol 18:37-52. 2004
  10. ncbi request reprint Nephrogenic fibrosing dermopathy: a novel, disabling disorder in patients with renal failure
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Nephrol Dial Transplant 19:469-73. 2004

Detail Information

Publications101 found, 100 shown here

  1. doi request reprint Recovery versus persistence of disordered mineral metabolism in kidney transplant recipients
    Pieter Evenepoel
    Department of Immunology and Microbiology, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
    Semin Nephrol 33:191-203. 2013
    ..Additional studies urgently are needed to get more insights into the pathophysiology of posttransplant CKD-MBD. These new insights will allow for a more targeted and causal therapeutic approach...
  2. doi request reprint Mineral metabolism in renal transplant recipients discontinuing cinacalcet at the time of transplantation: a prospective observational study
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospitals Leuven, Leuven, Belgium
    Clin Transplant 26:393-402. 2012
    ..Biochemical profiles and clinical outcomes in patients discontinuing cinacalcet at the time of transplantation are scarce...
  3. doi request reprint Calcium balance in chronic kidney disease: walking the tightrope
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Kidney Int 81:1057-9. 2012
    ..Methodological limitations such as unproven steady state warrant caution and confirmatory studies...
  4. doi request reprint Residual renal function is an independent determinant of serum FGF-23 levels in dialysis patients
    Liesbeth Viaene
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Nephrol Dial Transplant 27:2017-22. 2012
    ..Whether FGF-23 and RRF are interrelated is unknown...
  5. doi request reprint Dietary fiber and protein: nutritional therapy in chronic kidney disease and beyond
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Kidney Int 81:227-9. 2012
    ..Future nutrition guidelines should consider recommending a higher consumption of dietary fiber or potassium-free alternatives such as prebiotics in CKD patients...
  6. pmc Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure
    Wim Laleman
    Department of Hepatology, University Hospital Gasthuisberg, KU Leuven, Belgium
    Crit Care 10:R108. 2006
    ....
  7. ncbi request reprint Heparin-coated polyacrylonitrile membrane versus regional citrate anticoagulation: a prospective randomized study of 2 anticoagulation strategies in patients at risk of bleeding
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Am J Kidney Dis 49:642-9. 2007
    ..0), and heparin-coated membranes (1.3 m(2); AN69ST; Nephral 300ST, Gambro-Hospal, Meyzieu, France) may represent valid alternatives...
  8. ncbi request reprint Natural history of parathyroid function and calcium metabolism after kidney transplantation: a single-centre study
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Belgium
    Nephrol Dial Transplant 19:1281-7. 2004
    ..Our aim was to evaluate the post-transplant natural history of parathyroid function and calcium metabolism in patients with a functional renal graft and to identify risk factors for persistent HPT...
  9. ncbi request reprint Acute toxic renal failure
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospital Leuven, B 3000 Leuven, Belgium
    Best Pract Res Clin Anaesthesiol 18:37-52. 2004
    ....
  10. ncbi request reprint Nephrogenic fibrosing dermopathy: a novel, disabling disorder in patients with renal failure
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Nephrol Dial Transplant 19:469-73. 2004
  11. doi request reprint Calcimimetics in chronic kidney disease: evidence, opportunities and challenges
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Kidney Int 74:265-75. 2008
    ..In these patients, therapy for SHPT should rather be focused on the primary trigger, i.e. the high phosphate load relative to the functional nephron mass...
  12. doi request reprint Efficacy and safety of sevelamer hydrochloride and calcium acetate in patients on peritoneal dialysis
    Pieter Evenepoel
    1Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Nephrol Dial Transplant 24:278-85. 2009
    ..Although phosphate binders are often used in patients on peritoneal dialysis (PD), no large randomized controlled studies evaluating their use solely in this population have previously been reported...
  13. ncbi request reprint Parathyroidectomy after successful kidney transplantation: a single centre study
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Nephrol Dial Transplant 22:1730-7. 2007
    ..To gain insight into the incidence, risk factors and consequences of parathyroidectomy in patients with a functioning renal graft, we performed a retrospective case-controlled study...
  14. ncbi request reprint Tertiary 'hyperphosphatoninism' accentuates hypophosphatemia and suppresses calcitriol levels in renal transplant recipients
    P Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, B 3000 Leuven, Belgium
    Am J Transplant 7:1193-200. 2007
    ..In conclusion, our data indicate that persistence of FGF-23 contributes to hypophosphatemia and suboptimal calcitriol levels in renal transplant recipients...
  15. ncbi request reprint Heparin-coated hemodialyzers--the holy grail for patients at risk of bleeding?
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Nephron Clin Pract 97:c1-2. 2004
  16. ncbi request reprint Control of hyperphosphatemia beyond phosphate
    P Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Kidney Int 71:376-9. 2007
    ..This is the first intervention study in the field of mineral metabolism showing a beneficial effect on a hard end point...
  17. ncbi request reprint Impact of parathyroidectomy on renal graft function, blood pressure and serum lipids in kidney transplant recipients: a single centre study
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Nephrol Dial Transplant 20:1714-20. 2005
    ..To evaluate the impact of PTX on blood pressure (BP), renal graft function and serum lipids, we performed a retrospective case-controlled study in renal graft recipients...
  18. ncbi request reprint Detoxifying capacity and kinetics of prometheus--a new extracorporeal system for the treatment of liver failure
    Pieter Evenepoel
    Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Blood Purif 23:349-58. 2005
    ..The aim of the present study was to evaluate the removal capacity and selectivity of the different inbuilt dialyzers and adsorption columns during a single 6-hour treatment...
  19. ncbi request reprint Superior dialytic clearance of beta(2)-microglobulin and p-cresol by high-flux hemodialysis as compared to peritoneal dialysis
    P Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Kidney Int 70:794-9. 2006
    ..In conclusion, superior dialytic clearance of both water-soluble solutes, beta(2)M, and pcr is achieved by high-flux HD as compared to PD...
  20. ncbi request reprint Prometheus versus molecular adsorbents recirculating system: comparison of efficiency in two different liver detoxification devices
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Artif Organs 30:276-84. 2006
    ..PROM produces higher blood clearances for most toxins, which results in higher delivered treatment doses compared with a matching treatment with MARS...
  21. pmc Recovery of hyperphosphatoninism and renal phosphorus wasting one year after successful renal transplantation
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, B 3000 Leuven, Belgium
    Clin J Am Soc Nephrol 3:1829-36. 2008
    ..Transplant recipients were (1:1) matched for estimated GFR with chronic kidney disease (CKD) patients...
  22. ncbi request reprint Regional citrate anticoagulation for hemodialysis using a conventional calcium-containing dialysate
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Am J Kidney Dis 39:315-23. 2002
    ..Compared with the use of a calcium-free dialysate, the number of analyses can be reduced substantially, making this method financially attractive...
  23. ncbi request reprint Calcium metabolism in the early post-transplant period
    P Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Minerva Urol Nefrol 63:89-99. 2011
    ..These studies will definitely help to develop and implement guidelines with regard to the indication and timing of causal and symptomatic therapy...
  24. pmc Measuring total blood calcium displays a low sensitivity for the diagnosis of hypercalcemia in incident renal transplant recipients
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 5:2085-92. 2010
    ..The performance of total calcium (tCa) in the diagnosis of blood calcium disturbances in renal transplant recipients is unknown...
  25. ncbi request reprint Acarbose treatment lowers generation and serum concentrations of the protein-bound solute p-cresol: a pilot study
    P Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Kidney Int 70:192-8. 2006
    ..Although further confirmation is warranted, the data may point to a novel treatment option for chronic kidney disease patients in view of the potential toxic effects of p-cresol and related substances...
  26. ncbi request reprint Persistent hyperparathyroidism after kidney transplantation requiring parathyroidectomy
    P Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Acta Otorhinolaryngol Belg 55:177-86. 2001
    ..Parathyroidectomy (PTX) is ultimately required in some of these patients...
  27. pmc Fibroblast growth factor-23 in early chronic kidney disease: additional support in favor of a phosphate-centric paradigm for the pathogenesis of secondary hyperparathyroidism
    Pieter Evenepoel
    Department of Medicine, University Hos pital Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 5:1268-76. 2010
    ....
  28. ncbi request reprint Detoxifying capacity and kinetics of the molecular adsorbent recycling system. Contribution of the different inbuilt filters
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Blood Purif 21:244-52. 2003
    ..Our data suggest that the rate and efficacy of removal of albumin-bound toxins are related to both the strength of the albumin binding and the saturation of the adsorption columns...
  29. doi request reprint Localization, etiology and impact of calcium phosphate deposits in renal allografts
    P Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Am J Transplant 9:2470-8. 2009
    ..The clinical relevance of CaPhos deposition remains to be established...
  30. pmc Calcium metabolism in the early posttransplantation period
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 4:665-72. 2009
    ..Both the abrupt cessation of calcium-containing phosphorus binders and vitamin D (analogs) at the time of surgery and the recovery of renal function may be hypothesized to affect serum calcium levels in this period...
  31. ncbi request reprint Death with functioning graft--a preventable cause of graft loss
    P Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Ann Transplant 6:17-20. 2001
    ..Patient death continues to be a leading cause of renal transplant failure. This mortality of transplant patients is mainly due to cardiovascular disease (CVD). Identification of predictions of early CVD may provide targets for intervention...
  32. ncbi request reprint The use of an anti-CD25 monoclonal antibody and mycophenolate mofetil enables the use of a low-dose tacrolimus and early withdrawal of steroids in renal transplant recipients
    D R J Kuypers
    Department of Nephrology, University Hospitals Leuven, Leuven, Belgium
    Clin Transplant 17:234-41. 2003
    ....
  33. ncbi request reprint Long-term changes in mycophenolic acid exposure in combination with tacrolimus and corticosteroids are dose dependent and not reflected by trough plasma concentration: a prospective study in 100 de novo renal allograft recipients
    D R Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Clin Pharmacol 43:866-80. 2003
    ..Using the latter as a routine measure for therapeutic drug monitoring might mislead clinicians into drawing wrong conclusions in terms of relating questions of efficacy or toxicity to MPA exposure...
  34. doi request reprint Chronic histological damage in early indication biopsies is an independent risk factor for late renal allograft failure
    M Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium, EU
    Am J Transplant 13:86-99. 2013
    ..The global burden of early chronic histological damage within the first year after transplantation importantly affects the fate of the allografts...
  35. ncbi request reprint Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients
    B Bammens
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Kidney Int 69:1081-7. 2006
    ..These findings may encourage nephrologists to widen their field of interest beyond the scope of small water-soluble uremic solutes and middle molecules...
  36. ncbi request reprint Impairment of small intestinal protein assimilation in patients with end-stage renal disease: extending the malnutrition-inflammation-atherosclerosis concept
    Bert Bammens
    Department of Medicine, Division of Nephrology and the Laboratory of Digestion and Absorption, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Clin Nutr 80:1536-43. 2004
    ..Protein malnutrition is a common finding in renal disease. Recently, we showed that impaired protein assimilation (digestion and absorption) may contribute to protein malnutrition in nondiabetic patients with chronic renal failure...
  37. ncbi request reprint Post-streptococcal glomerulonephritis: not an extinct disease!
    M Demuynck
    Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, Belgium
    Acta Clin Belg 68:215-7. 2013
    ..Particular attention is needed for the fact that the clinical context in which the disease occurs may be different from the classical "post-angina" presentation...
  38. ncbi request reprint Posttransplantation diabetes mellitus in FK-506-treated renal transplant recipients: analysis of incidence and risk factors
    B D Maes
    Department of Medicine, University Hospital Gathuisberg, Leuven, Belgium
    Transplantation 72:1655-61. 2001
    ..Higher trough levels of FK-506 during the first month, acute rejections, and higher BMI were the most obvious risk factors...
  39. ncbi request reprint The rate of gastric emptying determines the timing but not the extent of oral tacrolimus absorption: simultaneous measurement of drug exposure and gastric emptying by carbon-14-octanoic acid breath test in stable renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Drug Metab Dispos 32:1421-5. 2004
    ....
  40. ncbi request reprint Long-term pharmacokinetic study of the novel combination of tacrolimus and sirolimus in de novo renal allograft recipients
    D R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospital Leuven, Leuven, Belgium
    Ther Drug Monit 25:447-51. 2003
    ....
  41. ncbi request reprint A comparative prospective study on the use of low concentrate citrate lock versus heparin lock in permanent dialysis catheters
    L Hendrickx
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Int J Artif Organs 24:208-11. 2001
    ..We found that low concentrate citrate is as safe as heparin for long-term interdialytic anticoagulation of permanent single lumen hemodialysis catheters but is more efficient from a pharmaco-economic viewpoint...
  42. ncbi request reprint The influence of inulin on the absorption of nitrogen and the production of metabolites of protein fermentation in the colon
    Karen P Geboes
    Laboratory of Digestion and Absorption, Department of Gastroenterology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Br J Nutr 96:1078-86. 2006
    ..Further studies are warranted to confirm these results in a larger cohort...
  43. ncbi request reprint Secondary effects of immunosuppressive drugs after simultaneous pancreas-kidney transplantation
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Nephrol Dial Transplant 20:ii33-9, ii62. 2005
    ..This report examines the early and late secondary effects of tacrolimus, cyclosporin microemulsion (ME), mycophenolate mofetil (MMF) and rabbit anti-thymocyte globulin (rATG) in simultaneous pancreas-kidney (SPK) recipients...
  44. doi request reprint Evidence in favor of a severely impaired net intestinal calcium absorption in patients with (early-stage) chronic kidney disease
    L Viaene
    Division of Nephrology, Dialysis and Renal Transplantation, Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Am J Nephrol 35:434-41. 2012
    ..Little is known about the net and fractional intestinal absorption of calcium and phosphorus in patients with chronic kidney disease (CKD) and their clinical and hormonal determinants...
  45. ncbi request reprint Influenza vaccination is efficacious and safe in renal transplant recipients
    J Scharpé
    Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, B 3000 Leuven, Belgium
    Am J Transplant 8:332-7. 2008
    ..A booster dose did not enhance SP or SR rates. Influenza vaccination neither affected allograft function nor caused rejection episodes. In conclusion, influenza vaccination is efficacious and safe in renal transplantation...
  46. doi request reprint Free p-cresol is associated with cardiovascular disease in hemodialysis patients
    B K I Meijers
    Division of Nephrology, Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Kidney Int 73:1174-80. 2008
    ..Our study shows that free p-cresol is a novel cardiovascular risk factor in non-diabetic hemodialysis patients...
  47. ncbi request reprint The value of tuberculin skin testing in haemodialysis patients
    Anne Wauters
    Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Nephrol Dial Transplant 19:433-8. 2004
    ..The aim of this prospective multi-centre study was to evaluate the tuberculin skin test (TST) as a screening method for detection of M.tuberculosis infection in haemodialysis patients...
  48. doi request reprint Combined kidney and intestinal transplantation in patients with enteric hyperoxaluria secondary to short bowel syndrome
    L J Ceulemans
    Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    Am J Transplant 13:1910-4. 2013
    ....
  49. ncbi request reprint Living donor kidney transplantation: analysis of the first 40 cases performed in UZ Leuven
    J Pirenne
    Abdominal Transplant Surgery Department and Transplant Coordination, University Hospitals Leuven, Leuven, Belgium
    Acta Chir Belg 108:39-44. 2008
    ..In our center a living donation kidney transplant programme was started in 1997. Since then 40 cases of live donation kidney transplantation have been performed and are reported herein...
  50. ncbi request reprint Evidence for impaired assimilation of protein in chronic renal failure
    Bert Bammens
    Department of Medicine, Division of Nephrology and Laboratory of Radiopharmaceutical Chemistry, University Hospital Gasthuisberg, Leuven, Belgium
    Kidney Int 64:2196-203. 2003
    ..We hypothesized that besides inadequate dietary protein intake and alterations in metabolism, deficient protein assimilation (digestion and absorption) might contribute to the pathogenesis of protein malnutrition in uremia...
  51. ncbi request reprint Surgical findings and post-operative parathormone levels in patients with secondary hyperparathyroidism
    J Verdonck
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Belgium
    B-ENT 5:143-8. 2009
    ..The peri-operative and immediate post-operative outcome of secondary hyperparathyroidism treated with subtotal parathyroidectomy is reported...
  52. pmc p-Cresyl sulfate and indoxyl sulfate in hemodialysis patients
    Bjorn K I Meijers
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 4:1932-8. 2009
    ..They share important features such as the albumin-binding site, low dialytic clearance, and both originate from protein fermentation. Whether serum concentrations are related is, however, not known...
  53. ncbi request reprint Major coagulation disturbances during fractionated plasma separation and adsorption
    B K I Meijers
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Am J Transplant 7:2195-9. 2007
    ..Direct contact between fractionated plasma and the Prometh02 anion exchanger causes significant adsorption of procoagulant and anti-coagulant factors, associated with clinically relevant adverse events...
  54. ncbi request reprint In vivo evaluation of a colonic delivery system using isotope techniques
    K Verbeke
    Department of Gastrointestinal Research, University Hospital Gasthuisberg, Leuven, Belgium
    Aliment Pharmacol Ther 21:187-94. 2005
    ..This study was repeated after a 2-week lactulose intake period...
  55. ncbi request reprint Magnesium chloride slows gastric emptying, but does not affect digestive functions
    K P Geboes
    Departments of Gastroenterology Leuven, Belgium
    Aliment Pharmacol Ther 16:1571-7. 2002
    ..We also investigated the influence of the administration of magnesium chloride on protein digestion and gastric emptying...
  56. ncbi request reprint Erosive enterocolitis in mycophenolate mofetil-treated renal-transplant recipients with persistent afebrile diarrhea
    Bart D Maes
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Transplantation 75:665-72. 2003
    ..The aim of this study was to explore the gastrointestinal tract in MMF-treated renal transplant recipients with persistent afebrile diarrhea to characterize its nature and etiology...
  57. ncbi request reprint Validation of a new test meal for a protein digestion breath test in humans
    Karen P Geboes
    Department of Gastroenterology, University Hospital Gasthuisberg, Catholic University of Leuven, 3000 Leuven, Belgium
    J Nutr 134:806-10. 2004
    ..The incorporation of differently labeled substrates into a single test meal allows the assessment of different gastrointestinal processes in the overall assimilation of proteins...
  58. ncbi request reprint An uncommon tumor in a renal graft recipient: a diagnostic and therapeutic challenge
    Kathleen Claes
    Department of Nephrology and Transplantation, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Kidney Dis 40:E21. 2002
    ..This case report also illustrates the different imaging modalities that can be used for the diagnosis of neuroendocrine tumors...
  59. doi request reprint Early clinical assessment of glucose metabolism in renal allograft recipients: diagnosis and prediction of post-transplant diabetes mellitus (PTDM)
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, Belgium
    Nephrol Dial Transplant 23:2033-42. 2008
    ..Post-transplant diabetes mellitus (PTDM) has serious consequences for renal allograft survival, cardiovascular risk and patient survival...
  60. ncbi request reprint Influence of SDZ RAD vs. MMF on gastric emptying in renal transplant recipients
    Bart D Maes
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Transplant 17:171-6. 2003
    ..Because of the impact on drug absorption and gastrointestinal symptoms, further studies are indicated to corroborate the potential prokinetic properties of SDZ RAD...
  61. ncbi request reprint Differential effect of diarrhea on FK506 versus cyclosporine A trough levels and resultant prevention of allograft rejection in renal transplant recipients
    Bart D Maes
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, B 3000 Leuven, Belgium
    Am J Transplant 2:989-92. 2002
    ..Therefore, dose adjustments of FK506 in patients with diarrhea must be carefully monitored, especially when doses of mycophenolate mofetil are also reduced...
  62. ncbi request reprint Validation of lactose[15N,15N]ureide as a tool to study colonic nitrogen metabolism
    Karen P Geboes
    Laboratory of Digestion and Absorption, Deptartment of Gastroenterology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 288:G994-9. 2005
    ..This instillation study shows that lactose[15N,15N]ureide is a tool with good properties to investigate the effect of different types of carbohydrates on nitrogen metabolism in the proximal colon in vivo...
  63. doi request reprint Calcium requirements after parathyroidectomy in patients with refractory secondary hyperparathyroidism
    Liesbeth Viaene
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Nephron Clin Pract 110:c80-5. 2008
    ..The current study aims to quantify these calcium needs and to identify predictors of a high calcium need present at the time of surgery...
  64. doi request reprint Troponin I is a predictor of acute cardiac events in the immediate postoperative renal transplant period
    Kathleen Claes
    Department of Nephrology and Transplantation, University Hospitals Gasthuisberg, Leuven, Belgium
    Transplantation 89:341-6. 2010
    ..Patients on the renal transplant waiting list and renal transplant recipients have an increased risk of premature cardiovascular (CV) disease and death...
  65. ncbi request reprint C3D deposition in peritubular capillaries indicates a variant of acute renal allograft rejection characterized by a worse clinical outcome
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transplantation 76:102-8. 2003
    ....
  66. doi request reprint Recipient-derived chronic lymphocytic leukaemia diagnosed shortly after kidney transplantation on protocol biopsy
    Daan Dierickx
    Department of Hematology, University Hospitals Gasthuisberg, Leuven, Belgium
    Nephrol Dial Transplant 24:3886-90. 2009
    ..The case underscores that it is extremely important to distinguish between a pre-existing lymphoma diagnosis after transplantation and a true PTLD as the treatment options of both are very divergent...
  67. ncbi request reprint Mycophenolate mofetil in IgA nephropathy: results of a 3-year prospective placebo-controlled randomized study
    Bart D Maes
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Kidney Int 65:1842-9. 2004
    ..Because humoral immunity is believed to play a pivotal role in the pathogenesis of IgA nephropathy (IgAN), a prospective placebo-controlled randomized study was started in patients with IgAN using mycophenolate mofetil (MMF)...
  68. ncbi request reprint Adjuvant low-dose cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Am J Transplant 5:1997-2004. 2005
    ..In this selected group of recipients with BKVIN, the use of adjuvant low-dose cidofovir therapy resulted in prolonged graft survival and stabilized graft function...
  69. ncbi request reprint A new acute inflammatory syndrome related to the introduction of mycophenolate mofetil in patients with Wegener's granulomatosis
    Bart Maes
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Nephrol Dial Transplant 17:923-6. 2002
    ..Because this side effect of MMF may also occur after solid organ transplantation and in other immune disorders, pharmacokinetic profiling of MPA and MPA acyl glucuronide is needed in future studies with MMF...
  70. ncbi request reprint Time profiles of peritoneal and renal clearances of different uremic solutes in incident peritoneal dialysis patients
    Bert Bammens
    Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Kidney Dis 46:512-9. 2005
    ..The beneficial impact of RRF also may be related to the preservation of specific renal elimination mechanisms, such as tubular metabolism or secretion, which are crucial for the removal of some uremic retention solutes...
  71. pmc p-Cresol and cardiovascular risk in mild-to-moderate kidney disease
    Bjorn K I Meijers
    Department of Medicine, Division of Nephrology and Laboratory for Gastro Intestinal Research and Leuven Food Science and Nutrition Research Centre LFoRCe, University Hospital Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 5:1182-9. 2010
    ..It is not known if p-cresol is associated with cardiovascular disease in patients with chronic kidney disease not yet on dialysis...
  72. ncbi request reprint A simplified strategy for clinical management of late cytomegalovirus infection after oral ganciclovir prophylaxis in renal recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Antimicrob Chemother 55:391-4. 2005
    ..Identifying patients at risk for late infection is clinically difficult; prolonged cytomegalovirus (CMV) monitoring is costly and cumbersome as follow-up intervals lengthen...
  73. ncbi request reprint The Molecular Adsorbent Recirculating System in patients with severe liver failure: clinical results at the K.U. Leuven
    Alexander Wilmer
    Medical Intensive Care Unit, UZ Gasthuisberg, Catholic University of Leuven, Belgium
    Liver 22:52-5. 2002
    ..The Molecular Adsorbent Recirculating System (MARS) is a novel extracorporeal technique for liver support. We report the clinical results in the first 13 patients with severe liver failure treated at our institution...
  74. ncbi request reprint Time-related clinical determinants of long-term tacrolimus pharmacokinetics in combination therapy with mycophenolic acid and corticosteroids: a prospective study in one hundred de novo renal transplant recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Pharmacokinet 43:741-62. 2004
    ..The specific characteristics of the inter-relationship between dose, concentration and clinical (side-)effects for tacrolimus have not yet been identified and extensive long-term pharmacokinetic studies are presently lacking...
  75. ncbi request reprint Recurrence of light chain deposit disease after renal allograft transplantation: potential role of rituximab?
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transpl Int 20:381-5. 2007
    ....
  76. ncbi request reprint A prospective proof of concept study of the efficacy of tacrolimus ointment on uraemic pruritus (UP) in patients on chronic dialysis therapy
    Dirk R Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Nephrol Dial Transplant 19:1895-901. 2004
    ..UP causes skin damage, discomfort, sleeping disorders and diminished quality of life. Since UP is considered to be in part an immune-mediated inflammatory process, immunosuppressive drugs like tacrolimus may be beneficial...
  77. ncbi request reprint Clinical efficacy and toxicity profile of tacrolimus and mycophenolic acid in relation to combined long-term pharmacokinetics in de novo renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Clin Pharmacol Ther 75:434-47. 2004
    ....
  78. ncbi request reprint Acute-onset, steroid-sensitive, encapsulating peritoneal sclerosis in a renal transplant recipient
    Tom Dejagere
    Department of Nephrology and Renal Transplantation, University Hospital Leuven, Leuven, Belgium
    Am J Kidney Dis 45:e33-7. 2005
    ..Our case strongly supports a therapeutic role for high-dose steroids in the treatment of encapsulating peritoneal sclerosis during its initial inflammatory stage...
  79. ncbi request reprint Removal of the protein-bound solute p-cresol by convective transport: a randomized crossover study
    Bert Bammens
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Kidney Dis 44:278-85. 2004
    ..The primary aim of this randomized crossover study is to evaluate the influence of internal filtration, postdilution HDF, and predilution HDF on removal of the protein-bound solute p-cresol...
  80. ncbi request reprint Improving removal of protein-bound retention solutes
    Bert Bammens
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Contrib Nephrol 149:175-84. 2005
    ..Furthermore, the toxicity profile of this group of molecules is discussed...
  81. ncbi request reprint Role of immunosuppressive drugs in the development of tissue-invasive cytomegalovirus infection in renal transplant recipients
    D R J Kuypers
    Department of Nephrology, University Hospitals, Leuven, Belgium
    Transplant Proc 34:1164-70. 2002
  82. ncbi request reprint Activity related increase of exhaled nitric oxide in Crohn's disease and ulcerative colitis: a manifestation of systemic involvement?
    G H Koek
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Respir Med 96:530-5. 2002
    ..These observations strengthen the arguments that IBD is a systemic disease. Further research is needed to try to explain the significance of an increased eNO in IBD...
  83. doi request reprint The uremic retention solute p-cresyl sulfate and markers of endothelial damage
    Bjorn K I Meijers
    Department of Medicine, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
    Am J Kidney Dis 54:891-901. 2009
    ..In hemodialysis patients, the protein-bound uremic retention solute p-cresol is independently associated with cardiovascular disease. The underlying mechanisms have not been elucidated...
  84. doi request reprint p-Cresyl sulfate serum concentrations in haemodialysis patients are reduced by the prebiotic oligofructose-enriched inulin
    Bjorn K I Meijers
    Division of Nephrology, Department of Medicine, University Hospital Leuven, 3000 Leuven, Belgium
    Nephrol Dial Transplant 25:219-24. 2010
    ..We investigated whether the prebiotic oligofructose-enriched inulin reduced serum concentration of p-cresyl sulfate and indoxyl sulfate, through interference with intestinal generation...
  85. doi request reprint Immunogenicity of a standard trivalent influenza vaccine in patients on long-term hemodialysis: an open-label trial
    Johan Scharpé
    Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Kidney Dis 54:77-85. 2009
    ..The present prospective trial aimed to: (1) evaluate the immunogenicity of a standard influenza vaccine in HD patients, and (2) identify determinants of the immune response...
  86. ncbi request reprint Genetic and clinical factors influence the baseline permeability of the peritoneal membrane
    Gaëlle Gillerot
    Division of Nephrology, and Division of Epidemiology and Statistics, Université Catholique de Louvain Medical School, Brussels, Belgium
    Kidney Int 67:2477-87. 2005
    ..The latter parameter determines dialysis prescription and survival. Clinical factors probably influence solute transport across the PM, but the putative role of genetic variants is unknown...
  87. ncbi request reprint Gas chromatographic-mass spectrometric analysis for measurement of p-cresol and its conjugated metabolites in uremic and normal serum
    Henriette de Loor
    Department of Medicine, University Hospital Gasthuisberg K U Leuven, Leuven, Belgium
    Clin Chem 51:1535-8. 2005
  88. doi request reprint Removal of the uremic retention solute p-cresol using fractionated plasma separation and adsorption
    Björn K Meijers
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Artif Organs 32:214-9. 2008
    ..We halted the study after four inclusions due to repeated thrombosis of the arterio-venous conduit. In conclusion, FPSA is a promising technique to improve clearance of protein-bound uremic retention solutes...
  89. ncbi request reprint A prospective, randomized, double-blind crossover study on the use of 5% citrate lock versus 10% citrate lock in permanent hemodialysis catheters
    Gert Meeus
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, Leuven, Belgium
    Blood Purif 23:101-5. 2005
    ....
  90. doi request reprint A review of albumin binding in CKD
    Bjorn K I Meijers
    Department of Medicine, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
    Am J Kidney Dis 51:839-50. 2008
    ..Other epuration techniques combining hemodialysis with adsorption have been developed. However, the benefit of these techniques remains to be proved...
  91. ncbi request reprint Late referral of patients with chronic kidney disease: no time to waste
    Ben Sprangers
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Mayo Clin Proc 81:1487-94. 2006
    ..This review presents the available data on the epidemiology, causes, and consequences of late patient referral. Furthermore, it offers information to prevent late referral, improve CKD patient care, and change clinical practice...
  92. ncbi request reprint Removal of middle molecules and protein-bound solutes by peritoneal dialysis and relation with uremic symptoms
    Bert Bammens
    Department of Medicine, Division of Nephrology and Laboratory of Radiopharmaceutical Chemistry, University Hospital Gasthuisberg, Leuven, Belgium
    Kidney Int 64:2238-43. 2003
    ....
  93. ncbi request reprint Alteration in digestion and absorption of nutrients during profound acid suppression
    P Evenepoel
    Department of Medicine, University Hospital Leuven, Leuven, B-3000, Belgium
    Best Pract Res Clin Gastroenterol 15:539-51. 2001
    ..Nevertheless, it seems prudent, while awaiting the results of additional long-term studies, regularly to monitor these patients, especially those with increased nutrient demand, poor intake or suboptimal stores...
  94. doi request reprint Sodium octanoate to reverse indoxyl sulfate and p-cresyl sulfate albumin binding in uremic and normal serum during sample preparation followed by fluorescence liquid chromatography
    Henriette de Loor
    Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    J Chromatogr A 1216:4684-8. 2009
    ..Sodium octanoate binding competition is a novel sample preparation that allows for direct quantification of indoxyl sulfate and p-cresyl sulfate...
  95. ncbi request reprint The molecular adsorbent recycling system (MARS) and transmembrane transport of albumin-bound toxins
    Pieter Evenepoel
    Liver Transpl 11:853-4; author reply 855. 2005
  96. ncbi request reprint Clinically relevant drug interaction between voriconazole and tacrolimus in a primary renal allograft recipient
    Dirk R Kuypers
    Transplantation 81:1750-2. 2006
  97. ncbi request reprint Drug interaction between itraconazole and sirolimus in a primary renal allograft recipient
    Dirk R Kuypers
    Transplantation 79:737. 2005
  98. ncbi request reprint Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
    Geoffrey A Block
    Denver Nephrologists, Denver, USA
    N Engl J Med 350:1516-25. 2004
    ..We report the results of two identical randomized, double-blind, placebo-controlled trials evaluating the safety and effectiveness of the calcimimetic agent cinacalcet hydrochloride...
  99. ncbi request reprint Kidney transplantation with rabbit antithymocyte globulin and sirolimus monotherapy
    Yves Vanrenterghem
    Lancet 361:969; author reply 969-70. 2003
  100. ncbi request reprint 13C-breath tests in peritoneal dialysis patients: influence of dialysis fluids
    Bert Bammens
    Eur J Gastroenterol Hepatol 15:931-2. 2003
  101. doi request reprint Surgical treatment of persistent hyperparathyroidism after renal transplantation
    Frederic Triponez
    Department of Thoracic and Endocrine Surgery, University Hospital of Geneva, Geneva, Switzerland
    Ann Surg 248:18-30. 2008
    ..To provide a review on current knowledge about the pathogenesis, epidemiology, and clinical complications of persistent hyperparathyroidism after kidney transplantation (3HPT) and to discuss the surgical approaches...