Research Topics
Genomes and Genes | Kris De BoeckSummaryAffiliation: Katholieke Universiteit Leuven Country: Belgium Publications
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Publications
Quality assessment of expert answers to lay questions about cystic fibrosis from various language zones in Europe: the ECORN-CF projectDaniela D'Alquen
Department of Pediatrics, University Hospital Wuerzburg, Josef Schneider Str, 2, 97080 Wuerzburg, Germany
BMC Med Res Methodol 12:11. 2012....
Treatment of Pseudomonas aeruginosa lung infection in cystic fibrosis with high or conventional doses of ceftazidimeK De Boeck
Department of Pediatrics, University Hospital of Leuven, Belgium
J Antimicrob Chemother 41:407-9. 1998..E.M. 8% +/- 2% vs 2% +/- 1 %; P < 0.01). All but one of the ALT values after treatment were within normal limits...- Mucociliary transport using 99mTc-albumin colloid: a reliable screening test for primary ciliary dyskinesiaK De Boeck
Department of Pediatrics, University of Leuven, Belgium
Thorax 60:414-7. 2005.... - Cystic fibrosis: terminology and diagnostic algorithmsK De Boeck
Department of Pediatrics, Pediatric Pulmonology, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
Thorax 61:627-35. 2006..Non-classic CF includes patients with multiorgan or single organ involvement. Most of these patients have exocrine pancreatic sufficiency and milder lung disease. Algorithms for a structured diagnostic process are proposed... - Pancreatitis among patients with cystic fibrosis: correlation with pancreatic status and genotypeKris De Boeck
University Hospital, Leuven, Belgium
Pediatrics 115:e463-9. 2005.... - Epidemiology of Burkholderia cepacia complex colonisation in cystic fibrosis patientsK De Boeck
University Hospital Gasthuisberg, Leuven, Belgium
Eur Respir J 23:851-6. 2004..The cross-infection rate is low. Three patients had transient colonisation. The impact of Burkholderia cepacia complex on morbidity in the Belgian cystic fibrosis population is high and not limited to Burkholderia cenocepacia... 
New clinical diagnostic procedures for cystic fibrosis in EuropeK De Boeck
Department of Pediatrics, University Hospital of Leuven, Leuven, Belgium
J Cyst Fibros 10:S53-66. 2011..New approaches to evaluate the sweat gland, future of genetic testing and methods on the horizon like CFTR expression in human leucocytes and erythrocytes are discussed briefly...- Introduction to Section I: the relevance of CF diagnostic tools for measuring restoration of CFTR function after therapeutic interventions in human clinical trialsKris De Boeck
Department of Pediatrics, University of Leuven, Leuven, Belgium
Methods Mol Biol 741:3-11. 2011..It is hoped that lessons learned through the use of these measures will inform the future development of other robust methods to assess novel therapeutic strategies uncovered by basic scientists... - Do inhaled corticosteroids impair long-term growth in prepubertal cystic fibrosis patients?Kris De Boeck
Department of Pediatric Pulmonology and Cystic Fibrosis Clinic, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
Eur J Pediatr 166:23-8. 2007..01 (0.07) in the placebo group (p<0.003, ANOVA). No catch-up growth was noted 1-2 years after discontinuation of inhaled steroids. The use of high-dose ICS in CF patients with mild lung disease may lead to persistent growth impairment... - Coprescription of antibiotics and asthma drugs in childrenKris De Boeck
Department of Pediatric Pulmonology and Infectious Diseases, University Hospital of Leuven, Leuven, Belgium
Pediatrics 127:1022-6. 2011..In children, antibiotics as well as asthma drugs are frequently prescribed. We investigated the effects of the codispensing of antibiotics and asthma drugs to children... - Coexistence of (partial) immune defects and risk of recurrent respiratory infectionsXavier Bossuyt
Department of Laboratory Medicine, University Hospital Leuven, Leuven, Belgium
Clin Chem 53:124-30. 2007..We studied whether and to what extent immunologic and genetic factors are associated with increased susceptibility to respiratory infections... - Laboratory diagnosis of specific antibody deficiency to pneumococcal capsular polysaccharide antigens by multiplexed bead assayHeleen Borgers
Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Biomedical Sciences Group, Catholic University Leuven, Leuven, Belgium
Clin Immunol 134:198-205. 2010..The XMAP pneumococcal immunity panel appears useful for identifying individuals with a low response to the unconjugated pneumococcal vaccine... - Human memory B lymphocyte subsets fulfill distinct roles in the anti-polysaccharide and anti-protein immune responseLeen Moens
Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Group Biomedical Sciences, Catholic University, Leuven, Belgium
J Immunol 181:5306-12. 2008..pneumoniae or soluble pneumococcal capsular polysaccharides. In conclusion, our findings provide evidence for a versatile role of IgM memory B cells in T-independent and T-dependent immune responses... - Complicated parapneumonic effusion in Belgian children: increased occurrence before routine pneumococcal vaccine implementationTine Van Ackere
Department of Pediatrics, University Hospital of Leuven, Herestraat 49, 3000, Leuven, Belgium
Eur J Pediatr 168:51-8. 2009..This increase is pronounced from 2003 onwards (late cohort) and, thus, occurred later than that reported in the UK and USA; several parameters point towards the occurrence of more serious disease in the late cohort patients... - Phenotypic characterisation of patients with intermediate sweat chloride values: towards validation of the European diagnostic algorithm for cystic fibrosisC Goubau
Department of Paediatrics, Paediatric Pulmonology, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
Thorax 64:683-91. 2009.... - Serum procalcitonin is not an early marker of pulmonary exacerbation in children with cystic fibrosisJacoba Johanna Louw
Catholic University of Leuven, Leuven, Belgium
Eur J Pediatr 171:139-42. 2012..In CF children, PCT values do not rise significantly at the onset of a respiratory exacerbation and thus hold no promise as an early marker to identify a pulmonary exacerbation... - What's new in cystic fibrosis? From treating symptoms to correction of the basic defectMarijke Proesmans
Department of Pediatrics, University Hospital of Leuven, Herestraat 49, 3000, Leuven, Belgium
Eur J Pediatr 167:839-49. 2008.... - Exhaled nitric oxide corresponds with office evaluation of asthma controlIsabelle Meyts
Pediatric Pulmonology Department, University Hospital Gasthuisberg Leuven, Herestraat 49, 3000 Leuven, Belgium
Pediatr Pulmonol 36:283-9. 2003..These results suggest that ENO measurements may be useful for monitoring asthma patients... - Toll-like receptor 2 and Toll-like receptor 4 polymorphisms in invasive pneumococcal diseaseLeen Moens
Department of Laboratory Medicine, University Hospital Leuven, Centraal Dienstengebouw, Herestraat 49, B 3000 Leuven, Belgium
Microbes Infect 9:15-20. 2007..Studies have revealed associations between polymorphisms in TLRs and human diseases. The effect of polymorphisms in TLR2 and TLR4 in the human defense to S. pneumoniae has not been studied... - Nasal potential measurements on the nasal floor and under the inferior turbinate: does it matter?Francois Vermeulen
Cystic Fibrosis Reference Centre, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
Pediatr Pulmonol 46:145-52. 2011..Several methods are used to measure NPD. This study explores the influence of the site of measurement and compares NPD results obtained on the nasal floor and under the inferior turbinate... - Omeprazole, a proton pump inhibitor, improves residual steatorrhoea in cystic fibrosis patients treated with high dose pancreatic enzymesMarijke Proesmans
Department of Paediatrics, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
Eur J Pediatr 162:760-3. 2003..001). CONCLUSION: Omeprazole improves fat digestion and absorption in cystic fibrosis patients with residual faecal fat loss despite maximal pancreatic enzyme substitution... - Airway clearance techniques to treat acute respiratory disorders in previously healthy children: where is the evidence?Kris De Boeck
Department of Paediatrics, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
Eur J Pediatr 167:607-12. 2008..Physicians routinely prescribing airway clearance techniques in previously healthy children should question their practice... - Real life evaluation of intravenous antibiotic treatment in a paediatric cystic fibrosis centre: outcome of home therapy is not inferiorM Proesmans
Department of Pediatrics, Pediatric Pulmonology, Cystic Fibrosis Centre, University Hospital of Leuven, Herestraat 49, B 3000 Leuven, Belgium
Respir Med 103:244-50. 2009..Limited data exist on the efficacy and safety of home intravenous antibiotic (IV-AB) therapy for pulmonary infection specifically in children with cystic fibrosis (CF)... - Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like diseaseAbul Kalam Azad
Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium
Hum Mutat 30:1093-103. 2009..W493R-SCNN1A mutation and a cystic fibrosis transmembrane conductance regulator (CFTR) gene that results in very low amounts (0-10%) functional CFTR. These ENaC/CFTR genotypes may play a hitherto unrecognized role in lung diseases... - Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patientsAnn Decraene
Laboratory of Pneumology, KULeuven, Herestraat, Leuven, Belgium
Respir Res 11:177. 2010.... - Guideline on the design and conduct of cystic fibrosis clinical trials: the European Cystic Fibrosis Society-Clinical Trials Network (ECFS-CTN)K De Boeck
Department of Pediatrics, University Hospital of Leuven, Leuven, Belgium
J Cyst Fibros 10:S67-74. 2011..A strong partnership with European CF patient parent organizations aims to increase awareness of the need for efficient clinical research and the participation of patients in clinical trials... - Lung transplantation in cystic fibrosis normalizes essential fatty acid profilesPeter Witters
Department of Paediatrics, University Hospitals Leuven, Kathollieke Universiteit Leuven, Leuven, Belgium Liver Facility, Katholieke Universiteit Leuven, Leuven, Belgium Electronic address
J Cyst Fibros 12:222-8. 2013..However, the mechanisms leading to these disturbances remain elusive. We wanted to investigate the role of the diseased CF lung on fatty acid profiles... - Impact of air pollution on cystic fibrosis pulmonary exacerbations: a case-crossover analysisPieter C Goeminne
Department of Lung Disease, UZ Leuven, Leuven, Belgium
Chest 143:946-54. 2013..Our aim was to evaluate whether exacerbations, defi ned by antibiotic use, were triggered by daily fl uctuations in air pollution... - Unusual and severe disease course in a child with ataxia-telangiectasiaIsabelle Meyts
University Hospital Gasthuisberg Leuven, Pediatric Department, Herestraat 49, 3000 Leuven, Belgium
Pediatr Allergy Immunol 14:330-3. 2003..At the age of 26 months she developed persistent fever, progressive lymphadenopathy and pulmonary nodular infiltrates, which were responsive to steroid therapy... - Tidal off-line exhaled nitric oxide measurements in a pre-school populationIsabelle Meyts
Paediatric Pulmonology Department, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
Eur J Pediatr 162:506-10. 2003..With this method, higher tidal exhaled nitric oxide levels were found in children with recurrent wheezing... - A 1-year old girl with fever and a unilateral swelling of the jawBrita de Jong
Department of Paediatrics, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
Eur J Pediatr 163:179-80. 2004 - IL-12 contributes to allergen-induced airway inflammation in experimental asthmaIsabelle Meyts
Laboratory of Experimental Immunology, University Hospitals, Faculty of Medicine, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
J Immunol 177:6460-70. 2006..IFN-gamma-producing cells or cells dependent on IFN-gamma activity, play a major role in this unexpected proinflammatory effect of IL-12 in allergic airway disease... - Fcgamma-receptor IIA genotype and invasive pneumococcal infectionLeen Moens
Department of Laboratory Medicine, University Hospital Leuven, Centraal Dienstengebouw, Herestraat 49, B 3000 Leuven, Belgium
Clin Immunol 118:20-3. 2006..In contrast to previous reports, we found no association between Fcgamma-RIIA genotype and invasive pneumococcal disease... - Primary ciliary dyskinesia, an orphan diseaseMieke Boon
Department of Pediatric Pulmonology, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
Eur J Pediatr 172:151-62. 2013..CONCLUSION: Respiratory infections, situs inversus and male infertility are typical manifestations of PCD, a rare autosomal recessive disorder... - Massive lung collapse with partial resolution after several years: a case reportElke Govaere
Dept of Pediatrics, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
BMC Pediatr 5:39. 2005..Of the rare cases reported in the literature all surviving children underwent surgical resection of the collapsed lung... - Distribution of human beta-defensin polymorphisms in various control and cystic fibrosis populationsAnne Vankeerberghen
Department of Human Genetics, KULeuven, Herestraat 49, O and N6, 3000 Louvain, Belgium
Genomics 85:574-81. 2005..No association with the age of first infection by Pseudomonas aeruginosa or with the FEV1 percentage at the age of 11-13 years could be found... - Clinical practice: treatment of childhood empyemaMarijke Proesmans
Department of Pediatric Pulmonology, UZ Leuven, Leuven, Belgium
Eur J Pediatr 168:639-45. 2009..Each referral center should agree on a diagnostic and therapeutic flowchart based on current evidence and local expertise. The flow chart outlined for our center is presented... - Survey of Pseudomonas aeruginosa genotypes in colonised cystic fibrosis patientsS Van Daele
Cystic Fibrosis Centre, University Hospital Ghent, 5K6, De Pintelaan 185, 9000 Gent, Belgium
Eur Respir J 28:740-7. 2006..The number of clusters is limited, and most patients seem to retain the same genotypic strain during both years... - National survey of molecular epidemiology of Staphylococcus aureus colonization in Belgian cystic fibrosis patientsA Vergison
Department of Pediatric Infectious Diseases, Hospital Epidemiology and Infection Control Unit, Universite Libre de Bruxelles, Hôpital des Enfants Reine Fabiola, Brussels, Belgium
J Antimicrob Chemother 59:893-9. 2007..We conducted a multicentre survey to determine the prevalence of S. aureus and MRSA colonization in Belgian CF patients and characterize the phenotype and clonal distribution of their staphylococcal strains... - [The pneumology department]P De Vuyst
Rev Med Brux 23:151-4. 2002..The following expertise fields have been largely developed: lung transplantation, treatment of cystic fibrosis in collaboration with the children's hospital Reine Fabiola, occupational... - Clostridium difficile colitis in cystic fibrosis patients with and without lung transplantationC Theunissen
Department of Infectious Diseases, Erasme University Hospital, Brussels, Belgium
Transpl Infect Dis 10:240-4. 2008..difficile-associated disease (CDAD) is rather rare. In case of lung transplantation, the incidence and clinical aspects of CDAD in this patient population are not well known... - Preferential reduction of quadriceps over respiratory muscle strength and bulk after lung transplantation for cystic fibrosisC Pinet
Department of Chest Medicine, Erasme University Hospital, Brussels, Belgium
Thorax 59:783-9. 2004..This atrophy is caused in part by corticosteroid therapy and correlates with the reduction in exercise capacity...