Peter Carmeliet

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi Angiogenesis in life, disease and medicine
    Peter Carmeliet
    Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology VIB, B 3000 Leuven, Belgium
    Nature 438:932-6. 2005
  2. ncbi Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way
    Peter Carmeliet
    Vesalius Research Center, VIB, KULeuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Nat Rev Clin Oncol 6:315-26. 2009
  3. ncbi Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium
    EMBO J 29:424-41. 2010
  4. ncbi Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
    Xuri Li
    Vesalius Research Center, VIB, 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 28:1614-20. 2008
  5. ncbi Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 113:188-99. 2004
  6. ncbi Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
    Ilse Geudens
    Vesalius Research Center, VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:1695-702. 2010
  7. ncbi Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:803-11. 2003
  8. ncbi Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    Christian Fischer
    Department for Transgene Technology and Gene Therapy, VIB, 3000, Leuven, Belgium
    Cell 131:463-75. 2007
  9. ncbi Role of synectin in lymphatic development in zebrafish and frogs
    Karlien Hermans
    Vesalius Research Center, Vlaams Iustituut voor Biotechnologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Blood 116:3356-66. 2010
  10. ncbi Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
    Sonja Loges
    Vesalius Research Center VRC, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
    Blood 115:2264-73. 2010

Detail Information

Publications113 found, 100 shown here

  1. ncbi Angiogenesis in life, disease and medicine
    Peter Carmeliet
    Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology VIB, B 3000 Leuven, Belgium
    Nature 438:932-6. 2005
    ..Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments...
  2. ncbi Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way
    Peter Carmeliet
    Vesalius Research Center, VIB, KULeuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Nat Rev Clin Oncol 6:315-26. 2009
    ..This Review provides a conceptual framework in which molecular discoveries and principles are discussed in light of clinical opportunities to develop new antiangiogenic agents...
  3. ncbi Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium
    EMBO J 29:424-41. 2010
    ..Moreover, the finding that VEGF can modulate beta-catenin activity may have widespread physiological and clinical ramifications...
  4. ncbi Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
    Xuri Li
    Vesalius Research Center, VIB, 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 28:1614-20. 2008
    ..The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear...
  5. ncbi Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 113:188-99. 2004
    ..These findings indicate that the insoluble VEGF(188) isoform is insufficient for establishing epiphyseal vascularization and regulating cartilage development during endochondral bone formation...
  6. ncbi Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
    Ilse Geudens
    Vesalius Research Center, VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:1695-702. 2010
    ..To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development...
  7. ncbi Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:803-11. 2003
    ..To evaluate the role of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in adhesion formation after laparoscopic surgery...
  8. ncbi Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    Christian Fischer
    Department for Transgene Technology and Gene Therapy, VIB, 3000, Leuven, Belgium
    Cell 131:463-75. 2007
    ..The efficacy and safety of alphaPlGF, its pleiotropic and complementary mechanism to VEGF(R)Is, and the negligible induction of an angiogenic rescue program suggest that alphaPlGF may constitute a novel approach for cancer treatment...
  9. ncbi Role of synectin in lymphatic development in zebrafish and frogs
    Karlien Hermans
    Vesalius Research Center, Vlaams Iustituut voor Biotechnologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Blood 116:3356-66. 2010
    ..These findings reveal a novel role for synectin in lymphatic development...
  10. ncbi Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
    Sonja Loges
    Vesalius Research Center VRC, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
    Blood 115:2264-73. 2010
    ..Hence, inhibition of Gas6 might offer novel opportunities for the treatment of cancer...
  11. ncbi Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1
    Carmen Ruiz de Almodovar
    Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Vesalius Research Center, Katholieke Universiteit Leuven, Belgium
    J Neurosci 30:15052-66. 2010
    ..These findings identify a previously unknown role for VEGF in neuronal migration...
  12. ncbi Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, B 3000, Belgium
    Nat Med 9:936-43. 2003
    ....
  13. ncbi Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation
    Lieve Coenegrachts
    Laboratory of Experimental Medicine and Endocrinology, Vesalius Research Center, KU Leuven, Belgium
    Cancer Res 70:6537-47. 2010
    ..These findings identify novel properties of PlGF and suggest that alphaPlGF might offer opportunities for adjuvant therapy of bone metastasis...
  14. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  15. ncbi Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis
    Xabier L Aranguren
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Onderwijs and Navorsing 1, Herestraat 49, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 410:121-6. 2011
    ..Therefore, the role of NR2F2 in EC fate determination is evolutionary conserved...
  16. ncbi VEGF: a modifier of the del22q11 (DiGeorge) syndrome?
    Ingeborg Stalmans
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium
    Nat Med 9:173-82. 2003
    ..These genetic data in mouse, fish and human indicate that VEGF is a modifier of cardiovascular birth defects in the del22q11 syndrome...
  17. ncbi Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration
    Koen Poesen
    Vesalius Research Center, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
    J Neurosci 28:10451-9. 2008
    ..The neuroprotective activity of VEGF-B, in combination with its negligible angiogenic/permeability activity, offers attractive opportunities for the treatment of neurodegenerative diseases...
  18. ncbi Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    Massimiliano Mazzone
    Vesalius Research Center, VIB Vlaams Instituut voor Biotechnologie, Leuven, Belgium
    Cell 136:839-51. 2009
    ..Inhibition of PHD2 may offer alternative therapeutic opportunities for anticancer therapy...
  19. ncbi Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery
    Erik Storkebaum
    Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium
    Circulation 122:273-81. 2010
    ..Control of peripheral resistance arteries by autonomic nerves is essential for the regulation of blood flow. The signals responsible for the maintenance of vascular neuroeffector mechanisms in the adult, however, remain largely unknown...
  20. ncbi Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation
    Marc Tjwa
    Vesalius Research Center, VIB, Leuven, Belgium
    J Cell Mol Med 13:4587-95. 2009
    ..These findings provide novel insights in how plasmin regulates haematopoietic recovery upon cytotoxic myeloablation...
  21. ncbi Engineering vascularized bone: osteogenic and proangiogenic potential of murine periosteal cells
    Nick van Gastel
    Laboratory of Clinical and Experimental Endocrinology, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium
    Stem Cells 30:2460-71. 2012
    ....
  22. ncbi VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection
    Erik Storkebaum
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Bioessays 26:943-54. 2004
    ..These findings have raised growing interest in assessing the therapeutic potential of VEGF for neurodegenerative disorders...
  23. ncbi Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions
    Carmen Roncal
    Vesalius Research Center, VIB, KULeuven, Campus Gasthuisberg, Herestraat 49, Box 912, 3000 Leuven, Belgium
    Cardiovasc Res 86:29-36. 2010
    ..Previous gene-inactivation studies revealed that the loss of PlGF delays atherosclerotic lesion development and inhibits macrophage infiltration, but the activity of an anti-PlGF antibody (alphaPlGF mAb) has not been evaluated yet...
  24. ncbi VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis
    Marta Koch
    Vesalius Research Centre, VIB, B 3000 Leuven, Belgium
    J Pathol 219:356-64. 2009
    ....
  25. ncbi Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts
    Ritsuko Masuyama
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 116:3150-9. 2006
    ..Taken together, our findings provide evidence that VDR signaling in chondrocytes is required for timely osteoclast formation during bone development and for the endocrine action of bone in phosphate homeostasis...
  26. ncbi Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
    Xuri Li
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology (VIB, University of Leuven, Leuven, Belgium
    J Clin Invest 115:118-27. 2005
    ..Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases...
  27. ncbi Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha
    Veerle Compernolle
    Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Cardiovasc Res 60:569-79. 2003
    ..We attempted to further characterize the underlying mechanisms resulting in abnormal cardiogenesis and defective angiogenesis in mice deficient for HIF-1alpha (HIF-1alpha(-/-))...
  28. ncbi Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 116:1230-42. 2006
    ..Therefore PlGF may potentially offer therapeutic advantages for fracture repair...
  29. ncbi Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes
    Marc Tjwa
    Department of Transgene Technology and Gene Therapy, Flanders Institute of Biotechnology VIB, Leuven, Belgium
    Blood 111:4096-105. 2008
    ..Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation...
  30. ncbi From vessel sprouting to normalization: role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery
    Cathy Coulon
    Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:2331-6. 2010
    ..Given the essential role of hypoxia as the driving force for initiating angiogenesis, it is not surprising that the hypoxia-sensing machinery controls key steps in physiological and pathological angiogenesis...
  31. ncbi VEGF mediates commissural axon chemoattraction through its receptor Flk1
    Carmen Ruiz de Almodovar
    VIB, Laboratory for Angiogenesis and the Neurovascular link, Vesalius Research Center, KULeuven, Leuven, Belgium
    Neuron 70:966-78. 2011
    ..Similar to Shh and Netrin-1, VEGF-mediated commissural axon guidance requires the activity of Src family kinases. Our results identify VEGF and Flk1 as a novel ligand/receptor pair controlling commissural axon guidance...
  32. ncbi Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
    Erik Storkebaum
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KU Leuven, Leuven B 3000, Belgium
    Nat Neurosci 8:85-92. 2005
    ..On i.c.v. delivery, Vegf is anterogradely transported and preserves neuromuscular junctions in SOD1(G93A) rats. Our findings in preclinical rodent models of ALS may have implications for treatment of neurodegenerative disease in general...
  33. ncbi Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:795-802. 2003
    ..To evaluate the role of hypoxia inducible factors (HIFs) 1alpha and 2alpha in adhesion formation after laparoscopic surgery...
  34. ncbi Blood vessels and nerves: common signals, pathways and diseases
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Rev Genet 4:710-20. 2003
    ..The realization that both systems use common genetic pathways should not only form links between vascular biology and neuroscience, but also promises to accelerate the discovery of new mechanistic insights and therapeutic opportunities...
  35. ncbi VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
    Diether Lambrechts
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology and Department of Neurology, University Hospital Gasthuisberg, KU Leuven, Leuven, B 3000, Belgium
    Nat Genet 34:383-94. 2003
    ..These findings indicate that VEGF is a modifier of motoneuron degeneration in human ALS and unveil a therapeutic potential of Vegfa for stressed motoneurons in mice...
  36. ncbi Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles
    Annelii Ny
    Vesalius Research Center, VIB KU Leuven, Leuven, Belgium
    Blood 112:1740-9. 2008
    ..These findings document a critical role of VEGFR-3 in embryonic lymphatic development and function, and reveal a previously unrecognized modifier role of VEGF-D in the regulation of embryonic lymphangiogenesis in frog embryos...
  37. ncbi Impaired adipose tissue development in mice with inactivation of placental growth factor function
    H Roger Lijnen
    Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O and N 1, Box 911, Herestraat 49, B 3000 Leuven, Belgium
    Diabetes 55:2698-704. 2006
    ..Thus, in murine models of diet-induced obesity, inactivation of PlGF impairs adipose tissue development, at least in part as a result of reduced angiogenesis...
  38. ncbi Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells
    Marc Tjwa
    VIB Vesalius Research Center, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 119:1008-18. 2009
    ..These findings identify MuPAR and plasmin as regulators of the proliferation, marrow pool size, homing, engraftment, and mobilization of HSPCs and possibly also of HSCs...
  39. ncbi A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia
    Koen Brusselmans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology (VIB, KULeuven, Leuven, B-3000, Belgium
    J Biol Chem 280:3493-9. 2005
    ..Thus, VEGF plays a critical role in survival of ES cells during prolonged hypoxia...
  40. ncbi Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease
    Sara Van de Veire
    Vesalius Research Center, KU Leuven, Leuven B 3000, Belgium
    Cell 141:178-90. 2010
    ..Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies...
  41. ncbi Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve
    An Van den Bergh
    Department of Cardiovascular Diseases, Division of Experimental Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Heart Fail 11:1118-25. 2009
    ..However, their effect on contractile dysfunction and impaired cardiac functional reserve is unknown...
  42. ncbi Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 104:14825-30. 2007
    ..These results reveal a mechanism through which astrocytes influence neuronal functioning in health and disease...
  43. ncbi Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice
    Stephane Heymans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute, Herestraat 49, B 3000 Leuven, Belgium
    Am J Pathol 166:15-25. 2005
    ..Deficiency of MMP-9 had an intermediate effect. These findings suggest that the use of u-PA- or MMP-inhibitors might preserve cardiac pump function in LV pressure overloading...
  44. ncbi Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium
    J Cell Biol 181:37-41. 2008
    ..These results demonstrate that PGRN/GRN is a neurotrophic factor with activities that may be involved in the development of the nervous system and in neurodegeneration...
  45. ncbi Regulation of angiogenesis by oxygen and metabolism
    Peter Fraisl
    Vesalius Research Center, Leuven, Belgium
    Dev Cell 16:167-79. 2009
    ..We will highlight advances in how oxygen and metabolism regulate angiogenesis as well as how angiogenic factors in turn also regulate metabolism...
  46. ncbi VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis
    Marc Tjwa
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, 3000, Leuven, Belgium
    Cell Tissue Res 314:5-14. 2003
    ..These new insights broaden the activity spectrum of these "angiogenic" growth factors, and may have therapeutic implications when using these growth factors for vascular and/or non-vascular purposes...
  47. ncbi Angiogenesis and lymphangiogenesis: highlights of the past year
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Curr Opin Hematol 11:262-71. 2004
    ....
  48. ncbi Similarities between angiogenesis and neural development: what small animal models can tell us
    Serena Zacchigna
    Department of Transgene Technology and Gene Therapy, VIB, Leuven, Belgium
    Curr Top Dev Biol 80:1-55. 2008
    ..In the first part of this chapter, we will discuss the more commonly used animal models; in the second part, the striking similarities occurring during the development of the vascular and the neural systems will be revised...
  49. ncbi Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration
    Serena Zacchigna
    Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Neurosci 29:2297-308. 2009
    ..These findings shed novel insight on how Prom-1 regulates neural retinal development and phototransduction in vertebrates...
  50. ncbi Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice
    Erik Maquoi
    Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 25:1002-7. 2005
    ..A potential role of growth arrest-specific gene 6 (Gas-6) in energy storage in adipose tissue was investigated in murine models of obesity. Gas-6 is a ligand for the Axl, C-Mer, and Sky family of tyrosine kinase receptors...
  51. ncbi Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets?
    Aernout Luttun
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1654:79-94. 2004
    ..Together, these insights may bring anti-angiogenic drugs closer from bench to bedside...
  52. ncbi Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons
    Joke Dhondt
    Vesalius Research Center, Katholieke Universiteit Leuven, Leuven, Belgium
    FASEB J 25:1461-73. 2011
    ..Overall, this indicates that VEGF-B, instead of acting as an angiogenic factor, exerts direct neuroprotective effects through FLT1. These findings also suggest a clinically relevant role for VEGF-B in preventing distal neuropathies...
  53. ncbi The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation
    Aleyde Van Eynde
    Division of Biochemistry, Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium
    Mol Cell Biol 24:5863-74. 2004
    ..We conclude that NIPP1 is indispensable for early embryonic development and cell proliferation...
  54. ncbi Role of vascular endothelial growth factor receptor 1 in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in mice
    Carlos Roger Molinas
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 82:1149-53. 2004
    ..To evaluate the role of vascular endothelial growth factor receptor-1 (VEGFR-1) in adhesion formation after laparoscopic surgery...
  55. ncbi Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy
    An Verheyen
    Laboratory for Translational Genetics, Department of Oncology, University of Leuven, B 3000 Leuven, Belgium
    Brain 135:2629-41. 2012
    ....
  56. ncbi Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain
    Els Melis
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KULeuven Campus Gasthuisberg, Leuven B 3000, Belgium
    Biochem Biophys Res Commun 333:488-95. 2005
    ..This severe thrombotic phenotype associated with the presence of a non-anchored soluble TF variant underscores the recently recognized significance of circulating TF for thrombus formation and development...
  57. ncbi Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia
    Thomas Schmidt
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center VRC, VIB, K U Leuven, Belgium
    Cancer Cell 19:740-53. 2011
    ..These results may warrant further investigation of the therapeutic potential of PlGF inhibition for (imatinib-resistant) CML...
  58. ncbi Role and therapeutic potential of VEGF in the nervous system
    Carmen Ruiz de Almodovar
    The Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium
    Physiol Rev 89:607-48. 2009
    ..We describe the molecular properties of VEGF and its receptors and review the current knowledge of its different functions and therapeutic potential in the nervous system during development, health, disease and in medicine...
  59. ncbi Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
    Veerle Compernolle
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium
    Nat Med 8:702-10. 2002
    ..The pneumotrophic effect of VEGF may have therapeutic potential for lung maturation in preterm infants...
  60. ncbi Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
    Peter Fraisl
    Vesalius Research Center, VIB, K U Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Nat Rev Drug Discov 8:139-52. 2009
    ..Advances in understanding of the role of these oxygen sensors in hypoxia tolerance, ischaemic preconditioning and inflammation are creating new opportunities for pharmacological interventions for ischaemic and inflammatory diseases...
  61. ncbi Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
    Koen Brusselmans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 111:1519-27. 2003
    ....
  62. ncbi Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited
    Sonja Loges
    Vesalius Research Center, VIB, B 3000 Leuven, Belgium
    Cancer Cell 15:167-70. 2009
    ..We discuss here how VEGF inhibitors can induce such divergent effects on primary tumor growth and metastasis...
  63. ncbi Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration
    Ludo Van Den Bosch
    Laboratory for Neurobiology, Department of Experimental Neurology, School of Medicine, University of Leuven, Leuven, Belgium
    Neurobiol Dis 17:21-8. 2004
    ..Our results show that VEGF is a neurotrophic factor for motor neurons in vitro, and shortage of this neurotrophic factor may contribute to the motor neuron death observed in humans and animals with low VEGF expression levels...
  64. ncbi Oxygen sensors at the crossroad of metabolism
    Julian Aragones
    Vesalius Research Center, K U Leuven, Leuven, B 3000, Belgium
    Cell Metab 9:11-22. 2009
    ..These insights may offer novel opportunities for the treatment of ischemic diseases...
  65. ncbi Manipulating angiogenesis in medicine
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Intern Med 255:538-61. 2004
    ..That such therapeutic strategies might change the face of medicine is witnessed by initial evidence of success in the clinic...
  66. ncbi Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, Leuven, Belgium
    Ann N Y Acad Sci 979:80-93. 2002
    ..Thus, PlGF and Flt-1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  67. ncbi Endothelial oxygen sensors regulate tumor vessel abnormalization by instructing phalanx endothelial cells
    Katrien De Bock
    Vesalius Research Center, K U Leuven, Belgium
    J Mol Med (Berl) 87:561-9. 2009
    ..This review discusses the role of PHD2 in the regulation of vessel (ab)normalization and the therapeutic potential of PHD2 inhibition for tumor invasiveness and metastasis...
  68. ncbi Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, KU Leuven, B 3000, Leuven, Belgium
    Mech Dev 111:61-73. 2002
    ....
  69. ncbi Gene prioritization through genomic data fusion
    Stein Aerts
    Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB, University of Leuven, Herestraat 49, bus 602, 3000 Leuven, Belgium
    Nat Biotechnol 24:537-44. 2006
    ..The approach described here offers an alternative integrative method for gene discovery...
  70. ncbi Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Semin Cell Dev Biol 13:39-53. 2002
    ..A challenge for the future is to unravel to what extent the effect of VEGF in these disorders relates to its angiogenic activity or direct neurotrophic effect...
  71. ncbi Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination
    Camila V Esguerra
    Center for Transgene Technology and Gene Therapy, VIB, Herestraat 49, B 3000 Leuven, Belgium
    Development 134:4381-93. 2007
    ....
  72. ncbi Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish
    Robin Lemmens
    Department of Neurology, University Hospital Gasthuisberg, K U Leuven, Belgium
    Hum Mol Genet 16:2359-65. 2007
    ....
  73. ncbi VEGF as a key mediator of angiogenesis in cancer
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flander s Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Oncology 69:4-10. 2005
    ..These characteristics mean that tumor blood flow is suboptimal, resulting in hypoxia and further VEGF production. This central role of VEGF in the production of tumor vasculature makes it a rational target for anticancer therapy...
  74. ncbi Role of neural guidance signals in blood vessel navigation
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B-3000 Leuven, Belgium
    Cardiovasc Res 65:629-38. 2005
    ....
  75. ncbi Angiogenesis in health and disease
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Med 9:653-60. 2003
    ..Molecular insights into these processes are being generated at a rapidly increasing pace, offering new therapeutic opportunities that are currently being evaluated...
  76. ncbi Genetics in zebrafish, mice, and humans to dissect congenital heart disease: insights in the role of VEGF
    Diether Lambrechts
    Flanders Interuniversity Institute for Biotechnology, Center for Transgene Technology and Gene Therapy, KU Leuven, Leuven, B-3000, Belgium
    Curr Top Dev Biol 62:189-224. 2004
    ....
  77. ncbi Neurovascular signalling defects in neurodegeneration
    Serena Zacchigna
    The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, B 3000, Belgium
    Nat Rev Neurosci 9:169-81. 2008
    ..Unravelling the molecular mechanisms by which these angioneurins act might create opportunities for developing new neurovascular medicine...
  78. ncbi Hungry for blood vessels: linking metabolism and angiogenesis
    Peter Fraisl
    Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, B 3000, Belgium
    Dev Cell 14:313-4. 2008
    ..These findings show that alterations in metabolic homeostasis are linked to angiogenesis, which raises exciting opportunities for novel proangiogenic and antiangiogenic therapies in various diseases...
  79. ncbi A surrogate marker to monitor angiogenesis at last
    Martin Schneider
    The Flanders Interuniversity Institute for Biotechnology, The Center for Transgene Technology and Gene Therapy, KULeuven, Leuven, B-3000, Belgium
    Cancer Cell 7:3-4. 2005
    ..These findings highlight the potential usefulness of CEPs as a surrogate marker to monitor and adjust antiangiogenic therapy...
  80. ncbi Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms
    Ingeborg Stalmans
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Catholic University Leuven, Leuven, Belgium
    J Clin Invest 109:327-36. 2002
    ..These findings reveal distinct roles of the various VEGF isoforms in vascular patterning and arterial development in the retina...
  81. ncbi Vascular progenitors: from biology to treatment
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Trends Cardiovasc Med 12:88-96. 2002
    ..This review discusses some of the recent insights and outstanding questions on EPCs, both from a biological and therapeutic perspective...
  82. ncbi "Antimyeloangiogenic" therapy for cancer by inhibiting PlGF
    Sonja Loges
    Vesalius Research Center VRC, VIB, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Cancer Res 15:3648-53. 2009
    ..Because of these promising results, a humanized alphaPlGF antibody (TB403) is currently evaluated in different phase I clinical trials in cancer patients...
  83. ncbi Sculpting heart valves with NFATc and VEGF
    Diether Lambrechts
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Cell 118:532-4. 2004
    ..reveal a novel role for calcineurin, NFATs, and VEGF in valve formation. Dynamic changes in NFAT/VEGF expression in regional myocardial and endocardial fields and developmental windows orchestrate this complex process...
  84. ncbi Zebrafish and Xenopus tadpoles: small animal models to study angiogenesis and lymphangiogenesis
    Annelii Ny
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Exp Cell Res 312:684-93. 2006
    ..The advantages of these two models will be discussed in the present review...
  85. ncbi De novo vasculogenesis in the heart
    Aernout Luttun
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KU Leuven, B 3000, Leuven, Belgium
    Cardiovasc Res 58:378-89. 2003
    ....
  86. ncbi Metabolism and therapeutic angiogenesis
    Peter Carmeliet
    Vesalius Research Center, VIB-KU Leuven, Leuven, Belgium
    N Engl J Med 358:2511-2. 2008
  87. ncbi Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 22:499-505. 2002
    ..Thus, although PAI-1 may promote plaque growth because of its antifibrinolytic properties, the present study reveals a protective role for PAI-1 by limiting plaque growth and preventing abnormal matrix remodeling...
  88. ncbi VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism
    Frederic Pipp
    Max Planck Institute for Physiological and Clinical Research, Dept of Experimental Cardiology, Benekestr 2, 61231 Bad Nauheim, Germany
    Circ Res 92:378-85. 2003
    ..Together, these data indicate that the arteriogenic activity observed with the VEGFR-1-specific PlGF is caused by its monocyte-activating properties...
  89. ncbi Loss of placental growth factor protects mice against vascular permeability in pathological conditions
    Aernout Luttun
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven B 3000, Belgium
    Biochem Biophys Res Commun 295:428-34. 2002
    ..These findings suggest that inhibition of PlGF might be an attractive tool to reduce vascular leakage in various diseases...
  90. ncbi Building in resistance to endothelial cell death
    Massimiliano Mazzone
    Nat Genet 39:1308-9. 2007
  91. ncbi Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice
    Virginie Mattot
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Belgium
    J Am Soc Nephrol 13:1548-60. 2002
    ..Thus, VEGF(164) and VEGF(188) not only mediate angiogenesis, but they also play an essential role in renal branching arteriogenesis...
  92. ncbi Selective regulation of arterial branching morphogenesis by synectin
    Thomas W Chittenden
    Angiogenesis Research Center, Section of Cardiology, Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Dev Cell 10:783-95. 2006
    ..We conclude that synectin is involved in selective regulation of arterial, but not venous, growth and branching morphogenesis and that Rac1 plays an important role in this process...
  93. ncbi Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling
    Heike Beck
    Institute of Neurology Edinger Institute, JWG University, Frankfurt am Main, Germany
    J Neuropathol Exp Neurol 61:339-50. 2002
    ..Possibly, the loss of semaphorins facilitates binding of the competing ligands (VEGF/PLGF), thus inducing angiogenesis. In addition, the observed expression patterns further suggest a neurotrophic/neuroprotective role of VEGF/PLGF...
  94. ncbi VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain
    Barbara Le Bras
    Institut National de la Sante et de la Recherche Medicale INSERM, U711, Paris F 75013, France
    Nat Neurosci 9:340-8. 2006
    ..VEGF-C thus has a new, evolutionary conserved function as a growth factor selectively required by neural progenitor cells expressing its receptor VEGFR-3...
  95. ncbi VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization
    Bin Li
    Department of Pathology, Vanderbilt University School of Medicine, 1161 21st Ave South, C2217 MCN, Nashville, Tennessee 37232, USA
    FASEB J 20:1495-7. 2006
    ..Our data suggest local VEGF and/or PlGF expression promote vasculogenesis; VEGF plays a role in EPC recruitment and subsequent formation of functional vessels...
  96. ncbi Tumoral and choroidal vascularization: differential cellular mechanisms involving plasminogen activator inhibitor type I
    Maud Jost
    Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie, CHU B23, Sart Tilman B 4000 Liège, Belgium
    Am J Pathol 171:1369-80. 2007
    ..Altogether, the present study demonstrates that different cellular mechanisms contribute to PAI-1-regulated tumoral and CNV. PAI-1 contributes to BM-dependent choroidal vascularization and to BM-independent tumor growth and angiogenesis...
  97. ncbi NKT cell-derived urokinase-type plasminogen activator promotes peripheral tolerance associated with eye
    Koh Hei Sonoda
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 179:2215-22. 2007
    ..In conclusion, uPA derived from iNKT cells is required to induce peripheral tolerance via the eye...
  98. ncbi Genetic deletion of placenta growth factor in mice alters uterine NK cells
    Chandrakant Tayade
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Immunol 178:4267-75. 2007
    ..Thus, in mice, PlGF plays an important role in successful uNK cell proliferation and/or differentiation...
  99. ncbi A critical role of placental growth factor in the induction of inflammation and edema formation
    Hajimu Oura
    Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Blood 101:560-7. 2003
    ..These findings reveal that placental growth factor plays a critical role in the control of cutaneous inflammation, and they suggest inhibition of PlGF bioactivity as a potential new approach for anti-inflammatory therapy...
  100. ncbi Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling
    Nynke M S Van Den Akker
    Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, PO Box 9600, 2300 RC Leiden, The Netherlands
    Cardiovasc Res 78:366-75. 2008
    ..Knowledge regarding the role of the VEGF/Notch/ephrinB2 cascade in (ab)normal coronary development will provide information on the subtle balance of VEGF signalling in coronary maturation and might enhance our therapeutic possibilities...
  101. ncbi Hyperthermia inhibits angiogenesis by a plasminogen activator inhibitor 1-dependent mechanism
    Cristina Roca
    Department of Oncological Sciences, School of Medicine, University of Torino, 10060 Candiolo, Italy
    Cancer Res 63:1500-7. 2003
    ..These results indicate that heat-mediated PAI-1 induction is an important pathway by which HT exerts its antitumor activity and may represent a rationale for a combined cancer therapy based on HT associated with antiangiogenic molecules...