Roger Bouillon

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi Vitamin D and diabetes
    Tatiana Takiishi
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, UZ Gasthuisberg, O and N I Herestraat, Leuven, Belgium
    Endocrinol Metab Clin North Am 39:419-46, table of contents. 2010
  2. ncbi Vitamin D and human health: lessons from vitamin D receptor null mice
    Roger Bouillon
    Katholieke Universiteit Leuven, Laboratory of Experimental Medicine and Endocrinology, Herestraat 49, O and N 1 bus 902, 3000 Leuven, Belgium
    Endocr Rev 29:726-76. 2008
  3. ncbi Vitamin D resistance
    Roger Bouillon
    Laboratory for Experimental Medicine and Endocrinology, Campus Gasthuisberg, Onderwijs and Navorsing 1, Herestraat 49, bus 902, B 3000 Leuven, Belgium
    Best Pract Res Clin Endocrinol Metab 20:627-45. 2006
  4. ncbi Vitamin D: a pleiotropic hormone
    Annemieke Verstuyf
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Kidney Int 78:140-5. 2010
  5. ncbi Acute adrenal insufficiency
    Roger Bouillon
    Clinic and Laboratory of Endocrinology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Endocrinol Metab Clin North Am 35:767-75, ix. 2006
  6. ncbi Vitamin D and cancer
    Roger Bouillon
    Laboratory for Experimental Medicine and Endocrinology, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 102:156-62. 2006
  7. ncbi Mechanisms for the selective action of Vitamin D analogs
    Roger Bouillon
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Onderwijs en Navorsing, 9th Floor, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 97:21-30. 2005
  8. ncbi Vitamin D and health: perspectives from mice and man
    Roger Bouillon
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    J Bone Miner Res 23:974-9. 2008
  9. ncbi Why modest but widespread improvement of the vitamin D status is the best strategy?
    Roger Bouillon
    Clinic and Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    Best Pract Res Clin Endocrinol Metab 25:693-702. 2011
  10. ncbi Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 113:188-99. 2004

Detail Information

Publications99

  1. ncbi Vitamin D and diabetes
    Tatiana Takiishi
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, UZ Gasthuisberg, O and N I Herestraat, Leuven, Belgium
    Endocrinol Metab Clin North Am 39:419-46, table of contents. 2010
    ..This article reviews the role of vitamin D in the pathogenesis of T1D and T2D, focusing on the therapeutic potential for vitamin D in the prevention/intervention of T1D and T2D as well as its complications...
  2. ncbi Vitamin D and human health: lessons from vitamin D receptor null mice
    Roger Bouillon
    Katholieke Universiteit Leuven, Laboratory of Experimental Medicine and Endocrinology, Herestraat 49, O and N 1 bus 902, 3000 Leuven, Belgium
    Endocr Rev 29:726-76. 2008
    ..Prospective vitamin D supplementation studies with multiple noncalcemic endpoints are needed to define the benefits of an optimal vitamin D status...
  3. ncbi Vitamin D resistance
    Roger Bouillon
    Laboratory for Experimental Medicine and Endocrinology, Campus Gasthuisberg, Onderwijs and Navorsing 1, Herestraat 49, bus 902, B 3000 Leuven, Belgium
    Best Pract Res Clin Endocrinol Metab 20:627-45. 2006
    ..Taken together, the vitamin D endocrine system not only regulates calcium homeostasis but affects several systems mainly by altering gene expression but also by ligand-independent actions...
  4. ncbi Vitamin D: a pleiotropic hormone
    Annemieke Verstuyf
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Kidney Int 78:140-5. 2010
    ....
  5. ncbi Acute adrenal insufficiency
    Roger Bouillon
    Clinic and Laboratory of Endocrinology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Endocrinol Metab Clin North Am 35:767-75, ix. 2006
    ..In contrast, the chronic replacement dosage for patients with adrenal insufficiency should be as low as possible with clear instructions for dosage adjustments in case of stress or acute emergencies...
  6. ncbi Vitamin D and cancer
    Roger Bouillon
    Laboratory for Experimental Medicine and Endocrinology, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 102:156-62. 2006
    ....
  7. ncbi Mechanisms for the selective action of Vitamin D analogs
    Roger Bouillon
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Onderwijs en Navorsing, 9th Floor, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 97:21-30. 2005
    ..g. anticancer or immune effects or bone anabolism versus hypercalcemia) when tested in appropriate in vivo models. The molecular basis for this selectivity is only partially understood and probably a variable mixture of mechanisms...
  8. ncbi Vitamin D and health: perspectives from mice and man
    Roger Bouillon
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    J Bone Miner Res 23:974-9. 2008
  9. ncbi Why modest but widespread improvement of the vitamin D status is the best strategy?
    Roger Bouillon
    Clinic and Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    Best Pract Res Clin Endocrinol Metab 25:693-702. 2011
    ..The recommended vitamin D₃ supplement of 400-800 IU/d for adults also corresponds to the daily replacement dose calculated from metabolic clearance studies...
  10. ncbi Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 113:188-99. 2004
    ..These findings indicate that the insoluble VEGF(188) isoform is insufficient for establishing epiphyseal vascularization and regulating cartilage development during endochondral bone formation...
  11. ncbi Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts
    Ritsuko Masuyama
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 116:3150-9. 2006
    ..Taken together, our findings provide evidence that VDR signaling in chondrocytes is required for timely osteoclast formation during bone development and for the endocrine action of bone in phosphate homeostasis...
  12. ncbi Differential regulation of bone and body composition in male mice with combined inactivation of androgen and estrogen receptor-alpha
    Filip Callewaert
    Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    FASEB J 23:232-40. 2009
    ..ERalpha activation alone is sufficient for the regulation of fat mass. Our findings clearly define the relative importance of AR and ERalpha signaling on trabecular and cortical bone mass as well as body composition in male mice...
  13. ncbi Unaltered diabetes presentation in NOD mice lacking the vitamin D receptor
    Conny Gysemans
    Laboratory of Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Diabetes 57:269-75. 2008
    ..Vitamin D deficiency increases risk for type 1 diabetes in genetically predisposed individuals, while high doses of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] prevent insulitis and diabetes in NOD mice...
  14. ncbi Molecular pathways involved in the anti-apoptotic effect of 1,25-dihydroxyvitamin D3 in primary human keratinocytes
    Petra De Haes
    Laboratory for Experimental Medicine and Endocrinology (LEGENDO, Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    J Cell Biochem 93:951-67. 2004
    ..In conclusion, 1,25(OH)2D3 clearly protects keratinocytes against apoptosis (1) by activating the MEK/ERK and the PI-3K/Akt survival pathways and (2) by increasing the Bcl-2 to Bax and Bad ratio...
  15. ncbi Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model
    Katrien Venken
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Bone Miner Res 21:576-85. 2006
    ..AR activation dominates normal trabecular bone development and cortical bone modeling in male mice. Moreover, optimal periosteal bone expansion is only observed in the presence of both AR and ER activation...
  16. ncbi Physical activity in the androgen receptor knockout mouse: evidence for reversal of androgen deficiency on cancellous bone
    Jill Ophoff
    Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 378:139-44. 2009
    ..Thus, voluntary running in ARKO mice was able to reduce cancellous bone resorption, suggesting that sustained exercise may potentially compensate the effects of androgen disruption on cancellous bone...
  17. ncbi Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization
    Liesbet Lieben
    Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium
    J Clin Invest 122:1803-15. 2012
    ....
  18. ncbi The vitamin D receptor gene FokI polymorphism: functional impact on the immune system
    Evelyne van Etten
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Immunol 37:395-405. 2007
    ..Together, these data provide the first evidence that the VDR FokI polymorphism affects immune cell behavior, with a more active immune system for the short F-VDR, thus possibly playing a role in immune-mediated diseases...
  19. ncbi Antiproliferative and calcemic actions of trans-decalin CD-ring analogs of 1,25-dihydroxyvitamin D3
    Guy Eelen
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Leuven, Belgium
    Anticancer Res 29:3579-84. 2009
    ..Therefore, analogs of 1,25-(OH)2D3 are designed with a clear dissociation between both effects. Here the biological activity of the trans-decalin CD-ring analog CY10012 is discussed...
  20. ncbi Duodenal calcium absorption in dexamethasone-treated mice: functional and molecular aspects
    Sophie J van Cromphaut
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Herestraat 49, Leuven B 3000, Belgium
    Arch Biochem Biophys 460:300-5. 2007
    ..Decreased osteocalcin levels suggested impaired bone formation. Hence, short-term glucocorticoid excess in young animals affected bone metabolism without detectable changes in intestinal or renal calcium handling...
  21. ncbi 1,25-Dihydroxyvitamin D3 and analogues protect primary human keratinocytes against UVB-induced DNA damage
    Petra De Haes
    Laboratory for Experimental Medicine and Endocrinology, Onderwijs en Navorsing, Katholieke Universiteit Leuven, Gasthuisberg, Herestraat 49, bus 902, 3000 Leuven, Belgium
    J Photochem Photobiol B 78:141-8. 2005
    ..These molecules are therefore promising candidates for the chemoprevention of UVB-induced skin cancer...
  22. ncbi Growth without growth hormone receptor: estradiol is a major growth hormone-independent regulator of hepatic IGF-I synthesis
    Katrien Venken
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Belgium
    J Bone Miner Res 20:2138-49. 2005
    ..These data show that E(2) rescues pubertal growth during GH resistance through a novel mechanism of GHR-independent stimulation of hepatic IGF-I production...
  23. ncbi Dermal fibroblasts pretreated with a sterol Delta7-reductase inhibitor produce 25-hydroxyvitamin D3 upon UVB irradiation
    Katleen Vantieghem
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie (LEGENDO, Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Photochem Photobiol B 85:72-8. 2006
    ..The physiological relevance of dermal vitamin D3 photoproduction and its subsequent conversion into 25OHD3 remains elusive...
  24. ncbi 1alpha,25-Dihydroxyvitamin D3-induced down-regulation of the checkpoint proteins, Chk1 and Claspin, is mediated by the pocket proteins p107 and p130
    Lieve Verlinden
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 103:411-5. 2007
    ....
  25. ncbi Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model
    Liesbeth Vandenput
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
    J Bone Miner Res 19:1462-70. 2004
    ..These data show an essential role for androgen receptor-mediated androgen action in periosteal bone formation...
  26. ncbi The effects of 1alpha,25-dihydroxyvitamin D3 on the expression of DNA replication genes
    Guy Eelen
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Leuven, Belgium
    J Bone Miner Res 19:133-46. 2004
    ....
  27. ncbi Microarray analysis of MCF-7 breast cancer cells treated with 1,25-dihydroxyvitamin D3 or a 17-methyl-D-ring analog
    Els Vanoirbeek
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Gasthuisberg, 3000 Leuven, Belgium
    Anticancer Res 29:3585-90. 2009
    ..This study aims to distinct the molecular activities of 1,25-(OH)2D3 and WY1112 and identify possible differences in gene expression...
  28. ncbi Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction
    Lut Overbergh
    LEGENDO, UZ-Gasthuisberg, Onderwijs en Navorsing, Herestraat 49, B-3000 Leuven, Belgium
    J Clin Endocrinol Metab 91:3566-74. 2006
    ....
  29. ncbi Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor
    Guy Eelen
    LEGENDO, K U Leuven, B 3000 Leuven, Belgium
    Chem Biol 15:1029-34. 2008
    ..These data show that fluorination not only affects degradation of an analog but can also have direct effects on H12 stabilization...
  30. ncbi Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation
    Lieve Coenegrachts
    Laboratory of Experimental Medicine and Endocrinology, Vesalius Research Center, KU Leuven, Belgium
    Cancer Res 70:6537-47. 2010
    ..These findings identify novel properties of PlGF and suggest that alphaPlGF might offer opportunities for adjuvant therapy of bone metastasis...
  31. ncbi Impact of androgens, growth hormone, and IGF-I on bone and muscle in male mice during puberty
    Katrien Venken
    Katholieke Universiteit Leuven, Belgium
    J Bone Miner Res 22:72-82. 2007
    ..GHR activation seems to be the main determinant of radial bone expansion, although GH and androgens are both necessary for optimal stimulation of periosteal growth during puberty...
  32. ncbi Altered Vitamin D receptor-coactivator interactions reflect superagonism of Vitamin D analogs
    Guy Eelen
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 97:65-8. 2005
    ..In conclusion, these data show that altered coactivator binding by the VDR is one possible explanation for the superagonistic action of the two 14-epi-analogs TX522 and TX527...
  33. ncbi Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-Dihydroxyvitamin D(3) works as anti-inflammatory
    Annapaula Giulietti
    Laboratory of Experimental Medicine and Endocrinology, Catholic University of Leuven, Herestraat 49, Leuven, Belgium
    Diabetes Res Clin Pract 77:47-57. 2007
    ..From these data we concluded that monocytes from type 2 diabetic patients have a pro-inflammatory profile. In addition, 1,25-dihydroxyvitamin D(3) was able to modulate inflammation in these monocytes...
  34. ncbi Two 14-epi analogues of 1,25-dihydroxyvitamin D3 protect human keratinocytes against the effects of UVB
    Petra De Haes
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Gasthuisberg O and N9, Herestraat 49, 3000 Leuven, Belgium
    Arch Dermatol Res 295:527-34. 2004
    ..Taken together, these findings create new perspectives for the use of active vitamin D analogues as photoprotective agents...
  35. ncbi Intensive insulin therapy in mixed medical/surgical intensive care units: benefit versus harm
    Greet Van den Berghe
    Department of Intensive Care Medicine, University Hospital Gasthuisberg, University of Leuven, B 3000 Leuven, Belgium
    Diabetes 55:3151-9. 2006
    ..A blood glucose target <110 mg/day was most effective but also carried the highest risk of hypoglycemia...
  36. ncbi Pregnancy in mice lacking the vitamin D receptor: normal maternal skeletal response, but fetal hypomineralization rescued by maternal calcium supplementation
    Katrien Rummens
    Department of Ob Gyn, Katholieke Universiteit Leuven, Belgium
    Pediatr Res 54:466-73. 2003
    ..Alternatively or additionally, elevated 1,25(OH)2D3 in utero may disturb bone development...
  37. ncbi Microarray analysis of 1alpha,25-dihydroxyvitamin D3-treated MC3T3-E1 cells
    Guy Eelen
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie (LEGENDO, Onderwijs en Navorsing, 9th Floor, Gasthuisberg, K.U. Leuven, Herestraat 49, B-3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 89:405-7. 2004
    ..In conclusion, cDNA microarrays revealed that treatment of MC3T3-E1 cells with 1,25-(OH)(2)D(3) resulted in the down-regulation of DNA replication genes in parallel with the observed G1/S-arrest...
  38. ncbi Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010
    ..Vitamin D deficiency has been associated with many chronic illnesses, but little is known about its relationship with chronic obstructive pulmonary disease (COPD)...
  39. ncbi Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 116:1230-42. 2006
    ..Therefore PlGF may potentially offer therapeutic advantages for fracture repair...
  40. ncbi UVB-induced 1,25(OH)2D3 production and vitamin D activity in intestinal CaCo-2 cells and in THP-1 macrophages pretreated with a sterol Delta7-reductase inhibitor
    Katleen Vantieghem
    Laboratory for Experimental Medicine and Endocrinology (LEGENDO, Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    J Cell Biochem 99:229-40. 2006
    ....
  41. ncbi Disorders of calcium homeostasis
    Geert Carmeliet
    Laboratory for Experimental Medicine and Endocrinology, K.U. Leuven, Gasthuisberg, Herestraat 49, Leuven B-3000, Belgium
    Best Pract Res Clin Endocrinol Metab 17:529-46. 2003
    ..Several new drugs have been developed based on factors in this axis, including calcimimetics, calcilytics, vitamin D analogues and parathyroid hormone-related peptide inhibitors...
  42. ncbi Vitamin D analogs and coactivators
    Guy Eelen
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
    Anticancer Res 26:2717-21. 2006
    ..This review focuses on the molecular mode of action of different 1,25-(OH)2D3 analogs and, in particular, on the recruitment of cofactor molecules to the vitamin D receptor by these analogs...
  43. ncbi Novel insights in the immune function of the vitamin D system: synergism with interferon-beta
    Evelyne van Etten
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Herestraat 49, O and N1 bus 902, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 103:546-51. 2007
    ....
  44. ncbi Synthesis, structure, and biological activity of des-side chain analogues of 1α,25-dihydroxyvitamin D3 with substituents at C18
    Lieve Verlinden
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Leuven, Belgium
    ChemMedChem 6:788-93. 2011
    ....
  45. ncbi 1,25-dihydroxyvitamin D3 and a superagonistic analog in combination with paclitaxel or suberoylanilide hydroxamic acid have potent antiproliferative effects on anaplastic thyroid cancer
    Isabelle Clinckspoor
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie LEGENDO, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium
    J Steroid Biochem Mol Biol 124:1-9. 2011
    ..Our in vitro findings demonstrate that the superagonistic vitamin D analog CD578 holds promise as adjuvant antiproliferative therapy of anaplastic thyroid cancer, especially in combination with other drugs such as paclitaxel or SAHA...
  46. ncbi Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin D3
    Lieve Verlinden
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Belgium
    J Biol Chem 280:37319-30. 2005
    ....
  47. ncbi Rickets in transgenic animals
    Geert Carmeliet
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Belgium
    Endocr Dev 6:200-19. 2003
  48. ncbi Prospects for vitamin D receptor modulators as candidate drugs for cancer and (auto)immune diseases
    Roger Bouillon
    LEGENDO, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    Recent Results Cancer Res 164:353-6. 2003
    ..Critical remarks are summarized on why the step towards the clinic has not yet been taken and how better selective vitamin D receptor modulators could be designed...
  49. ncbi A new approach to imprinting mutation detection in GNAS by Sequenom EpiTYPER system
    Benedetta Izzi
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, 3000, Belgium
    Clin Chim Acta 411:2033-9. 2010
    ..Overall GNAS methylation defects have recently been detected in some PHPIa patients...
  50. ncbi Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction
    Guy Eelen
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Belgium
    Mol Pharmacol 67:1566-73. 2005
    ..In conclusion, this study provides deeper insight into the docking of TX522 in the LBP and shows that stronger VDR-coactivator interactions underlie the superagonistic activity of the two 14-epi-analogs...
  51. ncbi Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act
    Wim Janssens
    Division of Respiratory Medicine, University Hospital Gasthuisberg KUL Herestraat 49, 3000 Leuven, Belgium
    Am J Respir Crit Care Med 179:630-6. 2009
    ..A further challenge of such studies is to define optimal serum 25-OHD levels for such noncalcemic endpoints...
  52. ncbi CD-ring modified vitamin D3 analogs and their superagonistic action
    Guy Eelen
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie LEGENDO, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 121:417-9. 2010
    ....
  53. ncbi TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts
    Ritsuko Masuyama
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, B 3000, Belgium
    Cell Metab 8:257-65. 2008
    ....
  54. ncbi AKT status controls susceptibility of malignant keratinocytes to the early-activated and UVB-induced apoptotic pathway
    David Decraene
    Department of Dermatology, Faculty of Medicine, Katholieke Universiteit Leuven, Belgium
    J Invest Dermatol 123:207-12. 2004
    ....
  55. ncbi Clinical Review: Sex steroids and the periosteum--reconsidering the roles of androgens and estrogens in periosteal expansion
    Dirk Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Gasthuisberg, Onderwijs and Navorsing, Herestraat 49, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 91:378-82. 2006
    ..However, recent data challenge this traditional concept...
  56. ncbi Bone and muscle protective potential of the prostate-sparing synthetic androgen 7alpha-methyl-19-nortestosterone: evidence from the aged orchidectomized male rat model
    Katrien Venken
    Laboratory for Experimental Medicine and Endocrinology, Onderwijs en Navorsing, Campus Gasthuisberg, Leuven, Belgium
    Bone 36:663-70. 2005
    ..Our findings support the need for human studies to explore the potential of MENT as an option for androgen replacement in aging men...
  57. ncbi Vitamin D and 1,25-dihydroxyvitamin D3 as modulators in the immune system
    Chantal Mathieu
    LEGENDO, Katholieke Universiteit Leuven, O and N, Herestraat 49, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 89:449-52. 2004
    ..These data further support a role for vitamin D and its metabolites in the pathogenesis of type 1 diabetes in NOD mice...
  58. ncbi Bone turnover in prolonged critical illness: effect of vitamin D
    Greet Van den Berghe
    Department of Intensive Care Medicine, University of Leuven, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 88:4623-32. 2003
    ..Furthermore, severe bone hyperresorption further aggravated (up to 15-fold the normal values) with time in intensive care and was associated with impaired osteoblast function...
  59. ncbi Defect in activation-induced cell death in non-obese diabetic (NOD) T lymphocytes
    Brigitte Decallonne
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Autoimmun 20:219-26. 2003
    ..In conclusion, we present cellular and molecular evidence for disturbed AICD mechanisms in NOD T lymphocytes. This resistance in AICD may contribute to defective tolerance induction to autoantigens in NOD mice...
  60. ncbi 1,25-Dihydroxyvitamin D3 inhibits ultraviolet B-induced apoptosis, Jun kinase activation, and interleukin-6 production in primary human keratinocytes
    Petra De Haes
    Laboratory for Experimental Medicine and Endocrinology (LEGENDO, Gasthuisberg, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    J Cell Biochem 89:663-73. 2003
    ....
  61. ncbi Clinical review: Intensive insulin therapy in critically ill patients: NICE-SUGAR or Leuven blood glucose target?
    Greet Van den Berghe
    Laboratory and Department of Intensive Care Medicine, Catholic University of Leuven K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 94:3163-70. 2009
    ..A recent large multicenter study, NICE-SUGAR, compared a similar age-normal with an intermediate glucose target and found the intermediate target superior. These results require explanation...
  62. ncbi Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes
    Katinka Stoffels
    Laboratory for Experimental Medicine and Endocrinology (LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    J Bone Miner Res 21:37-47. 2006
    ..Combined activation of the JAK-STAT, p38 MAPK, and NF-kappaB pathways is necessary, with C/EBPbeta most probably being the essential transcription factor controlling immune-mediated transcription...
  63. ncbi 1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice
    Conny A Gysemans
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Endocrinology 146:1956-64. 2005
    ..This beneficial effect of 1,25-(OH)(2)D(3) is associated with decreased chemokine and cytokine expression by the pancreatic islets...
  64. ncbi Intensive insulin therapy in the medical ICU
    Greet Van den Berghe
    Department of Intensive Care Medicine, Catholic University of Leuven, Leuven, Belgium
    N Engl J Med 354:449-61. 2006
    ..Intensive insulin therapy reduces morbidity and mortality in patients in surgical intensive care units (ICUs), but its role in patients in medical ICUs is unknown...
  65. ncbi GNAS defects identified by stimulatory G protein alpha-subunit signalling studies in platelets
    Kathleen Freson
    Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 93:4851-9. 2008
    ..Phenotypes resulting from genetic and epigenetic abnormalities of the GNAS region include Albright's hereditary osteodystrophy, pseudohypoparathyroidism types Ia (PHPIa) and Ib (PHPIb), and pseudopseudohypoparathyroidism (PPHP)...
  66. ncbi NIH deltanoids meeting on Vitamin D and cancer. Conclusion and strategic options
    Roger Bouillon
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 97:3-5. 2005
    ..In the mean time, the public should be informed about the risks of vitamin D deficiency and insufficiency and appropriate steps should be taken to improve the vitamin D nutritional status of large parts of the world population...
  67. ncbi Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases, Katholieke Universiteit Leuven, Belgium, and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Endocrinol Metab 92:1415-23. 2007
    ..which found that 700-800 IU/d vitamin D reduced hip fracture risk in elderly individuals by 25%, by defining the need for additional calcium supplementation in individuals receiving vitamin D for the prevention of hip fractures...
  68. ncbi Previtamin D3 with a trans-fused decalin CD-ring has pronounced genomic activity
    Lieve Verlinden
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Herestraat 49, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Biol Chem 278:35476-82. 2003
    ..This could be confirmed by modeling analysis of this compound in the ligand binding pocket of VDR. In conclusion, a previtamin D3 analog is presented with genomic activities equivalent to 1,25(OH)2D3...
  69. ncbi Bone and metabolism: a complex crosstalk
    Liesbet Lieben
    Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Horm Res 71:134-8. 2009
    ..CONCLUSIONS: Further study is needed to understand the physiological role of these complex interactions in man and their implications for human diseases...
  70. ncbi A structural basis for the unique binding features of the human vitamin D-binding protein
    Christel Verboven
    Laboratorium voor Analytische Chemie en Medicinale Fysicochemie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, E Van Evenstraat 4, B 3000 Leuven, Belgium
    Nat Struct Biol 9:131-6. 2002
    ..These observed structural differences explain the unique vitamin D3-binding property of DBP...
  71. ncbi A brown tumor after biliopancreatic diversion for severe obesity
    Katrien Benhalima
    Department of Endocrinology, University Hospital Gasthuisberg, Leuven, Belgium
    Endocr J 56:263-8. 2009
    ..This case illustrates the severity of potential bone complications after BPD and the necessity of lifelong surveillance and vitamin supplements after BPD...
  72. ncbi Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, KU Leuven, B 3000, Leuven, Belgium
    Mech Dev 111:61-73. 2002
    ....
  73. ncbi Hypogonadism, quadriceps weakness, and exercise intolerance in chronic obstructive pulmonary disease
    Monique Van Vliet
    Respiratory Rehabilitation, University Hospital Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium
    Am J Respir Crit Care Med 172:1105-11. 2005
    ..CONCLUSIONS: In contrast to exercise intolerance, quadriceps muscle weakness is related to low circulating levels of testosterone in men with COPD...
  74. ncbi Acute shock induced by antigen vaccination in NOD mice
    Lut Overbergh
    Laboratory for Experimental Medicine and Endocrinology (LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Belgium
    Diabetes 52:335-41. 2003
    ..In conclusion, in NOD mice, vaccination leading to a Th(2) immune shift can result in a lethal anaphylactic reaction...
  75. ncbi The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone
    Greet Van den Berghe
    Department of Intensive Care Medicine, University Hospital Gasthuisberg, University of Leuven, B 3000 Leuven, Belgium
    Clin Endocrinol (Oxf) 56:655-69. 2002
    ..This study evaluated the impact of combined treatment with GH-releasing peptide-2 (GHRP-2), TRH and GnRH for 5 days compared with GHRP-2 + TRH and with GHRP-2 alone...
  76. ncbi Regulation of 25-hydroxyvitamin d-1alpha-hydroxylase by IFNgamma in human monocytic THP1 cells
    Lut Overbergh
    Laboratory for Experimental Medicine and Endocrinology (LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    J Steroid Biochem Mol Biol 89:453-5. 2004
    ..The data presented indicate a role for 1,25(OH)(2)D(3), activated by 1alpha hydroxylase, as a late down-tapering signal in the immune cascade...
  77. ncbi Growth hormone and bone health
    Marie Bex
    Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Gasthuisberg, Leuven, Belgium
    Horm Res 60:80-6. 2003
    ..GH therapy for other bone disorders not associated with primary GHD needs further study but may well be beneficial because of its positive effects on the bone remodelling cycle...
  78. ncbi Androgens and bone
    Dirk Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Endocr Rev 25:389-425. 2004
    ..In conclusion, androgens may protect men against osteoporosis via maintenance of cancellous bone mass and expansion of cortical bone. Such androgen action on bone is mediated by the AR and ERalpha...
  79. ncbi Synthesis, biological activity, and conformational analysis of CD-ring modified trans-decalin 1 alpha,25-dihydroxyvitamin D analogs
    Yong-Jun Chen
    Laboratory for Organic Synthesis, Department of Organic Chemistry, Ghent University, Krijgslaan 281 (S4, B-9000 Gent, Belgium
    Org Biomol Chem 1:257-67. 2003
    ..The molecular origin of this behavior is still under study...
  80. ncbi Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control
    Greet Van den Berghe
    Department of Intensive Care Medicine, Catholic University of Leuven, Belgium
    Crit Care Med 31:359-66. 2003
    ..Here we report the factors determining insulin requirements and the impact of insulin dose vs. blood glucose control on the observed outcome benefits...
  81. ncbi Emergencies of calcium homeostasis
    Jean-Jacques Body
    Department of Medicine, Institut J Bordet, , Brussels, Belgium
    Rev Endocr Metab Disord 4:167-75. 2003
  82. ncbi Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k
    Bryan S Benn
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School Newark, New Jersey 07103, USA
    Endocrinology 149:3196-205. 2008
    ....
  83. ncbi A novel nonsense mutation in the ligand binding domain of the vitamin D receptor causes hereditary 1,25-dihydroxyvitamin D-resistant rickets
    Peter J Malloy
    Division of Endocrinology, Gerontology, and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford University Medical Center, Room S005, Stanford, CA 94305 5103, USA
    Mol Genet Metab 77:314-8. 2002
    ..The Q317X mutation deletes 110 amino acids of the ligand-binding domain of the VDR and results in the loss of [3H]1,25(OH)(2)D(3) binding and target gene transactivation...
  84. ncbi Cortisol response to critical illness: effect of intensive insulin therapy
    Ilse Vanhorebeek
    Department of Intensive Care Medicine, Catholic University of Leuven, B-3000 Leuven, Belgium
    J Clin Endocrinol Metab 91:3803-13. 2006
    ..The lower cortisol levels were not related to altered cortisol-binding capacity...
  85. ncbi Novel A-ring homodimeric C-3-carbamate analogues of 1alpha,25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation
    Daniel Oves
    , Universidad de Oviedo, 33006-Oviedo (Asturias, Spain
    Bioorg Med Chem 14:7512-9. 2006
    ..The analogues demonstrated no affinity for the vitamin D receptor and possessed no antiproliferative or transactivating properties...
  86. ncbi Optimal control of glycemia among critically ill patients
    Greet Van den Berghe
    JAMA 291:1198-9. 2004
  87. ncbi Insulin and pentastarch for severe sepsis
    Greet Van den Berghe
    N Engl J Med 358:2073; author reply 2074-5. 2008
  88. ncbi VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3
    Enrico Baroni
    Bioxell SpA, Via Olgettina, 58, 20132 Milano, Italy
    J Leukoc Biol 81:250-62. 2007
    ..These data support the hypothesis of a physiological role of 1,25(OH)2D3 in mast cell development and suggest novel, therapeutic uses of 1,25(OH)2D3 analogs...
  89. ncbi Removal of C-ring from the CD-ring skeleton of 1alpha,25-dihydroxyvitamin D3 does not alter its target tissue metabolism significantly
    G Satyanarayana Reddy
    Epimer LLC, 4 Richmond Square, Suite 500, Providence, RI 02906, USA
    Arch Biochem Biophys 460:254-61. 2007
    ..In summary, we report that removal of the C-ring from the CD-ring skeleton of 1alpha,25(OH)2D3 does not alter its target tissue metabolism significantly...
  90. ncbi Does the phosphate binder lanthanum carbonate affect bone in rats with chronic renal failure?
    Geert J Behets
    Department of Nephrology Hypertension, University of Antwerp, Belgium
    J Am Soc Nephrol 15:2219-28. 2004
    ..There was no evidence that lanthanum had a direct toxic effect on osteoblasts...
  91. ncbi Versatile synthesis and biological evaluation of 1,3-diamino-substituted 1alpha,25-dihydroxyvitamin D3 analogues
    Daniel Oves
    , , Universidad de Oviedo, Spain
    Bioorg Med Chem 14:928-37. 2006
    ..The most active compound in the inhibition of MCF-7 cell proliferation and HL 60 cell differentiation was 1alpha-amino analogue 3. Also, very low in vivo calcemic effects of derivatives 3 and 4 were found...
  92. ncbi Chemoenzymatic synthesis and biological evaluation of C-3 carbamate analogues of 1alpha,25-dihydroxyvitamin D3
    Vicente Gotor-Fernández
    Departamento de Quimica Organica e Inorganica, Facultad de Quimica, Universidad de Oviedo, 33071 Oviedo, Spain
    Bioorg Med Chem 12:5443-51. 2004
    ..Of all the five analogues, the 3-O-carbamoyl-1alpha,25-(OH)2-D3 analogue 10a was the most potent one in vitro. However, all investigated carbamate analogues demonstrated lower calcemic effects in vivo than the parent compound...
  93. ncbi Biological activity and conformational analysis of C20 and C14 epimers of CD-ring modified trans-decalin 1alpha,25-dihydroxyvitamin D analogs
    Pierre J De Clercq
    Laboratory for Organic Synthesis, Department of Organic Chemistry, Ghent University, Krijgslaan 281 S4, B 9000 Gent, Belgium
    J Steroid Biochem Mol Biol 89:61-6. 2004
    ..No better dissociation of the prodifferentiating and/or antiproliferative activities and the calcemic activity was achieved...
  94. ncbi The Impact of congenital, severe, untreated growth hormone (GH) deficiency on bone size and density in young adults: insights from genetic GH-releasing hormone receptor deficiency
    Hiralal G Maheshwari
    Center for Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Medical School and Veterans Administration Chicago Health Care System, Lakeside Division, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 88:2614-8. 2003
    ..We conclude that GH/IGF-I deficiency has relatively little impact on bone mineralization during the bone accretion phase. This is in marked contrast to their effect on bone elongation and overall bone size...
  95. ncbi Vitamin D deficiency
    Roger Bouillon
    N Engl J Med 357:1980-1; author reply 1981-2. 2007
  96. ncbi Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1alpha,25-dihydroxyvitamin D3: spiro[5.5]undecane CF-ring analogues
    Wim Schepens
    Department of Organic Chemistry, Ghent University, Krijgslaan 281 S4, B-9000 Gent, Belgium
    Bioorg Med Chem Lett 14:3889-92. 2004
    ..5]undecane CF-ring analogues), is described. The central ring system is conveniently synthesised from an achiral intermediate. The analogues have marginal binding affinity for the nVDR and possess low to moderate genomic activity...
  97. ncbi Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1alpha,25-dihydroxyvitamin D3: cis-perhydrindane CE-ring analogues
    Samuël Demin
    Department of Organic Chemistry, Ghent University, Krijgslaan 281 S4, B 9000 Gent, Belgium
    Bioorg Med Chem Lett 14:3885-8. 2004
    ..The analogues show a complete lack of binding affinity for the vitamin D receptor (pig nVDR) and of antiproliferative activity (MCF-7 cells), as compared to calcitriol...
  98. ncbi Age-, gender-, and weight-related effects on levels of 25-hydroxyvitamin D are not mediated by vitamin D binding protein
    Mark J Bolland
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Clin Endocrinol (Oxf) 67:259-64. 2007
    ..We hypothesized that these findings might be explained by effects of these variables on vitamin D binding protein (DBP) levels. We set out to determine the relationships between DBP and gender, 25OHD, body weight and body composition...
  99. ncbi Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice
    Sofia Moverare
    Center for Bone Research, Department of Internal Medicine, The Sahlgrenska Academy, Goteborg University, S 41345 Goteborg, Sweden
    Proc Natl Acad Sci U S A 100:13573-8. 2003
    ..Because these two pathways are clearly distinct from each other, one may speculate that a combined treatment of selective ER modulators and selective AR modulators might be beneficial in the treatment of osteoporosis...