Paul De Leyn

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Tracheotomy: clinical review and guidelines
    Paul De Leyn
    Department of Thoracic Surgery, University Hospital Leuven, Belgium
    Eur J Cardiothorac Surg 32:412-21. 2007
  2. doi request reprint Survival after trimodality treatment for superior sulcus and central T4 non-small cell lung cancer
    Paul De Leyn
    Department of Thoracic Surgery, University Hospitals and Leuven Lung Cancer Group, Leuven, Belgium
    J Thorac Oncol 4:62-8. 2009
  3. doi request reprint Impact of FDG-PET-induced treatment choices on long-term outcome in non-small cell lung cancer
    Isabelle Wauters
    Respiratory Oncology Unit Pulmonology and Leuven Lung Cancer Group, University Hospital Gasthuisberg, Catholic University, BE 3000 Leuven, Belgium
    Respiration 79:97-104. 2010
  4. pmc Trial on refinement of early stage non-small cell lung cancer. Adjuvant chemotherapy with pemetrexed and cisplatin versus vinorelbine and cisplatin: the TREAT protocol
    Michael Kreuter
    Department of Medicine Thoracic Oncology, Thoraxklinik at the University of Heidelberg, Heidelberg, Germany
    BMC Cancer 7:77. 2007
  5. ncbi request reprint Result of induction chemotherapy followed by surgery in patients with stage IIIA N2 NSCLC: importance of pre-treatment mediastinoscopy
    P De Leyn
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Catholic University, Leuven, Belgium
    Eur J Cardiothorac Surg 15:608-14. 1999
  6. doi request reprint Prospective European multicenter randomized trial of PleuraSeal for control of air leaks after elective pulmonary resection
    Paul De Leyn
    University Hospitals Leuven, Leuven, Belgium
    J Thorac Cardiovasc Surg 141:881-7. 2011
  7. ncbi request reprint [Surgical treatment of non-small cell lung cancer]
    P De Leyn
    Hôpital Universitaire de Leuven, Herestraat 49, 3000 Leuven, Belgium
    Rev Mal Respir 21:971-82. 2004
  8. ncbi request reprint Prospective comparative study of integrated positron emission tomography-computed tomography scan compared with remediastinoscopy in the assessment of residual mediastinal lymph node disease after induction chemotherapy for mediastinoscopy-proven stage II
    Paul De Leyn
    Department of Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Clin Oncol 24:3333-9. 2006
  9. doi request reprint Surgical multimodality treatment for baseline resectable stage IIIA-N2 non-small cell lung cancer. Degree of mediastinal lymph node involvement and impact on survival
    Herbert Decaluwe
    Leuven Lung Cancer Group, Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium
    Eur J Cardiothorac Surg 36:433-9. 2009
  10. doi request reprint Minimally invasive oesophagectomy: a valuable alternative to open oesophagectomy for the treatment of early oesophageal and gastro-oesophageal junction carcinoma
    Philippe Nafteux
    Department of Thoracic Surgery, UZ Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Cardiothorac Surg 40:1455-63; discussion 1463-4. 2011

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Tracheotomy: clinical review and guidelines
    Paul De Leyn
    Department of Thoracic Surgery, University Hospital Leuven, Belgium
    Eur J Cardiothorac Surg 32:412-21. 2007
    ..PDT should be considered the procedure of choice in elective non-urgent tracheotomy. There are some relative contraindications for PDT, but with growing experience, they become less frequent...
  2. doi request reprint Survival after trimodality treatment for superior sulcus and central T4 non-small cell lung cancer
    Paul De Leyn
    Department of Thoracic Surgery, University Hospitals and Leuven Lung Cancer Group, Leuven, Belgium
    J Thorac Oncol 4:62-8. 2009
    ..For sulcus superior tumors and central cT4 tumors, low resectability and poor long-term survival rates are obtained with single-modality treatment...
  3. doi request reprint Impact of FDG-PET-induced treatment choices on long-term outcome in non-small cell lung cancer
    Isabelle Wauters
    Respiratory Oncology Unit Pulmonology and Leuven Lung Cancer Group, University Hospital Gasthuisberg, Catholic University, BE 3000 Leuven, Belgium
    Respiration 79:97-104. 2010
    ..Addition of FDG-PET to conventional staging (CS) improves accuracy, but few data have described the impact of this on long-term survival in relation to treatment...
  4. pmc Trial on refinement of early stage non-small cell lung cancer. Adjuvant chemotherapy with pemetrexed and cisplatin versus vinorelbine and cisplatin: the TREAT protocol
    Michael Kreuter
    Department of Medicine Thoracic Oncology, Thoraxklinik at the University of Heidelberg, Heidelberg, Germany
    BMC Cancer 7:77. 2007
    ..Doublet regimens with pemetrexed, a multi-target folate inhibitor, and platin show clear activity in non-small cell lung cancer and are well tolerated with low toxicity rates and excellent delivery...
  5. ncbi request reprint Result of induction chemotherapy followed by surgery in patients with stage IIIA N2 NSCLC: importance of pre-treatment mediastinoscopy
    P De Leyn
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Catholic University, Leuven, Belgium
    Eur J Cardiothorac Surg 15:608-14. 1999
    ..The aim of this study was to look at the correlation between downstaging, survival and pre-treatment staging...
  6. doi request reprint Prospective European multicenter randomized trial of PleuraSeal for control of air leaks after elective pulmonary resection
    Paul De Leyn
    University Hospitals Leuven, Leuven, Belgium
    J Thorac Cardiovasc Surg 141:881-7. 2011
    ..We sought to evaluate the efficacy and safety of a synthetic bioresorbable pleural sealant (PleuraSeal; Covidien, Bedford, Mass) to treat air leaks after pulmonary resection...
  7. ncbi request reprint [Surgical treatment of non-small cell lung cancer]
    P De Leyn
    Hôpital Universitaire de Leuven, Herestraat 49, 3000 Leuven, Belgium
    Rev Mal Respir 21:971-82. 2004
    ..Surgery remains the best option for curative treatment of early stages Non-small cell lung cancer (NSCLC). In this article we review the current status and future perspectives of surgical treatment of NSCLC...
  8. ncbi request reprint Prospective comparative study of integrated positron emission tomography-computed tomography scan compared with remediastinoscopy in the assessment of residual mediastinal lymph node disease after induction chemotherapy for mediastinoscopy-proven stage II
    Paul De Leyn
    Department of Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Clin Oncol 24:3333-9. 2006
    ....
  9. doi request reprint Surgical multimodality treatment for baseline resectable stage IIIA-N2 non-small cell lung cancer. Degree of mediastinal lymph node involvement and impact on survival
    Herbert Decaluwe
    Leuven Lung Cancer Group, Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium
    Eur J Cardiothorac Surg 36:433-9. 2009
    ..Analysis of single centre results and identification of prognostic factors of surgical combined modality treatment in pathological proven stage IIIA-N2 non-small cell lung cancer (NSCLC)...
  10. doi request reprint Minimally invasive oesophagectomy: a valuable alternative to open oesophagectomy for the treatment of early oesophageal and gastro-oesophageal junction carcinoma
    Philippe Nafteux
    Department of Thoracic Surgery, UZ Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Cardiothorac Surg 40:1455-63; discussion 1463-4. 2011
    ..The aim was to conduct a comparative analysis of outcome after minimally invasive oesophagectomy (MIO) versus open oesophagectomy (OO) for early oesophageal and gastro-oesophageal junction (GOJ) carcinoma...
  11. doi request reprint Quality indicators of surgery for adenocarcinoma of the esophagus and gastroesophageal junction
    Toni Lerut
    Department of Thoracic and Esophageal Surgery, University Hospitals Leuven, 3000, Leuven, Belgium
    Recent Results Cancer Res 182:127-42. 2010
    ..Improvements in this wide spectrum of aspects is mandatory and will certainly be of great value to further improve both short and long term outcome after surgery for these complex cancers...
  12. doi request reprint Postoperative complications after transthoracic esophagectomy for cancer of the esophagus and gastroesophageal junction are correlated with early cancer recurrence: role of systematic grading of complications using the modified Clavien classification
    Toni Lerut
    From the Department of Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Ann Surg 250:798-807. 2009
    ..To assess the impact of postoperative complications after transthoracic esophagectomy, using the modified Clavien classification, on recurrence and on its timing in patients with cancer of the esophagus or gastroesophageal junction...
  13. doi request reprint Lung donor selection and management
    Dirk Van Raemdonck
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium
    Proc Am Thorac Soc 6:28-38. 2009
    ..This article aims to update the current evidence from the literature to identify and select potential lung donors and to manage cadaveric donors to maximally increase the organ yield for lung transplantation...
  14. doi request reprint Survival after resection of synchronous bilateral lung cancer
    Paul De Leyn
    Department of Thoracic Surgery, University Hospitals and Leuven Lung Cancer Group, Herestraat 49, 3000 Leuven, Belgium
    Eur J Cardiothorac Surg 34:1215-22. 2008
    ..In this retrospective study, the survival after resection of synchronous bilateral lung cancer is evaluated...
  15. doi request reprint Prognostic stratification of stage IIIA-N2 non-small-cell lung cancer after induction chemotherapy: a model based on the combination of morphometric-pathologic response in mediastinal nodes and primary tumor response on serial 18-fluoro-2-deoxy-glucose po
    Christophe Dooms
    Department of Pulmonology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Clin Oncol 26:1128-34. 2008
    ..We created a data-based restaging strategy combining morphometric tissue analysis of mediastinal lymph nodes (LNs) and 18-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) response monitoring in the primary tumor...
  16. doi request reprint The number of lung transplants can be safely doubled using extended criteria donors; a single-center review
    Caroline Meers
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium
    Transpl Int 23:628-35. 2010
    ..1%) in our donor network is 10-20% higher than reported figures. The number of lung transplants in our center doubled by accepting extended criteria donors. This policy did not negatively influence our results after lung transplantation...
  17. doi request reprint Multidisciplinary treatment of advanced cancer of the esophagus and gastroesophageal junction: a European center's approach
    Toni Lerut
    Department of Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Surg Oncol Clin N Am 17:485-502, vii-viii. 2008
    ..Therefore, further efforts are needed to elaborate more precise algorithms for selecting candidates for induction therapy versus primary surgery...
  18. doi request reprint Minimally invasive esophagectomy for cancer
    Georges Decker
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Cardiothorac Surg 35:13-20; discussion 20-1. 2009
    ..Oncological outcome of MIE remains largely unknown by lack of good quality data and selection bias. MIE remains an investigational and still evolving treatment for invasive cancer...
  19. ncbi request reprint Diagnosis and therapy in advanced cancer of the esophagus and the gastroesophageal junction
    Toni Lerut
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
    Curr Opin Gastroenterol 22:437-41. 2006
    ..The aim of this article is to discuss recent developments in the diagnosis and treatment with curative option of advanced cancer of the esophagus and gastroesophageal junction...
  20. doi request reprint Outcome after esophagectomy for cancer of the esophagus and GEJ in patients aged over 75 years
    Eveline Internullo
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
    Eur J Cardiothorac Surg 33:1096-104. 2008
    ..This study is a single institution retrospective analysis of outcome after esophagectomy for cancer of the esophagus and GEJ in patients aged over 75 years...
  21. doi request reprint Malignant pleural disease: diagnosis by using diffusion-weighted and dynamic contrast-enhanced MR imaging--initial experience
    Johan Coolen
    Department of Radiology, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Radiology 263:884-92. 2012
    ....
  22. doi request reprint Donor cause of brain death and related time intervals: does it affect outcome after lung transplantation?
    Shana Wauters
    Laboratory of Experimental Thoracic Surgery, Catholic University Leuven, Leuven, Belgium
    Eur J Cardiothorac Surg 39:e68-76. 2011
    ..In addition, it is unknown whether the length of time interval from brain insult to brain death [BI-BD] and from brain death to cold preservation [BD-CP] has an impact on outcome...
  23. doi request reprint Tracheal allotransplantation after withdrawal of immunosuppressive therapy
    Pierre Delaere
    Department of Otolaryngology and Head and Neck, University Hospital Leuven, Leuven, Belgium
    N Engl J Med 362:138-45. 2010
    ..After withdrawal of immunosuppressive therapy, the tracheal allograft was moved to its correct anatomical position with an intact blood supply. No treatment-limiting adverse effects occurred...
  24. doi request reprint Characterisation of solitary pulmonary lesions combining visual perfusion and quantitative diffusion MR imaging
    Johan Coolen
    Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur Radiol 24:531-41. 2014
    ..To evaluate the diagnostic accuracy of dynamic contrast-enhanced (DCE) magnetic resonance (MR) and diffusion-weighted imaging (DWI) sequences for defining benignity or malignancy of solitary pulmonary lesions (SPL)...
  25. ncbi request reprint Risk factors for airway complications within the first year after lung transplantation
    Caroline van de Wauwer
    Department of Thoracic Surgery, UZ Leuven, Belgium
    Eur J Cardiothorac Surg 31:703-10. 2007
    ..Nevertheless, airway anastomotic complications (AC) are still a potential cause of early morbidity and mortality. In this retrospective cohort study we looked at possible predictors of AC within the first year after LTx...
  26. doi request reprint Zenker's diverticulum
    Toni Lerut
    University Hospitals Leuven, Belgium
    Multimed Man Cardiothorac Surg 2009:mmcts.2007.002881. 2009
    ..This procedure is performed via a limited left cervicotomy. Results are excellent to very good in 94% of the patients in our own experience. ..
  27. doi request reprint Laparoscopic Nissen fundoplication
    Philippe Nafteux
    Department of Thoracic Surgery, UZ Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Multimed Man Cardiothorac Surg 2008:mmcts.2007.002931. 2008
    ..The left and right pillars of the right diaphragmatic crus are approximated using interrupted sutures. A short (≪2 cm), floppy 360° fundoplication anchored to the esophagus is created. ..
  28. ncbi request reprint Laparoscopic Nissen fundoplication in infants and children: analysis of 106 consecutive patients with special emphasis in neurologically impaired vs. neurologically normal patients
    Jan Mathei
    Thoracic Surgery, University Hospitals Gasthuisberg, 3000, Leuven, Belgium
    Surg Endosc 22:1054-9. 2008
    ..In this study we describe our 8-year experience with 106 consecutive laparoscopic Nissen fundoplications...
  29. doi request reprint Early outcome after lung transplantation from non-heart-beating donors is comparable to heart-beating donors
    Stéphanie De Vleeschauwer
    Laboratory of Pneumology, Kathoholieke Universiteit Leuven, Leuven, Belgium
    J Heart Lung Transplant 28:380-7. 2009
    ..The use of non-heart-beating donors (NHBD) to overcome organ shortage is moving into the clinic. In 2007, 5 of 51 lung transplantations (LTx) in our center were performed with lungs from controlled NHBD...
  30. doi request reprint Antireflux surgery after congenital diaphragmatic hernia repair: a plea for a tailored approach
    Tom Verbelen
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
    Eur J Cardiothorac Surg 44:263-7; discussion 268. 2013
    ..We evaluated the incidence and associated factors of gastro-oesophageal reflux disease (GERD) and the need for subsequent ARS in our CDH patients...
  31. doi request reprint Assessing the relationships between health-related quality of life and postoperative length of hospital stay after oesophagectomy for cancer of the oesophagus and the gastro-oesophageal junction
    Philippe Nafteux
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
    Eur J Cardiothorac Surg 44:525-33; discussion 533. 2013
    ....
  32. ncbi request reprint Clinical-radiological presentation and outcome of surgically treated pulmonary carcinoid tumours: a long-term single institution experience
    Liesbet Schrevens
    Respiratory Oncology Unit Pulmonology, Leuven Lung Cancer Group, Catholic University, Leuven, Belgium
    Lung Cancer 43:39-45. 2004
    ..To determine the presenting features and the outcome of surgically treated pulmonary carcinoid tumours...
  33. doi request reprint Video-assisted mediastinoscopic resection of a large symptomatic bronchogenic cyst
    Jan Lesaffer
    Department of Thoracic Surgery, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium
    Interact Cardiovasc Thorac Surg 12:1071-3. 2011
    ..We describe a case of a young female with a large symptomatic cyst located in the superior mediastinum. The cyst was completely removed through a video-assisted cervical mediastinoscopy...
  34. ncbi request reprint Long-segment tracheal stenosis treated with vascularized mucosa and short-term stenting
    Steven Stamenkovic
    Department of Thoracic Surgery, University Hospital K U Leuven, Leuven, Belgium
    Ann Thorac Surg 83:1213-5. 2007
    ..A case with an airway stenosis with a length greater than 5 cm is presented. The vascularized mucosa allowed for primary healing of the augmented airway. The tracheostomy could be closed shortly after stent removal...
  35. ncbi request reprint Combined liver and (heart-)lung transplantation in liver transplant candidates with refractory portopulmonary hypertension
    Jacques Pirenne
    Abdominal Transplant Surgery Department, University Hospital Leuven, Belgium
    Transplantation 73:140-2. 2002
    ..Prostacyclin can reduce PPHT to a level at which LiTx can be performed. In patients refractory to that treatment, combined (heart-)lung-LiTx is the only life-saving option...
  36. ncbi request reprint ESTS guidelines for preoperative lymph node staging for non-small cell lung cancer
    Paul De Leyn
    Eur J Cardiothorac Surg 32:1-8. 2007
    ..Both endoscopic techniques and surgical procedures are available. If they yield a positive result, non-surgical treatment is indicated in most patients...
  37. ncbi request reprint Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small cell lung cancer
    Johan Vansteenkiste
    J Thorac Oncol 2:684-5. 2007
  38. ncbi request reprint ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer
    Didier Lardinois
    Department of Thoracic Surgery, University Hospital, Zurich, Switzerland
    Eur J Cardiothorac Surg 30:787-92. 2006
    ..The adherence to these guidelines will standardize the intraoperative lymph node staging and pathologic evaluation, and improve pathologic staging, which will help decide on the best adjuvant therapy...