V M Darras

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc Changes in the central component of the hypothalamus-pituitary-thyroid axis in a rabbit model of prolonged critical illness
    Liese Mebis
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Herestraat 49, Leuven B 3000, Belgium
    Crit Care 13:R147. 2009
  2. doi request reprint Endocrine disrupting polyhalogenated organic pollutants interfere with thyroid hormone signalling in the developing brain
    V M Darras
    Laboratory of Comparative Endocrinology, Zoological Institute, Naamsestraat 61, B 3000, Leuven, Belgium
    Cerebellum 7:26-37. 2008
  3. doi request reprint Involvement of thyroid hormones in chicken embryonic brain development
    Veerle M Darras
    Laboratory of Comparative Endocrinology, Animal Physiology and Neurobiology Section, Department of Biology, Katholieke Universiteit Leuven, Naamsestraat 61, Box 2464, B 3000 Leuven, Belgium
    Gen Comp Endocrinol 163:58-62. 2009
  4. ncbi request reprint Thyroid hormone deiodination in birds
    Veerle M Darras
    Laboratory of Comparative Endocrinology, Zoological Institute, Leuven, Belgium
    Thyroid 16:25-35. 2006
  5. ncbi request reprint Pituitary and extrapituitary action sites of the novel nonpeptidyl growth hormone (GH) secretagogue L-692,429 in the chicken
    K L Geris
    Laboratory of Comparative Endocrinology, Naamsestraat 61, Leuven, B 3000, Belgium
    Gen Comp Endocrinol 111:186-96. 1998
  6. ncbi request reprint Regulation of thyroid hormone metabolism during fasting and refeeding in chicken
    S Van der Geyten
    Laboratory of Comparative Endocrinology, K U Leuven, Naamsestraat 61, Leuven, 3000, Belgium
    Gen Comp Endocrinol 116:272-80. 1999
  7. ncbi request reprint Evidence of a thyrotropin-releasing activity of ovine corticotropin-releasing factor in the domestic fowl (Gallus domesticus)
    K L Geris
    Laboratory of Comparative Endocrinology, K U Leuven, Louvain, Belgium
    Gen Comp Endocrinol 104:139-46. 1996
  8. doi request reprint Type 2 iodothyronine deiodinase is essential for thyroid hormone-dependent embryonic development and pigmentation in zebrafish
    Chaminda N Walpita
    Laboratory of Comparative Endocrinology, Division of Animal Physiology and Neurobiology, Katholieke Universiteit Leuven, Leuven, Belgium
    Endocrinology 150:530-9. 2009
  9. ncbi request reprint Transcriptional regulation of iodothyronine deiodinases during embryonic development
    S Van der Geyten
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    Mol Cell Endocrinol 183:1-9. 2001
  10. ncbi request reprint The drop in plasma thyrotropin concentrations in fasted chickens is caused by an action at the level of the hypothalamus: role of corticosterone
    K L Geris
    Laboratory of Comparative Endocrinology, K U Leuven, Belgium
    Domest Anim Endocrinol 16:231-7. 1999

Detail Information

Publications90

  1. pmc Changes in the central component of the hypothalamus-pituitary-thyroid axis in a rabbit model of prolonged critical illness
    Liese Mebis
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Herestraat 49, Leuven B 3000, Belgium
    Crit Care 13:R147. 2009
    ....
  2. doi request reprint Endocrine disrupting polyhalogenated organic pollutants interfere with thyroid hormone signalling in the developing brain
    V M Darras
    Laboratory of Comparative Endocrinology, Zoological Institute, Naamsestraat 61, B 3000, Leuven, Belgium
    Cerebellum 7:26-37. 2008
    ..The fact that persistent organohalogens can amplify the neurotoxic effects of other environmental pollutants, such as heavy metals, further increases their risk for human and animal neurodevelopment...
  3. doi request reprint Involvement of thyroid hormones in chicken embryonic brain development
    Veerle M Darras
    Laboratory of Comparative Endocrinology, Animal Physiology and Neurobiology Section, Department of Biology, Katholieke Universiteit Leuven, Naamsestraat 61, Box 2464, B 3000 Leuven, Belgium
    Gen Comp Endocrinol 163:58-62. 2009
    ..In vivo knockdown of TH transporters and deiodinases in chick embryos cultured ex ovo provides an excellent tool to study the role of THs in early brain development in more detail...
  4. ncbi request reprint Thyroid hormone deiodination in birds
    Veerle M Darras
    Laboratory of Comparative Endocrinology, Zoological Institute, Leuven, Belgium
    Thyroid 16:25-35. 2006
    ..The balance between the outer and inner ring deiodination resulting from the impact of all these factors ultimately controls T3 availability...
  5. ncbi request reprint Pituitary and extrapituitary action sites of the novel nonpeptidyl growth hormone (GH) secretagogue L-692,429 in the chicken
    K L Geris
    Laboratory of Comparative Endocrinology, Naamsestraat 61, Leuven, B 3000, Belgium
    Gen Comp Endocrinol 111:186-96. 1998
    ..It is concluded that in the chicken the GH secretagogue L-692,429 has a dual action site: (1) directly at the level of the pituitary and (2) centrally through an increase in hypothalamic TRH release...
  6. ncbi request reprint Regulation of thyroid hormone metabolism during fasting and refeeding in chicken
    S Van der Geyten
    Laboratory of Comparative Endocrinology, K U Leuven, Naamsestraat 61, Leuven, 3000, Belgium
    Gen Comp Endocrinol 116:272-80. 1999
    ..In addition, renal D3 may play a role in the regulation of local T(3) availability...
  7. ncbi request reprint Evidence of a thyrotropin-releasing activity of ovine corticotropin-releasing factor in the domestic fowl (Gallus domesticus)
    K L Geris
    Laboratory of Comparative Endocrinology, K U Leuven, Louvain, Belgium
    Gen Comp Endocrinol 104:139-46. 1996
    ..In chickens CRF is concluded to not only control the adrenal axis, but also to participate in the coordination of avian TSH release...
  8. doi request reprint Type 2 iodothyronine deiodinase is essential for thyroid hormone-dependent embryonic development and pigmentation in zebrafish
    Chaminda N Walpita
    Laboratory of Comparative Endocrinology, Division of Animal Physiology and Neurobiology, Katholieke Universiteit Leuven, Leuven, Belgium
    Endocrinology 150:530-9. 2009
    ..These data indicate that TH activation by D2 is essential for embryonic development and pigmentation in zebrafish...
  9. ncbi request reprint Transcriptional regulation of iodothyronine deiodinases during embryonic development
    S Van der Geyten
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    Mol Cell Endocrinol 183:1-9. 2001
    ....
  10. ncbi request reprint The drop in plasma thyrotropin concentrations in fasted chickens is caused by an action at the level of the hypothalamus: role of corticosterone
    K L Geris
    Laboratory of Comparative Endocrinology, K U Leuven, Belgium
    Domest Anim Endocrinol 16:231-7. 1999
    ..Because an i.v. injection of corticosterone-elevated hypothalamic TRH contents and decreased plasma TSH concentrations, a corticosterone-induced TSH decrease during fasting is suggested through an action at the level of the hypothalamus...
  11. ncbi request reprint Developmentally defined regulation of thyroid hormone metabolism by glucocorticoids in the rat
    S Van der Geyten
    Laboratory of Comparative Endocrinology, Zoological Institute, KU Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    J Endocrinol 185:327-36. 2005
    ..This was in contrast to the E20 and P12 brain, where the glucocorticoid-induced changes in type II deiodinase and D3 seemed to favor a status quo in local T(3) availability...
  12. ncbi request reprint Quantification of growth hormone receptor extra- and intracellular domain gene expression in chicken liver by quantitative competitive RT-PCR
    P Van As
    Leuven Poultry Research Group, Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, Leuven, B-3001, Belgium
    Gen Comp Endocrinol 122:213-24. 2001
    ..It is postulated that GHRe and GHRi gene expression may be regulated by different agonists/antagonists in different strains and depending on the age of the chicken...
  13. ncbi request reprint Food intake after hatching inhibits the growth hormone induced stimulation of the thyroxine to triiodothyronine conversion in the chicken
    V M Darras
    Laboratory of Comparative Endocrinology, K. U. Leuven, Belgium
    Horm Metab Res 23:469-72. 1991
    ..Food deprivation after a period of food intake restores the GH effect on plasma T3 but not on liver 5'-D...
  14. ncbi request reprint The chicken pituitary-specific transcription factor PIT-1 is involved in the hypothalamic regulation of pituitary hormones
    P Van As
    Division of Livestock Nutrition Quality, Department of Biosystems, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, B 3001, Leuven, Belgium
    Acta Vet Hung 54:455-71. 2006
    ..TRH affected both the GH and TSHbeta mRNA levels. The results of this in vitro study reveal that ggPit-1 * has a role in mediating the stimulatory effects of TRH on pituitary hormones like GH and TSHbeta in the chicken pituitary...
  15. ncbi request reprint Hypothyroidism induces type I iodothyronine deiodinase expression in tilapia liver
    S Van der Geyten
    Laboratory of Comparative Endocrinology, K U Leuven, 3000 Leuven, Belgium
    Gen Comp Endocrinol 124:333-42. 2001
    ....
  16. ncbi request reprint The release of growth hormone (GH): relation to the thyrotropic- and corticotropic axis in the chicken
    E R Kuhn
    Laboratory of Comparative Endocrinology, Naamsestraat 61, B 3000 Leuven, Belgium
    Domest Anim Endocrinol 29:43-51. 2005
    ..This way not only a multifactorial release mechanism exists for GH but also a functional entanglement of activities between the somatotropic-, thyrotropic- and corticotropic axis...
  17. doi request reprint Ontogenic expression profiles of thyroid-specific genes in embryonic and hatching chicks
    S V H Grommen
    Research Group of Comparative Endocrinology, Animal Physiology and Neurobiology Section, Department of Biology, Catholic University of Leuven, Leuven, Belgium
    Domest Anim Endocrinol 40:10-8. 2011
    ....
  18. ncbi request reprint Iodothyronine deiodinases and the control of plasma and tissue thyroid hormone levels in hyperthyroid tilapia (Oreochromis niloticus)
    S Van der Geyten
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    J Endocrinol 184:467-79. 2005
    ..However, the very short plasma half-life of exogenously administered T3 implies the existence of an efficient T3 clearing/degradation mechanism other than deiodination...
  19. ncbi request reprint Thyroid hormone availability and activity in avian species: a review
    E Decuypere
    Laboratory for Physiology and Immunology of Domestic Animals, Department of Animal Production, Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, B 3001 Leuven, Belgium
    Domest Anim Endocrinol 29:63-77. 2005
    ..TRs mediate their effects on transcription by binding as homodimers or heterodimers to the TH response elements (TREs). Also, unliganded TRs can bind to TREs and may so modulate transcription of target genes...
  20. ncbi request reprint Influence of feeding pattern on thyroid hormones in long-term food-restricted rats
    M Cokelaere
    Interdisciplinary Research Center, Katholieke Universiteit Leuven, Kortrijk, Belgium
    Horm Metab Res 28:315-8. 1996
    ..We conclude that total peripheral thyroid hormone levels infood-restricted rats are influenced, not only by the amount of food but also by the feeding pattern...
  21. ncbi request reprint Regulation of thyroid hormone availability in liver and brain by glucocorticoids
    G E Reyns
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    Gen Comp Endocrinol 140:101-8. 2005
    ..This observation points to the existence of a fine-tuning mechanism in brain that enables the brain to keep the T(3) concentrations within narrow limits...
  22. ncbi request reprint Regulation of thyroid hormone availability by iodothyronine deiodinases at the blood-brain barrier in birds
    C H J Verhoelst
    Laboratory of Comparative Endocrinology, Zoological Institute, Katholieke Universiteit Leuven, Belgium
    Ann N Y Acad Sci 1040:501-3. 2005
    ..Immunocytochemistry showed high D2 protein expression in the epithelial cells of the CP, whereas the D1 and D3 proteins were absent. Furthermore, dexamethasone treatment led to an upregulation of the D2 protein in these cells...
  23. ncbi request reprint Distribution and regulation of chicken growth hormone secretagogue receptor isoforms
    S M E Geelissen
    Laboratory of Comparative Endocrinology, KU Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    Gen Comp Endocrinol 134:167-74. 2003
    ..Thyrotropin-releasing hormone (1 microM) did not alter cGHS-R expression...
  24. ncbi request reprint Modulation of the growth hormone-releasing activity of thyrotropin-releasing hormone in the chicken by its gene-related peptide preproTRH((160-169))(Ps4): enhanced somatostatinergic tone?
    K L Geris
    Laboratory of Comparative Endocrinology, K U Leuven, Belgium
    Neuropeptides 34:51-7. 2000
    ..Since Ps4 is also produced by pituitary tissue, this may reflect a local or paracrine action on the regulation of GH release...
  25. ncbi request reprint Neurotoxicity of polychlorinated biphenyls (PCBs) by disturbance of thyroid hormone-regulated genes
    S A Roelens
    Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Belgium
    Ann N Y Acad Sci 1040:454-6. 2005
    ..It was found that the interaction of PCBs with the expression of TH-regulated genes is congener-specific and that both hyperthyroidism- and hypothyroidism-related effects occur...
  26. ncbi request reprint Peripheral ghrelin reduces food intake and respiratory quotient in chicken
    S M E Geelissen
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, Naamsestraat 61, 3000 Leuven, Belgium
    Domest Anim Endocrinol 30:108-16. 2006
    ..In conclusion, peripheral ghrelin reduces food intake as well as RQ and might influence the type of substrate (macronutrient) that is used as metabolic fuel...
  27. ncbi request reprint Dynamics and regulation of intracellular thyroid hormone concentrations in embryonic chicken liver, kidney, brain, and blood
    G E Reyns
    Laboratory of Comparative Endocrinology, Zoological Instistute, K U Leuven, Naamsestraat 61, Leuven B 3000, Belgium
    Gen Comp Endocrinol 134:80-7. 2003
    ....
  28. ncbi request reprint Regulation of growth hormone expression by thyrotropin-releasing hormone through the pituitary-specific transcription factor Pit-1 in chicken pituitary
    P Van As
    Laboratory for Physiology and Immunology of Domestic Animals, Department of Animal Production, Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, B 3001 Leuven, Belgium
    Acta Vet Hung 52:389-402. 2004
    ..TRH affected the GH mRNA levels at both developmental stages. These results, combined with the data on Pit-1 mRNA expression, indicate that Pit-1 has a role in mediating the stimulatory effects of TRH on pituitary hormones like GH...
  29. doi request reprint Chicken folliculo-stellate cells express thyrotropin receptor mRNA
    S V Grommen
    Department of Biology, Catholic University of Leuven, Leuven, Belgium
    Domest Anim Endocrinol 37:236-42. 2009
    ....
  30. ncbi request reprint Synthetic growth hormone secretagogues control growth hormone secretion in the chicken at pituitary and hypothalamic levels
    K L Geris
    Laboratory of Comparative Endocrinology, Leuven, Belgium
    Endocrine 14:67-72. 2001
    ..The GH response to GHS in birds may be regulated both directly at the level of the pituitary and by releasing another endogenous GH stimulator (TRH) from the hypothalamus...
  31. ncbi request reprint Role of spatiotemporal expression of iodothyronine deiodinase proteins in cerebellar cell organization
    C H J Verhoelst
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, B 3000 Leuven, Belgium
    Brain Res Bull 67:196-202. 2005
    ....
  32. pmc Effects of substitution and high-dose thyroid hormone therapy on deiodination, sulfoconjugation, and tissue thyroid hormone levels in prolonged critically ill rabbits
    Yves Debaveye
    Department of Intensive Care Medicine, Catholic University of Leuven, B 3000 Leuven, Belgium
    Endocrinology 149:4218-28. 2008
    ..This indicates thyroid hormone hypermetabolism, which in this model of critical illness is not entirely explained by deiodination or by sulfoconjugation...
  33. ncbi request reprint Molecular cloning and developmental expression of corticotropin-releasing factor in the chicken
    Kristien Vandenborne
    Laboratory of Comparative Endocrinology, Zoological Institute, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Endocrinology 146:301-8. 2005
    ..Changes in CRF production just before hatching may be causally related to the regulation of the thyroid and interrenal axes at this stage of chicken development...
  34. ncbi request reprint Effects of dexamethasone treatment on iodothyronine deiodinase activities and on metamorphosis-related morphological changes in the axolotl (Ambystoma mexicanum)
    Veerle M Darras
    Laboratory of Comparative Endocrinology, Zoological Institute, KU Leuven, Naamsestraat 61, Leuven B 3000, Belgium
    Gen Comp Endocrinol 127:157-64. 2002
    ..Although probably several mechanisms contribute to these DEX-induced metamorphic changes, the interaction with thyroid function via a sustained downregulation of hepatic D3 may be one of them...
  35. ncbi request reprint Involvement of thyrotropin-releasing hormone receptor, somatostatin receptor subtype 2 and corticotropin-releasing hormone receptor type 1 in the control of chicken thyrotropin secretion
    B De Groef
    Laboratory of Comparative Endocrinology, Naamsestraat 61, K U Leuven, B 3000 Leuven, Belgium
    Mol Cell Endocrinol 203:33-9. 2003
    ..Alternatively, a pro-opiomelanocortin (POMC)-derived peptide, secreted by the corticotropes following CRH stimulation, could act as an activator of TSH secretion in a paracrine way...
  36. ncbi request reprint Distribution of somatostatin in the brain and of somatostatin and thyrotropin-releasing hormone in peripheral tissues of the chicken
    K L Geris
    Laboratory of Comparative Endocrinology, K U Leuven, Naamsestraat 61, B 3000, Leuven, Belgium
    Brain Res 873:306-9. 2000
    ..Our results suggest that also in the chicken SRIH and TRH are implicated in the control of several physiological processes like growth, reproduction and digestion...
  37. doi request reprint Identification of unique thyrotropin receptor (TSHR) splice variants in the chicken: the chicken TSHR gene revisited
    Sylvia V H Grommen
    Research Group of Comparative Endocrinology, Animal Physiology and Neurobiology Section, Department of Biology, Catholic University of Leuven, Naamsestraat 61, Box 2464, 3000 Leuven, Belgium
    Gen Comp Endocrinol 156:460-3. 2008
    ..Whether these receptor transcripts are translated to functional proteins needs to be verified, but if so, they could be attributed various physiological roles...
  38. doi request reprint Thyroid hormone receptor beta2 is strongly up-regulated at all levels of the hypothalamo-pituitary-thyroidal axis during late embryogenesis in chicken
    Sylvia V H Grommen
    Research Group of Comparative Endocrinology, Animal Physiology and Neurobiology Section, Department of Biology, K U Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    J Endocrinol 196:519-28. 2008
    ..Finally, THs proved to exert an age-dependent effect on pituitary TRbeta2 mRNA expression...
  39. doi request reprint Expression of thyroid hormone transporters during critical illness
    Liese Mebis
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Eur J Endocrinol 161:243-50. 2009
    ..We examined the role of TH transporters monocarboxylate transporter 8 (MCT8, also known as SLC16A2) and MCT10 in the pathogenesis of the low T(3) syndrome in prolonged critical illness...
  40. doi request reprint Regulation of tissue iodothyronine deiodinase activity in a model of prolonged critical illness
    Yves Debaveye
    Department of Intensive Care Medicine, Catholic University of Leuven, Leuven, Belgium
    Thyroid 18:551-60. 2008
    ..Infusion of thyrotropin-releasing hormone (TRH) can restore D1 and D3 activity in critically ill rabbits, but it remains unknown whether this is a direct effect of TRH or the TRH-induced rise in circulating thyroxine (T4) and T3...
  41. ncbi request reprint Corticosterone-induced negative feedback mechanisms within the hypothalamo-pituitary-adrenal axis of the chicken
    Kristien Vandenborne
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    J Endocrinol 185:383-91. 2005
    ..The in vitro feedback effect on the proCRF gene expression, however, differed with age. In 9-day-old animals a decrease in gene expression was observed which was not detectable in embryonic tissue at day 18 of the ontogeny...
  42. doi request reprint Combined antisense knockdown of type 1 and type 2 iodothyronine deiodinases disrupts embryonic development in zebrafish (Danio rerio)
    Chaminda N Walpita
    Laboratory of Comparative Endocrinology, Division of Animal Physiology and Neurobiology, Katholieke Universiteit Leuven, BE 3000 Leuven, Belgium
    Gen Comp Endocrinol 166:134-41. 2010
    ....
  43. ncbi request reprint Type II iodothyronine deiodinase protein in chicken choroid plexus: additional perspectives on T3 supply in the avian brain
    C H J Verhoelst
    Laboratory of Comparative Endocrinology, Zoological Institute, Naamsestraat 61, B 3000 Leuven, Belgium
    J Endocrinol 183:235-41. 2004
    ....
  44. ncbi request reprint Interaction of PCBs with thyroid hormone levels and time of hatching in chicken embryos
    V Beck
    Laboratory of Comparative Endocrinology, Zoological Institute, KU Leuven, Belgium
    Ann N Y Acad Sci 1040:224-6. 2005
    ..Clear effects were only seen with PCB 77 around the period of hatching: a severely reduced TH peak, which normally coincides with the stage of internal pipping, and a considerable delay in the moment of hatching...
  45. ncbi request reprint Renal and hepatic distribution of type I and type III iodothyronine deiodinase protein in chicken
    C H J Verhoelst
    Laboratory of Comparative Endocrinology, Zoological Institute, Naamsestraat 61, B 3000 Leuven, Belgium
    J Endocrinol 181:85-90. 2004
    ..No staining could be detected in the lamina propria or in the fat tissue surrounding the ureter...
  46. ncbi request reprint Low submetamorphic doses of dexamethasone and thyroxine induce complete metamorphosis in the axolotl (Ambystoma mexicanum) when injected together
    Eduard R Kuhn
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, Naamsestraat 61, Leuven B 3000, Belgium
    Gen Comp Endocrinol 137:141-7. 2004
    ....
  47. ncbi request reprint In vitro study of corticotropin-releasing hormone-induced thyrotropin release: ontogeny and inhibition by somatostatin
    Kris L Geris
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    Gen Comp Endocrinol 132:272-7. 2003
    ....
  48. ncbi request reprint Pre- and postprandial changes in plasma hormone and metabolite levels and hepatic deiodinase activities in meal-fed broiler chickens
    Johan Buyse
    Laboratory for Physiology and Immunology of Domestic Animals, Department of Animal Production, Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, 3001 Leuven, Belgium
    Br J Nutr 88:641-53. 2002
    ..Glucose is believed to be the primary trigger for the normalisation of the effects of fasting on these plasma variables by restoring hepatic GH receptor capacity, as well as decreasing deiodinase type III activity...
  49. ncbi request reprint The use of real-time PCR to study the expression of thyroid hormone receptor beta 2 in the developing chicken
    Sylvia V H Grommen
    Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Belgium
    Ann N Y Acad Sci 1040:328-31. 2005
    ..We detected a strong TRbeta2 mRNA signal in the pituitary, confirmed with in situ hybridization, and in several other tissues. TRbeta2 mRNA was more abundant in the pituitary of newly hatched chicks than in 15-day-old embryos...
  50. doi request reprint Dynamic mRNA distribution pattern of thyroid hormone transporters and deiodinases during early embryonic chicken brain development
    S Geysens
    Laboratory of Comparative Endocrinology, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, B 3000 Leuven, Belgium
    Neuroscience 221:69-85. 2012
    ..It provides the essential background for further research aimed at understanding early developmental processes depending on maternal THs...
  51. ncbi request reprint Identification of somatostatin receptors controlling growth hormone and thyrotropin secretion in the chicken using receptor subtype-specific agonists
    K L Geris
    Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    J Endocrinol 177:279-86. 2003
    ..The possible stimulatory action of ag3 and ag4 may point towards a species-specific function of sstr3 and sstr4...
  52. ncbi request reprint Specific detection of type III iodothyronine deiodinase protein in chicken cerebellar purkinje cells
    C H J Verhoelst
    Laboratory of Comparative Endocrinology, K U Leuven, Zoological Institute, Belgium
    Endocrinology 143:2700-7. 2002
    ..RT-PCR as well as Northern blot analysis confirmed the presence of D3 mRNA in the cerebellum...
  53. ncbi request reprint Increasing plasma thyroxine levels during late embryogenesis and hatching in the chicken are not caused by an increased sensitivity of the thyrotropes to hypothalamic stimulation
    Bert De Groef
    Laboratory of Comparative Endocrinology, K U Leuven, Naamsestraat 61, B3000 Leuven, Belgium
    J Endocrinol 189:271-8. 2006
    ....
  54. ncbi request reprint The influence of stress on thyroid hormone production and peripheral deiodination in the Nile tilapia (Oreochromis niloticus)
    Chaminda N Walpita
    Laboratory of Comparative Endocrinology, Zoological Institute, KU Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    Gen Comp Endocrinol 150:18-25. 2007
    ..However, the effects of the long acting glucocorticoid analogue are more pronounced and result in a decrease in circulating T(3) availability...
  55. ncbi request reprint Feedback control of thyrotropin secretion in the chicken: thyroid hormones increase the expression of hypophyseal somatostatin receptor types 2 and 5
    Bert De Groef
    Laboratory of Comparative Endocrinology, Catholic University of Leuven, Naamsestraat 61, B3000 Leuven, Belgium
    Gen Comp Endocrinol 152:178-82. 2007
    ..We hypothesize that the negative feedback exerted by the increasing plasma T(3) levels towards hatching is at least in part mediated by an increased expression of SSTR2 and SSTR5...
  56. ncbi request reprint The effect of 3,5,3'-triiodothyronine supplementation on zebrafish (Danio rerio) embryonic development and expression of iodothyronine deiodinases and thyroid hormone receptors
    Chaminda N Walpita
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    Gen Comp Endocrinol 152:206-14. 2007
    ..Taken together, these data show that during embryonic development zebrafish already have the necessary regulatory machinery for TH activation and signaling, and that T(3) treatment at that stage indeed influence embryonic development...
  57. ncbi request reprint Corticotropin-releasing hormone-mediated metamorphosis in the neotenic axolotl Ambystoma mexicanum: synergistic involvement of thyroxine and corticoids on brain type II deiodinase
    Eduard R Kuhn
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, Naamsestraat 61, Leuven B 3000, Belgium
    Gen Comp Endocrinol 143:75-81. 2005
    ..This synergistic effect was not found in the liver. It is concluded that brain T(3) availability may play an important role for the onset of metamorphosis in the neotenic axolotl...
  58. ncbi request reprint Cloning and hypothalamic distribution of the chicken thyrotropin-releasing hormone precursor cDNA
    Kristien Vandenborne
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    J Endocrinol 186:387-96. 2005
    ..By means of in situ hybridization, preproTRH mRNA was detected in the chicken paraventricular nucleus (PVN) and in the lateral hypothalamus (LHy)...
  59. ncbi request reprint Endocrine and metabolic effects of growth hormone (GH) compared with GH-releasing peptide, thyrotropin-releasing hormone, and insulin infusion in a rabbit model of prolonged critical illness
    Frank Weekers
    Department of Intensive Care Medicine, Burn Unit and Center for Experimental Surgery and Anesthesiology, Catholic University of Leuven, Leuven, Belgium
    Endocrinology 145:205-13. 2004
    ..In contrast to the human model, high dose rhGH was not rapidly lethal in this rabbit model. Whether this is explained by lack of rhGH-induced insulin resistance and hyperglycemia remains unclear...
  60. doi request reprint Ghrelin modulates fatty acid synthase and related transcription factor mRNA levels in a tissue-specific manner in neonatal broiler chicks
    Johan Buyse
    Laboratory of Livestock Physiology, Immunology and Genetics, Department of Biosystems, K U Leuven, Kasteelpark Arenberg 30, 3001 Leuven, Belgium
    Peptides 30:1342-7. 2009
    ....
  61. ncbi request reprint Thyroid hormone deiodinases during embryonic development of the saltwater crocodile (Crocodylus porosus)
    Caroline A Shepherdley
    Laboratory of Comparative Endocrinology, Zoological Institute, B 3000 Leuven, Belgium
    Gen Comp Endocrinol 126:153-64. 2002
    ..T(3) inner ring deiodination activity was present only in the embryonic liver and peaked at day 49 (10.1 fmol T(3) deiodinated/mg protein/min), after which activity decreased...
  62. ncbi request reprint Cloning and tissue distribution of the chicken type 2 corticotropin-releasing hormone receptor
    Bert De Groef
    Laboratory of Comparative Endocrinology, Catholic University of Leuven, B3000 Leuven, Belgium
    Gen Comp Endocrinol 138:89-95. 2004
    ....
  63. ncbi request reprint Molecular cloning, tissue distribution, and ontogenic thyroidal expression of the chicken thyrotropin receptor
    Sylvia V H Grommen
    Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Belgium
    Endocrinology 147:3943-51. 2006
    ....
  64. ncbi request reprint Changes in thyroid hormone levels in chicken liver during fasting and refeeding
    G E Reyns
    Department of Biology, KU Leuven, Zoological Institute, Laboratory of Comparative Endocrinology, Leuven, Belgium
    Comp Biochem Physiol B Biochem Mol Biol 132:239-45. 2002
    ....
  65. ncbi request reprint Exposure to PCB 77 induces tissue-dependent changes in iodothyronine deiodinase activity patterns in the embryonic chicken
    Veerle Beck
    Laboratory of Comparative Endocrinology, K U Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    Gen Comp Endocrinol 148:327-35. 2006
    ..The changes in telencephalon occurred at the earlier stages and included an increase in both D2 and D3 activity...
  66. ncbi request reprint Characterization of outer ring iodothyronine deiodinases in tissues of the saltwater crocodile (Crocodylus porosus)
    Caroline A Shepherdley
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, B 3000 Leuven, Belgium
    Gen Comp Endocrinol 125:387-98. 2002
    ..Low-Km T3 IRD activity could not be detected in any tissues of the juvenile saltwater crocodile...
  67. doi request reprint Increasing intravenous glucose load in the presence of normoglycemia: effect on outcome and metabolism in critically ill rabbits
    Sarah Derde
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 38:602-11. 2010
    ..In critically ill rabbits, we investigated the impact of varying amounts of intravenous glucose while maintaining normoglycemia on mortality, organ damage, and markers of catabolism/anabolism...
  68. ncbi request reprint Corticotropin-releasing hormone (CRH)-induced thyrotropin release is directly mediated through CRH receptor type 2 on thyrotropes
    Bert De Groef
    Laboratories of Comparative Endocrinology, Catholic University of Leuven, Leuven, Belgium
    Endocrinology 144:5537-44. 2003
    ..We conclude that CRH-induced TSH secretion is mediated by CRH-R2 expressed on thyrotropes...
  69. ncbi request reprint Role of corticotropin-releasing hormone as a thyrotropin-releasing factor in non-mammalian vertebrates
    Bert De Groef
    Laboratory of Comparative Endocrinology, K U Leuven, B3000 Leuven, Belgium
    Gen Comp Endocrinol 146:62-8. 2006
    ....
  70. ncbi request reprint Hypothalamic control of the thyroidal axis in the chicken: over the boundaries of the classical hormonal axes
    Bert De Groef
    Laboratory of Comparative Endocrinology, Naamsestraat 61, B3000 Leuven, Belgium
    Domest Anim Endocrinol 29:104-10. 2005
    ..It remains to be demonstrated if these findings could also be extrapolated to other species or classes of vertebrates...
  71. ncbi request reprint The dioxin-like PCB 77 but not the ortho-substituted PCB 153 interferes with chicken embryo thyroid hormone homeostasis and delays hatching
    Simon A Roelens
    Laboratory of Comparative Endocrinology, K U Leuven, Naamsestraat 61, B 3000 Louvain, Belgium
    Gen Comp Endocrinol 143:1-9. 2005
    ..We conclude that the dioxin-like PCB 77, but not the ortho-substituted PCB 153, can decrease TH availability towards the end of embryonic development and hence disturb the process of hatching...
  72. ncbi request reprint Differential expression of iodothyronine deiodinases in chicken tissues during the last week of embryonic development
    Serge Van der Geyten
    Laboratory of Comparative Endocrinology, K U Leuven, Leuven 3000, Belgium
    Gen Comp Endocrinol 128:65-73. 2002
    ..This strongly suggests that in birds, as in mammals and amphibians, the correct spatial and temporal expression of iodothyronine deiodinases are essential for normal embryonic development...
  73. ncbi request reprint Internalization of the chicken growth hormone receptor complex and its effect on biological functions
    Eduard R Kuhn
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, B 3000 Leuven, Belgium
    Comp Biochem Physiol B Biochem Mol Biol 132:299-308. 2002
    ..Neither receptor nor ligand was transferred to the nucleus as confirmed by confocal laser microscopy. The JAK/STAT pathway however, as reported for mammalian GH receptors, mediated GH-induced gene transcription in chickens...
  74. ncbi request reprint Thyrotropin-releasing hormone concentrations in different regions of the chicken brain and pituitary: an ontogenetic study
    K L Geris
    Laboratory of Comparative Endocrinology, Zoological Institute, K U Leuven, Naamsestraat 61, B 3000, Louvain, Belgium
    Brain Res 818:260-6. 1999
    ..Therefore, the chicken pituitary may function as an important source of TRH during early in ovo development at least until the moment hypothalamic control develops...
  75. doi request reprint Endocrine disrupting, haematological and biochemical effects of polybrominated diphenyl ethers in a terrestrial songbird, the European starling (Sturnus vulgaris)
    Evi Van den Steen
    Laboratory of Ethology, Department of Biology, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Sci Total Environ 408:6142-7. 2010
    ..All together, our results suggest that European starlings, similar to other passerine species, may be less sensitive to the effects of organohalogenated pollutants, such as PBDEs, than other bird species...
  76. ncbi request reprint Type I iodothyronine deiodinase in euthyroid and hypothyroid chicken cerebellum
    Carla H J Verhoelst
    Laboratory of Comparative Endocrinology, Zoological Institute, KU Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    Mol Cell Endocrinol 214:97-105. 2004
    ....
  77. ncbi request reprint Cold-induced enhancement of avian uncoupling protein expression, heat production, and triiodothyronine concentrations in broiler chicks
    Anne Collin
    Station de Recherches Avicoles, Institut National de la Recherche Agronomique, F 37380 Nouzilly, France
    Gen Comp Endocrinol 130:70-7. 2003
    ..This study describes for the first time the induction of avUCP mRNA expression by low temperature in chickens, as it has been previously shown in ducklings, and supports the possible involvement of avUCP in avian thermogenesis...
  78. ncbi request reprint Effects of dietary macronutrient content on energy metabolism and uncoupling protein mRNA expression in broiler chickens
    Anne Collin
    Station de Recherches Avicoles, Institut National de la Recherche Agronomique, Nouzilly, France
    Br J Nutr 90:261-9. 2003
    ....
  79. ncbi request reprint Uptake and tissue-specific distribution of selected polychlorinated biphenyls in developing chicken embryos
    Johan Maervoet
    Toxicological Center, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Environ Toxicol Chem 24:597-602. 2005
    ..Lipid analysis of the organs suggested that the lipid composition of brain may be an important factor explaining the low PCB accumulation in this tissue...
  80. ncbi request reprint Glucocorticoids, thyroid hormones, and iodothyronine deiodinases in embryonic saltwater crocodiles
    Caroline A Shepherdley
    Department of Zoology, University of Melbourne, 3010, Victoria, Australia
    Am J Physiol Regul Integr Comp Physiol 283:R1155-63. 2002
    ..However, this decrease did not change plasma-free T(3) concentrations, which suggests that free thyroid hormone levels are likely to be tightly regulated during development...
  81. ncbi request reprint Thyroid status, but not insulin status, affects expression of avian uncoupling protein mRNA in chicken
    Anne Collin
    Station de Recherches Avicoles, Institut National de la Recherche Agronomique, F 37380 Nouzilly, France
    Am J Physiol Endocrinol Metab 284:E771-7. 2003
    ..This study describes for the first time induction of avUCP mRNA expression by the thermogenic hormone T(3) in chickens and supports a possible involvement of avUCP in avian thermogenesis...
  82. ncbi request reprint Tissue thyroid hormone levels in critical illness
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:6498-507. 2005
    ..Furthermore, we investigated the relationship between tissue thyroid hormone levels, deiodinase activities, and monocarboxylate transporter 8 expression...
  83. pmc Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8
    Marija Trajkovic
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    J Clin Invest 117:627-35. 2007
    ..In conclusion, the circulating thyroid hormone levels of MCT8-null mice closely resemble those of humans with MCT8 mutations, yet in the mice, CNS development is only partially affected...
  84. ncbi request reprint Temperature-induced changes in thyrotropin-releasing hormone sensitivity in carp melanotropes
    Erwin H van den Burg
    Department of Animal Physiology, Faculty of Science, University of Nijmegen, Nijmegen, The Netherlands
    Neuroendocrinology 77:15-23. 2003
    ..This effect, however, is not due to acute temperature change, but evolves during the acclimation process of carps to a new temperature...
  85. ncbi request reprint Deiodinase activity is present in Xenopus laevis during early embryogenesis
    Ghislaine Morvan Dubois
    Department of Regulations, Development, and Molecular Diversity, Museum national d histoire naturelle, 75231 Paris Cedex 05, France
    Endocrinology 147:4941-9. 2006
    ..These findings suggest that thyroid hormone signaling is a key component of early neuronal development in vertebrates...
  86. ncbi request reprint Circulating thyroid hormone levels and iodothyronine deiodinase activities in Nile tilapia (Oreochromis niloticus) following dietary exposure to Endosulfan and Aroclor 1254
    Ana Maria Coimbra
    Instituto de Ciencias Biomedicas de Abel Salazar, Laboratório de Fisiologia Aplicada, Largo do Prof Abel Salazar 2, 4099 003, Porto, Portugal
    Comp Biochem Physiol C Toxicol Pharmacol 141:8-14. 2005
    ..The changes in hormone metabolism differ between tissues, eventually reflecting tissue-specific differences in adaptation...
  87. ncbi request reprint cDNA cloning, functional expression, and characterization of chicken sulfotransferases belonging to the SULT1B and SULT1C families
    Lesley A Wilson
    Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Arch Biochem Biophys 428:64-72. 2004
    ..This is the first detailed characterization of sulfotransferases from the chicken, and it demonstrates that the avian and mammalian SULT1 enzymes are closely related in both structure and function...
  88. ncbi request reprint Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil
    George G J M Kuiper
    Department of Internal Medicine, Room Ee 502, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocrinology 147:3519-29. 2006
    ..These results indicate the existence of a 6-PTU-insensitive D1 enzyme in X. laevis tissues, but its role during tadpole metamorphosis remains to be defined...
  89. ncbi request reprint Characterization of an iodothyronine 5'-deiodinase in gilthead seabream (Sparus auratus) that is inhibited by dithiothreitol
    Peter H M Klaren
    Department of Organismal Animal Physiology, Institute for Neuroscience, Radboud University Nijmegen, The Netherlands
    Endocrinology 146:5621-30. 2005
    ..We suggest that the effects of DTT on rT(3) ORD can be explained by interactions with the cysteines unique to the putative saD1 protein...
  90. ncbi request reprint Chicken ghrelin: purification, cDNA cloning, and biological activity
    Hiroyuki Kaiya
    Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    Endocrinology 143:3454-63. 2002
    ..The present results indicate that the stimulatory effect of ghrelin on GH secretion is evolutionarily conserved, whereas its effect on adrenal function seems to be unique in the chicken...