Research Topics
Genomes and GenesSpecies | Marc De HertSummaryAffiliation: Katholieke Universiteit Leuven Country: Belgium Publications
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Publications
Remission criteria for schizophrenia: evaluation in a large naturalistic cohortMarc De Hert
University Psychiatric Centre Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
Schizophr Res 92:68-73. 2007..Little is known, however, about the added value of the time criterion in addition to the cross-sectional severity criterion...- Reversibility of antipsychotic treatment-related diabetes in patients with schizophrenia: a case series of switching to aripiprazoleMarc De Hert
Diabetes Care 29:2329-30. 2006 - Screening for diabetes and other metabolic abnormalities in patients with schizophrenia and schizoaffective disorder: evaluation of incidence and screening methodsRuud van Winkel
University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium
J Clin Psychiatry 67:1493-500. 2006..The alternative 2-step strategy was able to detect the vast majority of diabetes cases and should therefore be considered in the clinical routine of screening and monitoring patients with schizophrenia... 
Is the prevalence of metabolic syndrome and metabolic abnormalities increased in early schizophrenia? A comparative meta-analysis of first episode, untreated and treated patientsAlex J Mitchell
Leicestershire Partnership Trust, Leicester, UK
Schizophr Bull 39:295-305. 2013..We aimed to discover whether metabolic complications of schizophrenia (SZ) are present in first episode (FE) and unmedicated (UM) patients, in comparison with patients established on antipsychotic medication (AP)...
Cardiovascular disease and diabetes in people with severe mental illness position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESCM De Hert
University Psychiatric, Centre Catholic University, Leuven campus Kortenberg, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
Eur Psychiatry 24:412-24. 2009....- Prevalence and correlates of seclusion and restraint use in children and adolescents: a systematic reviewMarc De Hert
University Psychiatric Centre, KUL Campus Kortenberg, Leuvensesteenweg 517, Kortenberg, Belgium
Eur Child Adolesc Psychiatry 20:221-30. 2011..In addition, there is a clear need for transparent policies and guidelines... - The METEOR study of diabetes and other metabolic disorders in patients with schizophrenia treated with antipsychotic drugs. I. MethodologyMarc De Hert
UPC KUL Campus Kortenberg, Kortenberg, Belgium
Int J Methods Psychiatr Res 19:195-210. 2010..The proportion of subjects presenting the pathologies of interest was relatively high, ranging from 28% for glycaemic disorders to 70% for lipid disorders... - Typical and atypical antipsychotics differentially affect long-term incidence rates of the metabolic syndrome in first-episode patients with schizophrenia: a retrospective chart reviewMarc De Hert
University Psychiatric Center Katholieke Universiteit Leuven, Leuvense Steenweg 517, 3070 Kortenberg, Belgium
Schizophr Res 101:295-303. 2008..There are limited data on the prevalence of MetS in patients with schizophrenia at the onset of the disorder and specifically no data on patients treated in the era when only first-generation antipsychotics were available... - Knowledge about HIV in people with schizophrenia: a general population comparisonMarc De Hert
University Psychiatric Center Katholieke Universiteit Leuven, campus Kortenberg, Belgium
Clin Schizophr Relat Psychoses 5:80-6. 2011..Only a limited number of studies have evaluated the knowledge about HIV in people with schizophrenia... - Treatment with rosuvastatin for severe dyslipidemia in patients with schizophrenia and schizoaffective disorderMarc De Hert
University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium
J Clin Psychiatry 67:1889-96. 2006..Use of lipid-lowering drugs such as statins is recommended when lifestyle changes are not sufficient to reach the LDL goal. The efficacy and safety of rosuvastatin treatment were evaluated in schizophrenic patients... - Effects of cannabis use on age at onset in schizophrenia and bipolar disorderMarc De Hert
University Psychiatric Centre Catholic University Leuven campus Kortenberg, Leuvense Steenweg 517, 3070 Kortenberg, Belgium
Schizophr Res 126:270-6. 2011..Cannabis use may decrease age at onset in both schizophrenia and bipolar disorder, given the evidence for substantial phenotypic and genetic overlap between both disorders... - Anticholinergic use in hospitalised schizophrenic patients in BelgiumMarc De Hert
University Psychiatric Centre Katholieke Universiteit Leuven, campus Kortenberg, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
Psychiatry Res 152:165-72. 2007..However, there were no significant differences in the prevalence of EPS with the exception of akathisia between FGA and SGA. Thus, through the use of anticholinergics, EPS induced by FGA can be effectively reduced... - A case series: evaluation of the metabolic safety of aripiprazoleMarc De Hert
University Psychiatric Center Katholieke Universiteit Leuven, Leuvense Steenweg 517, 3070 Kortenberg, Belgium
Schizophr Bull 33:823-30. 2007..The MetS was reversed in 50% of patients at 3 months follow-up. Our results support the reversibility of recent onset diabetes on antipsychotic medication when detected early and followed by a switch to aripiprazole... - Guidelines for screening and monitoring of cardiometabolic risk in schizophrenia: systematic evaluationM De Hert
University Psychiatric Centre, KU Leuven, campus Kortenberg Leuvensesteenweg 517, 3070 Kortenberg, Belgium
Br J Psychiatry 199:99-105. 2011..Metabolic and cardiovascular health problems have become a major focus for clinical care and research in schizophrenia... - Do antipsychotic medications reduce or increase mortality in schizophrenia? A critical appraisal of the FIN-11 studyMarc De Hert
University Psychiatric Center, Catholic University Leuven, campus Kortenberg, Belgium
Schizophr Res 117:68-74. 2010.... - Prevalence and severity of antipsychotic related constipation in patients with schizophrenia: a retrospective descriptive studyMarc De Hert
University Psychiatric Centre Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
BMC Gastroenterol 11:17. 2011..They also have a number of side-effects. Constipation is thought to be common, and a potential serious side-effect, which has received little attention in recent literature... - Oral glucose tolerance tests in treated patients with schizophrenia. Data to support an adaptation of the proposed guidelines for monitoring of patients on second generation antipsychotics?Marc De Hert
University Centre Sint Jozef, Katholieke Universiteit Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
Eur Psychiatry 21:224-6. 2006..A recent consensus conference has proposed guidelines for the monitoring for diabetes in patients with schizophrenia and also identifies the need of long-term prospective studies... - Prevalence of the metabolic syndrome in patients with schizophrenia treated with antipsychotic medicationMarc A De Hert
University Center St Jozef, Catholic University Louvain, Leuvense Steenweg 517, 3070 Kortenberg, Belgium
Schizophr Res 83:87-93. 2006..The presence of the metabolic syndrome is an important risk factor for cardiovascular disease and diabetes. There are limited data on the prevalence of the metabolic syndrome in European patients suffering from schizophrenia... - Evaluation of the association between insight and symptoms in a large sample of patients with schizophreniaM A F De Hert
University Psychiatric Centre, Catholic University Leuven campus Kortenberg, Leuvense Steenweg 517, Kortenberg, Belgium
Eur Psychiatry 24:507-12. 2009..The objective of the present study was to examine the association of insight into the illness with demographic variables and symptomatology in a sample of 1213 patients with schizophrenia... - Metabolic and endocrine adverse effects of second-generation antipsychotics in children and adolescents: A systematic review of randomized, placebo controlled trials and guidelines for clinical practiceM De Hert
Centre Catholic University Leuven, campus Kortenberg, Leuvensesteenweg 517, Kortenberg, Belgium
Eur Psychiatry 26:144-58. 2011..A good collaboration between child- and adolescent psychiatrists, general practitioners and paediatricians is essential to maximize overall outcomes and to reduce the likelihood of premature cardiovascular morbidity and mortality... - Second-generation antipsychotics and constipation: a review of the literatureM De Hert
University Psychiatric Centre, campus Kortenberg, Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
Eur Psychiatry 26:34-44. 2011..Active screening, monitoring and treatment are recommended. Further research on incidence, prevalence, underlying mechanisms and preventive measures is required... - Metabolic parameters in the short- and long-term treatment of schizophrenia with sertindole or risperidoneMarc De Hert
University Psychiatric Center Catholic University Leuven, UPC KUL Campus Kortenberg, Leuvensesteenweg 517, Kortenberg, Belgium
Eur Arch Psychiatry Clin Neurosci 261:231-9. 2011..Treatment with either sertindole or risperidone did not appear to be associated with an increased comparative risk of developing metabolic syndrome. In general, the metabolic effects of sertindole and risperidone were similar... - Physical health management in psychiatric settingsM De Hert
University Psychiatric Center, Katholieke Universiteit Leuven, campus Kortenberg, Leuvensesteenweg 517, B 3070 Kortenberg, Belgium
Eur Psychiatry 25:S22-8. 2010..This paper describes the practical aspects of this monitoring protocol and the results obtained 4 years after its implementation... - Major changes in glucose metabolism, including new-onset diabetes, within 3 months after initiation of or switch to atypical antipsychotic medication in patients with schizophrenia and schizoaffective disorderRuud van Winkel
University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium
J Clin Psychiatry 69:472-9. 2008..To investigate 3-month changes in glucose metabolism in a naturalistic sample of patients with schizophrenia newly started on or switched to specific atypical antipsychotic medication therapy... - Lack of physical activity during leisure time contributes to an impaired health related quality of life in patients with schizophreniaDavy Vancampfort
University Psychiatric Centre Catholic University Leuven, campus Kortenberg, Kortenberg, Belgium
Schizophr Res 129:122-7. 2011..We also evaluated whether the presence of metabolic syndrome (MetS) could explain the variability in HRQL in patients... - Prevalence of diabetes and the metabolic syndrome in a sample of patients with bipolar disorderRuud van Winkel
University Psychiatric Center Katholieke Universiteit Leuven, Kortenberg, Belgium
Bipolar Disord 10:342-8. 2008..There are limited data on the prevalence of the metabolic abnormalities in disorders other than schizophrenia in which antipsychotic medication is part of routine treatment... - Psychiatric diagnosis as an independent risk factor for metabolic disturbances: results from a comprehensive, naturalistic screening programRuud van Winkel
University Psychiatric Center Catholic University Leuven, Kortenberg, Belgium
J Clin Psychiatry 69:1319-27. 2008..Unconfounded differences in inherent vulnerability to metabolic disturbance may be hypothesized for different diagnostic groups with severe mental illness... - Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysisMarc De Hert
University Psychiatric Centre, Catholic University Leuven, Kortenberg, Belgium
CNS Drugs 26:733-59. 2012..However, until now, the metabolic risk profile of the newly approved SGAs - asenapine, iloperidone, lurasidone and paliperidone (paliperidone extended release and paliperidone palmitate) - has not been compared... - Differential effects of olanzapine and risperidone on plasma adiponectin levels over time: results from a 3-month prospective open-label studyMartien Wampers
University Psychiatric Centre Catholic University Leuven, campus Kortenberg, Kortenberg, Belgium
Eur Neuropsychopharmacol 22:17-26. 2012..The observed olanzapine-associated reduction in plasma adiponectin levels may at least partially contribute to the increased metabolic risk of olanzapine compared to risperidone... - Body weight and self-esteem in patients with schizophrenia evaluated with B-WISEMarc De Hert
University Psychiatric Center Katholieke Universiteit Leuven, Leuvense Steenweg 517, 3070 Kortenberg, Belgium
Schizophr Res 88:222-6. 2006..The second objective was to explore the association of B-WISE scores with the metabolic syndrome and glucose abnormalities... - State anxiety, psychological stress and positive well-being responses to yoga and aerobic exercise in people with schizophrenia: a pilot studyDavy Vancampfort
Faculty of Kinesiology and Rehabilitation Sciences, Catholic University Leuven, Leuven, Belgium
Disabil Rehabil 33:684-9. 2011.... - Metabolic syndrome and metabolic abnormalities in bipolar disorder: a meta-analysis of prevalence rates and moderatorsDavy Vancampfort
University Psychiatric Centre KU Leuven, campus Kortenberg, Kortenberg, Belgium
Am J Psychiatry 170:265-74. 2013..The authors sought to clarify the prevalence and moderators of metabolic syndrome in bipolar patients, accounting for subgroup differences... - Quality assessment of physical activity recommendations within clinical practice guidelines for the prevention and treatment of cardio-metabolic risk factors in people with schizophreniaDavy Vancampfort
University Psychiatric Centre Catholic University Leuven, campus Kortenberg, Leuvensesteenweg 517, Kortenberg, Belgium
Community Ment Health J 47:703-10. 2011..High quality recommendations are highly needed along with specific practical advice for persons with schizophrenia, family members and health care professionals... - Considering a frame of reference for physical activity research related to the cardiometabolic risk profile in schizophreniaDavy Vancampfort
University Psychiatric Center, Catholic University Leuven, campus Kortenberg, Belgium
Psychiatry Res 177:271-9. 2010..More research is needed to assist in the practical development of effective evidence-based preventive and curative strategies in psychiatric services for metabolic syndrome in persons with schizophrenia... - Metabolic control in patients with schizophrenia treated with amisulpride or olanzapineJoseph Peuskens
UPC Katholieke Universiteit Leuven, campus Kortenberg, Kortenberg, Belgium
Int Clin Psychopharmacol 22:145-52. 2007..This should be taken into account in assessing risk-benefit of treatment options in schizophrenia... - Walking capacity is associated with health related quality of life and physical activity level in patients with schizophrenia: a preliminary reportAna Martín-Sierra
University Psychiatric Centre K U Leuven, campus Kortenberg, Belgium
Actas Esp Psiquiatr 39:211-6. 2011..To examine walking capacity in patients with schizophrenia and the relation with quality of life and physical activity level... - Effects of progressive muscle relaxation on state anxiety and subjective well-being in people with schizophrenia: a randomized controlled trialDavy Vancampfort
University Psychiatric Centre Catholic University Leuven, campus Kortenberg, Kortenberg, Belgium
Clin Rehabil 25:567-75. 2011..To examine the efficacy of a single progressive muscle relaxation session compared with a control condition on state anxiety, psychological stress, fatigue and subjective well-being in patients with schizophrenia... - Relationships between physical fitness, physical activity, smoking and metabolic and mental health parameters in people with schizophreniaDavy Vancampfort
University Psychiatric Centre Catholic University Leuven, campus Kortenberg, Kortenberg, Belgium Faculty of Kinesiology and Rehabilitation Sciences, Catholic University Leuven, Heverlee, Belgium Electronic address
Psychiatry Res 207:25-32. 2013..Less physically active patients who smoke and suffer from high levels of negative, depressive and/or cognitive symptoms might benefit from specific rehabilitation interventions aimed at increasing physical fitness... - Metabolic and cardiovascular adverse effects associated with antipsychotic drugsMarc De Hert
University Psychiatric Center, Catholic University Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium marc de hert uc kortenberg be
Nat Rev Endocrinol 8:114-26. 2012.... - A review of physical activity correlates in patients with bipolar disorderDavy Vancampfort
University Psychiatric Center, Catholic University Leuven, campus Kortenberg, Kortenberg, Belgium
J Affect Disord 145:285-91. 2013..The present review evaluates systematically quantitative studies of correlates of physical activity in patients with bipolar disorder... - International Organization of Physical Therapy in Mental Health consensus on physical activity within multidisciplinary rehabilitation programmes for minimising cardio-metabolic risk in patients with schizophreniaDavy Vancampfort
University Psychiatric Centre Catholic University Leuven, Kortenberg, Belgium
Disabil Rehabil 34:1-12. 2012..The aim of this paper is to improve physical activity (PA) within rehabilitation programmes for people with schizophrenia... - Metabolic abnormalities associated with second generation antipsychotics: fact or fiction? Development of guidelines for screening and monitoringMarc De Hert
Universitair Centrum Sint Jozef, Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
Int Clin Psychopharmacol 21:S11-5. 2006.... - Reliability, minimal detectable changes, practice effects and correlates of the 6-min walk test in patients with schizophreniaDavy Vancampfort
University Psychiatric Center, Catholic University Leuven, campus Kortenberg, Kortenberg, Belgium
Psychiatry Res 187:62-7. 2011..The 6 MWT can be recommended for evaluating the functional exercise capacity in patients with schizophrenia. Some practice effect could however not be excluded... - Age at onset of psychotic disorder: cannabis, BDNF Val66Met, and sex-specific models of gene-environment interactionJeroen Decoster
University Psychiatric Centre Catholic University Leuven, Kortenberg, Belgium
Am J Med Genet B Neuropsychiatr Genet 156:363-9. 2011..No compelling evidence was found that BDNF genotype is associated with age at onset of psychotic disorder in the absence of cannabis use... - Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress in psychosis: an experience-sampling studyRuud van Winkel
University Psychiatric Center Katholieke Universiteit Leuven, Leuvensesteenweg, Kortenberg, Belgium
Am J Med Genet B Neuropsychiatr Genet 147:10-7. 2008.... - Progressive muscle relaxation in persons with schizophrenia: a systematic review of randomized controlled trialsDavy Vancampfort
1University Psychiatric Centre Catholic University Leuven, campus Kortenberg, Kortenberg, Belgium
Clin Rehabil 27:291-8. 2013..Conclusion: Progressive muscle relaxation might be a useful add-on treatment to reduce state anxiety and psychological distress and improve subjective well-being in persons with schizophrenia... - Genetic association study of the P300 endophenotype in schizophreniaJeroen Decoster
Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
Schizophr Res 141:54-9. 2012..This study aims to examine associations between P300 and a range of candidate genetic variants, selected from either candidate gene studies or genome-wide association studies, in a large sample of patients with schizophrenia... - Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice dataCarla Truyers
Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium
BMC Fam Pract 12:132. 2011..Many studies are performed in specialized settings with a strong focus on schizophrenia. Somatic comorbidity after psychosis is studied, using a general practice comorbidity registration network... - Systematic review of the benefits of physical therapy within a multidisciplinary care approach for people with schizophreniaDavy Vancampfort
Faculty of Kinesiology and Rehabilitation Sciences, Catholic University Leuven, Leuven, Belgium
Phys Ther 92:11-23. 2012..Although schizophrenia is the fifth leading cause of disability-adjusted life years worldwide in people aged 15 to 44 years, the clinical evidence of physical therapy as a complementary treatment remains largely unknown... - Premorbid IQ as a predictor for the course of IQ in first onset patients with schizophrenia: a 10-year follow-up studyRuud van Winkel
University Psychiatric Center Katholieke Universiteit Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
Schizophr Res 88:47-54. 2006..Rather, catching up of cognitive function later in the course of the illness may take place in those whose deficits become apparent in the early phases of illness, whereas those with the most severe premorbid impairments remain stable... - CNR1 gene and risk of the metabolic syndrome in patients with schizophreniaWeiping Yu
University Psychiatric Center Campus Kortenberg, Katholieke University Leuven, Kortenberg, Belgium
J Clin Psychopharmacol 33:186-92. 2013..Further studies are needed to uncover the exact molecular basis for this association, which could provide novel treatment targets for the MetS... - An impaired health related muscular fitness contributes to a reduced walking capacity in patients with schizophrenia: a cross-sectional studyDavy Vancampfort
University Psychiatric Centre Catholic University Leuven, campus Kortenberg, Kortenberg, Belgium
BMC Psychiatry 13:5. 2013..Secondly, we identified variables that could explain the variability in walking capacity and in health related muscular fitness in patients with schizophrenia... - Associations between sedentary behaviour and metabolic parameters in patients with schizophreniaDavy Vancampfort
University Psychiatric Centre Catholic University Leuven, campus Kortenberg, Kortenberg, Belgium
Psychiatry Res 200:73-8. 2012..A stepwise backward-elimination multivariate regression analysis demonstrated that sitting time is a significant predictor for BMI. Current results suggest patients with schizophrenia may benefit from reducing total sitting time... - Metabolic syndrome in people with schizophrenia: a reviewMarc De Hert
University Psychiatric Center, Catholic University Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
World Psychiatry 8:15-22. 2009..The somatic treatments offered to people with severe and enduring mental illness should be at par with general health care in the non-psychiatrically ill population... - Safe ECT in a patient with the Ehlers-Danlos syndromePascal Sienaert
ECT Department, University Centre Sint Jozef, Leuvensesteenweg, Kortenberg, Belgium
J ECT 19:230-3. 2003..Even without specific measures to lower blood pressure, a course of ECT was finished without any complication... - Glucose abnormalities in a non-psychotic patient treated with risperidoneKristel Lauwers
J Am Acad Child Adolesc Psychiatry 44:629-30. 2005 - Stereotypy in schizophreniaManuel Morrens
Collaborative Antwerp Psychiatric Research Institute CAPRI, Building A, Campus Drie Eiken, Universiteitsplein 1, B 2610 Antwerp Wilrijk, Belgium
Schizophr Res 84:397-404. 2006..We used a newly designed computerized version of the Zeigeversuch, the Stereotypy Test Apparatus (STA) to evaluate the evolution of STA performance through the course of the illness... - Usefulness of glycosylated haemoglobin (HbA1c) to screen for diabetes in patients with schizophreniaLinda Hanssens
Schizophr Res 85:296-7. 2006 - Comorbid somatic illnesses in patients with severe mental disorders: clinical, policy, and research challengesW Wolfgang Fleischhacker
Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria
J Clin Psychiatry 69:514-9. 2008.... - Pharmacological treatment of severe dyslipidaemia in patients with schizophreniaLinda Hanssens
Department of Epidemiology and Public Health, Nutrition and Metabolic Disorders CHU Sart Tilman, University Liege, Liege, Belgium
Int Clin Psychopharmacol 22:43-9. 2007..Statins proved effective in the management of dyslipidaemia in patients with schizophrenia treated with antipsychotics. More complex treatment may be required for associated metabolic disturbances... - Magnetization transfer imaging in chronic schizophreniaAneta Antosik-Biernacka
Department of Radiology, Medical University of Łódź, Łódź, Poland
Med Sci Monit 12:MT17-21. 2006..The aim of the study was to investigate whether MTI, analyzed on a voxel-by-voxel basis, could identify areas of abnormal magnetization transfer ratio (MTR) in patients with schizophrenia... - The generic alternative in schizophrenia: opportunity or threat?Philippe Nuss
Psychiatry Department, Hopital St Antoine, Paris 75012, France
CNS Drugs 18:769-75. 2004.... - The five-factor model of the Positive and Negative Syndrome Scale II: a ten-fold cross-validation of a revised modelMark van der Gaag
Parnassia Psychiatric Institute, Oude Haagweg 353, The Hague, The Netherlands
Schizophr Res 85:280-7. 2006..Complex means that symptoms can have multiple factor loadings, because they have multiple causes, not because they are ill defined. Stable means that the complex structure is found repeatedly in validations... - The five-factor model of the Positive and Negative Syndrome Scale I: confirmatory factor analysis fails to confirm 25 published five-factor solutionsMark van der Gaag
Parnassia Psychiatric Institute, Oude Haagweg 353, The Hague, The Netherlands
Schizophr Res 85:273-9. 2006..The aim of this study was to test the goodness-of-fit of all previously published five-factor models of the Positive and Negative Syndrome Scale (PANSS)...