Edward Conway

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy
    Anne Angelillo-Scherrer
    Division of Angiology and Hemostasis, Department of Internal Medicine, Faculty of Medicine and University Hospitals of Geneva, Geneva, Switzerland
    J Clin Invest 115:237-46. 2005
  2. ncbi Structure-function analyses of thrombomodulin by gene-targeting in mice: the cytoplasmic domain is not required for normal fetal development
    E M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Blood 93:3442-50. 1999
  3. pmc The diversity of endothelial cells: a challenge for therapeutic angiogenesis
    Edward M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven Gasthuisberg O and N, Herestraat 49, 3000 Leuven, Belgium
    Genome Biol 5:207. 2004
  4. ncbi Angiogenesis: a link to thrombosis in athero-thrombotic disease
    Edward M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Pathophysiol Haemost Thromb 33:241-8. 2003
  5. pmc Survivin-dependent angiogenesis in ischemic brain: molecular mechanisms of hypoxia-induced up-regulation
    Edward M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Gasthuisberg O and N, 9th Floor, Herestraat 49, B 3000 Leuven, Belgium
    Am J Pathol 163:935-46. 2003
  6. pmc The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways
    Edward M Conway
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    J Exp Med 196:565-77. 2002
  7. ncbi Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways
    Edward M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Gastroenterology 123:619-31. 2002
  8. ncbi Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions
    E M Conway
    Departments of Medicine and the Institute of Medical Science, University of Toronto, Toronto, Canada
    Blood 95:1435-42. 2000
  9. ncbi Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, B 3000, Belgium
    Nat Med 9:936-43. 2003
  10. pmc Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure
    Femke Zwerts
    Center for Transgene Technology and Gene Therapy, University of Leuven, Gasthuisberg O and N1, Herestraat 49, 3000 Leuven, Belgium
    Blood 109:4742-52. 2007

Research Grants

  1. Thrombomodulin Links Coagulation to Inflammation
    Edward Conway; Fiscal Year: 2006

Collaborators

Detail Information

Publications27

  1. pmc Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy
    Anne Angelillo-Scherrer
    Division of Angiology and Hemostasis, Department of Internal Medicine, Faculty of Medicine and University Hospitals of Geneva, Geneva, Switzerland
    J Clin Invest 115:237-46. 2005
    ..Blocking the Gas6-R-alphaIIbbeta3 integrin cross-talk might be a novel approach to the reduction of thrombosis...
  2. ncbi Structure-function analyses of thrombomodulin by gene-targeting in mice: the cytoplasmic domain is not required for normal fetal development
    E M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Blood 93:3442-50. 1999
    ..In conclusion, these studies exclude the cytoplasmic domain of TM from playing a role in the early embryonic lethality of TM-null mice and support its function in regulating plasmin generation in plasma...
  3. pmc The diversity of endothelial cells: a challenge for therapeutic angiogenesis
    Edward M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven Gasthuisberg O and N, Herestraat 49, 3000 Leuven, Belgium
    Genome Biol 5:207. 2004
    ..Characterization of endothelial-cell diversity will facilitate the development of novel, highly specific and safe therapies for many diseases...
  4. ncbi Angiogenesis: a link to thrombosis in athero-thrombotic disease
    Edward M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Pathophysiol Haemost Thromb 33:241-8. 2003
    ..The findings, in the face of efforts to use angiogenic agents to enhance vascular function, underline the challenge in treating atherothrombotic disease...
  5. pmc Survivin-dependent angiogenesis in ischemic brain: molecular mechanisms of hypoxia-induced up-regulation
    Edward M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Gasthuisberg O and N, 9th Floor, Herestraat 49, B 3000 Leuven, Belgium
    Am J Pathol 163:935-46. 2003
    ....
  6. pmc The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways
    Edward M Conway
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    J Exp Med 196:565-77. 2002
    ..These data suggest that TM has antiinflammatory properties in addition to its role in coagulation and fibrinolysis...
  7. ncbi Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways
    Edward M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Gastroenterology 123:619-31. 2002
    ..IAPs participate in regulating Fas ligand-induced hepatic apoptosis. The aim was to study the contribution of survivin to hepatic apoptosis by generating transgenic mice lacking survivin...
  8. ncbi Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions
    E M Conway
    Departments of Medicine and the Institute of Medical Science, University of Toronto, Toronto, Canada
    Blood 95:1435-42. 2000
    ..The presence of distinct isoforms of survivin that are expressed differentially suggests that survivin plays a complex role in regulating apoptosis. (Blood. 2000;95:1435-1442)..
  9. ncbi Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, B 3000, Belgium
    Nat Med 9:936-43. 2003
    ....
  10. pmc Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure
    Femke Zwerts
    Center for Transgene Technology and Gene Therapy, University of Leuven, Gasthuisberg O and N1, Herestraat 49, 3000 Leuven, Belgium
    Blood 109:4742-52. 2007
    ..Thus, regulation of endothelial cell survival, and maintenance of vascular integrity by survivin are crucial for normal embryonic angiogenesis, cardiogenesis, and neurogenesis...
  11. pmc Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin
    Vanessa Coremans
    KU Leuven, VIB Vesalius Research Center, Herestraat 49, Gasthuisberg O and N1, B3000 Leuven, Belgium
    BMC Neurosci 11:2. 2010
    ..Survivin is highly expressed in neural precursor cells in the brain, yet its function there has not been elucidated...
  12. pmc Role of the 2 zebrafish survivin genes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis
    Mieke Delvaeye
    KU Leuven, VIB Vesalius Research Center VRC, Gasthuisberg O and N 1, Herestraat 49, 3000 Leuven, Belgium
    BMC Dev Biol 9:25. 2009
    ..Prenatally, survivin is also highly expressed in several tissues. Fully delineating the properties of survivin in vivo in mice has been confounded by early lethal phenotypes following survivin gene inactivation...
  13. ncbi Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation
    Marlies Van de Wouwer
    The Center for Transgene Technology and Gene Therapy, University of Leuven and the Flanders Interuniversity Institute for Biotechnology VIB, Belgium
    Arterioscler Thromb Vasc Biol 24:1374-83. 2004
    ..Overall, the described advances underscore the usefulness of elucidating the relevant molecular pathways that link both systems for the development of novel therapeutic and diagnostic targets for a wide range of inflammatory diseases...
  14. ncbi Protective role of the inhibitor of apoptosis protein, survivin, in toxin-induced acute renal failure
    Nele Kindt
    Center for Transgene Technology and Gene Therapy, Flanders Institute for Biotechnology, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    FASEB J 22:510-21. 2008
    ..These results encourage further evaluation of survivin, its active structural domains, and other inhibitors of apoptosis proteins, for preventing and/or treating acute renal failure...
  15. ncbi Novel functions of thrombomodulin in inflammation
    Marlies Van de Wouwer
    Flanders Interuniversity Institute for Biotechnology and the Center for Transgene Technology and Gene Therapy, University of Leuven, Leuven, Belgium
    Crit Care Med 32:S254-61. 2004
    ..Elucidation of the molecular mechanisms by which TM functions will likely provide novel targets for therapeutic intervention...
  16. ncbi Another angiogenic gene linked to amyotrophic lateral sclerosis
    Diether Lambrechts
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KU Leuven, B 3000 Leuven, Belgium
    Trends Mol Med 12:345-7. 2006
    ..Overall, these findings identify angiogenin as a novel candidate gene in the pathogenesis of ALS--a discovery that ultimately might lead to the development of new therapeutic strategies...
  17. pmc Thrombomodulin mutations in atypical hemolytic-uremic syndrome
    Mieke Delvaeye
    VIB K U Leuven Vesalius Research Center, Leuven, Belgium
    N Engl J Med 361:345-57. 2009
    ..Genetic factors in the remaining cases are unknown. We studied the role of thrombomodulin, an endothelial glycoprotein with anticoagulant, antiinflammatory, and cytoprotective properties, in atypical hemolytic-uremic syndrome...
  18. ncbi Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
    Erik Storkebaum
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KU Leuven, Leuven B 3000, Belgium
    Nat Neurosci 8:85-92. 2005
    ..On i.c.v. delivery, Vegf is anterogradely transported and preserves neuromuscular junctions in SOD1(G93A) rats. Our findings in preclinical rodent models of ALS may have implications for treatment of neurodegenerative disease in general...
  19. doi Survivin determines cardiac function by controlling total cardiomyocyte number
    Bodo Levkau
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Essen Germany
    Circulation 117:1583-93. 2008
    ..Survivin inhibits apoptosis and regulates cell division in many organs, but its function in the heart is unknown...
  20. pmc Role of Gas6 in erythropoiesis and anemia in mice
    Anne Angelillo-Scherrer
    Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    J Clin Invest 118:583-96. 2008
    ..These findings may have implications for the treatment of patients with anemia who fail to adequately respond to Epo...
  21. pmc Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils
    Frank Altznauer
    Dept of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    J Exp Med 199:1343-54. 2004
    ..These data provide new insights into the regulation and function of survivin and have important implications for the pathogenesis, diagnosis, and treatment of inflammatory diseases and cancer...
  22. ncbi Cardiovascular biology: signalling silenced
    Edward M Conway
    Nature 425:139-41. 2003
  23. ncbi Essential role for survivin in early brain development
    Yuying Jiang
    Center for Childhood Cancer, Columbus Children s Research Institute, Columbus, Ohio 43205, USA
    J Neurosci 25:6962-70. 2005
    ..Our study is the first to solidify a role for survivin as an antiapoptotic protein during normal neuronal development in vivo...
  24. pmc Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis
    Zheng Xing
    Department of Molecular and Cell Biology, Division of Immunology and Cancer Research Laboratory, University of California at Berkeley, 469 LSA, Berkeley, CA 94720, USA
    J Exp Med 199:69-80. 2004
    ..These data suggest that survivin is not essential for T cell apoptosis but is crucial for T cell maturation and proliferation, and survivin-mediated homeostatic expansion is an important physiological process of T cell development...
  25. ncbi Survivin splice variants regulate the balance between proliferation and cell death
    Hugo Caldas
    Center for Childhood Cancer, Columbus Children s Research Institute, The Ohio State University, Columbus, OH, USA
    Oncogene 24:1994-2007. 2005
    ..These findings are likely to have a significant impact in the design of biologic agents for clinical therapy...
  26. ncbi Lymph makes you fat
    Martin Schneider
    Nat Genet 37:1023-4. 2005
  27. ncbi VEGF inhibitors make blood
    Christian Fischer
    Nat Med 12:732-4. 2006

Research Grants4

  1. Thrombomodulin Links Coagulation to Inflammation
    Edward Conway; Fiscal Year: 2006
    ..The results of the studies, to be tested in an excellent environment, will hopefully provide new insights that will lead to the design of more effective therapeutic approaches for inflammatory disease. ..