Dominique M A Bullens

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patients
    Ann Decraene
    Laboratory of Pneumology, KULeuven, Herestraat, Leuven, Belgium
    Respir Res 11:177. 2010
  2. ncbi request reprint Influence of Toll-like-receptor ligands on the dendritic cell-T cell interactions: therapeutic options for allergic diseases? Mini-review
    Dominique M A Bullens
    Clinical Immunology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    Inflamm Allergy Drug Targets 7:211-6. 2008
  3. ncbi request reprint House dust mite-specific T cells in healthy non-atopic children
    D M A Bullens
    Clinical Immunology, Department of Pathophysiology, Catholic University of Leuven KULeuven, Leuven, Belgium
    Clin Exp Allergy 35:1535-41. 2005
  4. pmc IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?
    Dominique M A Bullens
    Department of Experimental Medicine, Clinical Immunology, Katholieke Universiteit Leuven, KULeuven, Leuven, Belgium
    Respir Res 7:135. 2006
  5. doi request reprint Type III IFN-lambda mRNA expression in sputum of adult and school-aged asthmatics
    Dominique M A Bullens
    Clinical Immunology, Department of Experimental Medicine, Katholieke Universiteit Leuven KULeuven, Leuven, Belgium
    Clin Exp Allergy 38:1459-67. 2008
  6. ncbi request reprint Measuring T cell cytokines in allergic upper and lower airway inflammation: can we move to the clinic?
    Dominique M A Bullens
    Clinical Immunology, Department of Experimental Medicine, Katholieke Universiteit Leuven, KULeuven, Leuven, Belgium
    Inflamm Allergy Drug Targets 6:81-90. 2007
  7. doi request reprint T-cell mediated late increase in bronchial tone after allergen provocation in a murine asthma model
    Isabelle Meyts
    Division of Clinical Immunology, Katholieke Universiteit Leuven, Belgium
    Clin Immunol 128:248-58. 2008
  8. ncbi request reprint Effects of interleukin 4 on CD25+CD4+ regulatory T cell function
    Philippe Maerten
    Laboratory of Experimental Immunology, University Hospital, Katholieke Universiteit Leuven, Belgium
    J Autoimmun 25:112-20. 2005
  9. doi request reprint Effects of high altitude and cold air exposure on airway inflammation in patients with asthma
    Sven F Seys
    Department of Immunology and Microbiology, Laboratory of Clinical Immunology, KU Leuven, Leuven, Belgium
    Thorax 68:906-13. 2013
  10. doi request reprint Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice
    Valerie Hox
    Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KULeuven, Leuven, Belgium
    Am J Respir Crit Care Med 187:486-93. 2013

Collaborators

Detail Information

Publications16

  1. pmc Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patients
    Ann Decraene
    Laboratory of Pneumology, KULeuven, Herestraat, Leuven, Belgium
    Respir Res 11:177. 2010
    ....
  2. ncbi request reprint Influence of Toll-like-receptor ligands on the dendritic cell-T cell interactions: therapeutic options for allergic diseases? Mini-review
    Dominique M A Bullens
    Clinical Immunology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    Inflamm Allergy Drug Targets 7:211-6. 2008
    ..Furthermore we discuss the activation of DC by TLR-ligands and their differential cytokine induction. Finally, we discuss preclinical studies and potentially therapeutic options using TLR-ligands for allergic diseases...
  3. ncbi request reprint House dust mite-specific T cells in healthy non-atopic children
    D M A Bullens
    Clinical Immunology, Department of Pathophysiology, Catholic University of Leuven KULeuven, Leuven, Belgium
    Clin Exp Allergy 35:1535-41. 2005
    ..Recent studies have demonstrated that allergen-specific T cells can also be found in the blood of healthy individuals. Both IL-10 and IFN-gamma might modulate the induction and maintenance of allergen-specific tolerance...
  4. pmc IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?
    Dominique M A Bullens
    Department of Experimental Medicine, Clinical Immunology, Katholieke Universiteit Leuven, KULeuven, Leuven, Belgium
    Respir Res 7:135. 2006
    ..Neutrophilic infiltration in the airways is prominent in severe asthma exacerbations and may contribute to airway gland hypersecretion, bronchial hyper-reactivity and airway wall remodelling in asthma...
  5. doi request reprint Type III IFN-lambda mRNA expression in sputum of adult and school-aged asthmatics
    Dominique M A Bullens
    Clinical Immunology, Department of Experimental Medicine, Katholieke Universiteit Leuven KULeuven, Leuven, Belgium
    Clin Exp Allergy 38:1459-67. 2008
    ..The increased susceptibility of asthmatics to rhinovirus infection has recently been related to deficient IFN-lambda 1 (IL-29) and IFN-lambda 2/3 (IL-28) production by bronchial epithelial cells and macrophages...
  6. ncbi request reprint Measuring T cell cytokines in allergic upper and lower airway inflammation: can we move to the clinic?
    Dominique M A Bullens
    Clinical Immunology, Department of Experimental Medicine, Katholieke Universiteit Leuven, KULeuven, Leuven, Belgium
    Inflamm Allergy Drug Targets 6:81-90. 2007
    ..Finally, we discuss whether measuring these T cell cytokines in the airways might be of diagnostic importance or could help to follow-up patients with allergy/asthma...
  7. doi request reprint T-cell mediated late increase in bronchial tone after allergen provocation in a murine asthma model
    Isabelle Meyts
    Division of Clinical Immunology, Katholieke Universiteit Leuven, Belgium
    Clin Immunol 128:248-58. 2008
    ..We conclude that allergen inhalation in sensitized mice induces airway narrowing similar to the late asthmatic reactions in humans and that this phenomenon is based on activation of CD4(+) T cells...
  8. ncbi request reprint Effects of interleukin 4 on CD25+CD4+ regulatory T cell function
    Philippe Maerten
    Laboratory of Experimental Immunology, University Hospital, Katholieke Universiteit Leuven, Belgium
    J Autoimmun 25:112-20. 2005
    ..In conclusion, our data suggest that the anti-inflammatory function of IL-4 could partly be mediated by effects on Tregs function...
  9. doi request reprint Effects of high altitude and cold air exposure on airway inflammation in patients with asthma
    Sven F Seys
    Department of Immunology and Microbiology, Laboratory of Clinical Immunology, KU Leuven, Leuven, Belgium
    Thorax 68:906-13. 2013
    ....
  10. doi request reprint Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice
    Valerie Hox
    Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KULeuven, Leuven, Belgium
    Am J Respir Crit Care Med 187:486-93. 2013
    ..Conclusions: Induction of AHR by exposure to ClO(-)-OVA depends on a neuroimmune interaction that involves TRPA1-dependent stimulation of sensory neurons and mast cell activation...
  11. doi request reprint Effect of nasal anti-inflammatory treatment in chronic obstructive pulmonary disease
    Ina Callebaut
    Clinical Immunology, Department of Microbiology and Immunology, Catholic University of Leuven, Belgium
    Am J Rhinol Allergy 27:273-7. 2013
    ..This study was designed to examine the effects of nasal anti-inflammatory treatment on sinonasal symptoms and cough in COPD patients...
  12. doi request reprint Selective nasal allergen provocation induces substance P-mediated bronchial hyperresponsiveness
    Greet Hens
    University Hospital Leuven, Division of Otorhinolaryngology, Kapucijnevoer 33, 3000 Leuven, Belgium
    Am J Respir Cell Mol Biol 44:517-23. 2011
    ..Nasal allergen provocation rapidly induces bronchial hyperresponsiveness via pulmonary up-regulation of SP and activation of NK1 receptors...
  13. ncbi request reprint Contribution of regulatory T cells and effector T cell deletion in tolerance induction by costimulation blockade
    Bert Verbinnen
    Division of Clinical Immunology, University Hospital, Catholic University of Leuven, Leuven, Belgium
    J Immunol 181:1034-42. 2008
    ..At later time points (>30 days after splenocyte transfer), clonal deletion of host-reactive T cells was found to be a major mechanism responsible for tolerance...
  14. ncbi request reprint Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's disease
    Philippe Maerten
    Clinical Immunology, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Immunol 112:239-46. 2004
    ..Taken together, our data suggest that 4-1BB/4-1BBL interactions contribute to the persistence of gut inflammation in CD...
  15. doi request reprint Placental growth factor contributes to bronchial neutrophilic inflammation and edema in allergic asthma
    Sonja Bobic
    Department of Otorhinolaryngology and Head and Neck Surgery, Catholic University Hospitals, Kapucijnevoer 33, Leuven, Belgium
    Am J Respir Cell Mol Biol 46:781-9. 2012
    ..PlGF and its receptor VEGFR1 are up-regulated in allergic asthma and play a proinflammatory role by inducing tissue edema, and increasing tissue neutrophilia and the production of IL-17...
  16. ncbi request reprint Remission-inducing effect of anti-TNF monoclonal antibody in TNBS colitis: mechanisms beyond neutralization?
    Chong Shen
    Laboratory of Experimental Immunology, Katholike Universiteit Leuven, Belgium
    Inflamm Bowel Dis 13:308-16. 2007
    ..The aim was to investigate the pathogenic role of TNF in hapten-induced colitis models and to study the relationship between apoptosis induction and disease remission...