Peter Carmeliet

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
    Veerle Compernolle
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium
    Nat Med 8:702-10. 2002
  2. ncbi Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice
    Erik Maquoi
    Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 25:1002-7. 2005
  3. ncbi Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    Massimiliano Mazzone
    Vesalius Research Center, VIB Vlaams Instituut voor Biotechnologie, Leuven, Belgium
    Cell 136:839-51. 2009
  4. ncbi VEGF as a key mediator of angiogenesis in cancer
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flander s Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Oncology 69:4-10. 2005
  5. ncbi Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
    Ilse Geudens
    Vesalius Research Center, VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:1695-702. 2010
  6. ncbi Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium
    EMBO J 29:424-41. 2010
  7. ncbi Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:803-11. 2003
  8. ncbi Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    Christian Fischer
    Department for Transgene Technology and Gene Therapy, VIB, 3000, Leuven, Belgium
    Cell 131:463-75. 2007
  9. ncbi Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, B 3000, Belgium
    Nat Med 9:936-43. 2003
  10. ncbi Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
    Sonja Loges
    Vesalius Research Center VRC, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
    Blood 115:2264-73. 2010

Detail Information

Publications108 found, 100 shown here

  1. ncbi Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
    Veerle Compernolle
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium
    Nat Med 8:702-10. 2002
    ..The pneumotrophic effect of VEGF may have therapeutic potential for lung maturation in preterm infants...
  2. ncbi Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice
    Erik Maquoi
    Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 25:1002-7. 2005
    ..A potential role of growth arrest-specific gene 6 (Gas-6) in energy storage in adipose tissue was investigated in murine models of obesity. Gas-6 is a ligand for the Axl, C-Mer, and Sky family of tyrosine kinase receptors...
  3. ncbi Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    Massimiliano Mazzone
    Vesalius Research Center, VIB Vlaams Instituut voor Biotechnologie, Leuven, Belgium
    Cell 136:839-51. 2009
    ..Inhibition of PHD2 may offer alternative therapeutic opportunities for anticancer therapy...
  4. ncbi VEGF as a key mediator of angiogenesis in cancer
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flander s Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Oncology 69:4-10. 2005
    ..These characteristics mean that tumor blood flow is suboptimal, resulting in hypoxia and further VEGF production. This central role of VEGF in the production of tumor vasculature makes it a rational target for anticancer therapy...
  5. ncbi Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
    Ilse Geudens
    Vesalius Research Center, VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:1695-702. 2010
    ..To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development...
  6. ncbi Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium
    EMBO J 29:424-41. 2010
    ..Moreover, the finding that VEGF can modulate beta-catenin activity may have widespread physiological and clinical ramifications...
  7. ncbi Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:803-11. 2003
    ..To evaluate the role of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in adhesion formation after laparoscopic surgery...
  8. ncbi Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    Christian Fischer
    Department for Transgene Technology and Gene Therapy, VIB, 3000, Leuven, Belgium
    Cell 131:463-75. 2007
    ..The efficacy and safety of alphaPlGF, its pleiotropic and complementary mechanism to VEGF(R)Is, and the negligible induction of an angiogenic rescue program suggest that alphaPlGF may constitute a novel approach for cancer treatment...
  9. ncbi Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, B 3000, Belgium
    Nat Med 9:936-43. 2003
    ....
  10. ncbi Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
    Sonja Loges
    Vesalius Research Center VRC, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
    Blood 115:2264-73. 2010
    ..Hence, inhibition of Gas6 might offer novel opportunities for the treatment of cancer...
  11. ncbi Role of synectin in lymphatic development in zebrafish and frogs
    Karlien Hermans
    Vesalius Research Center, Vlaams Iustituut voor Biotechnologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Blood 116:3356-66. 2010
    ..These findings reveal a novel role for synectin in lymphatic development...
  12. ncbi Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation
    Marc Tjwa
    Vesalius Research Center, VIB, Leuven, Belgium
    J Cell Mol Med 13:4587-95. 2009
    ..These findings provide novel insights in how plasmin regulates haematopoietic recovery upon cytotoxic myeloablation...
  13. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  14. ncbi Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
    Xuri Li
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology (VIB, University of Leuven, Leuven, Belgium
    J Clin Invest 115:118-27. 2005
    ..Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases...
  15. ncbi Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery
    Erik Storkebaum
    Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium
    Circulation 122:273-81. 2010
    ..Control of peripheral resistance arteries by autonomic nerves is essential for the regulation of blood flow. The signals responsible for the maintenance of vascular neuroeffector mechanisms in the adult, however, remain largely unknown...
  16. ncbi Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes
    Marc Tjwa
    Department of Transgene Technology and Gene Therapy, Flanders Institute of Biotechnology VIB, Leuven, Belgium
    Blood 111:4096-105. 2008
    ..Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation...
  17. ncbi VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection
    Erik Storkebaum
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Bioessays 26:943-54. 2004
    ..These findings have raised growing interest in assessing the therapeutic potential of VEGF for neurodegenerative disorders...
  18. ncbi Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 113:188-99. 2004
    ..These findings indicate that the insoluble VEGF(188) isoform is insufficient for establishing epiphyseal vascularization and regulating cartilage development during endochondral bone formation...
  19. ncbi A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia
    Koen Brusselmans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology (VIB, KULeuven, Leuven, B-3000, Belgium
    J Biol Chem 280:3493-9. 2005
    ..Thus, VEGF plays a critical role in survival of ES cells during prolonged hypoxia...
  20. ncbi Blood vessels and nerves: common signals, pathways and diseases
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Rev Genet 4:710-20. 2003
    ..The realization that both systems use common genetic pathways should not only form links between vascular biology and neuroscience, but also promises to accelerate the discovery of new mechanistic insights and therapeutic opportunities...
  21. ncbi Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts
    Ritsuko Masuyama
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 116:3150-9. 2006
    ..Taken together, our findings provide evidence that VDR signaling in chondrocytes is required for timely osteoclast formation during bone development and for the endocrine action of bone in phosphate homeostasis...
  22. ncbi Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 116:1230-42. 2006
    ..Therefore PlGF may potentially offer therapeutic advantages for fracture repair...
  23. ncbi VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
    Diether Lambrechts
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology and Department of Neurology, University Hospital Gasthuisberg, KU Leuven, Leuven, B 3000, Belgium
    Nat Genet 34:383-94. 2003
    ..These findings indicate that VEGF is a modifier of motoneuron degeneration in human ALS and unveil a therapeutic potential of Vegfa for stressed motoneurons in mice...
  24. ncbi VEGF: a modifier of the del22q11 (DiGeorge) syndrome?
    Ingeborg Stalmans
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium
    Nat Med 9:173-82. 2003
    ..These genetic data in mouse, fish and human indicate that VEGF is a modifier of cardiovascular birth defects in the del22q11 syndrome...
  25. ncbi Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:795-802. 2003
    ..To evaluate the role of hypoxia inducible factors (HIFs) 1alpha and 2alpha in adhesion formation after laparoscopic surgery...
  26. ncbi Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells
    Marc Tjwa
    VIB Vesalius Research Center, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 119:1008-18. 2009
    ..These findings identify MuPAR and plasmin as regulators of the proliferation, marrow pool size, homing, engraftment, and mobilization of HSPCs and possibly also of HSCs...
  27. ncbi Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice
    Stephane Heymans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute, Herestraat 49, B 3000 Leuven, Belgium
    Am J Pathol 166:15-25. 2005
    ..Deficiency of MMP-9 had an intermediate effect. These findings suggest that the use of u-PA- or MMP-inhibitors might preserve cardiac pump function in LV pressure overloading...
  28. ncbi Similarities between angiogenesis and neural development: what small animal models can tell us
    Serena Zacchigna
    Department of Transgene Technology and Gene Therapy, VIB, Leuven, Belgium
    Curr Top Dev Biol 80:1-55. 2008
    ..In the first part of this chapter, we will discuss the more commonly used animal models; in the second part, the striking similarities occurring during the development of the vascular and the neural systems will be revised...
  29. ncbi Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 104:14825-30. 2007
    ..These results reveal a mechanism through which astrocytes influence neuronal functioning in health and disease...
  30. ncbi Angiogenesis and lymphangiogenesis: highlights of the past year
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Curr Opin Hematol 11:262-71. 2004
    ....
  31. ncbi VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis
    Marc Tjwa
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, 3000, Leuven, Belgium
    Cell Tissue Res 314:5-14. 2003
    ..These new insights broaden the activity spectrum of these "angiogenic" growth factors, and may have therapeutic implications when using these growth factors for vascular and/or non-vascular purposes...
  32. ncbi Role of vascular endothelial growth factor receptor 1 in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in mice
    Carlos Roger Molinas
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 82:1149-53. 2004
    ..To evaluate the role of vascular endothelial growth factor receptor-1 (VEGFR-1) in adhesion formation after laparoscopic surgery...
  33. ncbi Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve
    An Van den Bergh
    Department of Cardiovascular Diseases, Division of Experimental Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Heart Fail 11:1118-25. 2009
    ..However, their effect on contractile dysfunction and impaired cardiac functional reserve is unknown...
  34. ncbi Regulation of angiogenesis by oxygen and metabolism
    Peter Fraisl
    Vesalius Research Center, Leuven, Belgium
    Dev Cell 16:167-79. 2009
    ..We will highlight advances in how oxygen and metabolism regulate angiogenesis as well as how angiogenic factors in turn also regulate metabolism...
  35. ncbi Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles
    Annelii Ny
    Vesalius Research Center, VIB KU Leuven, Leuven, Belgium
    Blood 112:1740-9. 2008
    ..These findings document a critical role of VEGFR-3 in embryonic lymphatic development and function, and reveal a previously unrecognized modifier role of VEGF-D in the regulation of embryonic lymphangiogenesis in frog embryos...
  36. ncbi Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, KU Leuven, B 3000, Leuven, Belgium
    Mech Dev 111:61-73. 2002
    ....
  37. ncbi Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy
    An Verheyen
    Laboratory for Translational Genetics, Department of Oncology, University of Leuven, B 3000 Leuven, Belgium
    Brain 135:2629-41. 2012
    ....
  38. ncbi Role and therapeutic potential of VEGF in the nervous system
    Carmen Ruiz de Almodovar
    The Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium
    Physiol Rev 89:607-48. 2009
    ..We describe the molecular properties of VEGF and its receptors and review the current knowledge of its different functions and therapeutic potential in the nervous system during development, health, disease and in medicine...
  39. ncbi VEGF mediates commissural axon chemoattraction through its receptor Flk1
    Carmen Ruiz de Almodovar
    VIB, Laboratory for Angiogenesis and the Neurovascular link, Vesalius Research Center, KULeuven, Leuven, Belgium
    Neuron 70:966-78. 2011
    ..Similar to Shh and Netrin-1, VEGF-mediated commissural axon guidance requires the activity of Src family kinases. Our results identify VEGF and Flk1 as a novel ligand/receptor pair controlling commissural axon guidance...
  40. ncbi Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
    Koen Brusselmans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 111:1519-27. 2003
    ....
  41. ncbi Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice
    Virginie Mattot
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Belgium
    J Am Soc Nephrol 13:1548-60. 2002
    ..Thus, VEGF(164) and VEGF(188) not only mediate angiogenesis, but they also play an essential role in renal branching arteriogenesis...
  42. ncbi Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way
    Peter Carmeliet
    Vesalius Research Center, VIB, KULeuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Nat Rev Clin Oncol 6:315-26. 2009
    ..This Review provides a conceptual framework in which molecular discoveries and principles are discussed in light of clinical opportunities to develop new antiangiogenic agents...
  43. ncbi Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration
    Ludo Van Den Bosch
    Laboratory for Neurobiology, Department of Experimental Neurology, School of Medicine, University of Leuven, Leuven, Belgium
    Neurobiol Dis 17:21-8. 2004
    ..Our results show that VEGF is a neurotrophic factor for motor neurons in vitro, and shortage of this neurotrophic factor may contribute to the motor neuron death observed in humans and animals with low VEGF expression levels...
  44. ncbi VEGF at the neurovascular interface: therapeutic implications for motor neuron disease
    Diether Lambrechts
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1762:1109-21. 2006
    ....
  45. ncbi The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation
    Aleyde Van Eynde
    Division of Biochemistry, Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium
    Mol Cell Biol 24:5863-74. 2004
    ..We conclude that NIPP1 is indispensable for early embryonic development and cell proliferation...
  46. ncbi Manipulating angiogenesis in medicine
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Intern Med 255:538-61. 2004
    ..That such therapeutic strategies might change the face of medicine is witnessed by initial evidence of success in the clinic...
  47. ncbi Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
    Julian Aragones
    The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit K U Leuven, Leuven, B 3000, Belgium
    Nat Genet 40:170-80. 2008
    ..These findings delineate a new role of Phd1 in hypoxia tolerance and offer new treatment perspectives for disorders characterized by oxidative stress...
  48. ncbi Neurovascular signalling defects in neurodegeneration
    Serena Zacchigna
    The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, B 3000, Belgium
    Nat Rev Neurosci 9:169-81. 2008
    ..Unravelling the molecular mechanisms by which these angioneurins act might create opportunities for developing new neurovascular medicine...
  49. ncbi Oxygen sensors at the crossroad of metabolism
    Julian Aragones
    Vesalius Research Center, K U Leuven, Leuven, B 3000, Belgium
    Cell Metab 9:11-22. 2009
    ..These insights may offer novel opportunities for the treatment of ischemic diseases...
  50. ncbi Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, Leuven, Belgium
    Ann N Y Acad Sci 979:80-93. 2002
    ..Thus, PlGF and Flt-1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  51. ncbi Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms
    Ingeborg Stalmans
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Catholic University Leuven, Leuven, Belgium
    J Clin Invest 109:327-36. 2002
    ..These findings reveal distinct roles of the various VEGF isoforms in vascular patterning and arterial development in the retina...
  52. ncbi The neurovascular link in health and disease: molecular mechanisms and therapeutic implications
    Annelies Quaegebeur
    The laboratory of Angiogenesis and Neurovascular link Vesalius Research Center, K U Leuven, Leuven, B 3000, Belgium
    Neuron 71:406-24. 2011
    ..Moreover, neurovascular strategies offer novel therapeutic opportunities for neurodegenerative disorders...
  53. ncbi "Antimyeloangiogenic" therapy for cancer by inhibiting PlGF
    Sonja Loges
    Vesalius Research Center VRC, VIB, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Cancer Res 15:3648-53. 2009
    ..Because of these promising results, a humanized alphaPlGF antibody (TB403) is currently evaluated in different phase I clinical trials in cancer patients...
  54. ncbi Sculpting heart valves with NFATc and VEGF
    Diether Lambrechts
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Cell 118:532-4. 2004
    ..reveal a novel role for calcineurin, NFATs, and VEGF in valve formation. Dynamic changes in NFAT/VEGF expression in regional myocardial and endocardial fields and developmental windows orchestrate this complex process...
  55. ncbi Genetics in zebrafish, mice, and humans to dissect congenital heart disease: insights in the role of VEGF
    Diether Lambrechts
    Flanders Interuniversity Institute for Biotechnology, Center for Transgene Technology and Gene Therapy, KU Leuven, Leuven, B-3000, Belgium
    Curr Top Dev Biol 62:189-224. 2004
    ....
  56. ncbi Metabolism and therapeutic angiogenesis
    Peter Carmeliet
    Vesalius Research Center, VIB-KU Leuven, Leuven, Belgium
    N Engl J Med 358:2511-2. 2008
  57. ncbi Hungry for blood vessels: linking metabolism and angiogenesis
    Peter Fraisl
    Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, B 3000, Belgium
    Dev Cell 14:313-4. 2008
    ..These findings show that alterations in metabolic homeostasis are linked to angiogenesis, which raises exciting opportunities for novel proangiogenic and antiangiogenic therapies in various diseases...
  58. ncbi Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation
    Karen D Cowden Dahl
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium
    Mol Cell Biol 25:10479-91. 2005
    ..This novel genetic approach provides new insights into the role of O2 tension in the development of life-threatening pregnancy-related diseases such as preeclampsia...
  59. ncbi Zebrafish and Xenopus tadpoles: small animal models to study angiogenesis and lymphangiogenesis
    Annelii Ny
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Exp Cell Res 312:684-93. 2006
    ..The advantages of these two models will be discussed in the present review...
  60. ncbi Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination
    Camila V Esguerra
    Center for Transgene Technology and Gene Therapy, VIB, Herestraat 49, B 3000 Leuven, Belgium
    Development 134:4381-93. 2007
    ....
  61. ncbi A genetic Xenopus laevis tadpole model to study lymphangiogenesis
    Annelii Ny
    Flanders Interuniversity Institute for Biotechnology, Center for Transgene Technology and Gene Therapy, Campus Gasthuisberg O and N, Herestraat 49, KULeuven, Leuven, B-3000
    Nat Med 11:998-1004. 2005
    ..Knockdown of VEGF-C also resulted in aberrant blood vessel formation in tadpoles. This tadpole model offers opportunities for the discovery of new regulators of lymphangiogenesis...
  62. ncbi Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin
    Mieke Dewerchin
    Center for Transgene Technology and Gene Therapy, VIB, KULeuven Campus Gasthuisberg O and N, Herestraat 49, B 3000 Leuven, Belgium
    Circ Res 93:1120-6. 2003
    ....
  63. ncbi Gene prioritization through genomic data fusion
    Stein Aerts
    Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB, University of Leuven, Herestraat 49, bus 602, 3000 Leuven, Belgium
    Nat Biotechnol 24:537-44. 2006
    ..The approach described here offers an alternative integrative method for gene discovery...
  64. ncbi Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, Belgium
    Circulation 109:1408-14. 2004
    ..However, the role of specific MMPs, such as MMP-9 and MMP-12, in atherosclerosis remains undefined...
  65. ncbi Role of neural guidance signals in blood vessel navigation
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B-3000 Leuven, Belgium
    Cardiovasc Res 65:629-38. 2005
    ....
  66. ncbi De novo vasculogenesis in the heart
    Aernout Luttun
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KU Leuven, B 3000, Leuven, Belgium
    Cardiovasc Res 58:378-89. 2003
    ....
  67. ncbi Angiogenesis in health and disease
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Med 9:653-60. 2003
    ..Molecular insights into these processes are being generated at a rapidly increasing pace, offering new therapeutic opportunities that are currently being evaluated...
  68. ncbi Role of the plasminogen system in basal adhesion formation and carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:184-92. 2003
    ..To evaluate the role of plasminogen activator inhibitor-1 (PAI-1), urokinase plasminogen activator (uPA), and tissue-type plasminogen activator (tPA) in adhesion formation after laparoscopic surgery...
  69. ncbi Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Semin Cell Dev Biol 13:39-53. 2002
    ..A challenge for the future is to unravel to what extent the effect of VEGF in these disorders relates to its angiogenic activity or direct neurotrophic effect...
  70. ncbi The diversity of endothelial cells: a challenge for therapeutic angiogenesis
    Edward M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven Gasthuisberg O and N, Herestraat 49, 3000 Leuven, Belgium
    Genome Biol 5:207. 2004
    ..Characterization of endothelial-cell diversity will facilitate the development of novel, highly specific and safe therapies for many diseases...
  71. ncbi Angiogenesis in life, disease and medicine
    Peter Carmeliet
    Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology VIB, B 3000 Leuven, Belgium
    Nature 438:932-6. 2005
    ..Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments...
  72. ncbi A surrogate marker to monitor angiogenesis at last
    Martin Schneider
    The Flanders Interuniversity Institute for Biotechnology, The Center for Transgene Technology and Gene Therapy, KULeuven, Leuven, B-3000, Belgium
    Cancer Cell 7:3-4. 2005
    ..These findings highlight the potential usefulness of CEPs as a surrogate marker to monitor and adjust antiangiogenic therapy...
  73. ncbi Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered?
    Aernout Luttun
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 111:600-2. 2003
  74. ncbi Vascular progenitors: from biology to treatment
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Trends Cardiovasc Med 12:88-96. 2002
    ..This review discusses some of the recent insights and outstanding questions on EPCs, both from a biological and therapeutic perspective...
  75. ncbi Common mechanisms of nerve and blood vessel wiring
    Peter Carmeliet
    The Center for Transgene Technology and Gene Therapy (CTG, Flanders Interuniversity Institute for Biotechnology (VIB, University of Leuven, 3000 Leuven, Belgium
    Nature 436:193-200. 2005
    ..Parallels have also emerged between the actions of growth factors that direct angiogenic sprouting and those that regulate axon terminal arborization...
  76. ncbi Plasmin therapy enhances mobilization of HPCs after G-CSF
    Marc Tjwa
    Vesalius Research Center, Leuven, Belgium
    Blood 112:4048-50. 2008
    ..Moreover, thrombolytic agents, such as tenecteplase and microplasmin, enhance HPC mobilization in mice and humans. Taken together, these findings identify a novel role for plasmin in augmenting HPC mobilization in response to G-CSF...
  77. ncbi NKT cell-derived urokinase-type plasminogen activator promotes peripheral tolerance associated with eye
    Koh Hei Sonoda
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 179:2215-22. 2007
    ..In conclusion, uPA derived from iNKT cells is required to induce peripheral tolerance via the eye...
  78. ncbi Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization
    Jean Marie Rakic
    Department of Ophthalmology, University Hospital, Sart Tilman, Liege, Belgium
    Invest Ophthalmol Vis Sci 44:1732-9. 2003
    ..To evaluate the presence and potential involvement of members of the plasminogen/plasminogen activator (Plg/PA) system in the exudative form of age-related macular degeneration (AMD)...
  79. ncbi Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A
    Himadri Roy
    Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio 70211, Finland
    Hum Gene Ther 16:1422-8. 2005
    ..Both sVEGFR-1 and sVEGFR-2 can inhibit PlGF-2-mediated angiogenesis. PlGF-2 is a potentially useful candidate for the induction of therapeutic angiogenesis in vivo...
  80. ncbi VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism
    Frederic Pipp
    Max Planck Institute for Physiological and Clinical Research, Dept of Experimental Cardiology, Benekestr 2, 61231 Bad Nauheim, Germany
    Circ Res 92:378-85. 2003
    ..Together, these data indicate that the arteriogenic activity observed with the VEGFR-1-specific PlGF is caused by its monocyte-activating properties...
  81. ncbi Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis
    Fabian Docagne
    , CNRS UMR 6551, Bd H. Becquerel, B.P. 5229, 14074 Caen Cedex, France
    Mol Cell Neurosci 21:634-44. 2002
    ..Overall, this study underlines the critical role of the t-PA/PAI-1 axis in the regulation of glutamatergic neurotransmission...
  82. ncbi Plasminogen activator inhibitor 1 and vitronectin protect against stenosis in a murine carotid artery ligation model
    Vivian De Waard
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 22:1978-83. 2002
    ..Furthermore, we demonstrated in human atherosclerotic plaques the colocalization of thrombin, PAI-1, and VN, as well as activity of thrombin and PAI-1. Here, we show that PAI-1 is a local thrombin inhibitor in vivo...
  83. ncbi uPAR: a versatile signalling orchestrator
    Francesco Blasi
    Department of Molecular Biology and Functional Genomics, DIBIT, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Nat Rev Mol Cell Biol 3:932-43. 2002
    ....
  84. ncbi Loss of placental growth factor protects mice against vascular permeability in pathological conditions
    Aernout Luttun
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven B 3000, Belgium
    Biochem Biophys Res Commun 295:428-34. 2002
    ..These findings suggest that inhibition of PlGF might be an attractive tool to reduce vascular leakage in various diseases...
  85. ncbi Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization
    Jean Marie Rakic
    Department of Ophthalmology, University Hospital, Sart Tilman, Liege, Belgium
    Invest Ophthalmol Vis Sci 44:3186-93. 2003
    ..In the current study, the influence of placental growth factor (PlGF), a member of the VEGF family, in human and experimental choroidal neovascularization (CNV) was investigated...
  86. ncbi Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy
    Yuval Dor
    Department of Molecular Biology, Hebrew University Hadassah Medical School, MRI MRS Laboratory, HBRC, Hadassah University Hospital, Jerusalem 91120, Israel
    EMBO J 21:1939-47. 2002
    ..This novel genetic system thus highlights remaining problems in the implementation of pro-angiogenic therapy...
  87. ncbi Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling
    Heike Beck
    Institute of Neurology Edinger Institute, JWG University, Frankfurt am Main, Germany
    J Neuropathol Exp Neurol 61:339-50. 2002
    ..Possibly, the loss of semaphorins facilitates binding of the competing ligands (VEGF/PLGF), thus inducing angiogenesis. In addition, the observed expression patterns further suggest a neurotrophic/neuroprotective role of VEGF/PLGF...
  88. ncbi Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo
    Monica Suelves
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, Barcelona, Spain
    Blood 99:2835-44. 2002
    ..Altogether, these studies demonstrate the requirement of plasmin during myogenesis in vitro and muscle regeneration in vivo...
  89. ncbi Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice
    Hidefumi Kojima
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Proc Natl Acad Sci U S A 99:2170-4. 2002
    ....
  90. ncbi Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture
    Susanna M Müller
    Department of Immunology, University of Ulm, D 89081 Ulm, Germany
    Proc Natl Acad Sci U S A 102:10587-92. 2005
    ..These experiments provide insights into Foxn1-dependent and Foxn1-independent stromal cell development and demonstrate the value of this chimeric approach to analyzing gene function in thymus epithelium...
  91. ncbi Hyperthermia inhibits angiogenesis by a plasminogen activator inhibitor 1-dependent mechanism
    Cristina Roca
    Department of Oncological Sciences, School of Medicine, University of Torino, 10060 Candiolo, Italy
    Cancer Res 63:1500-7. 2003
    ..These results indicate that heat-mediated PAI-1 induction is an important pathway by which HT exerts its antitumor activity and may represent a rationale for a combined cancer therapy based on HT associated with antiangiogenic molecules...
  92. ncbi Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy
    Guoqiang Zhang
    Children s Hospital and Regional Medical Center, Division of Nephrology, University of Washington, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    J Am Soc Nephrol 14:1234-53. 2003
    ....
  93. ncbi Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration
    Koen Poesen
    Vesalius Research Center, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
    J Neurosci 28:10451-9. 2008
    ..The neuroprotective activity of VEGF-B, in combination with its negligible angiogenic/permeability activity, offers attractive opportunities for the treatment of neurodegenerative diseases...
  94. ncbi Genetic deletion of placenta growth factor in mice alters uterine NK cells
    Chandrakant Tayade
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Immunol 178:4267-75. 2007
    ..Thus, in mice, PlGF plays an important role in successful uNK cell proliferation and/or differentiation...
  95. ncbi Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets?
    Aernout Luttun
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1654:79-94. 2004
    ..Together, these insights may bring anti-angiogenic drugs closer from bench to bedside...
  96. ncbi Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice
    Daniela Tirziu
    Angiogenesis Research Center, Section of Cardiology, Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03756, USA
    J Clin Invest 117:3188-97. 2007
    ..Thus stimulation of vascular growth in normal adult mouse hearts leads to an increase in cardiac mass...
  97. ncbi The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
    Xiaowei Lu
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Nature 432:179-86. 2004
    ..Netrin-1 causes endothelial filopodial retraction, but only when UNC5B is present. Thus, UNC5B functions as a repulsive netrin receptor in endothelial cells controlling morphogenesis of the vascular system...
  98. ncbi Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha
    Veerle Compernolle
    Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Cardiovasc Res 60:569-79. 2003
    ..We attempted to further characterize the underlying mechanisms resulting in abnormal cardiogenesis and defective angiogenesis in mice deficient for HIF-1alpha (HIF-1alpha(-/-))...
  99. ncbi Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling
    Nynke M S Van Den Akker
    Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, PO Box 9600, 2300 RC Leiden, The Netherlands
    Cardiovasc Res 78:366-75. 2008
    ..Knowledge regarding the role of the VEGF/Notch/ephrinB2 cascade in (ab)normal coronary development will provide information on the subtle balance of VEGF signalling in coronary maturation and might enhance our therapeutic possibilities...
  100. ncbi Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis
    Stephane Heymans
    Molecular and Experimental Cardiology, CARIM, Department of Cardiology, P Debyelaan 25, PO Box 5800, 6202AZ Maastricht, The Netherlands
    Circulation 114:565-73. 2006
    ....
  101. ncbi Cardiovascular biology: signalling silenced
    Edward M Conway
    Nature 425:139-41. 2003