M Decramer

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi Rocuronium exacerbates mechanical ventilation-induced diaphragm dysfunction in rats
    Dries Testelmans
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 34:3018-23. 2006
  2. ncbi Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered
    Karen Maes
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Respir Res 11:178. 2010
  3. ncbi Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial
    Marc Decramer
    Respiratory Division, University Hospitals, Leuven, Belgium
    COPD 1:303-12. 2004
  4. ncbi Treatment of chronic respiratory failure: lung volume reduction surgery versus rehabilitation
    M Decramer
    Respiratory Division, University Hospital, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur Respir J Suppl 47:47s-56s. 2003
  5. ncbi (Ex-)smoking asthma patients in general and specialized Belgian practice
    M Decramer
    Department of Pneumology, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium
    Respir Med 105:1203-10. 2011
  6. ncbi Early changes in rat diaphragm biology with mechanical ventilation
    Gabor Z Racz
    Respiratory Division, University Hospital, Leuven, Belgium
    Am J Respir Crit Care Med 168:297-304. 2003
  7. ncbi Systemic effects of COPD
    Marc Decramer
    Respiratory Division, Katholieke Universiteit, University Hospital, Leuven, Belgium
    Respir Med 99:S3-10. 2005
  8. ncbi COPD as a lung disease with systemic consequences--clinical impact, mechanisms, and potential for early intervention
    Marc Decramer
    Respiratory Division and Department of Rehabilitation Science, University Hospital, Katholieke Universiteit, Leuven, Belgium
    COPD 5:235-56. 2008
  9. ncbi Assessment of progression of COPD: report of a workshop held in Leuven, 11-12 March 2004
    M Decramer
    Respiratory Division, University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Thorax 60:335-42. 2005
  10. ncbi Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial
    Marc Decramer
    Respiratory Division, University Hospital, Katholieke Universiteit Leuven, Belgium
    Lancet 365:1552-60. 2005

Detail Information

Publications106 found, 100 shown here

  1. ncbi Rocuronium exacerbates mechanical ventilation-induced diaphragm dysfunction in rats
    Dries Testelmans
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 34:3018-23. 2006
    ..These findings could be important with regard to weaning failure in patients receiving this drug for prolonged periods in the intensive care unit setting...
  2. ncbi Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered
    Karen Maes
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Respir Res 11:178. 2010
    ..This may be important for patients undergoing mechanical ventilation and receiving corticosteroids...
  3. ncbi Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial
    Marc Decramer
    Respiratory Division, University Hospitals, Leuven, Belgium
    COPD 1:303-12. 2004
    ....
  4. ncbi Treatment of chronic respiratory failure: lung volume reduction surgery versus rehabilitation
    M Decramer
    Respiratory Division, University Hospital, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur Respir J Suppl 47:47s-56s. 2003
    ..The technique is undergoing considerable progress as numerous new surgical and endoscopic procedures are currently being developed. The results of these procedures have not yet been systematically evaluated...
  5. ncbi (Ex-)smoking asthma patients in general and specialized Belgian practice
    M Decramer
    Department of Pneumology, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium
    Respir Med 105:1203-10. 2011
    ..In the present study, data are presented on the prevalence, characteristics and management approach of this patient population in the Belgian practice both at the level of general practitioners (GPs) and specialists...
  6. ncbi Early changes in rat diaphragm biology with mechanical ventilation
    Gabor Z Racz
    Respiratory Division, University Hospital, Leuven, Belgium
    Am J Respir Crit Care Med 168:297-304. 2003
    ..Whether immobilization-induced deconditioning and/or passive shortening play a role in these alterations could not be fully unraveled...
  7. ncbi Systemic effects of COPD
    Marc Decramer
    Respiratory Division, Katholieke Universiteit, University Hospital, Leuven, Belgium
    Respir Med 99:S3-10. 2005
    ..An increase in our understanding in this field will doubtless highlight potential therapeutic targets, and assist in guiding future therapeutic development...
  8. ncbi COPD as a lung disease with systemic consequences--clinical impact, mechanisms, and potential for early intervention
    Marc Decramer
    Respiratory Division and Department of Rehabilitation Science, University Hospital, Katholieke Universiteit, Leuven, Belgium
    COPD 5:235-56. 2008
    ....
  9. ncbi Assessment of progression of COPD: report of a workshop held in Leuven, 11-12 March 2004
    M Decramer
    Respiratory Division, University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Thorax 60:335-42. 2005
    ..Finding the appropriate mix of outcome measures to capture all aspects of disease progression is a significant challenge...
  10. ncbi Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial
    Marc Decramer
    Respiratory Division, University Hospital, Katholieke Universiteit Leuven, Belgium
    Lancet 365:1552-60. 2005
    ..We postulated that treatment with the antioxidant N-acetylcysteine would reduce the rate of lung-function decline, reduce yearly exacerbation rate, and improve outcomes...
  11. ncbi Effect of treatments on the progression of COPD: report of a workshop held in Leuven, 11-12 March 2004
    M Decramer
    Respiratory Division, University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Thorax 60:343-9. 2005
    ..Several treatments affect the exacerbation rate and therefore might affect the progression of the disease. Further studies are warranted to examine this effect...
  12. ncbi Asthma and COPD: differences and similarities. With special reference to the usefulness of budesonide/formoterol in a single inhaler (Symbicort) in both diseases
    M Decramer
    Respiratory Division, U Z Gasthuisberg, Katholieke University, Leuven, Belgium
    Int J Clin Pract 59:385-98. 2005
    ....
  13. ncbi Tiotropium as a first maintenance drug in COPD: secondary analysis of the UPLIFT trial
    T Troosters
    Respiratory Division and Pulmonary Rehabilitation, UZ Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium
    Eur Respir J 36:65-73. 2010
    ..6 units (p<0.001) with tiotropium compared to placebo. In patients with COPD who are not on maintenance therapy, tiotropium is associated with significant benefits in disease progression...
  14. ncbi Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial
    Marc Decramer
    Respiratory Division, University of Leuven, Leuven, Belgium
    Lancet 374:1171-8. 2009
    ..However, there are few data for treatment in the early stages of the disease. We examined the effect of tiotropium on outcomes in a large subgroup of patients with moderate COPD...
  15. ncbi Skeletal muscle weakness, exercise tolerance and physical activity in adults with cystic fibrosis
    T Troosters
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Respir J 33:99-106. 2009
    ..Physical inactivity is a factor significantly contributing to exercise tolerance and skeletal muscle force in adults with cystic fibrosis, but these impairments are in excess to that expected from physical inactivity only...
  16. ncbi Skeletal muscle weakness in patients with sarcoidosis and its relationship with exercise intolerance and reduced health status
    M A Spruit
    Respiratory Rehabilitation, University Hospital Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium
    Thorax 60:32-8. 2005
    ..CONCLUSION: Skeletal muscle weakness occurs in patients with sarcoidosis who complain of fatigue and is associated with reduced health status and exercise intolerance...
  17. ncbi The Bronchitis Randomized On NAC Cost-Utility Study (BRONCUS): hypothesis and design. BRONCUS-trial Committee
    M Decramer
    Respiratory Division, University Hospital, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 17:329-36. 2001
    ..The final results of the trial will be available in about 2 yrs. The study will provide objective data on the effects of N-acetylcysteine on outcome variables in chronic obstructive pulmonary disease...
  18. ncbi Markers of inflammation and disuse in vastus lateralis of chronic obstructive pulmonary disease patients
    T Crul
    Respiratory Muscle Research Unit, Laboratory of Pneumology, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Clin Invest 37:897-904. 2007
    ....
  19. ncbi Determinants of physical activity in daily life in candidates for lung transplantation
    D Langer
    Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Belgium Department of Respiratory Rehabilitation and Respiratory Division, University Hospital Leuven, Leuven, Belgium
    Respir Med 106:747-54. 2012
    ..The main research questions were: 1) How active are LTx-candidates in daily life? 2) What are determinants of activity behavior before LTX?..
  20. ncbi Muscle force during an acute exacerbation in hospitalised patients with COPD and its relationship with CXCL8 and IGF-I
    M A Spruit
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Thorax 58:752-6. 2003
    ..CONCLUSIONS: Peripheral muscle weakness is enhanced during an acute exacerbation of COPD. CXCL8 and IGF-I may be involved in the development of peripheral muscle weakness in hospitalised and in stable patients with COPD...
  21. ncbi Rehabilitation and acute exacerbations
    C Burtin
    University Hospitals KU Leuven, Respiratory Rehabilitation and Respiratory Division, Leuven, Belgium
    Eur Respir J 38:702-12. 2011
    ..Self-management strategies play a crucial role in changing disease-related health behaviour and preventing hospital admissions...
  22. ncbi Sinonasal pathology in nonallergic asthma and COPD: 'united airway disease' beyond the scope of allergy
    G Hens
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Catholic University Leuven, Leuven, Belgium
    Allergy 63:261-7. 2008
    ..Here, sinonasal pathology is studied in patients with allergic asthma, nonallergic asthma and COPD...
  23. ncbi Incentive spirometry does not enhance recovery after thoracic surgery
    R Gosselink
    Respiratory Rehabilitation and Respiratory Division, University Hospitals, Katholieke Universiteit Leuven, and the Faculty of Physical Education and Physiotherapy, Belgium
    Crit Care Med 28:679-83. 2000
    ..To investigate the additional effect of incentive spirometry to chest physiotherapy to prevent postoperative pulmonary complications after thoracic surgery for lung and esophageal resections...
  24. ncbi Effects of acute administration of corticosteroids during mechanical ventilation on rat diaphragm
    Karen Maes
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Respir Crit Care Med 178:1219-26. 2008
    ..Mechanical ventilation is known to induce ventilator-induced diaphragm dysfunction. Patients submitted to mechanical ventilation often receive massive doses of corticosteroids that may cause further deterioration of diaphragm function...
  25. ncbi The TERT-CLPTM1L locus for lung cancer predisposes to bronchial obstruction and emphysema
    E Wauters
    Vesalius Research Center, VIB, KU Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Eur Respir J 38:924-31. 2011
    ..11, 95% CI 1.04-4.26; p=0.038). The rs31489 variant on 5p15.33 is associated with bronchial obstruction, presence and severity of emphysema, and lung cancer...
  26. ncbi [COPD and bone metabolism: a clinical update]
    A Lehouck
    Service de Pneumologie, Hôpital Universitaire Gasthuisberg, Katholieke Universiteit, 3000 Leuven, Belgique
    Rev Mal Respir 27:1231-42. 2010
    ..Hence, a rigorous application of the current treatment guidelines with respect to osteoporosis in general would already be a major step forward in the treatment of COPD...
  27. ncbi Alterations in gene expression in hamster diaphragm after emphysema and lung volume reduction surgery
    V Reynders
    Respiratory Muscle Research Unit, University Hospitals, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 19:1064-71. 2002
    ....
  28. ncbi A clinical practice guideline for physiotherapists treating patients with chronic obstructive pulmonary disease based on a systematic review of available evidence
    D Langer
    Departments of Pneumology and Respiratory Rehabilitation, University Hospital Leuven and Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Rehabil 23:445-62. 2009
    ..Update of a clinical practice guideline for the physiotherapy management of patients with chronic obstructive pulmonary disease supporting the clinical decision-making process...
  29. ncbi [Physiological effects of lung reduction surgery: the contribution of an animal model of emphysema]
    E Marchand
    Unité de Recherche sur la Musculature Respiratoire, Laboratoire de Pneumologie, Hôpital Universitaire de Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgique
    Rev Mal Respir 20:539-48. 2003
    ..Despite some encouraging early results, it is often still regarded as an experimental technique due to the significant associated mortality and unpredictable results...
  30. ncbi Quantifying physical activity in daily life with questionnaires and motion sensors in COPD
    F Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospitals, Leuven, Belgium
    Eur Respir J 27:1040-55. 2006
    ..The selection of which motion sensor to use for quantification of physical activity in daily life should depend mainly on the purpose of its use...
  31. ncbi Exercise training and pulmonary rehabilitation: new insights and remaining challenges
    T Troosters
    Dept of Rehabilitation Sciences and Respiratory Rehabilitation and Respiratory Division, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Eur Respir Rev 19:24-9. 2010
    ..Further research is needed in order to apply the now well-established principles of pulmonary rehabilitation to unusual patient populations, or patient populations that are unlikely to participate in conventional outpatient programmes...
  32. ncbi Exercise training after lung transplantation improves participation in daily activity: a randomized controlled trial
    D Langer
    Faculty of Kinesiology and Rehabilitation Sciences, KULeuven, Tervuursevest, Heverlee, Belgium
    Am J Transplant 12:1584-92. 2012
    ..01). Based on these results patients should be strongly encouraged to participate in an exercise training intervention after lung transplantation...
  33. ncbi Atrophy and hypertrophy signalling in the diaphragm of patients with COPD
    D Testelmans
    Katholieke Universiteit Leuven, Belgium
    Eur Respir J 35:549-56. 2010
    ..These alterations may contribute to diaphragm remodeling in COPD...
  34. ncbi What is the optimal treatment strategy for chronic obstructive pulmonary disease exacerbations?
    W Willaert
    Respiratory Division, University Hosital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 19:928-35. 2002
    ....
  35. ncbi Inspiratory flow rates at different levels of resistance in elderly COPD patients
    W Janssens
    Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur Respir J 31:78-83. 2008
    ....
  36. ncbi Cardiopulmonary stress during exercise training in patients with COPD
    V S Probst
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Respir J 27:1110-8. 2006
    ..In addition, exercise testing based on guidelines using a fixed percentage of baseline peak performance and symptom scores achieves and sustains training intensities recommended according to the American College of Sports Medicine...
  37. ncbi Leupeptin inhibits ventilator-induced diaphragm dysfunction in rats
    Karen Maes
    Respiratory Muscle Research Unit, Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Respir Crit Care Med 175:1134-8. 2007
    ..Controlled mechanical ventilation (CMV) has been shown to result in elevated diaphragmatic proteolysis and atrophy together with diaphragmatic contractile dysfunction...
  38. ncbi Management of COPD according to guidelines. A national survey among Belgian physicians
    M Decramer
    Respiratory Division, University Hospital, Herestraat 49, B-3000 Leuven, Belgium
    Monaldi Arch Chest Dis 59:62-80. 2003
    ..Some interesting differences between Dutch and French speaking physicians were noted. These specific deviations from the guidelines will be addressed in a second phase implementation project...
  39. ncbi Resistance versus endurance training in patients with COPD and peripheral muscle weakness
    M A Spruit
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Leuven, Belgium
    Eur Respir J 19:1072-8. 2002
    ..Resistance training and endurance training have similar effects on peripheral muscle force, exercise capacity and health-related quality of life in chronic obstructive pulmonary disease patients with peripheral muscle weakness...
  40. ncbi Respiratory muscle function and drive in chronic obstructive pulmonary disease
    E Marchand
    Respiratory Muscle Research Unit, Laboratory of Pneumology, Universitair Ziekenhuis Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Chest Med 21:679-92. 2000
    ..Because much of the lung and airway derangements are irreversible in COPD, the respiratory muscles appear to be an attractive target for therapeutic interventions...
  41. ncbi [The interest of animal models for the understanding of respiratory muscle dysfunction]
    G Gayan-Ramirez
    , Leuven, Belgique
    Rev Mal Respir 22:2S100-9. 2005
  42. ncbi Distribution of muscle weakness in patients with stable chronic obstructive pulmonary disease
    R Gosselink
    Division of Respiratory Rehabilitation, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven Belgium
    J Cardiopulm Rehabil 20:353-60. 2000
    ..In addition, this information may add to the knowledge on the mechanisms of muscle weakness...
  43. ncbi Modification of COPD presentation during the last 25 years
    Antoine Fremault
    University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    COPD 7:345-51. 2010
    ..As the length of hospitalization and the overall survival were not different between the two samples, a currently improved management of COPD can be hypothesized...
  44. ncbi Interleukin-6 causes myocardial failure and skeletal muscle atrophy in rats
    Sofie P M Janssen
    Laboratory of Pneumology, Respiratory Muscle Research Unit, Katholieke Universiteit Leuven, Leuven, Belgium
    Circulation 111:996-1005. 2005
    ..Blood flow redistribution, resulting from the myocardial failure induced by IL-6, was likely responsible for this muscle atrophy, because IL-6 did not exert any direct effect on the diaphragm...
  45. ncbi Chronic obstructive pulmonary disease and chronic heart failure: two muscle diseases?
    Thierry Troosters
    Respiratory Division and Respiratory Rehabilitation, Respiratory Muscle Research Unit, Katholieke Universiteit Leuven, Herestraat 49, B3000 Leuven, Belgium
    J Cardiopulm Rehabil 24:137-45. 2004
    ....
  46. ncbi Mechanisms of improvement in exercise capacity using a rollator in patients with COPD
    Vanessa S Probst
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Chest 126:1102-7. 2004
    ....
  47. ncbi High-dose lidocaine reduces airway mucus transport velocity in intubated anesthetized dogs
    Rik Gosselink
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Respir Med 100:258-63. 2006
    ..However, the effects of lidocaine administration on mucus transport in airways are inconclusive. Therefore, detailed information is needed to establish the effects of high- and low-dose lidocaine administration...
  48. ncbi Psychosocial conditions do not affect short-term outcome of multidisciplinary rehabilitation in chronic obstructive pulmonary disease
    Jacob C Trappenburg
    Respiratory Rehabilitation and Respiratory Division, University Hospitals, Katholieke Universiteit, Leuven, Belgium
    Arch Phys Med Rehabil 86:1788-92. 2005
    ..Patients with less favorable psychologic or sociodemographic conditions can also benefit from pulmonary rehabilitation. The multidisciplinary approach of the rehabilitation program might have contributed to this improvement...
  49. ncbi Pulmonary rehabilitation in chronic obstructive pulmonary disease
    Thierry Troosters
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
    Am J Respir Crit Care Med 172:19-38. 2005
  50. ncbi Characteristics of physical activities in daily life in chronic obstructive pulmonary disease
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
    Am J Respir Crit Care Med 171:972-7. 2005
    ..28 < r < 0.64, p < 0.05). Patients with chronic obstructive pulmonary disease are markedly inactive in daily life. Functional exercise capacity is the strongest correlate of physical activities in daily life...
  51. ncbi Age at death from different diseases: the flemish experience during the period 2000-2004
    H Kesteloot
    Dept of Epidemiology, SMG, Kapucijnenvoer 35, 3000 Leuven, Belgium
    Acta Clin Belg 63:256-61. 2008
    ..The age at death from different diseases is a good indicator of their relative importance at the population level...
  52. ncbi Respiratory muscles in COPD: regulation of trophical status
    M Decramer
    KULeuven-Faculty of Medicine, Respiratory Division, Respiratory Muscle Research Unit, Laboratory for Pneumology, Herestraat 49, B 3000 Leuven
    Verh K Acad Geneeskd Belg 63:577-602; discussion 602-4. 2001
    ..It does not appear to improve intrinsic inspiratory muscle function...
  53. ncbi Mucoactive therapy in COPD
    M Decramer
    Respiratory Division, University of Leuven, Herestraat 49, Leuven, Belgium
    Eur Respir Rev 19:134-40. 2010
    ..It is unclear what the mechanisms underlying these effects may be and which phenotypes benefit from this treatment. On the basis of this evidence mucoactive drugs may deserve consideration in the long-term treatment of COPD...
  54. ncbi Effects of mechanical ventilation on diaphragm function and biology
    G Gayan-Ramirez
    Respiratory Muscle Research Unit and Respiratory Division, Laboratory of Pneumology, University Hospitals, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur Respir J 20:1579-86. 2002
    ..These may include: adaptation of medication, training of the diaphragm, stabilisation of the catabolic state and pharmacotherapy...
  55. ncbi Clinical and economic analysis of antimicrobial therapy of chronic obstructive pulmonary disease exacerbations
    S Simoens
    Research Centre for Pharmaceutical Care and Pharmaco economics, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Clin Pract 61:200-6. 2007
    ..Fluoroquinolones were used to treat more severe exacerbations. Treatment of acute exacerbations of COPD imposes a significant clinical and economic burden on patients, the healthcare system and the society...
  56. ncbi Effects of lung volume reduction surgery in hamsters with elastase-induced emphysema
    E Marchand
    Laboratory of Pneumology, University Hospitals, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 19:422-8. 2002
    ..These findings appear to be largely explained by the high compliance of the hamster chest wall. This allows for better matching between the emphysematous lung and the chest-wall sizes than in humans...
  57. ncbi Effect of creatine supplementation as a potential adjuvant therapy to exercise training in cardiac patients: a randomized controlled trial
    V A Cornelissen
    Cardiovascular Rehabilitation Unit, Department of Rehabilitation Sciences, K U Leuven, Leuven, Belgium
    Clin Rehabil 24:988-99. 2010
    ..To investigate the effect of oral creatine supplementation in conjunction with an exercise programme on physical fitness in patients with coronary artery disease or chronic heart failure...
  58. ncbi Physical inactivity in patients with COPD, a controlled multi-center pilot-study
    Thierry Troosters
    Pulmonary Rehabilitation and Respiratory Division, UZ Gasthuisberg, Leuven, Belgium
    Respir Med 104:1005-11. 2010
    ..Studies in moderate COPD are currently scarce. The aim of the present study was to investigate physical activity in daily life in patients with COPD (n=70) and controls (n=30)...
  59. ncbi Are patients with COPD more active after pulmonary rehabilitation?
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Chest 134:273-80. 2008
    ..Despite a variety of benefits brought by pulmonary rehabilitation to patients with COPD, it is unclear whether these patients are more active during daily life after the program...
  60. ncbi Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010
    ..Vitamin D deficiency has been associated with many chronic illnesses, but little is known about its relationship with chronic obstructive pulmonary disease (COPD)...
  61. ncbi Clinical safety of long-acting beta2-agonist and inhaled corticosteroid combination therapy in COPD
    Marc Decramer
    Respiratory Division University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
    COPD 3:163-71. 2006
    ..Clinical data indicate that LABA/ICS combination therapy is more effective in COPD than either agent used alone and is not associated with any additional AEs...
  62. ncbi Exercise training during rehabilitation of patients with COPD: a current perspective
    Martijn A Spruit
    Respiratory Rehabilitation and Respiratory Division, University Hospitals, and Department of Rehabilitation Sciences, Faculty of Physical Education and Physiotherapy, Katholieke Universiteit Leuven, Leuven, Belgium
    Patient Educ Couns 52:243-8. 2004
    ....
  63. ncbi Hypogonadism, quadriceps weakness, and exercise intolerance in chronic obstructive pulmonary disease
    Monique Van Vliet
    Respiratory Rehabilitation, University Hospital Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium
    Am J Respir Crit Care Med 172:1105-11. 2005
    ..CONCLUSIONS: In contrast to exercise intolerance, quadriceps muscle weakness is related to low circulating levels of testosterone in men with COPD...
  64. ncbi Resistance training prevents deterioration in quadriceps muscle function during acute exacerbations of chronic obstructive pulmonary disease
    Thierry Troosters
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, Leuven, Belgium
    Am J Respir Crit Care Med 181:1072-7. 2010
    ..Exacerbations of chronic obstructive pulmonary disease (COPD) acutely reduce skeletal muscle strength and result in long-term loss of functional capacity...
  65. ncbi Accuracy of office spirometry performed by trained primary-care physicians using the MIR Spirobank hand-held spirometer
    J Degryse
    Department of Primary Health Care, KU Leuven, Leuven, Belgium
    Respiration 83:543-52. 2012
    ..However, the perception persists that small flow-sensing devices are less accurate than volume-sensing spirometers...
  66. ncbi Reversibility of paraneoplastic bilateral diaphragmatic paralysis after nephrectomy for renal cell carcinoma
    B Rijnders
    Respiratory Division, University Hospitals, Katholieke Universiteit Leuven, Belgium
    Ann Oncol 11:221-5. 2000
    ..We believe this is the first report of a paraneoplastic bilateral diaphragmatic paralysis with actual recovery after tumour therapy...
  67. ncbi Physical activity and hospitalization for exacerbation of COPD
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
    Chest 129:536-44. 2006
    ..CONCLUSIONS: Patients with COPD are markedly inactive during and after hospitalization for an AE. Efforts to enhance physical activity should be among the aims of the disease management during and following the AE periods...
  68. ncbi [Pulmonary rehabilitation in patients with chronic obstructive pulmonary disease]
    Ghislaine Gayan-Ramirez
    Departement de Pneumologie, Unité de Recherche des Muscles Respiratoires, Katholieke Universiteit Leuven, Leuven, Belgium
    Presse Med 38:452-61. 2009
    ..The beneficial effects of pulmonary rehabilitation on exercise tolerance, muscle strength, symptoms, quality of life are now well recognized...
  69. ncbi Office spirometry significantly improves early detection of COPD in general practice: the DIDASCO Study
    Johan Buffels
    Department of General Practice, Katholieke Universiteit, Leuven, Belgium
    Chest 125:1394-9. 2004
    ..To determine if spirometry is essential for the early detection of COPD in general practice, compared to the screening value of a short questionnaire...
  70. ncbi Pulmonary rehabilitation 2007: from bench to practice and back
    Marc Decramer
    Respiratory Division, University Hospital Katholieke Universiteit, Leuven, Belgium
    Clin Invest Med 31:E312-8. 2008
    ..A better understanding of the factors controlling the response to rehabilitation, may lead to significant advances in this field...
  71. ncbi Infusions of rocuronium and cisatracurium exert different effects on rat diaphragm function
    Dries Testelmans
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, O and N 1, bus 706, Herestraat 49, 3000, Leuven, Belgium
    Intensive Care Med 33:872-9. 2007
    ..The aim of our study was to compare the effects of 24 h infusion of rocuronium or cisatracurium on the diaphragm in mechanically ventilated rats...
  72. ncbi Treatment of COPD: the sooner the better?
    Marc Decramer
    Respiratory Division, University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:837-41. 2010
    ..New trials, particularly demonstrating the detrimental effects of delaying treatment until later in the course of the disease, are required to render the evidence for early intensive intervention irrefutable...
  73. ncbi Detrimental effects of short-term mechanical ventilation on diaphragm function and IGF-I mRNA in rats
    Ghislaine Gayan-Ramirez
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Rehabilitation and Respiratory Division, University Hospitals, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Intensive Care Med 29:825-33. 2003
    ..51, P=0.0056). CONCLUSIONS: We conclude that 24 h of mechanical ventilation in rats, independently of anesthesia, already significantly reduced diaphragm force, fiber dimensions, and its IGF-I mRNA levels...
  74. ncbi The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema
    Diether Lambrechts
    Vesalius Research Center, K U Leuven, Leuven, Belgium
    Am J Respir Crit Care Med 181:486-93. 2010
    ..Assessment of bronchial obstruction by spirometry, typically used for diagnosing COPD, fails, however, to detect emphysema...
  75. ncbi Alveolar and bronchial exhaled nitric oxide in chronic obstructive pulmonary disease
    An Lehouck
    Respiratory Division, University Hospital Gasthuisberg Katholieke Universiteit Leuven, Herestraat 49, bus 706, 3000 Leuven, Belgium
    Respir Med 104:1020-6. 2010
    ..We examined whether the use of Fe,NO, CAlv,NO and J'aw,NO may contribute to the clinical diagnosis of COPD...
  76. ncbi Distorted symptom perception in patients with medically unexplained symptoms
    Katleen Bogaerts
    Department of Psychology, University of Leuven, Leuven, Belgium
    J Abnorm Psychol 119:226-34. 2010
    ..This suggests a stronger role for top-down psychological processes in the symptom perception of patients with MUS...
  77. ncbi Impact of care pathways for in-hospital management of COPD exacerbation: a systematic review
    C Lodewijckx
    Respiratory Division, University Hospitals Leuven, Belgium
    Int J Nurs Stud 48:1445-56. 2011
    ..In-hospital management of COPD exacerbation is suboptimal, and outcomes are poor. Care pathways are a possible strategy for optimizing care processes and outcomes...
  78. ncbi Platypnea-orthodeoxia syndrome: a report of two cases
    C Timmermans
    Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium
    Acta Cardiol 48:583-90. 1993
    ..The other case illustrates that, despite actual technical possibilities, clinical suspicion remains a prerequisite for proper diagnosis of the entity...
  79. ncbi Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases
    Jeroen A J Vanoirbeek
    Lung Toxicology Research Unit, Katholieke Universiteit Leuven, Herestraat 49 bus 706, Leuven, Belgium
    Am J Respir Cell Mol Biol 42:96-104. 2010
    ..Invasive pulmonary functions allow distinction between respiratory diseases in mice by clinically relevant variables, and should become standard in the functional evaluation of pathological disease models...
  80. ncbi Acute inflammatory and anabolic systemic responses to peak and constant-work-rate exercise bout in hospitalized patients with COPD
    Martijn A Spruit
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Leuven, Belgium
    Int J Chron Obstruct Pulmon Dis 2:575-83. 2007
    ..To explore the acute systemic inflammatory and anabolic effects of cycling in hospital admitted patients with chronic obstructive pulmonary disease (COPD) and in patients with clinically stable disease...
  81. ncbi Pharmacoeconomics of the management of acute exacerbations of chronic obstructive pulmonary disease
    Steven Simoens
    Research Centre for Pharmaceutical Care and Pharmaco economics, Faculty of Pharmaceutical Sciences, K U Leuven, Onderwijs en Navorsing 2, Leuven, Belgium
    Expert Opin Pharmacother 8:633-48. 2007
    ..It presents estimates of the level and distribution of costs associated with exacerbations and reports on the cost-effectiveness or cost-utility of antimicrobial therapy and other approaches to the management of exacerbations...
  82. ncbi Activity monitoring for assessment of physical activities in daily life in patients with chronic obstructive pulmonary disease
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospitals, Katholieke Universiteit Leuven, Leuven, Belgium
    Arch Phys Med Rehabil 86:1979-85. 2005
    ..Patients' estimations of time spent on physical activities in daily life disagreed with objective assessment...
  83. ncbi Functional recovery of diaphragm paralysis: a long-term follow-up study
    Ghislaine Gayan-Ramirez
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, Onderwijs en Navorsing 1 bus 706, Herestraat 49, B 3000 Leuven, Belgium
    Respir Med 102:690-8. 2008
    ..Long-term functional outcome of diaphragm paralysis is largely unknown...
  84. ncbi Targeting the COPD exacerbation
    Marc Decramer
    Respiratory Division, University Hospitals Leuven, and Katholieke Universiteit Leuven, Leuven, Belgium
    Respir Med 102:S3-15. 2008
    ..Not surprisingly, pulmonary rehabilitation after such events has been shown to prevent relapse, improve survival and enhance patients' overall function after acute exacerbations...
  85. ncbi Inhospital management of COPD exacerbations: a systematic review of the literature with regard to adherence to international guidelines
    Cathy Lodewijckx
    University Hospitals Leuven, Leuven, Belgium
    J Eval Clin Pract 15:1101-10. 2009
    ..Further investigation is recommended to explore strategies like care pathways that improve performance of recommended interventions...
  86. ncbi Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease
    Wim Janssens
    Department of Human Genetics, Katholieke Universiteit Leuven, Gasthuisberg O and N1 602, Herestraat 49, B 3000, Leuven, Belgium
    Am J Respir Crit Care Med 182:163-9. 2010
    ..Objectives: We investigated whether genomic copy number variations of the beta-defensin gene cluster have a functional role in airway epithelial cells and associate with the presence of COPD...
  87. ncbi Economic aspects of antimicrobial therapy of acute exacerbations of COPD
    Steven Simoens
    Research Centre for Pharmaceutical Care and Pharmaco economics, Faculty of Pharmaceutical Sciences, KU Leuven, Onderwijs en Navorsing 2, Herestraat 49, 3000 Leuven, Belgium
    Respir Med 101:15-26. 2007
    ..The small number of economic evaluations and their methodological limitations precludes the recommendation of a specific antibiotic for use in the management of COPD exacerbations on economic grounds...
  88. ncbi Spirometry and smoking cessation advice in general practice: a randomised clinical trial
    Johan Buffels
    Department of General Practice, Academisch Centrum voor Huisartsgeneeskunde, Katholieke Universiteit Leuven, Kapucijnenvoer 33 Blok J, B 3000 Leuven, Belgium
    Respir Med 100:2012-7. 2006
    ..To assess the success rate of smoking cessation with the "minimal intervention strategy" in general practice, and to determine the influence of spirometry on this success rate...
  89. ncbi Gene expression profiling in vastus lateralis muscle during an acute exacerbation of COPD
    Tim Crul
    Respiratory Muscle Research Unit, Laboratory of Pneumology, Leuven, Belgium
    Cell Physiol Biochem 25:491-500. 2010
    ..A cross-sectional study was designed to compare the gene expression profile of the vastus lateralis muscle in patients with an acute COPD exacerbation and in stable COPD patients...
  90. ncbi Early exercise in critically ill patients enhances short-term functional recovery
    Chris Burtin
    Faculty of Kinesiology and Rehabilitation Sciences CB, BC, CR, DL, TT, RG, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 37:2499-505. 2009
    ..No evidence is available concerning the effectiveness of an early exercise training intervention to prevent these detrimental complications...
  91. ncbi Inspired fraction of carbon dioxide in oxygen supply to chronic pulmonary disease
    Antoine Fremault
    Department of Pneumology, University Hospital, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Respir Med 102:1827-9. 2008
    ..We found no significant increase in inspiratory CO(2) concentration. These findings suggest that inspired fraction of CO(2) does not increase markedly during controlled oxygen therapy...
  92. ncbi Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act
    Wim Janssens
    Division of Respiratory Medicine, University Hospital Gasthuisberg KUL Herestraat 49, 3000 Leuven, Belgium
    Am J Respir Crit Care Med 179:630-6. 2009
    ..A further challenge of such studies is to define optimal serum 25-OHD levels for such noncalcemic endpoints...
  93. ncbi Response of the respiratory muscles to rehabilitation in COPD
    Marc Decramer
    Respiratory Division, University Hospital, University of Leuven, 3000 Leuven, Belgium
    J Appl Physiol 107:971-6. 2009
    ..Eight randomized studies examined the effects of the combination. Greater improvements in exercise capacity were only found in three studies, and none showed a greater reduction in dyspnea...
  94. ncbi Physical activity in daily life 1 year after lung transplantation
    Daniel Langer
    Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Tervuursevest 101, Leuven, Belgium
    J Heart Lung Transplant 28:572-8. 2009
    ..However, daily physical activity has not been objectively assessed so far in lung recipients. The purpose of this study was to objectively measure daily physical activity in lung recipients...
  95. ncbi Ventilator-induced diaphragmatic dysfunction: toward a better treatment?
    Marc Decramer
    Am J Respir Crit Care Med 170:1141-2. 2004
  96. ncbi Gender differences in the management and experience of Chronic Obstructive Pulmonary Disease
    Louise Watson
    Department of Worldwide Epidemiology, GlaxoSmithKline, Greenford, UK
    Respir Med 98:1207-13. 2004
    ..08, 0.92-1.27) and less sputum (OR 0.84, 0.72-0.98). There were no differences in the risk of hospitalisation or emergency room visit. This study indicates that gender differences in COPD care and outcomes exist...
  97. ncbi Reloading the diaphragm following mechanical ventilation does not promote injury
    Darin Van Gammeren
    Department of Applied Psychology, Center for Exercise Science, University of Florida, Room 25 FLG, Gainesville, FL 32611, USA
    Chest 127:2204-10. 2005
    ..CONCLUSION: We conclude that the return to spontaneous breathing following 24 h of controlled MV does not exacerbate MV-induced diaphragm contractile dysfunction or result in fiber membrane damage, but increases neutrophil infiltration...
  98. ncbi Intermittent spontaneous breathing protects the rat diaphragm from mechanical ventilation effects
    Ghislaine Gayan-Ramirez
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, Leuven Belgium
    Crit Care Med 33:2804-9. 2005
    ....
  99. ncbi A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    ..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy...
  100. ncbi Potential consequences for stable chronic obstructive pulmonary disease patients who do not get the recommended minimum daily amount of physical activity
    Fabio Pitta
    Departamento de Fisioterapia, Universidade Estadual de LondrinaParaná, Brasil
    J Bras Pneumol 32:301-8. 2006
    ....
  101. ncbi Hypogonadism in male outpatients with sarcoidosis
    Martijn A Spruit
    Department of Research, Development and Education, Centre for Integrated Rehabilitation of Organ Failure CIRO, Hornerheide 1, 6085 NM, Horn, The Netherlands
    Respir Med 101:2502-10. 2007
    ..Indeed, poor inspiratory and quadriceps muscle function, exercise intolerance, diminished vitality and depressed mood were not related to hypogonadism in these patients...