M Decramer

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Rocuronium exacerbates mechanical ventilation-induced diaphragm dysfunction in rats
    Dries Testelmans
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 34:3018-23. 2006
  2. ncbi request reprint Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial
    Marc Decramer
    Respiratory Division, University Hospitals, Leuven, Belgium
    COPD 1:303-12. 2004
  3. ncbi request reprint Age at death from different diseases: the flemish experience during the period 2000-2004
    H Kesteloot
    Dept of Epidemiology, SMG, Kapucijnenvoer 35, 3000 Leuven, Belgium
    Acta Clin Belg 63:256-61. 2008
  4. ncbi request reprint COPD awareness survey: do Belgian pulmonary physicians comply with the GOLD guidelines 2010?
    M Decramer
    UZ Leuven, Respiratory Division, Leuven, Belgium
    Acta Clin Belg 68:325-40. 2013
  5. pmc Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease
    Bartolome R Celli
    Pulmonary Division, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 13:66. 2012
  6. pmc Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered
    Karen Maes
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Respir Res 11:178. 2010
  7. ncbi request reprint Early changes in rat diaphragm biology with mechanical ventilation
    Gabor Z Racz
    Respiratory Division, University Hospital, Leuven, Belgium
    Am J Respir Crit Care Med 168:297-304. 2003
  8. ncbi request reprint Treatment of chronic respiratory failure: lung volume reduction surgery versus rehabilitation
    M Decramer
    Respiratory Division, University Hospital, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur Respir J Suppl 47:47s-56s. 2003
  9. doi request reprint (Ex-)smoking asthma patients in general and specialized Belgian practice
    M Decramer
    Department of Pneumology, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium
    Respir Med 105:1203-10. 2011
  10. doi request reprint COPD as a lung disease with systemic consequences--clinical impact, mechanisms, and potential for early intervention
    Marc Decramer
    Respiratory Division and Department of Rehabilitation Science, University Hospital, Katholieke Universiteit, Leuven, Belgium
    COPD 5:235-56. 2008

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Rocuronium exacerbates mechanical ventilation-induced diaphragm dysfunction in rats
    Dries Testelmans
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 34:3018-23. 2006
    ....
  2. ncbi request reprint Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial
    Marc Decramer
    Respiratory Division, University Hospitals, Leuven, Belgium
    COPD 1:303-12. 2004
    ....
  3. ncbi request reprint Age at death from different diseases: the flemish experience during the period 2000-2004
    H Kesteloot
    Dept of Epidemiology, SMG, Kapucijnenvoer 35, 3000 Leuven, Belgium
    Acta Clin Belg 63:256-61. 2008
    ..The age at death from different diseases is a good indicator of their relative importance at the population level...
  4. ncbi request reprint COPD awareness survey: do Belgian pulmonary physicians comply with the GOLD guidelines 2010?
    M Decramer
    UZ Leuven, Respiratory Division, Leuven, Belgium
    Acta Clin Belg 68:325-40. 2013
    ..This survey demonstrated that management of COPD by PPs in Belgium is generally in line with the GOLD guidelines 2010 and that they perceive morning symptoms as being frequent and having an impact on patient's life...
  5. pmc Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease
    Bartolome R Celli
    Pulmonary Division, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 13:66. 2012
    ..The changes in inspiratory capacity (IC) over time in chronic obstructive pulmonary disease (COPD) patients are unknown. The Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT®) trial included IC measurements...
  6. pmc Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered
    Karen Maes
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Respir Res 11:178. 2010
    ..This may be important for patients undergoing mechanical ventilation and receiving corticosteroids...
  7. ncbi request reprint Early changes in rat diaphragm biology with mechanical ventilation
    Gabor Z Racz
    Respiratory Division, University Hospital, Leuven, Belgium
    Am J Respir Crit Care Med 168:297-304. 2003
    ..Whether immobilization-induced deconditioning and/or passive shortening play a role in these alterations could not be fully unraveled...
  8. ncbi request reprint Treatment of chronic respiratory failure: lung volume reduction surgery versus rehabilitation
    M Decramer
    Respiratory Division, University Hospital, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur Respir J Suppl 47:47s-56s. 2003
    ..The technique is undergoing considerable progress as numerous new surgical and endoscopic procedures are currently being developed. The results of these procedures have not yet been systematically evaluated...
  9. doi request reprint (Ex-)smoking asthma patients in general and specialized Belgian practice
    M Decramer
    Department of Pneumology, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium
    Respir Med 105:1203-10. 2011
    ..In the present study, data are presented on the prevalence, characteristics and management approach of this patient population in the Belgian practice both at the level of general practitioners (GPs) and specialists...
  10. doi request reprint COPD as a lung disease with systemic consequences--clinical impact, mechanisms, and potential for early intervention
    Marc Decramer
    Respiratory Division and Department of Rehabilitation Science, University Hospital, Katholieke Universiteit, Leuven, Belgium
    COPD 5:235-56. 2008
    ....
  11. pmc Assessment of progression of COPD: report of a workshop held in Leuven, 11-12 March 2004
    M Decramer
    Respiratory Division, University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Thorax 60:335-42. 2005
    ..Finding the appropriate mix of outcome measures to capture all aspects of disease progression is a significant challenge...
  12. pmc Effect of treatments on the progression of COPD: report of a workshop held in Leuven, 11-12 March 2004
    M Decramer
    Respiratory Division, University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Thorax 60:343-9. 2005
    ..Several treatments affect the exacerbation rate and therefore might affect the progression of the disease. Further studies are warranted to examine this effect...
  13. ncbi request reprint Systemic effects of COPD
    Marc Decramer
    Respiratory Division, Katholieke Universiteit, University Hospital, Leuven, Belgium
    Respir Med 99:S3-10. 2005
    ..An increase in our understanding in this field will doubtless highlight potential therapeutic targets, and assist in guiding future therapeutic development...
  14. ncbi request reprint Asthma and COPD: differences and similarities. With special reference to the usefulness of budesonide/formoterol in a single inhaler (Symbicort) in both diseases
    M Decramer
    Respiratory Division, U Z Gasthuisberg, Katholieke University, Leuven, Belgium
    Int J Clin Pract 59:385-98. 2005
    ....
  15. ncbi request reprint Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial
    Marc Decramer
    Respiratory Division, University Hospital, Katholieke Universiteit Leuven, Belgium
    Lancet 365:1552-60. 2005
    ..We postulated that treatment with the antioxidant N-acetylcysteine would reduce the rate of lung-function decline, reduce yearly exacerbation rate, and improve outcomes...
  16. doi request reprint Tiotropium as a first maintenance drug in COPD: secondary analysis of the UPLIFT trial
    T Troosters
    Respiratory Division and Pulmonary Rehabilitation, UZ Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium
    Eur Respir J 36:65-73. 2010
    ..6 units (p<0.001) with tiotropium compared to placebo. In patients with COPD who are not on maintenance therapy, tiotropium is associated with significant benefits in disease progression...
  17. pmc Skeletal muscle weakness in patients with sarcoidosis and its relationship with exercise intolerance and reduced health status
    M A Spruit
    Respiratory Rehabilitation, University Hospital Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Thorax 60:32-8. 2005
    ..Moreover, its relationship with previously observed exercise intolerance and reduced health status has never been studied in these patients...
  18. doi request reprint Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial
    Marc Decramer
    Respiratory Division, University of Leuven, Leuven, Belgium
    Lancet 374:1171-8. 2009
    ..However, there are few data for treatment in the early stages of the disease. We examined the effect of tiotropium on outcomes in a large subgroup of patients with moderate COPD...
  19. doi request reprint Skeletal muscle weakness, exercise tolerance and physical activity in adults with cystic fibrosis
    T Troosters
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Respir J 33:99-106. 2009
    ..Physical inactivity is a factor significantly contributing to exercise tolerance and skeletal muscle force in adults with cystic fibrosis, but these impairments are in excess to that expected from physical inactivity only...
  20. ncbi request reprint Markers of inflammation and disuse in vastus lateralis of chronic obstructive pulmonary disease patients
    T Crul
    Respiratory Muscle Research Unit, Laboratory of Pneumology, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Clin Invest 37:897-904. 2007
    ....
  21. ncbi request reprint The Bronchitis Randomized On NAC Cost-Utility Study (BRONCUS): hypothesis and design. BRONCUS-trial Committee
    M Decramer
    Respiratory Division, University Hospital, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 17:329-36. 2001
    ..The final results of the trial will be available in about 2 yrs. The study will provide objective data on the effects of N-acetylcysteine on outcome variables in chronic obstructive pulmonary disease...
  22. doi request reprint Determinants of physical activity in daily life in candidates for lung transplantation
    D Langer
    Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Belgium
    Respir Med 106:747-54. 2012
    ..The main research questions were: 1) How active are LTx-candidates in daily life? 2) What are determinants of activity behavior before LTX?..
  23. pmc Muscle force during an acute exacerbation in hospitalised patients with COPD and its relationship with CXCL8 and IGF-I
    M A Spruit
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Thorax 58:752-6. 2003
    ..The effect of an acute exacerbation on quadriceps peak torque (QPT) was therefore studied in hospitalised patients, and the aforementioned correlations were examined in hospitalised and in stable patients...
  24. doi request reprint Quality and reproducibility of spirometry in COPD patients in a randomized trial (UPLIFT®)
    W Janssens
    University Hospital Leuven, Leuven, Belgium
    Respir Med 107:1409-16. 2013
    ..This study explores spirometry quality and reproducibility in the Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT(®)) trial...
  25. doi request reprint Rehabilitation and acute exacerbations
    C Burtin
    University Hospitals KU Leuven, Respiratory Rehabilitation and Respiratory Division, Leuven, Belgium
    Eur Respir J 38:702-12. 2011
    ..Self-management strategies play a crucial role in changing disease-related health behaviour and preventing hospital admissions...
  26. ncbi request reprint Sinonasal pathology in nonallergic asthma and COPD: 'united airway disease' beyond the scope of allergy
    G Hens
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Catholic University Leuven, Leuven, Belgium
    Allergy 63:261-7. 2008
    ..Here, sinonasal pathology is studied in patients with allergic asthma, nonallergic asthma and COPD...
  27. ncbi request reprint Incentive spirometry does not enhance recovery after thoracic surgery
    R Gosselink
    Respiratory Rehabilitation and Respiratory Division, University Hospitals, Katholieke Universiteit Leuven, and the Faculty of Physical Education and Physiotherapy, Belgium
    Crit Care Med 28:679-83. 2000
    ..To investigate the additional effect of incentive spirometry to chest physiotherapy to prevent postoperative pulmonary complications after thoracic surgery for lung and esophageal resections...
  28. pmc Effects of acute administration of corticosteroids during mechanical ventilation on rat diaphragm
    Karen Maes
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Respir Crit Care Med 178:1219-26. 2008
    ..Mechanical ventilation is known to induce ventilator-induced diaphragm dysfunction. Patients submitted to mechanical ventilation often receive massive doses of corticosteroids that may cause further deterioration of diaphragm function...
  29. doi request reprint The TERT-CLPTM1L locus for lung cancer predisposes to bronchial obstruction and emphysema
    E Wauters
    Vesalius Research Center, VIB, KU Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Eur Respir J 38:924-31. 2011
    ..11, 95% CI 1.04-4.26; p=0.038). The rs31489 variant on 5p15.33 is associated with bronchial obstruction, presence and severity of emphysema, and lung cancer...
  30. ncbi request reprint Alterations in gene expression in hamster diaphragm after emphysema and lung volume reduction surgery
    V Reynders
    Respiratory Muscle Research Unit, University Hospitals, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 19:1064-71. 2002
    ....
  31. doi request reprint A clinical practice guideline for physiotherapists treating patients with chronic obstructive pulmonary disease based on a systematic review of available evidence
    D Langer
    Departments of Pneumology and Respiratory Rehabilitation, University Hospital Leuven and Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Rehabil 23:445-62. 2009
    ..Update of a clinical practice guideline for the physiotherapy management of patients with chronic obstructive pulmonary disease supporting the clinical decision-making process...
  32. doi request reprint [COPD and bone metabolism: a clinical update]
    A Lehouck
    Service de Pneumologie, Hôpital Universitaire Gasthuisberg, Katholieke Universiteit, 3000 Leuven, Belgique
    Rev Mal Respir 27:1231-42. 2010
    ..Hence, a rigorous application of the current treatment guidelines with respect to osteoporosis in general would already be a major step forward in the treatment of COPD...
  33. ncbi request reprint Inspiratory flow rates at different levels of resistance in elderly COPD patients
    W Janssens
    Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur Respir J 31:78-83. 2008
    ....
  34. doi request reprint Measurement validity of an electronic inspiratory loading device during a loaded breathing task in patients with COPD
    D Langer
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Leuven, Belgium
    Respir Med 107:633-5. 2013
    ..This enables health care providers to quantify the load on inspiratory muscles during these tests in daily clinical practice...
  35. ncbi request reprint Quantifying physical activity in daily life with questionnaires and motion sensors in COPD
    F Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospitals, Leuven, Belgium
    Eur Respir J 27:1040-55. 2006
    ..The selection of which motion sensor to use for quantification of physical activity in daily life should depend mainly on the purpose of its use...
  36. ncbi request reprint [Physiological effects of lung reduction surgery: the contribution of an animal model of emphysema]
    E Marchand
    Unité de Recherche sur la Musculature Respiratoire, Laboratoire de Pneumologie, Hôpital Universitaire de Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgique
    Rev Mal Respir 20:539-48. 2003
    ..Despite some encouraging early results, it is often still regarded as an experimental technique due to the significant associated mortality and unpredictable results...
  37. doi request reprint Exercise training and pulmonary rehabilitation: new insights and remaining challenges
    T Troosters
    Dept of Rehabilitation Sciences and Respiratory Rehabilitation and Respiratory Division, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Eur Respir Rev 19:24-9. 2010
    ..Further research is needed in order to apply the now well-established principles of pulmonary rehabilitation to unusual patient populations, or patient populations that are unlikely to participate in conventional outpatient programmes...
  38. ncbi request reprint Management of COPD according to guidelines. A national survey among Belgian physicians
    M Decramer
    Respiratory Division, University Hospital, Herestraat 49, B 3000 Leuven, Belgium
    Monaldi Arch Chest Dis 59:62-80. 2003
    ..Some interesting differences between Dutch and French speaking physicians were noted. These specific deviations from the guidelines will be addressed in a second phase implementation project...
  39. ncbi request reprint Resistance versus endurance training in patients with COPD and peripheral muscle weakness
    M A Spruit
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Leuven, Belgium
    Eur Respir J 19:1072-8. 2002
    ..Resistance training and endurance training have similar effects on peripheral muscle force, exercise capacity and health-related quality of life in chronic obstructive pulmonary disease patients with peripheral muscle weakness...
  40. doi request reprint Exercise training after lung transplantation improves participation in daily activity: a randomized controlled trial
    D Langer
    Faculty of Kinesiology and Rehabilitation Sciences, KULeuven, Tervuursevest, Heverlee, Belgium
    Am J Transplant 12:1584-92. 2012
    ..01). Based on these results patients should be strongly encouraged to participate in an exercise training intervention after lung transplantation...
  41. ncbi request reprint What is the optimal treatment strategy for chronic obstructive pulmonary disease exacerbations?
    W Willaert
    Respiratory Division, University Hosital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 19:928-35. 2002
    ....
  42. doi request reprint Atrophy and hypertrophy signalling in the diaphragm of patients with COPD
    D Testelmans
    Katholieke Universiteit Leuven, Belgium
    Eur Respir J 35:549-56. 2010
    ..These alterations may contribute to diaphragm remodeling in COPD...
  43. ncbi request reprint Cardiopulmonary stress during exercise training in patients with COPD
    V S Probst
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Respir J 27:1110-8. 2006
    ..In addition, exercise testing based on guidelines using a fixed percentage of baseline peak performance and symptom scores achieves and sustains training intensities recommended according to the American College of Sports Medicine...
  44. ncbi request reprint Leupeptin inhibits ventilator-induced diaphragm dysfunction in rats
    Karen Maes
    Respiratory Muscle Research Unit, Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Respir Crit Care Med 175:1134-8. 2007
    ..Controlled mechanical ventilation (CMV) has been shown to result in elevated diaphragmatic proteolysis and atrophy together with diaphragmatic contractile dysfunction...
  45. ncbi request reprint Diaphragm plication for unilateral diaphragm paralysis: a case report and review of the literature
    S Declerck
    Respiratory Division, University of Leuven, Leuven, Belgium
    Acta Clin Belg 68:311-5. 2013
    ..Consequently, it seems appropriate to propose plication to patients with clear symptoms from the moment spontaneous recovery seems unlikely; yet, prospective randomised controlled studies are needed to prove this...
  46. ncbi request reprint Effects of lung volume reduction surgery in hamsters with elastase-induced emphysema
    E Marchand
    Laboratory of Pneumology, University Hospitals, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 19:422-8. 2002
    ..These findings appear to be largely explained by the high compliance of the hamster chest wall. This allows for better matching between the emphysematous lung and the chest-wall sizes than in humans...
  47. ncbi request reprint Respiratory muscle function and drive in chronic obstructive pulmonary disease
    E Marchand
    Respiratory Muscle Research Unit, Laboratory of Pneumology, Universitair Ziekenhuis Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Chest Med 21:679-92. 2000
    ..Because much of the lung and airway derangements are irreversible in COPD, the respiratory muscles appear to be an attractive target for therapeutic interventions...
  48. ncbi request reprint [The interest of animal models for the understanding of respiratory muscle dysfunction]
    G Gayan-Ramirez
    Chargé de Recherche du Fonds voor Wetenschappelijk Onderzoek Vlaanderen FWO Vlaanderen, Leuven, Belgique
    Rev Mal Respir 22:2S100-9. 2005
  49. ncbi request reprint Distribution of muscle weakness in patients with stable chronic obstructive pulmonary disease
    R Gosselink
    Division of Respiratory Rehabilitation, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven Belgium
    J Cardiopulm Rehabil 20:353-60. 2000
    ..In addition, this information may add to the knowledge on the mechanisms of muscle weakness...
  50. ncbi request reprint Interleukin-6 causes myocardial failure and skeletal muscle atrophy in rats
    Sofie P M Janssen
    Laboratory of Pneumology, Respiratory Muscle Research Unit, Katholieke Universiteit Leuven, Leuven, Belgium
    Circulation 111:996-1005. 2005
    ..The impact of interleukin (IL)-6 on skeletal muscle function remains the subject of controversy...
  51. ncbi request reprint High-dose lidocaine reduces airway mucus transport velocity in intubated anesthetized dogs
    Rik Gosselink
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Respir Med 100:258-63. 2006
    ..However, the effects of lidocaine administration on mucus transport in airways are inconclusive. Therefore, detailed information is needed to establish the effects of high- and low-dose lidocaine administration...
  52. ncbi request reprint Characteristics of physical activities in daily life in chronic obstructive pulmonary disease
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 171:972-7. 2005
    ..28 < r < 0.64, p < 0.05). Patients with chronic obstructive pulmonary disease are markedly inactive in daily life. Functional exercise capacity is the strongest correlate of physical activities in daily life...
  53. ncbi request reprint Pulmonary rehabilitation in chronic obstructive pulmonary disease
    Thierry Troosters
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 172:19-38. 2005
  54. ncbi request reprint Chronic obstructive pulmonary disease and chronic heart failure: two muscle diseases?
    Thierry Troosters
    Respiratory Division and Respiratory Rehabilitation, Respiratory Muscle Research Unit, Katholieke Universiteit Leuven, Herestraat 49, B3000 Leuven, Belgium
    J Cardiopulm Rehabil 24:137-45. 2004
    ....
  55. ncbi request reprint Mechanisms of improvement in exercise capacity using a rollator in patients with COPD
    Vanessa S Probst
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Chest 126:1102-7. 2004
    ....
  56. doi request reprint Modification of COPD presentation during the last 25 years
    Antoine Fremault
    University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    COPD 7:345-51. 2010
    ..As the length of hospitalization and the overall survival were not different between the two samples, a currently improved management of COPD can be hypothesized...
  57. ncbi request reprint Psychosocial conditions do not affect short-term outcome of multidisciplinary rehabilitation in chronic obstructive pulmonary disease
    Jacob C Trappenburg
    Respiratory Rehabilitation and Respiratory Division, University Hospitals, Katholieke Universiteit, Leuven, Belgium
    Arch Phys Med Rehabil 86:1788-92. 2005
    ..To characterize patients referred for pulmonary rehabilitation on a large number of psychologic and sociodemographic variables and to determine the contribution of these variables on the response to rehabilitation...
  58. doi request reprint Probe-based confocal laser endomicroscopy of the respiratory tract: a data consistency analysis
    J Yserbyt
    Respiratory Division, University Hospitals Leuven, Belgium
    Respir Med 107:1234-40. 2013
    ..It enables a real-time and bedside qualitative characterization at the level of small airways but due to a relatively small field of view the reliability of quantification remains uncertain...
  59. doi request reprint Effect of creatine supplementation as a potential adjuvant therapy to exercise training in cardiac patients: a randomized controlled trial
    V A Cornelissen
    Cardiovascular Rehabilitation Unit, Department of Rehabilitation Sciences, K U Leuven, Leuven, Belgium
    Clin Rehabil 24:988-99. 2010
    ..To investigate the effect of oral creatine supplementation in conjunction with an exercise programme on physical fitness in patients with coronary artery disease or chronic heart failure...
  60. ncbi request reprint Effects of mechanical ventilation on diaphragm function and biology
    G Gayan-Ramirez
    Respiratory Muscle Research Unit and Respiratory Division, Laboratory of Pneumology, University Hospitals, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur Respir J 20:1579-86. 2002
    ..These may include: adaptation of medication, training of the diaphragm, stabilisation of the catabolic state and pharmacotherapy...
  61. doi request reprint Mucoactive therapy in COPD
    M Decramer
    Respiratory Division, University of Leuven, Herestraat 49, Leuven, Belgium
    Eur Respir Rev 19:134-40. 2010
    ..It is unclear what the mechanisms underlying these effects may be and which phenotypes benefit from this treatment. On the basis of this evidence mucoactive drugs may deserve consideration in the long-term treatment of COPD...
  62. ncbi request reprint Respiratory muscles in COPD: regulation of trophical status
    M Decramer
    KULeuven-Faculty of Medicine, Respiratory Division, Respiratory Muscle Research Unit, Laboratory for Pneumology, Herestraat 49, B 3000 Leuven
    Verh K Acad Geneeskd Belg 63:577-602; discussion 602-4. 2001
    ..It does not appear to improve intrinsic inspiratory muscle function...
  63. ncbi request reprint Clinical and economic analysis of antimicrobial therapy of chronic obstructive pulmonary disease exacerbations
    S Simoens
    Research Centre for Pharmaceutical Care and Pharmaco economics, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Clin Pract 61:200-6. 2007
    ..Fluoroquinolones were used to treat more severe exacerbations. Treatment of acute exacerbations of COPD imposes a significant clinical and economic burden on patients, the healthcare system and the society...
  64. doi request reprint Resistance training prevents deterioration in quadriceps muscle function during acute exacerbations of chronic obstructive pulmonary disease
    Thierry Troosters
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, Leuven, Belgium
    Am J Respir Crit Care Med 181:1072-7. 2010
    ..Exacerbations of chronic obstructive pulmonary disease (COPD) acutely reduce skeletal muscle strength and result in long-term loss of functional capacity...
  65. ncbi request reprint Hypogonadism, quadriceps weakness, and exercise intolerance in chronic obstructive pulmonary disease
    Monique Van Vliet
    Respiratory Rehabilitation, University Hospital Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Am J Respir Crit Care Med 172:1105-11. 2005
    ..Moreover, the relationship of hypogonadism with quadriceps muscle weakness and exercise intolerance has been studied scarcely in men with COPD...
  66. doi request reprint Are patients with COPD more active after pulmonary rehabilitation?
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Chest 134:273-80. 2008
    ..Despite a variety of benefits brought by pulmonary rehabilitation to patients with COPD, it is unclear whether these patients are more active during daily life after the program...
  67. pmc Physical inactivity in patients with COPD, a controlled multi-center pilot-study
    Thierry Troosters
    Pulmonary Rehabilitation and Respiratory Division, UZ Gasthuisberg, Leuven, Belgium
    Respir Med 104:1005-11. 2010
    ..Studies in moderate COPD are currently scarce. The aim of the present study was to investigate physical activity in daily life in patients with COPD (n=70) and controls (n=30)...
  68. ncbi request reprint Exercise training during rehabilitation of patients with COPD: a current perspective
    Martijn A Spruit
    Respiratory Rehabilitation and Respiratory Division, University Hospitals, and Department of Rehabilitation Sciences, Faculty of Physical Education and Physiotherapy, Katholieke Universiteit Leuven, Leuven, Belgium
    Patient Educ Couns 52:243-8. 2004
    ....
  69. ncbi request reprint Clinical safety of long-acting beta2-agonist and inhaled corticosteroid combination therapy in COPD
    Marc Decramer
    Respiratory Division University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
    COPD 3:163-71. 2006
    ..Clinical data indicate that LABA/ICS combination therapy is more effective in COPD than either agent used alone and is not associated with any additional AEs...
  70. doi request reprint Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010
    ..Vitamin D deficiency has been associated with many chronic illnesses, but little is known about its relationship with chronic obstructive pulmonary disease (COPD)...
  71. doi request reprint Accuracy of office spirometry performed by trained primary-care physicians using the MIR Spirobank hand-held spirometer
    J Degryse
    Department of Primary Health Care, KU Leuven, Leuven, Belgium
    Respiration 83:543-52. 2012
    ..However, the perception persists that small flow-sensing devices are less accurate than volume-sensing spirometers...
  72. ncbi request reprint Reversibility of paraneoplastic bilateral diaphragmatic paralysis after nephrectomy for renal cell carcinoma
    B Rijnders
    Respiratory Division, University Hospitals, Katholieke Universiteit Leuven, Belgium
    Ann Oncol 11:221-5. 2000
    ..We believe this is the first report of a paraneoplastic bilateral diaphragmatic paralysis with actual recovery after tumour therapy...
  73. doi request reprint Distorted symptom perception in patients with medically unexplained symptoms
    Katleen Bogaerts
    Department of Psychology, University of Leuven, Leuven, Belgium
    J Abnorm Psychol 119:226-34. 2010
    ..This suggests a stronger role for top-down psychological processes in the symptom perception of patients with MUS...
  74. doi request reprint [Pulmonary rehabilitation in patients with chronic obstructive pulmonary disease]
    Ghislaine Gayan-Ramirez
    Departement de Pneumologie, Unité de Recherche des Muscles Respiratoires, Katholieke Universiteit Leuven, Leuven, Belgium
    Presse Med 38:452-61. 2009
    ..The beneficial effects of pulmonary rehabilitation on exercise tolerance, muscle strength, symptoms, quality of life are now well recognized...
  75. ncbi request reprint Office spirometry significantly improves early detection of COPD in general practice: the DIDASCO Study
    Johan Buffels
    Department of General Practice, Katholieke Universiteit, Leuven, Belgium
    Chest 125:1394-9. 2004
    ..To determine if spirometry is essential for the early detection of COPD in general practice, compared to the screening value of a short questionnaire...
  76. ncbi request reprint Physical activity and hospitalization for exacerbation of COPD
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Chest 129:536-44. 2006
    ....
  77. doi request reprint The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema
    Diether Lambrechts
    Vesalius Research Center, K U Leuven, Leuven, Belgium
    Am J Respir Crit Care Med 181:486-93. 2010
    ..Assessment of bronchial obstruction by spirometry, typically used for diagnosing COPD, fails, however, to detect emphysema...
  78. doi request reprint Treatment of COPD: the sooner the better?
    Marc Decramer
    Respiratory Division, University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:837-41. 2010
    ..New trials, particularly demonstrating the detrimental effects of delaying treatment until later in the course of the disease, are required to render the evidence for early intensive intervention irrefutable...
  79. ncbi request reprint Pulmonary rehabilitation 2007: from bench to practice and back
    Marc Decramer
    Respiratory Division, University Hospital Katholieke Universiteit, Leuven, Belgium
    Clin Invest Med 31:E312-8. 2008
    ..A better understanding of the factors controlling the response to rehabilitation, may lead to significant advances in this field...
  80. ncbi request reprint Detrimental effects of short-term mechanical ventilation on diaphragm function and IGF-I mRNA in rats
    Ghislaine Gayan-Ramirez
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Rehabilitation and Respiratory Division, University Hospitals, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Intensive Care Med 29:825-33. 2003
    ....
  81. ncbi request reprint Infusions of rocuronium and cisatracurium exert different effects on rat diaphragm function
    Dries Testelmans
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, O and N 1, bus 706, Herestraat 49, 3000, Leuven, Belgium
    Intensive Care Med 33:872-9. 2007
    ..The aim of our study was to compare the effects of 24 h infusion of rocuronium or cisatracurium on the diaphragm in mechanically ventilated rats...
  82. doi request reprint Alveolar and bronchial exhaled nitric oxide in chronic obstructive pulmonary disease
    An Lehouck
    Respiratory Division, University Hospital Gasthuisberg Katholieke Universiteit Leuven, Herestraat 49, bus 706, 3000 Leuven, Belgium
    Respir Med 104:1020-6. 2010
    ..We examined whether the use of Fe,NO, CAlv,NO and J'aw,NO may contribute to the clinical diagnosis of COPD...
  83. doi request reprint Impact of care pathways for in-hospital management of COPD exacerbation: a systematic review
    C Lodewijckx
    Respiratory Division, University Hospitals Leuven, Belgium
    Int J Nurs Stud 48:1445-56. 2011
    ..In-hospital management of COPD exacerbation is suboptimal, and outcomes are poor. Care pathways are a possible strategy for optimizing care processes and outcomes...
  84. ncbi request reprint Platypnea-orthodeoxia syndrome: a report of two cases
    C Timmermans
    Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium
    Acta Cardiol 48:583-90. 1993
    ..The other case illustrates that, despite actual technical possibilities, clinical suspicion remains a prerequisite for proper diagnosis of the entity...
  85. pmc Acute inflammatory and anabolic systemic responses to peak and constant-work-rate exercise bout in hospitalized patients with COPD
    Martijn A Spruit
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Leuven, Belgium
    Int J Chron Obstruct Pulmon Dis 2:575-83. 2007
    ..To explore the acute systemic inflammatory and anabolic effects of cycling in hospital admitted patients with chronic obstructive pulmonary disease (COPD) and in patients with clinically stable disease...
  86. doi request reprint Functional recovery of diaphragm paralysis: a long-term follow-up study
    Ghislaine Gayan-Ramirez
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, Onderwijs en Navorsing 1 bus 706, Herestraat 49, B 3000 Leuven, Belgium
    Respir Med 102:690-8. 2008
    ..Long-term functional outcome of diaphragm paralysis is largely unknown...
  87. doi request reprint Targeting the COPD exacerbation
    Marc Decramer
    Respiratory Division, University Hospitals Leuven, and Katholieke Universiteit Leuven, Leuven, Belgium
    Respir Med 102:S3-15. 2008
    ..Not surprisingly, pulmonary rehabilitation after such events has been shown to prevent relapse, improve survival and enhance patients' overall function after acute exacerbations...
  88. ncbi request reprint Activity monitoring for assessment of physical activities in daily life in patients with chronic obstructive pulmonary disease
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospitals, Katholieke Universiteit Leuven, Leuven, Belgium
    Arch Phys Med Rehabil 86:1979-85. 2005
    ....
  89. ncbi request reprint Pharmacoeconomics of the management of acute exacerbations of chronic obstructive pulmonary disease
    Steven Simoens
    Research Centre for Pharmaceutical Care and Pharmaco economics, Faculty of Pharmaceutical Sciences, K U Leuven, Onderwijs en Navorsing 2, Leuven, Belgium
    Expert Opin Pharmacother 8:633-48. 2007
    ..It presents estimates of the level and distribution of costs associated with exacerbations and reports on the cost-effectiveness or cost-utility of antimicrobial therapy and other approaches to the management of exacerbations...
  90. doi request reprint Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases
    Jeroen A J Vanoirbeek
    Lung Toxicology Research Unit, Katholieke Universiteit Leuven, Herestraat 49 bus 706, Leuven, Belgium
    Am J Respir Cell Mol Biol 42:96-104. 2010
    ..Invasive pulmonary functions allow distinction between respiratory diseases in mice by clinically relevant variables, and should become standard in the functional evaluation of pathological disease models...
  91. ncbi request reprint Economic aspects of antimicrobial therapy of acute exacerbations of COPD
    Steven Simoens
    Research Centre for Pharmaceutical Care and Pharmaco economics, Faculty of Pharmaceutical Sciences, KU Leuven, Onderwijs en Navorsing 2, Herestraat 49, 3000 Leuven, Belgium
    Respir Med 101:15-26. 2007
    ..The small number of economic evaluations and their methodological limitations precludes the recommendation of a specific antibiotic for use in the management of COPD exacerbations on economic grounds...
  92. doi request reprint Inspired fraction of carbon dioxide in oxygen supply to chronic pulmonary disease
    Antoine Fremault
    Department of Pneumology, University Hospital, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Respir Med 102:1827-9. 2008
    ..We found no significant increase in inspiratory CO(2) concentration. These findings suggest that inspired fraction of CO(2) does not increase markedly during controlled oxygen therapy...
  93. doi request reprint Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act
    Wim Janssens
    Division of Respiratory Medicine, University Hospital Gasthuisberg KUL Herestraat 49, 3000 Leuven, Belgium
    Am J Respir Crit Care Med 179:630-6. 2009
    ..A further challenge of such studies is to define optimal serum 25-OHD levels for such noncalcemic endpoints...
  94. doi request reprint Response of the respiratory muscles to rehabilitation in COPD
    Marc Decramer
    Respiratory Division, University Hospital, University of Leuven, 3000 Leuven, Belgium
    J Appl Physiol (1985) 107:971-6. 2009
    ..Eight randomized studies examined the effects of the combination. Greater improvements in exercise capacity were only found in three studies, and none showed a greater reduction in dyspnea...
  95. doi request reprint Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease
    Wim Janssens
    Department of Human Genetics, Katholieke Universiteit Leuven, Gasthuisberg O and N1 602, Herestraat 49, B 3000, Leuven, Belgium
    Am J Respir Crit Care Med 182:163-9. 2010
    ..Objectives: We investigated whether genomic copy number variations of the beta-defensin gene cluster have a functional role in airway epithelial cells and associate with the presence of COPD...
  96. doi request reprint Inhospital management of COPD exacerbations: a systematic review of the literature with regard to adherence to international guidelines
    Cathy Lodewijckx
    University Hospitals Leuven, Leuven, Belgium
    J Eval Clin Pract 15:1101-10. 2009
    ..Further investigation is recommended to explore strategies like care pathways that improve performance of recommended interventions...
  97. doi request reprint Gene expression profiling in vastus lateralis muscle during an acute exacerbation of COPD
    Tim Crul
    Respiratory Muscle Research Unit, Laboratory of Pneumology, Leuven, Belgium
    Cell Physiol Biochem 25:491-500. 2010
    ..A cross-sectional study was designed to compare the gene expression profile of the vastus lateralis muscle in patients with an acute COPD exacerbation and in stable COPD patients...
  98. doi request reprint Physical activity in daily life 1 year after lung transplantation
    Daniel Langer
    Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Tervuursevest 101, Leuven, Belgium
    J Heart Lung Transplant 28:572-8. 2009
    ..However, daily physical activity has not been objectively assessed so far in lung recipients. The purpose of this study was to objectively measure daily physical activity in lung recipients...
  99. doi request reprint Early exercise in critically ill patients enhances short-term functional recovery
    Chris Burtin
    Faculty of Kinesiology and Rehabilitation Sciences CB, BC, CR, DL, TT, RG, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 37:2499-505. 2009
    ..No evidence is available concerning the effectiveness of an early exercise training intervention to prevent these detrimental complications...
  100. ncbi request reprint Spirometry and smoking cessation advice in general practice: a randomised clinical trial
    Johan Buffels
    Department of General Practice, Academisch Centrum voor Huisartsgeneeskunde, Katholieke Universiteit Leuven, Kapucijnenvoer 33 Blok J, B 3000 Leuven, Belgium
    Respir Med 100:2012-7. 2006
    ..To assess the success rate of smoking cessation with the "minimal intervention strategy" in general practice, and to determine the influence of spirometry on this success rate...
  101. ncbi request reprint Ventilator-induced diaphragmatic dysfunction: toward a better treatment?
    Marc Decramer
    Am J Respir Crit Care Med 170:1141-2. 2004