Koen Demyttenaere

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate
    Michael Kluge
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstrasse 10, 04103, Leipzig, Germany
    BMC Psychiatry 13:71. 2013
  2. ncbi request reprint Getting what you ask for: on the selectivity of depression rating scales
    Koen Demyttenaere
    University Hospital Gasthuisberg, Department of Psychiatry, Leuven, Belgium
    Psychother Psychosom 72:61-70. 2003
  3. doi request reprint Presence and predictors of pain in depression: results from the FINDER study
    K Demyttenaere
    Univerity Psychiatric Centre, KULeuven, Campus Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Affect Disord 125:53-60. 2010
  4. ncbi request reprint Development of an antidepressant compliance questionnaire
    K Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    Acta Psychiatr Scand 110:201-7. 2004
  5. ncbi request reprint The many faces of fatigue in major depressive disorder
    Koen Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    Int J Neuropsychopharmacol 8:93-105. 2005
  6. ncbi request reprint What happens with adverse events during 6 months of treatment with selective serotonin reuptake inhibitors?
    Koen Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Belgium
    J Clin Psychiatry 66:859-63. 2005
  7. ncbi request reprint Tamsulosin as an effective treatment for reboxetine-associated urinary hesitancy
    K Demyttenaere
    Department of Psychiatry and Institute for Familial and Sexological Sciences, University Hospital Gasthuisberg, Leuven, Belgium
    Int Clin Psychopharmacol 16:353-5. 2001
  8. ncbi request reprint Compliance with antidepressants in a primary care setting, 1: Beyond lack of efficacy and adverse events
    K Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    J Clin Psychiatry 62:30-3. 2001
  9. doi request reprint Clinical factors influencing the prescription of antidepressants and benzodiazepines: results from the European study of the epidemiology of mental disorders (ESEMeD)
    Koen Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    J Affect Disord 110:84-93. 2008
  10. pmc Treatment of suicidal people around the world
    Ronny Bruffaerts
    Universitair Psychiatrisch Centrum Katholieke Universiteit Leuven UPC KUL, University Hospitals Gasthuisberg, Leuven, Belgium
    Br J Psychiatry 199:64-70. 2011

Detail Information

Publications98

  1. pmc Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate
    Michael Kluge
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstrasse 10, 04103, Leipzig, Germany
    BMC Psychiatry 13:71. 2013
    ..We present here the study protocol of a trial intended to study the efficacy and safety of methylphenidate in the initial treatment of acute mania...
  2. ncbi request reprint Getting what you ask for: on the selectivity of depression rating scales
    Koen Demyttenaere
    University Hospital Gasthuisberg, Department of Psychiatry, Leuven, Belgium
    Psychother Psychosom 72:61-70. 2003
    ..The present paper does not suggest that one scale is better than another, but suggests that a better knowledge of their differential background can help the researcher choose the correct scale for his purposes...
  3. doi request reprint Presence and predictors of pain in depression: results from the FINDER study
    K Demyttenaere
    Univerity Psychiatric Centre, KULeuven, Campus Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Affect Disord 125:53-60. 2010
    ..This exploratory study assesses pain severity and interference of pain with functioning in a clinically depressed population and investigates the relation between the different groups of symptoms...
  4. ncbi request reprint Development of an antidepressant compliance questionnaire
    K Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    Acta Psychiatr Scand 110:201-7. 2004
    ..The development of the Antidepressant Compliance Questionnaire (ADCQ), assessing patients' attitudes and beliefs on depression and antidepressants...
  5. ncbi request reprint The many faces of fatigue in major depressive disorder
    Koen Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    Int J Neuropsychopharmacol 8:93-105. 2005
    ....
  6. ncbi request reprint What happens with adverse events during 6 months of treatment with selective serotonin reuptake inhibitors?
    Koen Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Belgium
    J Clin Psychiatry 66:859-63. 2005
    ..Although adverse events are a key factor in compliance, their evolution during treatment with antidepressants is poorly documented. Therefore, the time course of adverse events during 6 months of antidepressant treatment was investigated...
  7. ncbi request reprint Tamsulosin as an effective treatment for reboxetine-associated urinary hesitancy
    K Demyttenaere
    Department of Psychiatry and Institute for Familial and Sexological Sciences, University Hospital Gasthuisberg, Leuven, Belgium
    Int Clin Psychopharmacol 16:353-5. 2001
    ..04 and P = 0.007, respectively). Furthermore, tamsulosin was well tolerated in all patients. These results suggest that tamsulosin is an effective treatment for reboxetine-associated urinary hesitancy...
  8. ncbi request reprint Compliance with antidepressants in a primary care setting, 1: Beyond lack of efficacy and adverse events
    K Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    J Clin Psychiatry 62:30-3. 2001
    ..Factors leading patients to discontinuation of therapy are not well understood. This study investigates when and why patients stop treatment and whether they inform their doctors...
  9. doi request reprint Clinical factors influencing the prescription of antidepressants and benzodiazepines: results from the European study of the epidemiology of mental disorders (ESEMeD)
    Koen Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    J Affect Disord 110:84-93. 2008
    ..To examine factors associated with the use of antidepressants (AD) and benzodiazepines (BZD) in 6 European countries...
  10. pmc Treatment of suicidal people around the world
    Ronny Bruffaerts
    Universitair Psychiatrisch Centrum Katholieke Universiteit Leuven UPC KUL, University Hospitals Gasthuisberg, Leuven, Belgium
    Br J Psychiatry 199:64-70. 2011
    ..Suicide is a leading cause of death worldwide; however, little information is available about the treatment of suicidal people, or about barriers to treatment...
  11. doi request reprint Comorbid painful physical symptoms and anxiety: prevalence, work loss and help-seeking
    Koen Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    J Affect Disord 109:264-72. 2008
    ..In addition, the impact of PPS on work loss days (WLDs) and help-seeking was examined...
  12. ncbi request reprint The relation between body mass index, mental health, and functional disability: a European population perspective
    Ronny Bruffaerts
    Department of Neurosciences and Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    Can J Psychiatry 53:679-88. 2008
    ..To examine the association between body mass, mental disorders, and functional disability in the general population of 6 European countries...
  13. doi request reprint Regional brain activity in functional dyspepsia: a H(2)(15)O-PET study on the role of gastric sensitivity and abuse history
    Lukas Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Gastroenterology 139:36-47. 2010
    ..Therefore, we aimed to determine the influence of gastric sensitivity and abuse history on gastric sensation scores and brain activity in homeostatic-afferent, emotional-arousal, and cortical-modulatory brain regions in FD...
  14. ncbi request reprint Partners of mutation-carriers for Huntington's disease: forgotten persons?
    Marleen Decruyenaere
    Psychosocial Genetics Unit, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Eur J Hum Genet 13:1077-85. 2005
    ..We moreover interpreted the results referring to concepts such as anticipatory grief, psychological defences, dissonance processes and imbalanced partner relationship. Finally, we formulated some implications for genetic counselling...
  15. doi request reprint Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H(2)(15)O-PET study
    Lukas Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 105:913-24. 2010
    ....
  16. ncbi request reprint The complexity of reproductive decision-making in asymptomatic carriers of the Huntington mutation
    Marleen Decruyenaere
    Psychosocial Genetics Unit, University of Leuven, Herestraat, Leuven, Belgium
    Eur J Hum Genet 15:453-62. 2007
    ..The results illustrate the complexity of the decision-making process and the necessity of in-depth counselling. Counselling should pay special attention to conflicting values and beliefs and to all kinds of pressure...
  17. pmc Role of common mental and physical disorders in partial disability around the world
    Ronny Bruffaerts
    Universitair Psychiatrisch Centrum Katholieke Universiteit Leuven, Campus Leuven, Belgium
    Br J Psychiatry 200:454-61. 2012
    ..Mental and physical disorders are associated with total disability, but their effects on days with partial disability (i.e. the ability to perform some, but not full-role, functioning in daily life) are not well understood...
  18. doi request reprint The individual and societal effects of non-psychotic serious mental disorders on earnings in Belgium
    Ronny Bruffaerts
    Department of Neurosciences, University Psychiatric Centre, Katholieke Universiteit Leuven UPC KUL, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Psychiatry 24:207-13. 2009
    ..The purpose of this study is to examine the association between non-psychotic serious mental disorders and earnings in the general population of Belgium on both the individual- and society-level...
  19. doi request reprint Depressive symptomatology in pregnant and postpartum women. An exploratory study of the role of maternal antenatal orientations
    Johan C H van Bussel
    Katholieke Universiteit Leuven, Faculty of Medicine, Institute of Family and Sexuality Studies, Kapucijnenvoer 33, 3000, Leuven, Belgium
    Arch Womens Ment Health 12:155-66. 2009
    ..The maternal orientations have a small but significant and independent contribution in the variance of depressive symptomatology in pregnant and postpartum women...
  20. ncbi request reprint Who visits the psychiatric emergency room for the first time?
    Ronny Bruffaerts
    Dept of Neurosciences and Psychiatry, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
    Soc Psychiatry Psychiatr Epidemiol 41:580-6. 2006
    ..To examine patient and system characteristics of first-time ("incident") vs. recurrent ("recurrent") use of a psychiatric emergency room (PER)...
  21. ncbi request reprint Relationship between anxiety and gastric sensorimotor function in functional dyspepsia
    Lukas Van Oudenhove
    Department of Pathophysiology, Gastroenterology Section, University Hospital Gasthuisberg, Leuven, Belgium
    Psychosom Med 69:455-63. 2007
    ..Experimentally induced anxiety in healthy volunteers is associated with changes in sensorimotor function of the proximal stomach...
  22. doi request reprint Abuse history, depression, and somatization are associated with gastric sensitivity and gastric emptying in functional dyspepsia
    Lukas Van Oudenhove
    Universitary Psychiatric Centre, Universitary Psychiatric Centre, University Hospital Gasthuisberg, B 3000 Leuven, Belgium
    Psychosom Med 73:648-55. 2011
    ..This study sought to determine the association of abuse history, psychiatric comorbidity, and somatization with gastric sensorimotor function...
  23. doi request reprint Well-being and relationship satisfaction of couples dealing with an in vitro fertilization/ intracytoplasmic sperm injection procedure: a multilevel approach on the role of self-criticism, dependency, and romantic attachment
    Benedicte Lowyck
    Department of Psychology, University of Leuven, Leuven, Belgium
    Fertil Steril 91:387-94. 2009
    ....
  24. pmc Dimensions in major depressive disorder and their relevance for treatment outcome
    Elske Vrieze
    Department of Psychiatry, University Psychiatric Center, Campus Leuven, Leuven, Belgium Electronic address
    J Affect Disord 155:35-41. 2014
    ..The first aim of this study was to find potential dimensions within a broad psychopathological assessment in depressed patients. Second, we aimed at examining how these dimensions predicted course in MDD...
  25. ncbi request reprint Lifetime risk and age-of-onset of mental disorders in the Belgian general population
    Anke Bonnewyn
    Dept of Neurosciences and Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    Soc Psychiatry Psychiatr Epidemiol 42:522-9. 2007
    ..To estimate lifetime risk and age of onset of mental disorders in the adult general population of Belgium...
  26. doi request reprint Quality of life measurement in antidepressant trials. Is there an added value?
    Jurgen De Fruyt
    Department of Psychiatry, General Hospital Sint Jan AV, Brugge, Belgium
    Psychother Psychosom 78:212-9. 2009
    ..Different theoretical concepts are discussed. A closer look is taken at the use of QoL measurements in antidepressant trials...
  27. ncbi request reprint Regional cerebral blood flow during gastric balloon distention in functional dyspepsia
    Joris Vandenberghe
    Department of Psychiatry, Division of Liaison Psychiatry, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Gastroenterology 132:1684-93. 2007
    ..Our aim was to investigate regional cerebral blood flow during painful proximal gastric distention in hypersensitive FD...
  28. doi request reprint Overgeneral memory predicts stability of short-term outcome of electroconvulsive therapy for depression
    Filip Raes
    Department of Psychology, University of Leuven, Leuven, Belgium
    J ECT 24:81-3. 2008
    ..To investigate the predictive value of overgeneral memory (OGM) for outcome of electroconvulsive therapy (ECT) for depression...
  29. ncbi request reprint Impact of escitalopram treatment on Quality of Life Enjoyment and Satisfaction Questionnaire scores in major depressive disorder and generalized anxiety disorder
    Koen Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Herestraat 49, Leuven, Belgium
    Int Clin Psychopharmacol 23:276-86. 2008
    ..Both response and remission in patients with GAD and remission in patients with MDD are correlated with a 'normal' quality of life enjoyment and satisfaction...
  30. ncbi request reprint Delays in seeking treatment for mental disorders in the Belgian general population
    Ronny Bruffaerts
    Dept of Neurosciences and Psychiatry, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
    Soc Psychiatry Psychiatr Epidemiol 42:937-44. 2007
    ..To provide data on rates and predictors of lifetime treatment for mental disorders in Belgium from the European Study on the Epidemiology of Mental Disorders (ESEMeD)...
  31. ncbi request reprint Comorbid painful physical symptoms and depression: prevalence, work loss, and help seeking
    Koen Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    J Affect Disord 92:185-93. 2006
    ..Finally, help seeking and delay in help seeking were explored...
  32. ncbi request reprint Six-month compliance with antidepressant medication in the treatment of major depressive disorder
    Koen Demyttenaere
    University Hospital Gasthuisberg, Belgium
    Int Clin Psychopharmacol 23:36-42. 2008
    ..Completers show a higher adherence than drop-outs. The outcome was worse in recurrent episode patients than first episode patients although they had a higher adherence...
  33. doi request reprint Overgeneral autobiographical memory predicts diagnostic status in depression
    Dirk Hermans
    Department of Psychology, University of Leuven, Tiensestraat 102, 3000 Leuven, Belgium
    Behav Res Ther 46:668-77. 2008
    ..These memory variables outperformed other relevant indices, such as depression severity, rumination, level of self-esteem and dysfunctional attitudes...
  34. doi request reprint Predictors of psychological distress in patients starting IVF treatment: infertility-specific versus general psychological characteristics
    Uschi Van den Broeck
    Leuven University Fertility Centre LUFC, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Hum Reprod 25:1471-80. 2010
    ....
  35. pmc Reduced reward learning predicts outcome in major depressive disorder
    Elske Vrieze
    Department of Psychiatry, University Psychiatric Center, Campus Leuven, Belgium
    Biol Psychiatry 73:639-45. 2013
    ..Our goal was to test whether MDD is characterized by reduced reward learning, especially in the presence of anhedonic symptoms, and to investigate the relationship between reward learning and MDD diagnosis after 8 weeks of treatment...
  36. doi request reprint A pooled analysis of six month comparative efficacy and tolerability in four randomized clinical trials: agomelatine versus escitalopram, fluoxetine, and sertraline
    Koen Demyttenaere
    Department of Psychiatry, University Psychiatric Center KU Leuven, Leuven, Belgium
    CNS Spectr 18:163-70. 2013
    ....
  37. doi request reprint Time course of improvement of different symptom clusters in patients with major depression and pain treated with duloxetine or placebo
    Koen Demyttenaere
    University Psychiatric Center KuLeuven, Campus Gasthuisberg, Leuven, Belgium
    Curr Med Res Opin 28:41-8. 2012
    ....
  38. doi request reprint Reliability and validity of the Dutch version of the maternal antenatal attachment scale
    Johan C H van Bussel
    Institute of Family and Sexuality Sciences, Department of Public Health, Faculty of Medicine, Katholieke Universiteit Leuven, Kapucijnenvoer 33, 3000, Leuven, Belgium
    Arch Womens Ment Health 13:267-77. 2010
    ..Overall, our findings suggest that the Dutch version of the Maternal Antenatal Attachment Scale is a reliable and valid measure of the early emotional tie between a pregnant woman and her unborn child...
  39. ncbi request reprint Mental disorders among persons with chronic back or neck pain: results from the World Mental Health Surveys
    Koen Demyttenaere
    Department of Neurosciences and Psychiatry, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Pain 129:332-42. 2007
    ..The association of mental disorders with back/neck pain showed a consistent pattern across both developed and developing countries...
  40. doi request reprint Three self-report questionnaires of the early mother-to-infant bond: reliability and validity of the Dutch version of the MPAS, PBQ and MIBS
    Johan C H van Bussel
    Department of Neurosciences, Faculty of Medicine, Katholieke Universiteit Leuven, Herestraat 49, 3000, Leuven, Belgium
    Arch Womens Ment Health 13:373-84. 2010
    ..Overall, our findings suggest that the MPAS, the PBQ and the MIBS provide a reliable and valid indication of the early emotional tie between a woman and her newborn infant...
  41. ncbi request reprint Clinical factors associated with treatment resistance in major depressive disorder: results from a European multicenter study
    Daniel Souery
    Department of Psychiatry, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Clin Psychiatry 68:1062-70. 2007
    ....
  42. pmc Childhood adversities as risk factors for onset and persistence of suicidal behaviour
    Ronny Bruffaerts
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    Br J Psychiatry 197:20-7. 2010
    ..Suicide is a leading cause of death worldwide, but the precise effect of childhood adversities as risk factors for the onset and persistence of suicidal behaviour (suicide ideation, plans and attempts) are not well understood...
  43. doi request reprint Psychosocial factors, psychiatric illness and functional gastrointestinal disorders: a historical perspective
    Lukas Van Oudenhove
    University Psychiatric Centre, University Hospital Gasthuisberg, Leuven, Belgium
    Digestion 82:201-10. 2010
    ..This provides further support for an integrative, multidisciplinary biopsychosocial approach to FGID...
  44. ncbi request reprint Painful ejaculation and urinary hesitancy in association with antidepressant therapy: relief with tamsulosin
    Koen Demyttenaere
    University Hospitals Gasthuisberg, Department of Psychiatry and Institute for Family and Sexological Sciences, Herestraat 49, 3000 Leuven, Belgium
    Eur Neuropsychopharmacol 12:337-41. 2002
    ..A re-challenge in one patient resulted in a prompt reappearance of both side effects. Tamsulosin resolved the problem of painful ejaculation in these patients; however, larger studies are needed to confirm these results...
  45. doi request reprint Emergency psychiatry in the 21st century: critical issues for the future
    Ronny Bruffaerts
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Emerg Med 15:276-8. 2008
    ..In this paper we aim to address some contemporary problems of emergency psychiatry, and then we try to outline some issues that may be of importance in the future of the psychiatric emergency room...
  46. ncbi request reprint Bipolar (spectrum) disorder and mood stabilization: standing at the crossroads?
    Jurgen De Fruyt
    Department of Psychiatry, General Hospital Sint Jan AV, Brugge, Belgium
    Psychother Psychosom 76:77-88. 2007
    ..Given the complexity of the disorder and the many clinical uncertainties, effectiveness studies should be installed...
  47. pmc Measuring extrastriatal dopamine release during a reward learning task
    Elske Vrieze
    Department of Psychiatry, University Hospital Leuven, Belgium
    Hum Brain Mapp 34:575-86. 2013
    ..Conclusions: These findings support the hypothesis that DA release in mOFC, vmPFC, and dACC regions plays an important role in reinforcement learning in the human brain...
  48. ncbi request reprint Sexual dysfunction in women with type 1 diabetes: a controlled study
    Paul Enzlin
    Department of Psychiatry, University Hospitals Gasthuisberg, Leuven, Belgium
    Diabetes Care 25:672-7. 2002
    ....
  49. ncbi request reprint Effects of patient and health-system characteristics on community tenure of discharged psychiatric inpatients
    Ronny Bruffaerts
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    Psychiatr Serv 55:685-90. 2004
    ..The purpose of this study was to identify the differential effect of patient and health-system characteristics on length of stay in the community among recidivist psychiatric patients...
  50. ncbi request reprint [The epidemiology of depression in Belgium. A review and some reflections for the future]
    R Bruffaerts
    Dienst Neurowetenschappen en Psychiatrie, Afdeling Psychiatrie, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven
    Tijdschr Psychiatr 50:655-65. 2008
    ..Little is known on epidemiological aspects of depression in the Belgian general population, despite the fact that this disorder is known as a burdensome disorder...
  51. ncbi request reprint [Emergency psychiatry in Belgium; a challenge for the mental health services]
    R Bruffaerts
    UZ Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Tijdschr Psychiatr 50:35-9. 2008
    ..More than 4 in 10 patients were admitted to a psychiatric clinic after being referred to a per. Research suggests that the link to continuous care may reduce the 'revolving-door' phenomenon...
  52. doi request reprint Pain and depression in older people: comorbidity and patterns of help seeking
    A Bonnewyn
    University Psychiatric Center KuLeuven, Campus Gasthuisberg, Leuven, Belgium
    J Affect Disord 117:193-6. 2009
    ..Chronic pain and mood disorders are common in older people. Their relationship however remains unclear. Only a few studies have investigated the role of pain in mental health service use and received psychopharmacological treatment...
  53. doi request reprint Reasons for dropout in infertility treatment
    U Van den Broeck
    Leuven University Fertility Centre, University Hospital Leuven, Leuven, Belgium
    Gynecol Obstet Invest 68:58-64. 2009
    ..The objective of this study was to explore the reasons why couples discontinue fertility treatment...
  54. ncbi request reprint Sexual functioning in a population-based study of men aged 40-69 years: the good news
    P Enzlin
    Institute for Family and Sexuality Studies, Catholic University, Leuven, Belgium
    Int J Impot Res 16:512-20. 2004
    ..This study showed that sexuality still matters at middle to high age and that it deserves to be regarded as an important and continuing aspect of the overall adaptation to getting older...
  55. ncbi request reprint Adherence to treatment regimen in depressed patients treated with amitriptyline or fluoxetine
    K Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium
    J Affect Disord 65:243-52. 2001
    ..Adherence was measured electronically with the MEMS (Medication Event Monitoring System)...
  56. ncbi request reprint Coping with infertility: a body-mind group intervention programme for infertile couples
    G M D Lemmens
    Section of Family Therapy, Department of Psychiatry, University Hospital Leuven, Leuven, Belgium
    Hum Reprod 19:1917-23. 2004
    ..At the Leuven University Fertility Centre, a body-mind marital group intervention was developed to help infertile couples cope with the distress related to infertility...
  57. ncbi request reprint Compliance with antidepressants in a primary care setting, 2: the influence of gender and type of impairment
    K Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    J Clin Psychiatry 62:34-7. 2001
    ..This study examines the use of the Sheehan Disability Scale as a possible method of assessing impairment, as well as the relationship between functioning and discontinuation of antidepressant medication...
  58. ncbi request reprint Predictive testing for Huntington's disease: relationship with partners after testing
    M Decruyenaere
    Psychosocial Genetics Unit, University of Leuven Herestraat, Leuven, Belgium
    Clin Genet 65:24-31. 2004
    ..Counselling after testing should stimulate an open communication between partners with consideration of needs and anxieties of both partners...
  59. ncbi request reprint Attenders of a university hospital psychiatric emergency service in Belgium - general characteristics and gender differences
    R Bruffaerts
    Dept of Psychiatry, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
    Soc Psychiatry Psychiatr Epidemiol 39:146-53. 2004
    ..The aim of this study was to provide a clinical and epidemiological profile of patients consulting the psychiatric emergency team (PET) of an emergency service of a Belgian university hospital...
  60. ncbi request reprint Risk factors and predictors of compliance in depression
    Koen Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium
    Eur Neuropsychopharmacol 13:S69-75. 2003
    ..The physician's attitude about the medication is also important. Strategies should be adapted to the stage of treatment, as common reasons for discontinuation change as treatment progresses...
  61. ncbi request reprint Predicting aftercare in psychiatric emergencies
    Ronny Bruffaerts
    Dept of Psychiatry, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
    Soc Psychiatry Psychiatr Epidemiol 40:829-34. 2005
    ..It is unknown to what extent there are differences in predicting follow-up after psychiatric emergency room (PER) visits when focusing on a broader scope of aftercare possibilities...
  62. ncbi request reprint Influence of experimentally induced anxiety on gastric sensorimotor function in humans
    Brecht Geeraerts
    Center for Gastroenterological Research, Leuven, Belgium
    Gastroenterology 129:1437-44. 2005
    ..It is unclear whether this reflects common predisposition or a causal relationship. The aim of this study was to investigate whether experimentally induced anxiety would alter gastric sensorimotor function in health...
  63. ncbi request reprint Psychological distress in the 5-year period after predictive testing for Huntington's disease
    Marleen Decruyenaere
    Psychosocial Genetics Unit, University of Leuven, Herestraat 49, Belgium
    Eur J Hum Genet 11:30-8. 2003
    ....
  64. ncbi request reprint Personality and intrapersonal and interpersonal functioning of women starting their first IVF treatment
    B Lowyck
    Department of Psychology, University of Leuven, Tiensestraat 102, 3000 Leuven, Belgium
    Hum Reprod 24:524-9. 2009
    ....
  65. ncbi request reprint Reflections of older adults on the process preceding their suicide attempt: a qualitative approach
    Anke Bonnewyn
    a Department of Psychiatry, University Psychiatric Centre, Catholic University of Leuven, Leuven, Belgium
    Death Stud 38:612-8. 2014
    ..The findings suggest that the concurrence of these constructs precedes a suicide attempt in later life. ..
  66. doi request reprint Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid receptor gene (NR3C1) promoter region in cord blood
    Titia Hompes
    Department of Psychiatry, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Psychiatr Res 47:880-91. 2013
    ..This study investigates both the association between maternal cortisol and emotional state during pregnancy and the methylation state of the promoter region of NR3C1 gene...
  67. doi request reprint Agomelatine: a narrative review
    Koen Demyttenaere
    University Psychiatric Center KuLeuven, Campus Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur Neuropsychopharmacol 21:S703-9. 2011
    ..Transient aminotransferase elevations without clinical signs of liver damage have been observed more frequently than with placebo (1.1% versus 0.7%), and a hepatic monitoring schedule is therefore recommended...
  68. ncbi request reprint Reduced specificity of autobiographical memory: a mediator between rumination and ineffective social problem-solving in major depression?
    Filip Raes
    Department of Psychology, University of Leuven, Tiensestraat 102, 3000 Leuven, Belgium
    J Affect Disord 87:331-5. 2005
    ..The present study investigated the role of reduced specificity of autobiographical memories as a mediator of this relationship...
  69. ncbi request reprint Predicting community tenure in patients with recurrent utilization of a psychiatric emergency service
    Ronny Bruffaerts
    Department of Psychiatry, University Hospital Gasthuisberg, B 3000 Leuven, Belgium
    Gen Hosp Psychiatry 27:269-74. 2005
    ..We investigated the differential effect of patient and health system characteristics on the CT of patients with a previous referral to a PER...
  70. doi request reprint The effects on mood of adjunctive single-family and multi-family group therapy in the treatment of hospitalized patients with major depression. A 15-month follow-up study
    Gilbert M D Lemmens
    University Psychiatric Centre K U Leuven, Campus Leuven, Leuven, Belgium
    Psychother Psychosom 78:98-105. 2009
    ..This study assesses the value of the additional use of single-family or multi-family group therapy within this patient population...
  71. doi request reprint Determinants of symptoms in functional dyspepsia: gastric sensorimotor function, psychosocial factors or somatisation?
    L Van Oudenhove
    Department of Pathophysiology, Gastroenterology Section, University of Leuven and University Hospital Gasthuisberg, Leuven, Belgium
    Gut 57:1666-73. 2008
    ..Gastric sensorimotor dysfunction, psychosocial factors and somatisation are all implicated in symptom generation in functional dyspepsia (FD)...
  72. ncbi request reprint Women's mental health before, during, and after pregnancy: a population-based controlled cohort study
    Johan C H van Bussel
    Institute of Family and Sexuality Sciences, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Birth 33:297-302. 2006
    ..This study compared women's mental health before, during, and after pregnancy with a control group of nonpregnant women...
  73. ncbi request reprint Gender differences in the psychological adjustment to type 1 diabetes mellitus: an explorative study
    Paul Enzlin
    Department of Psychiatry, University Hospitals Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
    Patient Educ Couns 48:139-45. 2002
    ..The psychological factors negatively related with the psychological adjustment to diabetes in men and women are depressive coping and depressive symptomatology...
  74. ncbi request reprint Rapid tranquilization: new approaches in the emergency treatment of behavioral disturbances
    Jurgen De Fruyt
    Department of Psychiatry, University Hospital Gasthuisberg, Merestraat 49, 3000 Leuven, Belgium
    Eur Psychiatry 19:243-9. 2004
    ..The perspective of the patient and the interaction between the emergency care setting and treatment regimen also need further attention. All these important, but often neglected issues are covered in a selective review of the literature...
  75. ncbi request reprint Central nervous system involvement in functional gastrointestinal disorders
    Lukas Van Oudenhove
    Department of Psychiatry, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Best Pract Res Clin Gastroenterol 18:663-80. 2004
    ..Third, we will address the issue of high comorbidity with psychiatric disorders. Some hypotheses about common pathophysiological substrates will be discussed...
  76. ncbi request reprint A cost-effectiveness model of escitalopram, citalopram,and venlafaxine as first-line treatment for major depressive disorder in Belgium
    Koen Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Ther 27:111-24. 2005
    ..Economic evaluations aim to combine costs and patient outcomes in one analysis...
  77. ncbi request reprint Has the prevalence of congenital abnormalities after intracytoplasmic sperm injection increased? The Leuven data 1994-2000 and a review of the literature
    An Hindryckx
    Leuven University Fertility Center, UZ Gasthuisberg, Herestraat 49, Leuven, Belgium
    Gynecol Obstet Invest 70:11-22. 2010
    ..We reviewed the literature with respect to the prevalence of major congenital malformations after the ICSI technique and supplemented these data with the results of a prospective follow-up study performed in our center...
  78. pmc Dyspeptic patients with visceral hypersensitivity: sensitisation of pain specific or multimodal pathways?
    J Vandenberghe
    Department of Psychiatry, Division of Liaison Psychiatry, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Gut 54:914-9. 2005
    ..The aim of the study was to analyse whether the symptom profile during gastric dissentions in functional dyspepsia patients with hyperalgesia reflects sensitisation of pain specific or multimodal pathways...
  79. ncbi request reprint The role of somatosensory cortical regions in the processing of painful gastric fundic distension: an update of brain imaging findings
    L Van Oudenhove
    Division of Gastroenterology, Department of Pathophysiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 20:479-87. 2008
    ..Methodological differences between the brain imaging studies on gastric distension may account for these somewhat discrepant findings...
  80. ncbi request reprint Cortical deactivations during gastric fundus distension in health: visceral pain-specific response or attenuation of 'default mode' brain function? A H2 15O-PET study
    L Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 21:259-71. 2009
    ..Whether this represents task-independent suspension of 'default mode' activity (as described in various cognitive tasks) or an visceral pain/interoception-specific process remains to be elucidated...
  81. doi request reprint Medication information for Flemish inpatients with major depression: evaluation and construct validity of the Consumer Information Rating Form
    F Desplenter
    Research Centre for Pharmaceutical Care and Pharmaco economics, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Pharm Ther 34:645-55. 2009
    ....
  82. ncbi request reprint The impact of major depressive disorder on the short- and long-term outcome of Crohn's disease treatment with infliximab
    P Persoons
    Department of Neurosciences and Psychiatry, Psychiatry Section, Katholieke Universiteit Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 22:101-10. 2005
    ..In other chronic diseases, evidence suggests that depression influences the course of the disease. Strong evidence of such a mediating role of major depressive disorder in Crohn's disease has never been found...
  83. ncbi request reprint Population level of unmet need for mental healthcare in Europe
    Jordi Alonso
    Health Services Research Unit, Institut Municipal d Investigacio Medica, Carrer del Doctor Aiguader, 88 E 08003 Barcelona, Spain
    Br J Psychiatry 190:299-306. 2007
    ..The high prevalence of mental disorders has fuelled controversy about the need for mental health services...
  84. ncbi request reprint The relation between multiple pains and mental disorders: results from the World Mental Health Surveys
    Oye Gureje
    Department of Psychiatry, University of Ibadan, Ibadan, Nigeria
    Pain 135:82-91. 2008
    ....
  85. ncbi request reprint Improving the chance of recovery from the short- and long-term consequences of depression
    Hans Jurgen Moller
    Ludwig Maximilians University, Department of Psychiatry, Munich, Germany
    Int Clin Psychopharmacol 18:219-25. 2003
    ..In conclusion, there remains considerable scope for improving the identification, treatment and management of patients with MDD...
  86. ncbi request reprint Prevalence and predictors of sexual dysfunction in patients with type 1 diabetes
    Paul Enzlin
    Katholieke Universiteit Leuven, Institute for Family and Sexuality Studies, Belgium
    Diabetes Care 26:409-14. 2003
    ....
  87. ncbi request reprint The other face of depression, reduced positive affect: the role of catecholamines in causation and cure
    David Nutt
    University of Bristol Psychopharmacology Unit, Bristol, UK
    J Psychopharmacol 21:461-71. 2007
    ..Focusing treatment on the predominant or driving symptomatology for an individual patient with major depression could potentially improve rates of response and remission...
  88. ncbi request reprint A European approach to rural-urban differences in mental health: the ESEMeD 2000 comparative study
    Viviane Kovess-Masfety
    MGEN Public Health Foundation, Paris 5 University affiliated, France
    Can J Psychiatry 50:926-36. 2005
    ..for, and are any of these differences observed in EU countries? Did the individuals suffering from mental health disorders have the same characteristics in rural and urban areas, particularly concerning self-reported impairment?..
  89. ncbi request reprint Efficacy and safety of duloxetine 60 mg once daily in the treatment of pain in patients with major depressive disorder and at least moderate pain of unknown etiology: a randomized controlled trial
    Stephan Brecht
    Boehringer Ingelheim GmbH, Ingelheim, Germany
    J Clin Psychiatry 68:1707-16. 2007
    ..This study evaluated the efficacy and safety of duloxetine in the treatment of patients with moderate pain associated with depression...
  90. doi request reprint Prescribing patterns of antidepressants in Europe: results from the Factors Influencing Depression Endpoints Research (FINDER) study
    Michael Bauer
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Eur Psychiatry 23:66-73. 2008
    ..In conclusion, the prescribing of antidepressants varies by country, and the type of antidepressant chosen is influenced by physician- as well as patient-related factors...
  91. ncbi request reprint Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys
    Koen Demyttenaere
    JAMA 291:2581-90. 2004
    ..Little is known about the extent or severity of untreated mental disorders, especially in less-developed countries...
  92. ncbi request reprint Depressive and bipolar disorders: patients' attitudes and beliefs towards depression and antidepressants
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet University Hospital of Copenhagen, Copenhagen, Denmark
    Psychol Med 35:1205-13. 2005
    ..However, these attitudes have received little study in patients whose disorders were sufficiently severe to require hospitalization...
  93. ncbi request reprint Factors influencing depression endpoints research (FINDER): study design and population characteristics
    Ana Garcia-Cebrian
    Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, UK
    Eur Psychiatry 23:57-65. 2008
    ..Further investigation into factors associated with HRQoL in depression after treatment initiation is warranted...
  94. pmc Disability and treatment of specific mental and physical disorders across the world
    Johan Ormel
    Department of Psychiatry, University Medical Center Groningen, and Graduate School of Behavioural and Cognitive Neurosciences and Graduate School for Experimental Psychopathology, University of Groningen, The Netherlands
    Br J Psychiatry 192:368-75. 2008
    ..Advocates of expanded mental health treatment assert that mental disorders are as disabling as physical disorders, but little evidence supports this assertion...
  95. ncbi request reprint [Epidemiology of late life depression]
    Anke Bonnewyn
    UZ Gasthuisberg, Leuven
    Tijdschr Gerontol Geriatr 37:122-3; discussion 123. 2006
  96. pmc Mental disorders among persons with heart disease - results from World Mental Health surveys
    Johan Ormel
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    Gen Hosp Psychiatry 29:325-34. 2007
    ..Consistency across emotional disorders and cultures would suggest that relatively universal mechanisms underlie the association...
  97. ncbi request reprint Is overgeneral autobiographical memory an isolated memory phenomenon in major depression?
    Filip Raes
    University of Leuven, Belgium
    Memory 14:584-94. 2006
    ..Furthermore, in line with Ramponi et al. (2004), rumination was found to be related to both overgeneral AM and poor source memory...
  98. ncbi request reprint Patient satisfaction after electroconvulsive therapy
    Pascal Sienaert
    ECT Department, University Center Sint Jozef, Katholieke Universiteit Leuven, Leuvensesteenweg Kortenberg, Belgium
    J ECT 21:227-31. 2005
    ....