Kris De Boeck

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc Quality assessment of expert answers to lay questions about cystic fibrosis from various language zones in Europe: the ECORN-CF project
    Daniela D'Alquen
    Department of Pediatrics, University Hospital Wuerzburg, Josef Schneider Str, 2, 97080 Wuerzburg, Germany
    BMC Med Res Methodol 12:11. 2012
  2. ncbi request reprint Treatment of Pseudomonas aeruginosa lung infection in cystic fibrosis with high or conventional doses of ceftazidime
    K De Boeck
    Department of Pediatrics, University Hospital of Leuven, Belgium
    J Antimicrob Chemother 41:407-9. 1998
  3. ncbi request reprint Do inhaled corticosteroids impair long-term growth in prepubertal cystic fibrosis patients?
    Kris De Boeck
    Department of Pediatric Pulmonology and Cystic Fibrosis Clinic, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 166:23-8. 2007
  4. pmc Cystic fibrosis: terminology and diagnostic algorithms
    K De Boeck
    Department of Pediatrics, Pediatric Pulmonology, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Thorax 61:627-35. 2006
  5. doi request reprint Introduction to Section I: the relevance of CF diagnostic tools for measuring restoration of CFTR function after therapeutic interventions in human clinical trials
    Kris De Boeck
    Department of Pediatrics, University of Leuven, Leuven, Belgium
    Methods Mol Biol 741:3-11. 2011
  6. pmc Mucociliary transport using 99mTc-albumin colloid: a reliable screening test for primary ciliary dyskinesia
    K De Boeck
    Department of Pediatrics, University of Leuven, Belgium
    Thorax 60:414-7. 2005
  7. doi request reprint Coprescription of antibiotics and asthma drugs in children
    Kris De Boeck
    Department of Pediatric Pulmonology and Infectious Diseases, University Hospital of Leuven, Leuven, Belgium
    Pediatrics 127:1022-6. 2011
  8. ncbi request reprint Pancreatitis among patients with cystic fibrosis: correlation with pancreatic status and genotype
    Kris De Boeck
    University Hospital, Leuven, Belgium
    Pediatrics 115:e463-9. 2005
  9. ncbi request reprint Epidemiology of Burkholderia cepacia complex colonisation in cystic fibrosis patients
    K De Boeck
    University Hospital Gasthuisberg, Leuven, Belgium
    Eur Respir J 23:851-6. 2004
  10. doi request reprint New clinical diagnostic procedures for cystic fibrosis in Europe
    K De Boeck
    Department of Pediatrics, University Hospital of Leuven, Leuven, Belgium
    J Cyst Fibros 10:S53-66. 2011

Detail Information

Publications43

  1. pmc Quality assessment of expert answers to lay questions about cystic fibrosis from various language zones in Europe: the ECORN-CF project
    Daniela D'Alquen
    Department of Pediatrics, University Hospital Wuerzburg, Josef Schneider Str, 2, 97080 Wuerzburg, Germany
    BMC Med Res Methodol 12:11. 2012
    ....
  2. ncbi request reprint Treatment of Pseudomonas aeruginosa lung infection in cystic fibrosis with high or conventional doses of ceftazidime
    K De Boeck
    Department of Pediatrics, University Hospital of Leuven, Belgium
    J Antimicrob Chemother 41:407-9. 1998
    ..E.M. 8% +/- 2% vs 2% +/- 1 %; P < 0.01). All but one of the ALT values after treatment were within normal limits...
  3. ncbi request reprint Do inhaled corticosteroids impair long-term growth in prepubertal cystic fibrosis patients?
    Kris De Boeck
    Department of Pediatric Pulmonology and Cystic Fibrosis Clinic, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 166:23-8. 2007
    ..01 (0.07) in the placebo group (p<0.003, ANOVA). No catch-up growth was noted 1-2 years after discontinuation of inhaled steroids. The use of high-dose ICS in CF patients with mild lung disease may lead to persistent growth impairment...
  4. pmc Cystic fibrosis: terminology and diagnostic algorithms
    K De Boeck
    Department of Pediatrics, Pediatric Pulmonology, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Thorax 61:627-35. 2006
    ..Non-classic CF includes patients with multiorgan or single organ involvement. Most of these patients have exocrine pancreatic sufficiency and milder lung disease. Algorithms for a structured diagnostic process are proposed...
  5. doi request reprint Introduction to Section I: the relevance of CF diagnostic tools for measuring restoration of CFTR function after therapeutic interventions in human clinical trials
    Kris De Boeck
    Department of Pediatrics, University of Leuven, Leuven, Belgium
    Methods Mol Biol 741:3-11. 2011
    ..It is hoped that lessons learned through the use of these measures will inform the future development of other robust methods to assess novel therapeutic strategies uncovered by basic scientists...
  6. pmc Mucociliary transport using 99mTc-albumin colloid: a reliable screening test for primary ciliary dyskinesia
    K De Boeck
    Department of Pediatrics, University of Leuven, Belgium
    Thorax 60:414-7. 2005
    ....
  7. doi request reprint Coprescription of antibiotics and asthma drugs in children
    Kris De Boeck
    Department of Pediatric Pulmonology and Infectious Diseases, University Hospital of Leuven, Leuven, Belgium
    Pediatrics 127:1022-6. 2011
    ..In children, antibiotics as well as asthma drugs are frequently prescribed. We investigated the effects of the codispensing of antibiotics and asthma drugs to children...
  8. ncbi request reprint Pancreatitis among patients with cystic fibrosis: correlation with pancreatic status and genotype
    Kris De Boeck
    University Hospital, Leuven, Belgium
    Pediatrics 115:e463-9. 2005
    ....
  9. ncbi request reprint Epidemiology of Burkholderia cepacia complex colonisation in cystic fibrosis patients
    K De Boeck
    University Hospital Gasthuisberg, Leuven, Belgium
    Eur Respir J 23:851-6. 2004
    ..The cross-infection rate is low. Three patients had transient colonisation. The impact of Burkholderia cepacia complex on morbidity in the Belgian cystic fibrosis population is high and not limited to Burkholderia cenocepacia...
  10. doi request reprint New clinical diagnostic procedures for cystic fibrosis in Europe
    K De Boeck
    Department of Pediatrics, University Hospital of Leuven, Leuven, Belgium
    J Cyst Fibros 10:S53-66. 2011
    ..New approaches to evaluate the sweat gland, future of genetic testing and methods on the horizon like CFTR expression in human leucocytes and erythrocytes are discussed briefly...
  11. ncbi request reprint Coexistence of (partial) immune defects and risk of recurrent respiratory infections
    Xavier Bossuyt
    Department of Laboratory Medicine, University Hospital Leuven, Leuven, Belgium
    Clin Chem 53:124-30. 2007
    ..We studied whether and to what extent immunologic and genetic factors are associated with increased susceptibility to respiratory infections...
  12. doi request reprint Laboratory diagnosis of specific antibody deficiency to pneumococcal capsular polysaccharide antigens by multiplexed bead assay
    Heleen Borgers
    Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Biomedical Sciences Group, Catholic University Leuven, Leuven, Belgium
    Clin Immunol 134:198-205. 2010
    ..The XMAP pneumococcal immunity panel appears useful for identifying individuals with a low response to the unconjugated pneumococcal vaccine...
  13. ncbi request reprint Human memory B lymphocyte subsets fulfill distinct roles in the anti-polysaccharide and anti-protein immune response
    Leen Moens
    Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Group Biomedical Sciences, Catholic University, Leuven, Belgium
    J Immunol 181:5306-12. 2008
    ..pneumoniae or soluble pneumococcal capsular polysaccharides. In conclusion, our findings provide evidence for a versatile role of IgM memory B cells in T-independent and T-dependent immune responses...
  14. doi request reprint Complicated parapneumonic effusion in Belgian children: increased occurrence before routine pneumococcal vaccine implementation
    Tine Van Ackere
    Department of Pediatrics, University Hospital of Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Pediatr 168:51-8. 2009
    ..This increase is pronounced from 2003 onwards (late cohort) and, thus, occurred later than that reported in the UK and USA; several parameters point towards the occurrence of more serious disease in the late cohort patients...
  15. doi request reprint Phenotypic characterisation of patients with intermediate sweat chloride values: towards validation of the European diagnostic algorithm for cystic fibrosis
    C Goubau
    Department of Paediatrics, Paediatric Pulmonology, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Thorax 64:683-91. 2009
    ....
  16. doi request reprint Serum procalcitonin is not an early marker of pulmonary exacerbation in children with cystic fibrosis
    Jacoba Johanna Louw
    Catholic University of Leuven, Leuven, Belgium
    Eur J Pediatr 171:139-42. 2012
    ..In CF children, PCT values do not rise significantly at the onset of a respiratory exacerbation and thus hold no promise as an early marker to identify a pulmonary exacerbation...
  17. ncbi request reprint Toll-like receptor 2 and Toll-like receptor 4 polymorphisms in invasive pneumococcal disease
    Leen Moens
    Department of Laboratory Medicine, University Hospital Leuven, Centraal Dienstengebouw, Herestraat 49, B 3000 Leuven, Belgium
    Microbes Infect 9:15-20. 2007
    ..Studies have revealed associations between polymorphisms in TLRs and human diseases. The effect of polymorphisms in TLR2 and TLR4 in the human defense to S. pneumoniae has not been studied...
  18. ncbi request reprint Exhaled nitric oxide corresponds with office evaluation of asthma control
    Isabelle Meyts
    Pediatric Pulmonology Department, University Hospital Gasthuisberg Leuven, Herestraat 49, 3000 Leuven, Belgium
    Pediatr Pulmonol 36:283-9. 2003
    ..These results suggest that ENO measurements may be useful for monitoring asthma patients...
  19. doi request reprint What's new in cystic fibrosis? From treating symptoms to correction of the basic defect
    Marijke Proesmans
    Department of Pediatrics, University Hospital of Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Pediatr 167:839-49. 2008
    ....
  20. ncbi request reprint Impact of air pollution on cystic fibrosis pulmonary exacerbations: a case-crossover analysis
    Pieter C Goeminne
    Department of Lung Disease, UZ Leuven, Leuven, Belgium
    Chest 143:946-54. 2013
    ..Our aim was to evaluate whether exacerbations, defi ned by antibiotic use, were triggered by daily fl uctuations in air pollution...
  21. doi request reprint Nasal potential measurements on the nasal floor and under the inferior turbinate: does it matter?
    Francois Vermeulen
    Cystic Fibrosis Reference Centre, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Pediatr Pulmonol 46:145-52. 2011
    ..Several methods are used to measure NPD. This study explores the influence of the site of measurement and compares NPD results obtained on the nasal floor and under the inferior turbinate...
  22. ncbi request reprint Omeprazole, a proton pump inhibitor, improves residual steatorrhoea in cystic fibrosis patients treated with high dose pancreatic enzymes
    Marijke Proesmans
    Department of Paediatrics, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 162:760-3. 2003
    ..001). CONCLUSION: Omeprazole improves fat digestion and absorption in cystic fibrosis patients with residual faecal fat loss despite maximal pancreatic enzyme substitution...
  23. doi request reprint Primary ciliary dyskinesia, an orphan disease
    Mieke Boon
    Department of Pediatric Pulmonology, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Pediatr 172:151-62. 2013
    ..Given the heterogeneity and the rarity of the disorder, therapy is not evidence-based. Many treatment schedules are proposed in analogy with the treatment for cystic fibrosis...
  24. pmc Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patients
    Ann Decraene
    Laboratory of Pneumology, KULeuven, Herestraat, Leuven, Belgium
    Respir Res 11:177. 2010
    ....
  25. doi request reprint Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease
    Abul Kalam Azad
    Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium
    Hum Mutat 30:1093-103. 2009
    ..W493R-SCNN1A mutation and a cystic fibrosis transmembrane conductance regulator (CFTR) gene that results in very low amounts (0-10%) functional CFTR. These ENaC/CFTR genotypes may play a hitherto unrecognized role in lung diseases...
  26. doi request reprint Airway clearance techniques to treat acute respiratory disorders in previously healthy children: where is the evidence?
    Kris De Boeck
    Department of Paediatrics, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 167:607-12. 2008
    ..Physicians routinely prescribing airway clearance techniques in previously healthy children should question their practice...
  27. doi request reprint Real life evaluation of intravenous antibiotic treatment in a paediatric cystic fibrosis centre: outcome of home therapy is not inferior
    M Proesmans
    Department of Pediatrics, Pediatric Pulmonology, Cystic Fibrosis Centre, University Hospital of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Respir Med 103:244-50. 2009
    ..Limited data exist on the efficacy and safety of home intravenous antibiotic (IV-AB) therapy for pulmonary infection specifically in children with cystic fibrosis (CF)...
  28. doi request reprint Guideline on the design and conduct of cystic fibrosis clinical trials: the European Cystic Fibrosis Society-Clinical Trials Network (ECFS-CTN)
    K De Boeck
    Department of Pediatrics, University Hospital of Leuven, Leuven, Belgium
    J Cyst Fibros 10:S67-74. 2011
    ..A strong partnership with European CF patient parent organizations aims to increase awareness of the need for efficient clinical research and the participation of patients in clinical trials...
  29. doi request reprint Comparison of lung clearance index measured during helium washin and washout in children with cystic fibrosis
    Francois Vermeulen
    University Hospital Leuven, Cystic Fibrosis Centre, Leuven, Belgium
    Pediatr Pulmonol 48:962-9. 2013
    ..This preliminary study compares results obtained from the washin and the washout phase of the multiple breath washout in CF children and healthy controls using an early commercially available device...
  30. doi request reprint Lung transplantation in cystic fibrosis normalizes essential fatty acid profiles
    Peter Witters
    Department of Paediatrics, University Hospitals Leuven, Kathollieke Universiteit Leuven, Leuven, Belgium Liver Facility, Katholieke Universiteit Leuven, Leuven, Belgium Electronic address
    J Cyst Fibros 12:222-8. 2013
    ..However, the mechanisms leading to these disturbances remain elusive. We wanted to investigate the role of the diseased CF lung on fatty acid profiles...
  31. ncbi request reprint A 1-year old girl with fever and a unilateral swelling of the jaw
    Brita de Jong
    Department of Paediatrics, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Pediatr 163:179-80. 2004
  32. ncbi request reprint IL-12 contributes to allergen-induced airway inflammation in experimental asthma
    Isabelle Meyts
    Laboratory of Experimental Immunology, University Hospitals, Faculty of Medicine, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Immunol 177:6460-70. 2006
    ..IFN-gamma-producing cells or cells dependent on IFN-gamma activity, play a major role in this unexpected proinflammatory effect of IL-12 in allergic airway disease...
  33. ncbi request reprint Tidal off-line exhaled nitric oxide measurements in a pre-school population
    Isabelle Meyts
    Paediatric Pulmonology Department, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 162:506-10. 2003
    ..6+/-1.9 ppb; 95%CI 14.5-22.7 ppb; t-test P<0.0001). Mean tENO in 16 children with a single wheezing episode was 11.4+/-1.0 ppb (95%CI 9.2-13.6 ppb) and thus significantly different from the recurrent wheezing group (t-test P=0.0024)...
  34. ncbi request reprint Fcgamma-receptor IIA genotype and invasive pneumococcal infection
    Leen Moens
    Department of Laboratory Medicine, University Hospital Leuven, Centraal Dienstengebouw, Herestraat 49, B 3000 Leuven, Belgium
    Clin Immunol 118:20-3. 2006
    ..In contrast to previous reports, we found no association between Fcgamma-RIIA genotype and invasive pneumococcal disease...
  35. ncbi request reprint Unusual and severe disease course in a child with ataxia-telangiectasia
    Isabelle Meyts
    University Hospital Gasthuisberg Leuven, Pediatric Department, Herestraat 49, 3000 Leuven, Belgium
    Pediatr Allergy Immunol 14:330-3. 2003
    ..At the age of 26 months she developed persistent fever, progressive lymphadenopathy and pulmonary nodular infiltrates, which were responsive to steroid therapy...
  36. ncbi request reprint Distribution of human beta-defensin polymorphisms in various control and cystic fibrosis populations
    Anne Vankeerberghen
    Department of Human Genetics, KULeuven, Herestraat 49, O and N6, 3000 Louvain, Belgium
    Genomics 85:574-81. 2005
    ..No association with the age of first infection by Pseudomonas aeruginosa or with the FEV1 percentage at the age of 11-13 years could be found...
  37. doi request reprint Clinical practice: treatment of childhood empyema
    Marijke Proesmans
    Department of Pediatric Pulmonology, UZ Leuven, Leuven, Belgium
    Eur J Pediatr 168:639-45. 2009
    ..As to the surgical interventions, there is at present insufficient evidence that early surgery is superior to noninvasive medical treatment. Therefore, video-assisted thoracoscopy cannot be advised as general first-line therapy...
  38. pmc Massive lung collapse with partial resolution after several years: a case report
    Elke Govaere
    Dept of Pediatrics, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    BMC Pediatr 5:39. 2005
    ..Of the rare cases reported in the literature all surviving children underwent surgical resection of the collapsed lung...
  39. ncbi request reprint Survey of Pseudomonas aeruginosa genotypes in colonised cystic fibrosis patients
    S Van Daele
    Cystic Fibrosis Centre, University Hospital Ghent, 5K6, De Pintelaan 185, 9000 Gent, Belgium
    Eur Respir J 28:740-7. 2006
    ..The number of clusters is limited, and most patients seem to retain the same genotypic strain during both years...
  40. ncbi request reprint National survey of molecular epidemiology of Staphylococcus aureus colonization in Belgian cystic fibrosis patients
    A Vergison
    Department of Pediatric Infectious Diseases, Hospital Epidemiology and Infection Control Unit, Universite Libre de Bruxelles, Hôpital des Enfants Reine Fabiola, Brussels, Belgium
    J Antimicrob Chemother 59:893-9. 2007
    ..We conducted a multicentre survey to determine the prevalence of S. aureus and MRSA colonization in Belgian CF patients and characterize the phenotype and clonal distribution of their staphylococcal strains...
  41. pmc Preferential reduction of quadriceps over respiratory muscle strength and bulk after lung transplantation for cystic fibrosis
    C Pinet
    Department of Chest Medicine, Erasme University Hospital, Brussels, Belgium
    Thorax 59:783-9. 2004
    ..In the absence of complications, recipients of lung transplants for cystic fibrosis have normal pulmonary function but the impact of the procedure on the strength and bulk of respiratory and limb muscles has not been studied...
  42. ncbi request reprint Clostridium difficile colitis in cystic fibrosis patients with and without lung transplantation
    C Theunissen
    Department of Infectious Diseases, Erasme University Hospital, Brussels, Belgium
    Transpl Infect Dis 10:240-4. 2008
    ..difficile-associated disease (CDAD) is rather rare. In case of lung transplantation, the incidence and clinical aspects of CDAD in this patient population are not well known...
  43. ncbi request reprint [The pneumology department]
    P De Vuyst
    Rev Med Brux 23:151-4. 2002
    ..The following expertise fields have been largely developed: lung transplantation, treatment of cystic fibrosis in collaboration with the children's hospital Reine Fabiola, occupational...