Peter Carmeliet

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
    Veerle Compernolle
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium
    Nat Med 8:702-10. 2002
  2. ncbi request reprint Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice
    Erik Maquoi
    Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 25:1002-7. 2005
  3. doi request reprint Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    Massimiliano Mazzone
    Vesalius Research Center, VIB Vlaams Instituut voor Biotechnologie, Leuven, Belgium
    Cell 136:839-51. 2009
  4. ncbi request reprint VEGF as a key mediator of angiogenesis in cancer
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flander s Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Oncology 69:4-10. 2005
  5. doi request reprint Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
    Ilse Geudens
    Vesalius Research Center, VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:1695-702. 2010
  6. pmc Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium
    EMBO J 29:424-41. 2010
  7. ncbi request reprint Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    Christian Fischer
    Department for Transgene Technology and Gene Therapy, VIB, 3000, Leuven, Belgium
    Cell 131:463-75. 2007
  8. ncbi request reprint Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:803-11. 2003
  9. doi request reprint Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
    Sonja Loges
    Vesalius Research Center VRC, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
    Blood 115:2264-73. 2010
  10. ncbi request reprint Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, B 3000, Belgium
    Nat Med 9:936-43. 2003

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
    Veerle Compernolle
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium
    Nat Med 8:702-10. 2002
    ..The pneumotrophic effect of VEGF may have therapeutic potential for lung maturation in preterm infants...
  2. ncbi request reprint Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice
    Erik Maquoi
    Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 25:1002-7. 2005
    ..A potential role of growth arrest-specific gene 6 (Gas-6) in energy storage in adipose tissue was investigated in murine models of obesity. Gas-6 is a ligand for the Axl, C-Mer, and Sky family of tyrosine kinase receptors...
  3. doi request reprint Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    Massimiliano Mazzone
    Vesalius Research Center, VIB Vlaams Instituut voor Biotechnologie, Leuven, Belgium
    Cell 136:839-51. 2009
    ..Inhibition of PHD2 may offer alternative therapeutic opportunities for anticancer therapy...
  4. ncbi request reprint VEGF as a key mediator of angiogenesis in cancer
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flander s Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Oncology 69:4-10. 2005
    ..These characteristics mean that tumor blood flow is suboptimal, resulting in hypoxia and further VEGF production. This central role of VEGF in the production of tumor vasculature makes it a rational target for anticancer therapy...
  5. doi request reprint Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
    Ilse Geudens
    Vesalius Research Center, VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:1695-702. 2010
    ..To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development...
  6. pmc Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium
    EMBO J 29:424-41. 2010
    ..Moreover, the finding that VEGF can modulate beta-catenin activity may have widespread physiological and clinical ramifications...
  7. ncbi request reprint Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    Christian Fischer
    Department for Transgene Technology and Gene Therapy, VIB, 3000, Leuven, Belgium
    Cell 131:463-75. 2007
    ..The efficacy and safety of alphaPlGF, its pleiotropic and complementary mechanism to VEGF(R)Is, and the negligible induction of an angiogenic rescue program suggest that alphaPlGF may constitute a novel approach for cancer treatment...
  8. ncbi request reprint Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:803-11. 2003
    ..To evaluate the role of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in adhesion formation after laparoscopic surgery...
  9. doi request reprint Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
    Sonja Loges
    Vesalius Research Center VRC, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
    Blood 115:2264-73. 2010
    ..Hence, inhibition of Gas6 might offer novel opportunities for the treatment of cancer...
  10. ncbi request reprint Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, B 3000, Belgium
    Nat Med 9:936-43. 2003
    ....
  11. pmc Role of synectin in lymphatic development in zebrafish and frogs
    Karlien Hermans
    Vesalius Research Center, Vlaams Iustituut voor Biotechnologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Blood 116:3356-66. 2010
    ..These findings reveal a novel role for synectin in lymphatic development...
  12. doi request reprint Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation
    Marc Tjwa
    Vesalius Research Center, VIB, Leuven, Belgium
    J Cell Mol Med 13:4587-95. 2009
    ..These findings provide novel insights in how plasmin regulates haematopoietic recovery upon cytotoxic myeloablation...
  13. ncbi request reprint Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  14. ncbi request reprint A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia
    Koen Brusselmans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KULeuven, Leuven, B 3000, Belgium
    J Biol Chem 280:3493-9. 2005
    ..Thus, VEGF plays a critical role in survival of ES cells during prolonged hypoxia...
  15. ncbi request reprint VEGF: a modifier of the del22q11 (DiGeorge) syndrome?
    Ingeborg Stalmans
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium
    Nat Med 9:173-82. 2003
    ..These genetic data in mouse, fish and human indicate that VEGF is a modifier of cardiovascular birth defects in the del22q11 syndrome...
  16. doi request reprint Engineering vascularized bone: osteogenic and proangiogenic potential of murine periosteal cells
    Nick van Gastel
    Laboratory of Clinical and Experimental Endocrinology, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium
    Stem Cells 30:2460-71. 2012
    ....
  17. ncbi request reprint VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection
    Erik Storkebaum
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Bioessays 26:943-54. 2004
    ..These findings have raised growing interest in assessing the therapeutic potential of VEGF for neurodegenerative disorders...
  18. pmc Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 113:188-99. 2004
    ..These findings indicate that the insoluble VEGF(188) isoform is insufficient for establishing epiphyseal vascularization and regulating cartilage development during endochondral bone formation...
  19. ncbi request reprint Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes
    Marc Tjwa
    Department of Transgene Technology and Gene Therapy, Flanders Institute of Biotechnology VIB, Leuven, Belgium
    Blood 111:4096-105. 2008
    ..Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation...
  20. doi request reprint Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery
    Erik Storkebaum
    Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium
    Circulation 122:273-81. 2010
    ..Control of peripheral resistance arteries by autonomic nerves is essential for the regulation of blood flow. The signals responsible for the maintenance of vascular neuroeffector mechanisms in the adult, however, remain largely unknown...
  21. pmc Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
    Xuri Li
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology VIB, University of Leuven, Leuven, Belgium
    J Clin Invest 115:118-27. 2005
    ..Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases...
  22. ncbi request reprint VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
    Diether Lambrechts
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology and Department of Neurology, University Hospital Gasthuisberg, KU Leuven, Leuven, B 3000, Belgium
    Nat Genet 34:383-94. 2003
    ..These findings indicate that VEGF is a modifier of motoneuron degeneration in human ALS and unveil a therapeutic potential of Vegfa for stressed motoneurons in mice...
  23. ncbi request reprint Blood vessels and nerves: common signals, pathways and diseases
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Rev Genet 4:710-20. 2003
    ..The realization that both systems use common genetic pathways should not only form links between vascular biology and neuroscience, but also promises to accelerate the discovery of new mechanistic insights and therapeutic opportunities...
  24. pmc Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts
    Ritsuko Masuyama
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 116:3150-9. 2006
    ..Taken together, our findings provide evidence that VDR signaling in chondrocytes is required for timely osteoclast formation during bone development and for the endocrine action of bone in phosphate homeostasis...
  25. pmc Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 116:1230-42. 2006
    ..Therefore PlGF may potentially offer therapeutic advantages for fracture repair...
  26. ncbi request reprint Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:795-802. 2003
    ..To evaluate the role of hypoxia inducible factors (HIFs) 1alpha and 2alpha in adhesion formation after laparoscopic surgery...
  27. doi request reprint Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles
    Annelii Ny
    Vesalius Research Center, VIB KU Leuven, Leuven, Belgium
    Blood 112:1740-9. 2008
    ..These findings document a critical role of VEGFR-3 in embryonic lymphatic development and function, and reveal a previously unrecognized modifier role of VEGF-D in the regulation of embryonic lymphangiogenesis in frog embryos...
  28. pmc Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice
    Stephane Heymans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute, Herestraat 49, B 3000 Leuven, Belgium
    Am J Pathol 166:15-25. 2005
    ..Deficiency of MMP-9 had an intermediate effect. These findings suggest that the use of u-PA- or MMP-inhibitors might preserve cardiac pump function in LV pressure overloading...
  29. pmc Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells
    Marc Tjwa
    VIB Vesalius Research Center, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 119:1008-18. 2009
    ..These findings identify MuPAR and plasmin as regulators of the proliferation, marrow pool size, homing, engraftment, and mobilization of HSPCs and possibly also of HSCs...
  30. pmc VEGF mediates commissural axon chemoattraction through its receptor Flk1
    Carmen Ruiz de Almodovar
    VIB, Laboratory for Angiogenesis and the Neurovascular link, Vesalius Research Center, KULeuven, Leuven, Belgium
    Neuron 70:966-78. 2011
    ..Similar to Shh and Netrin-1, VEGF-mediated commissural axon guidance requires the activity of Src family kinases. Our results identify VEGF and Flk1 as a novel ligand/receptor pair controlling commissural axon guidance...
  31. ncbi request reprint VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis
    Marc Tjwa
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, 3000, Leuven, Belgium
    Cell Tissue Res 314:5-14. 2003
    ..These new insights broaden the activity spectrum of these "angiogenic" growth factors, and may have therapeutic implications when using these growth factors for vascular and/or non-vascular purposes...
  32. ncbi request reprint Role of vascular endothelial growth factor receptor 1 in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in mice
    Carlos Roger Molinas
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 82:1149-53. 2004
    ..To evaluate the role of vascular endothelial growth factor receptor-1 (VEGFR-1) in adhesion formation after laparoscopic surgery...
  33. doi request reprint Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve
    An Van den Bergh
    Department of Cardiovascular Diseases, Division of Experimental Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Heart Fail 11:1118-25. 2009
    ..However, their effect on contractile dysfunction and impaired cardiac functional reserve is unknown...
  34. doi request reprint Regulation of angiogenesis by oxygen and metabolism
    Peter Fraisl
    Vesalius Research Center, Leuven, Belgium
    Dev Cell 16:167-79. 2009
    ..We will highlight advances in how oxygen and metabolism regulate angiogenesis as well as how angiogenic factors in turn also regulate metabolism...
  35. pmc Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 104:14825-30. 2007
    ..These results reveal a mechanism through which astrocytes influence neuronal functioning in health and disease...
  36. ncbi request reprint Similarities between angiogenesis and neural development: what small animal models can tell us
    Serena Zacchigna
    Department of Transgene Technology and Gene Therapy, VIB, Leuven, Belgium
    Curr Top Dev Biol 80:1-55. 2008
    ..In the first part of this chapter, we will discuss the more commonly used animal models; in the second part, the striking similarities occurring during the development of the vascular and the neural systems will be revised...
  37. ncbi request reprint Angiogenesis and lymphangiogenesis: highlights of the past year
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Curr Opin Hematol 11:262-71. 2004
    ..The authors apologize for their inability, because of space restrictions, to reference all other relevant work of the past or previous years...
  38. ncbi request reprint Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, KU Leuven, B 3000, Leuven, Belgium
    Mech Dev 111:61-73. 2002
    ....
  39. doi request reprint Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis
    Sandra Schoors
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, Department of Oncology, University of Leuven, Leuven 3000, Belgium Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven 3000, Belgium
    Cell Metab 19:37-48. 2014
    ..Although 3PO reduced glycolysis only partially and transiently in vivo, this sufficed to decrease pathological neovascularization in ocular and inflammatory models. These insights may offer therapeutic antiangiogenic opportunities. ..
  40. doi request reprint Role of PFKFB3-driven glycolysis in vessel sprouting
    Katrien De Bock
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, Department of Oncology, University of Leuven, Leuven 3000, Belgium
    Cell 154:651-63. 2013
    ....
  41. doi request reprint Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy
    An Verheyen
    Laboratory for Translational Genetics, Department of Oncology, University of Leuven, B 3000 Leuven, Belgium
    Brain 135:2629-41. 2012
    ....
  42. doi request reprint Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way
    Peter Carmeliet
    Vesalius Research Center, VIB, KULeuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Nat Rev Clin Oncol 6:315-26. 2009
    ..This Review provides a conceptual framework in which molecular discoveries and principles are discussed in light of clinical opportunities to develop new antiangiogenic agents...
  43. pmc Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
    Koen Brusselmans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 111:1519-27. 2003
    ....
  44. doi request reprint Role and therapeutic potential of VEGF in the nervous system
    Carmen Ruiz de Almodovar
    The Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium
    Physiol Rev 89:607-48. 2009
    ..We describe the molecular properties of VEGF and its receptors and review the current knowledge of its different functions and therapeutic potential in the nervous system during development, health, disease and in medicine...
  45. ncbi request reprint Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice
    Virginie Mattot
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Belgium
    J Am Soc Nephrol 13:1548-60. 2002
    ..Thus, VEGF(164) and VEGF(188) not only mediate angiogenesis, but they also play an essential role in renal branching arteriogenesis...
  46. ncbi request reprint Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration
    Ludo Van Den Bosch
    Laboratory for Neurobiology, Department of Experimental Neurology, School of Medicine, University of Leuven, Leuven, Belgium
    Neurobiol Dis 17:21-8. 2004
    ..Our results show that VEGF is a neurotrophic factor for motor neurons in vitro, and shortage of this neurotrophic factor may contribute to the motor neuron death observed in humans and animals with low VEGF expression levels...
  47. pmc MOSAIC: a multiscale model of osteogenesis and sprouting angiogenesis with lateral inhibition of endothelial cells
    Aurélie Carlier
    Biomechanics Section, KU Leuven, Leuven, Belgium
    PLoS Comput Biol 8:e1002724. 2012
    ....
  48. doi request reprint Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone
    Katrin Martens
    Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, KU Leuven, Leuven, Belgium
    Mol Genet Metab 107:735-47. 2012
    ..We conclude that peroxisomal metabolism is necessary to maintain the adrenergic tone in mice, which in turn determines metabolic homeostasis...
  49. ncbi request reprint VEGF at the neurovascular interface: therapeutic implications for motor neuron disease
    Diether Lambrechts
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1762:1109-21. 2006
    ....
  50. ncbi request reprint Manipulating angiogenesis in medicine
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Intern Med 255:538-61. 2004
    ..That such therapeutic strategies might change the face of medicine is witnessed by initial evidence of success in the clinic...
  51. doi request reprint Neurovascular signalling defects in neurodegeneration
    Serena Zacchigna
    The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, B 3000, Belgium
    Nat Rev Neurosci 9:169-81. 2008
    ..Unravelling the molecular mechanisms by which these angioneurins act might create opportunities for developing new neurovascular medicine...
  52. doi request reprint Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
    Julian Aragones
    The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit K U Leuven, Leuven, B 3000, Belgium
    Nat Genet 40:170-80. 2008
    ..These findings delineate a new role of Phd1 in hypoxia tolerance and offer new treatment perspectives for disorders characterized by oxidative stress...
  53. ncbi request reprint Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, Leuven, Belgium
    Ann N Y Acad Sci 979:80-93. 2002
    ..Thus, PlGF and Flt-1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  54. doi request reprint Oxygen sensors at the crossroad of metabolism
    Julian Aragones
    Vesalius Research Center, K U Leuven, Leuven, B 3000, Belgium
    Cell Metab 9:11-22. 2009
    ..These insights may offer novel opportunities for the treatment of ischemic diseases...
  55. pmc The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation
    Aleyde Van Eynde
    Division of Biochemistry, Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium
    Mol Cell Biol 24:5863-74. 2004
    ..We conclude that NIPP1 is indispensable for early embryonic development and cell proliferation...
  56. pmc Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms
    Ingeborg Stalmans
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Catholic University Leuven, Leuven, Belgium
    J Clin Invest 109:327-36. 2002
    ..These findings reveal distinct roles of the various VEGF isoforms in vascular patterning and arterial development in the retina...
  57. pmc Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
    Jonathan Welti
    Vesalius Research Center, University of Leuven, Leuven, Belgium
    J Clin Invest 123:3190-200. 2013
    ..Here, we examine recent discoveries of new mechanisms underlying angiogenesis, discuss successes and challenges of current antiangiogenic therapy, and highlight emerging antiangiogenic paradigms. ..
  58. ncbi request reprint Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin
    Mieke Dewerchin
    Center for Transgene Technology and Gene Therapy, VIB, KULeuven Campus Gasthuisberg O and N, Herestraat 49, B 3000 Leuven, Belgium
    Circ Res 93:1120-6. 2003
    ....
  59. doi request reprint Markers of response for the antiangiogenic agent bevacizumab
    Diether Lambrechts
    Vesalius Research Center, VIB, Herestraat 49, bus 912, Leuven, Belgium
    J Clin Oncol 31:1219-30. 2013
    ....
  60. pmc Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance
    Roel Quintens
    Gene Expression Unit, Department of Molecular and Cellular Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS ONE 8:e56719. 2013
    ..Our data indicate that COX6A2 is a regulator of respiratory uncoupling in muscle and we demonstrate that a novel and direct link exists between muscle respiratory chain activity and diet-induced obesity/insulin resistance...
  61. doi request reprint VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration
    Peter Carmeliet
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, K U Leuven, 3000, Leuven, Belgium
    Cell Mol Life Sci 70:1763-78. 2013
    ..We also discuss recent findings demonstrating that other VEGF ligands influence processes such as neurogenesis and dendrite arborization and participate in neurodegeneration...
  62. doi request reprint "Antimyeloangiogenic" therapy for cancer by inhibiting PlGF
    Sonja Loges
    Vesalius Research Center VRC, VIB, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Cancer Res 15:3648-53. 2009
    ..Because of these promising results, a humanized alphaPlGF antibody (TB403) is currently evaluated in different phase I clinical trials in cancer patients...
  63. doi request reprint Hungry for blood vessels: linking metabolism and angiogenesis
    Peter Fraisl
    Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, B 3000, Belgium
    Dev Cell 14:313-4. 2008
    ..These findings show that alterations in metabolic homeostasis are linked to angiogenesis, which raises exciting opportunities for novel proangiogenic and antiangiogenic therapies in various diseases...
  64. ncbi request reprint Genetics in zebrafish, mice, and humans to dissect congenital heart disease: insights in the role of VEGF
    Diether Lambrechts
    Flanders Interuniversity Institute for Biotechnology, Center for Transgene Technology and Gene Therapy, KU Leuven, Leuven, B 3000, Belgium
    Curr Top Dev Biol 62:189-224. 2004
    ....
  65. ncbi request reprint Sculpting heart valves with NFATc and VEGF
    Diether Lambrechts
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Cell 118:532-4. 2004
    ..reveal a novel role for calcineurin, NFATs, and VEGF in valve formation. Dynamic changes in NFAT/VEGF expression in regional myocardial and endocardial fields and developmental windows orchestrate this complex process...
  66. doi request reprint The neurovascular link in health and disease: molecular mechanisms and therapeutic implications
    Annelies Quaegebeur
    The laboratory of Angiogenesis and Neurovascular link Vesalius Research Center, K U Leuven, Leuven, B 3000, Belgium
    Neuron 71:406-24. 2011
    ..Moreover, neurovascular strategies offer novel therapeutic opportunities for neurodegenerative disorders...
  67. pmc Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation
    Karen D Cowden Dahl
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium
    Mol Cell Biol 25:10479-91. 2005
    ..This novel genetic approach provides new insights into the role of O2 tension in the development of life-threatening pregnancy-related diseases such as preeclampsia...
  68. doi request reprint Metabolism and therapeutic angiogenesis
    Peter Carmeliet
    Vesalius Research Center, VIB KU Leuven, Leuven, Belgium
    N Engl J Med 358:2511-2. 2008
  69. ncbi request reprint Gene prioritization through genomic data fusion
    Stein Aerts
    Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB, University of Leuven, Herestraat 49, bus 602, 3000 Leuven, Belgium
    Nat Biotechnol 24:537-44. 2006
    ..The approach described here offers an alternative integrative method for gene discovery...
  70. ncbi request reprint Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination
    Camila V Esguerra
    Center for Transgene Technology and Gene Therapy, VIB, Herestraat 49, B 3000 Leuven, Belgium
    Development 134:4381-93. 2007
    ....
  71. ncbi request reprint Zebrafish and Xenopus tadpoles: small animal models to study angiogenesis and lymphangiogenesis
    Annelii Ny
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Exp Cell Res 312:684-93. 2006
    ..The advantages of these two models will be discussed in the present review...
  72. ncbi request reprint Role of neural guidance signals in blood vessel navigation
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    Cardiovasc Res 65:629-38. 2005
    ....
  73. ncbi request reprint Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, Belgium
    Circulation 109:1408-14. 2004
    ..However, the role of specific MMPs, such as MMP-9 and MMP-12, in atherosclerosis remains undefined...
  74. ncbi request reprint A genetic Xenopus laevis tadpole model to study lymphangiogenesis
    Annelii Ny
    Flanders Interuniversity Institute for Biotechnology, Center for Transgene Technology and Gene Therapy, Campus Gasthuisberg O and N, Herestraat 49, KULeuven, Leuven, B 3000
    Nat Med 11:998-1004. 2005
    ..Knockdown of VEGF-C also resulted in aberrant blood vessel formation in tadpoles. This tadpole model offers opportunities for the discovery of new regulators of lymphangiogenesis...
  75. pmc The diversity of endothelial cells: a challenge for therapeutic angiogenesis
    Edward M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven Gasthuisberg O and N, Herestraat 49, 3000 Leuven, Belgium
    Genome Biol 5:207. 2004
    ..Characterization of endothelial-cell diversity will facilitate the development of novel, highly specific and safe therapies for many diseases...
  76. ncbi request reprint Role of the plasminogen system in basal adhesion formation and carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:184-92. 2003
    ..To evaluate the role of plasminogen activator inhibitor-1 (PAI-1), urokinase plasminogen activator (uPA), and tissue-type plasminogen activator (tPA) in adhesion formation after laparoscopic surgery...
  77. ncbi request reprint Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Semin Cell Dev Biol 13:39-53. 2002
    ..A challenge for the future is to unravel to what extent the effect of VEGF in these disorders relates to its angiogenic activity or direct neurotrophic effect...
  78. ncbi request reprint Angiogenesis in health and disease
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Med 9:653-60. 2003
    ..Molecular insights into these processes are being generated at a rapidly increasing pace, offering new therapeutic opportunities that are currently being evaluated...
  79. ncbi request reprint De novo vasculogenesis in the heart
    Aernout Luttun
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KU Leuven, B 3000, Leuven, Belgium
    Cardiovasc Res 58:378-89. 2003
    ....
  80. ncbi request reprint A surrogate marker to monitor angiogenesis at last
    Martin Schneider
    The Flanders Interuniversity Institute for Biotechnology, The Center for Transgene Technology and Gene Therapy, KULeuven, Leuven, B 3000, Belgium
    Cancer Cell 7:3-4. 2005
    ..These findings highlight the potential usefulness of CEPs as a surrogate marker to monitor and adjust antiangiogenic therapy...
  81. ncbi request reprint Angiogenesis in life, disease and medicine
    Peter Carmeliet
    Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology VIB, B 3000 Leuven, Belgium
    Nature 438:932-6. 2005
    ..Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments...
  82. ncbi request reprint Vascular progenitors: from biology to treatment
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Trends Cardiovasc Med 12:88-96. 2002
    ..This review discusses some of the recent insights and outstanding questions on EPCs, both from a biological and therapeutic perspective...
  83. pmc Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered?
    Aernout Luttun
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 111:600-2. 2003
  84. ncbi request reprint Common mechanisms of nerve and blood vessel wiring
    Peter Carmeliet
    The Center for Transgene Technology and Gene Therapy CTG, Flanders Interuniversity Institute for Biotechnology VIB, University of Leuven, 3000 Leuven, Belgium
    Nature 436:193-200. 2005
    ..Parallels have also emerged between the actions of growth factors that direct angiogenic sprouting and those that regulate axon terminal arborization...
  85. pmc Plasmin therapy enhances mobilization of HPCs after G-CSF
    Marc Tjwa
    Vesalius Research Center, Leuven, Belgium
    Blood 112:4048-50. 2008
    ..Moreover, thrombolytic agents, such as tenecteplase and microplasmin, enhance HPC mobilization in mice and humans. Taken together, these findings identify a novel role for plasmin in augmenting HPC mobilization in response to G-CSF...
  86. ncbi request reprint VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain
    Barbara Le Bras
    Institut National de la Sante et de la Recherche Medicale INSERM, U711, Paris F 75013, France
    Nat Neurosci 9:340-8. 2006
    ..VEGF-C thus has a new, evolutionary conserved function as a growth factor selectively required by neural progenitor cells expressing its receptor VEGFR-3...
  87. pmc Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice
    Daniela Tirziu
    Angiogenesis Research Center, Section of Cardiology, Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03756, USA
    J Clin Invest 117:3188-97. 2007
    ..Thus stimulation of vascular growth in normal adult mouse hearts leads to an increase in cardiac mass...
  88. ncbi request reprint Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization
    Jean Marie Rakic
    Department of Ophthalmology, University Hospital, Sart Tilman, Liege, Belgium
    Invest Ophthalmol Vis Sci 44:1732-9. 2003
    ..To evaluate the presence and potential involvement of members of the plasminogen/plasminogen activator (Plg/PA) system in the exudative form of age-related macular degeneration (AMD)...
  89. ncbi request reprint Selective regulation of arterial branching morphogenesis by synectin
    Thomas W Chittenden
    Angiogenesis Research Center, Section of Cardiology, Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Dev Cell 10:783-95. 2006
    ..We conclude that synectin is involved in selective regulation of arterial, but not venous, growth and branching morphogenesis and that Rac1 plays an important role in this process...
  90. pmc Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice
    Hidefumi Kojima
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Proc Natl Acad Sci U S A 99:2170-4. 2002
    ....
  91. ncbi request reprint uPAR: a versatile signalling orchestrator
    Francesco Blasi
    Department of Molecular Biology and Functional Genomics, DIBIT, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Nat Rev Mol Cell Biol 3:932-43. 2002
    ....
  92. ncbi request reprint Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis
    Fabian Docagne
    Universite de Caen, CNRS UMR 6551, Bd H Becquerel, B P 5229, 14074 Caen Cedex, France
    Mol Cell Neurosci 21:634-44. 2002
    ..Overall, this study underlines the critical role of the t-PA/PAI-1 axis in the regulation of glutamatergic neurotransmission...
  93. ncbi request reprint The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent
    Laetitia Devy
    Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie B23, Sart Tilman, B 4000 Liege, Belgium
    FASEB J 16:147-54. 2002
    ..Using specific PAI-1 mutants, we could demonstrate that PAI-1 promotes angiogenesis at physiological (nanomolar) concentrations through its antiproteolytic activity rather than by interacting with vitronectin...
  94. ncbi request reprint Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A
    Himadri Roy
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio 70211, Finland
    Hum Gene Ther 16:1422-8. 2005
    ..Both sVEGFR-1 and sVEGFR-2 can inhibit PlGF-2-mediated angiogenesis. PlGF-2 is a potentially useful candidate for the induction of therapeutic angiogenesis in vivo...
  95. ncbi request reprint Hyperthermia inhibits angiogenesis by a plasminogen activator inhibitor 1-dependent mechanism
    Cristina Roca
    Department of Oncological Sciences, School of Medicine, University of Torino, 10060 Candiolo, Italy
    Cancer Res 63:1500-7. 2003
    ..These results indicate that heat-mediated PAI-1 induction is an important pathway by which HT exerts its antitumor activity and may represent a rationale for a combined cancer therapy based on HT associated with antiangiogenic molecules...
  96. ncbi request reprint Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy
    Guoqiang Zhang
    Children s Hospital and Regional Medical Center, Division of Nephrology, University of Washington, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    J Am Soc Nephrol 14:1234-53. 2003
    ....
  97. ncbi request reprint Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha
    Veerle Compernolle
    Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Cardiovasc Res 60:569-79. 2003
    ..We attempted to further characterize the underlying mechanisms resulting in abnormal cardiogenesis and defective angiogenesis in mice deficient for HIF-1alpha (HIF-1alpha(-/-))...
  98. ncbi request reprint The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
    Xiaowei Lu
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Nature 432:179-86. 2004
    ..Netrin-1 causes endothelial filopodial retraction, but only when UNC5B is present. Thus, UNC5B functions as a repulsive netrin receptor in endothelial cells controlling morphogenesis of the vascular system...
  99. ncbi request reprint Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization
    Jean Marie Rakic
    Department of Ophthalmology, University Hospital, Sart Tilman, Liege, Belgium
    Invest Ophthalmol Vis Sci 44:3186-93. 2003
    ..In the current study, the influence of placental growth factor (PlGF), a member of the VEGF family, in human and experimental choroidal neovascularization (CNV) was investigated...
  100. ncbi request reprint Cardiovascular biology: signalling silenced
    Edward M Conway
    Nature 425:139-41. 2003
  101. ncbi request reprint Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo
    Monica Suelves
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, Barcelona, Spain
    Blood 99:2835-44. 2002
    ..Altogether, these studies demonstrate the requirement of plasmin during myogenesis in vitro and muscle regeneration in vivo...