S Boonen

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc Time to onset of antifracture efficacy and year-by-year persistence of effect of zoledronic acid in women with osteoporosis
    Steven Boonen
    University of Leuven, Leuven, Belgium
    J Bone Miner Res 27:1487-93. 2012
  2. pmc Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men
    Delnaz Roshandel
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, UK
    Calcif Tissue Int 89:446-55. 2011
  3. pmc A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study
    Delnaz Roshandel
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    BMC Med Genet 12:19. 2011
  4. ncbi Functional outcome and quality of life following hip fracture in elderly women: a prospective controlled study
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine, Katholieke Universiteit Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Osteoporos Int 15:87-94. 2004
  5. ncbi Addressing and meeting the needs of osteoporotic patients with strontium ranelate: a review
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    Curr Opin Rheumatol 18:S21-7. 2006
  6. ncbi Preventing osteoporotic fractures with antiresorptive therapy: implications of microarchitectural changes
    S Boonen
    Center for Metabolic Bone Diseases Department of Geriatric Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    J Intern Med 255:1-12. 2004
  7. ncbi Calcium and vitamin D in the prevention and treatment of osteoporosis - a clinical update
    S Boonen
    Leuven University Center for Metabolic Bone Diseases, Katholieke Universiteit Leuven, Belgium
    J Intern Med 259:539-52. 2006
  8. ncbi The need for clinical guidance in the use of calcium and vitamin D in the management of osteoporosis: a consensus report
    S Boonen
    Leuven University Centre for Metabolic Bone Diseases and Division of Geriatric Medicine, University Hospital Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Osteoporos Int 15:511-9. 2004
  9. ncbi Safety and efficacy of teriparatide in elderly women with established osteoporosis: bone anabolic therapy from a geriatric perspective
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Am Geriatr Soc 54:782-9. 2006
  10. ncbi Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence
    S Boonen
    Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Calcif Tissue Int 78:257-70. 2006

Detail Information

Publications104 found, 100 shown here

  1. pmc Time to onset of antifracture efficacy and year-by-year persistence of effect of zoledronic acid in women with osteoporosis
    Steven Boonen
    University of Leuven, Leuven, Belgium
    J Bone Miner Res 27:1487-93. 2012
    ..097). This analysis shows that zoledronic acid offered significant protection from clinical fractures as early as 12 months. When administered annually, its beneficial effects persisted for at least 3 years...
  2. pmc Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men
    Delnaz Roshandel
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, UK
    Calcif Tissue Int 89:446-55. 2011
    ..90 [0.92-16.88], P = 0.029). No significant association was observed between RANKL SNPs and pQCT parameters. Our findings suggest that genetic variation in OPG and RANK influences radius vBMD and geometry in men...
  3. pmc A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study
    Delnaz Roshandel
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    BMC Med Genet 12:19. 2011
    ..The association between these SNPs and bone mineral density (BMD) measured using dual-energy X-ray absorptiometry (DXA) was also tested...
  4. ncbi Functional outcome and quality of life following hip fracture in elderly women: a prospective controlled study
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine, Katholieke Universiteit Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Osteoporos Int 15:87-94. 2004
    ..Function upon hospital discharge is the strongest predictor of functional status 1 year later. Assessing QoL in hip fracture women through self-administered questionnaires is subject to considerable bias due to non-response...
  5. ncbi Addressing and meeting the needs of osteoporotic patients with strontium ranelate: a review
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    Curr Opin Rheumatol 18:S21-7. 2006
    ..Together with the antifracture data, the clinical benefits and quality of life data endorse the treatment of postmenopausal osteoporosis with strontium ranelate...
  6. ncbi Preventing osteoporotic fractures with antiresorptive therapy: implications of microarchitectural changes
    S Boonen
    Center for Metabolic Bone Diseases Department of Geriatric Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    J Intern Med 255:1-12. 2004
    ..When treating individuals with osteoporosis, these microarchitectural changes contribute to the reduction of fracture risk achieved by antiresorptive therapies...
  7. ncbi Calcium and vitamin D in the prevention and treatment of osteoporosis - a clinical update
    S Boonen
    Leuven University Center for Metabolic Bone Diseases, Katholieke Universiteit Leuven, Belgium
    J Intern Med 259:539-52. 2006
    ..Benefits are most apparent when 800 IU day(-1) vitamin D is complemented with a dose of 1000-1200 mg day(-1) elemental calcium. Compliance is also key to optimizing clinical efficacy...
  8. ncbi The need for clinical guidance in the use of calcium and vitamin D in the management of osteoporosis: a consensus report
    S Boonen
    Leuven University Centre for Metabolic Bone Diseases and Division of Geriatric Medicine, University Hospital Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Osteoporos Int 15:511-9. 2004
    ....
  9. ncbi Safety and efficacy of teriparatide in elderly women with established osteoporosis: bone anabolic therapy from a geriatric perspective
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Am Geriatr Soc 54:782-9. 2006
    ..To assess the safety and efficacy of teriparatide in patients aged 75 and older and compare these findings with those of women younger than 75 using data from the Fracture Prevention Trial (FPT)...
  10. ncbi Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence
    S Boonen
    Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Calcif Tissue Int 78:257-70. 2006
    ....
  11. doi Assessment of the relationship between age and the effect of risedronate treatment in women with postmenopausal osteoporosis: a pooled analysis of four studies
    Steven Boonen
    Bone Research Unit, Department of Experimental Medicine, Leuven University, Leuven, Belgium
    J Am Geriatr Soc 58:658-63. 2010
    ..To quantify the effect of age on the incidence of osteoporosis-related fractures and of risedronate treatment on fracture risk in different age groups in women with postmenopausal osteoporosis...
  12. ncbi Effect of osteoporosis treatments on risk of non-vertebral fractures: review and meta-analysis of intention-to-treat studies
    Steven Boonen
    Division of Geriatric Medicine, Center for Metabolic Bone Diseases, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Osteoporos Int 16:1291-8. 2005
    ..Risedronate was the only agent shown to demonstrate efficacy in more than one trial. Meta-analysis showed that both alendronate and risedronate provide non-vertebral anti-fracture efficacy...
  13. doi Sequential therapy in the treatment of osteoporosis
    Steven Boonen
    Katholieke Universiteit Leuven, Centre for Metabolic Bone Diseases, and Division of Geriatric Medicine, Leuven, Belgium
    Curr Med Res Opin 27:1149-55. 2011
    ..To review the clinical data in the sequential use of antiresorptive and anabolic agents for the treatment of osteoporosis...
  14. doi Once-weekly risedronate in men with osteoporosis: results of a 2-year, placebo-controlled, double-blind, multicenter study
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases, Division of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium
    J Bone Miner Res 24:719-25. 2009
    ..The effects of risedronate treatment on BMD and BTMs in this study were similar to those previously shown to be associated with fracture risk reductions in women with postmenopausal osteoporosis...
  15. ncbi Effects of previous antiresorptive therapy on the bone mineral density response to two years of teriparatide treatment in postmenopausal women with osteoporosis
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine, Universitaire Ziekenhuizen, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 93:852-60. 2008
    ..The present secondary analysis examined the effects of 2 yr of open-label teriparatide in women previously treated with antiresorptive drugs for at least 1 yr...
  16. doi Recent developments in the management of postmenopausal osteoporosis with bisphosphonates: enhanced efficacy by enhanced compliance
    S Boonen
    Leuven University, Department of Experimental Medicine, Leuven, Belgium
    J Intern Med 264:315-32. 2008
    ..v.) injection regimen of ibandronate and yearly i.v. infusion of zoledronic acid are attractive options in the management of postmenopausal osteoporosis. These regimens may assure quarterly and year long compliance...
  17. ncbi Osteoporosis management: impact of fracture type on cost and quality of life in patients at risk for fracture I
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine, Leuven, Belgium
    Curr Med Res Opin 24:1781-8. 2008
    ..It is a chronic disease in which fracture is the main outcome, and the impact of these fractures can vary depending on the age of the individual and the severity of the fracture...
  18. ncbi Primary hyperparathyroidism: pathophysiology, diagnosis and indications for surgery
    S Boonen
    Leuven University Center for Metabolic Bone Diseases
    Acta Otorhinolaryngol Belg 55:119-27. 2001
    ..In most patients, deferral of surgery is not a one-time decision, but rather one that is reviewed and reconsidered in conjunction with meticulous monitoring...
  19. doi Impact of treatment efficacy and dosing frequency on cost-effectiveness of bisphosphonate treatment for osteoporosis: a perspective
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine, Herestraat 49, B 3000 Leuven, Belgium
    Curr Med Res Opin 25:2335-41. 2009
    ..Efficacy and persistence with therapy influence fracture risk-reduction and should be considered when determining the best osteoporosis therapy for each patient...
  20. ncbi Primary hyperparathyroidism: diagnosis and management in the older individual
    S Boonen
    Division of Geriatric Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Endocrinol 151:297-304. 2004
    ..In a subset of older individuals, surgery may not be an option because of coexisting medical problems even though surgical indications are present...
  21. ncbi Musculoskeletal effects of the recombinant human IGF-I/IGF binding protein-3 complex in osteoporotic patients with proximal femoral fracture: a double-blind, placebo-controlled pilot study
    Steven Boonen
    Katholieke Universiteit Leuven, Belgium
    J Clin Endocrinol Metab 87:1593-9. 2002
    ....
  22. ncbi Osteoporosis management: a perspective based on bisphosphonate data from randomised clinical trials and observational databases
    S Boonen
    Division of Gerontology and Geriatrics and Center for Musculoskeletal Research, Leuven University Department of Experimental Medicine, Leuven, Belgium
    Int J Clin Pract 63:1792-804. 2009
    ..This article aims to comprehensively review the evidence for bisphosphonate anti-fracture efficacy in postmenopausal women, discussing the strengths and limitations associated with each study method...
  23. ncbi Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases, Katholieke Universiteit Leuven, Belgium, and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Endocrinol Metab 92:1415-23. 2007
    ..which found that 700-800 IU/d vitamin D reduced hip fracture risk in elderly individuals by 25%, by defining the need for additional calcium supplementation in individuals receiving vitamin D for the prevention of hip fractures...
  24. doi Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men
    S Verschueren
    Research Group for Musculoskeletal Rehabilitation, Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium
    Osteoporos Int 24:87-98. 2013
    ..Men with sarcopenia had significantly lower BMD(a) and were more likely to have osteoporosis compared with men without sarcopenia...
  25. ncbi An aged rat model of partial androgen deficiency: prevention of both loss of bone and lean body mass by low-dose androgen replacement
    D Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Belgium
    Endocrinology 141:1642-7. 2000
    ..Therefore, the threshold concentration of testosterone necessary for prevention of both bone and lean body mass loss in aged male rats is clearly lower than for prostate and seminal vesicles...
  26. ncbi Sex steroids during bone growth: a comparative study between mouse models for hypogonadal and senile osteoporosis
    J Ophoff
    Bone Research Unit, Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, 3000, Leuven, Belgium
    Osteoporos Int 20:1749-57. 2009
    ..To this end, a mouse model for senile and hypogonadal osteoporosis was used. Longitudinal follow-up showed that bone fragility in both models results from deficient bone build-up during early puberty...
  27. ncbi The estrogen receptor ligand ICI 182,780 does not impair the bone-sparing effects of testosterone in the young orchidectomized rat model
    L Vandenput
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Leuven, Belgium
    Calcif Tissue Int 70:170-5. 2002
    ..The absence of effects on body growth via the growth hormone--insulin-like growth factor-I axis may be a possible explanation for the lack of skeletal effects of this selective estrogen receptor antagonist...
  28. ncbi Structural and material mechanical properties of human vertebral cancellous bone
    P H Nicholson
    Division of Biomechanics and Engineering Design, Katholieke Universiteit Leuven, Belgium
    Med Eng Phys 19:729-37. 1997
    ....
  29. ncbi Evidence from the aged orchidectomized male rat model that 17beta-estradiol is a more effective bone-sparing and anabolic agent than 5alpha-dihydrotestosterone
    L Vandenput
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Belgium
    J Bone Miner Res 17:2080-6. 2002
    ..Overall, these data suggest that androgen action on bone and body composition is dependent on stimulation of both androgen receptors (ARs) and estrogen receptors (ERs)...
  30. doi Sex hormones, their receptors and bone health
    K Venken
    Bone Research Unit, Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, BOX 902, B 3000, Leuven, Belgium
    Osteoporos Int 19:1517-25. 2008
    ..This review will focus on our current understanding of gonadal steroid metabolism, receptor activation, and their most relevant cellular and biological actions on bone...
  31. ncbi Process evaluation of a nurse-led multifactorial intervention protocol for risk screening and assessment of fall problems among community-dwelling older persons: a pilot-study
    K Milisen
    Center for Health Services and Nursing Research, Katholieke Universiteit Leuven, Kapucijnenvoer 35, 4th Floor, 3000 Leuven, Belgium
    J Nutr Health Aging 10:446-52. 2006
    ..However, further investigation to increase compliance with recommendations and more insight in the GP's role relating to the management of patients at risk for falls is needed...
  32. ncbi Androgens and bone
    Dirk Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Endocr Rev 25:389-425. 2004
    ..In conclusion, androgens may protect men against osteoporosis via maintenance of cancellous bone mass and expansion of cortical bone. Such androgen action on bone is mediated by the AR and ERalpha...
  33. ncbi Do quantitative ultrasound measurements reflect structure independently of density in human vertebral cancellous bone?
    P H Nicholson
    Division of Biomechanics and Engineering Design, Katholieke Universiteit Leuven, Belgium
    Bone 23:425-31. 1998
    ....
  34. ncbi Gonadal sex steroid status and bone health in middle-aged and elderly European men
    D Vanderschueren
    Department of Andrology and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Osteoporos Int 21:1331-9. 2010
    ..Higher free and total E(2) though not testosterone, were independently associated with higher QUS parameters...
  35. ncbi Safety and efficacy of risedronate in reducing fracture risk in osteoporotic women aged 80 and older: implications for the use of antiresorptive agents in the old and oldest old
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Am Geriatr Soc 52:1832-9. 2004
    ..To determine the efficacy of risedronate in reducing vertebral fracture risk in women aged 80 and older with osteoporosis...
  36. pmc 7α-methyl-19-nortestosterone vs. testosterone implants for hypogonadal osteoporosis: a preclinical study in the aged male orchidectomized rat model
    M Sinnesael
    Department of Experimental Medicine, Center for Musculoskeletal Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Androl 34:e601-11. 2011
    ..MENT and T are both effective replacement therapies to stimulate bone and muscle in hypogonadal rats, with stronger lipolytic action of MENT...
  37. ncbi IOF position statement: vitamin D recommendations for older adults
    B Dawson-Hughes
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Osteoporos Int 21:1151-4. 2010
    ..This position paper of the International Osteoporosis Foundation makes recommendations for vitamin D nutrition in elderly men and women from an evidence-based perspective...
  38. ncbi Renal safety of annual zoledronic acid infusions in osteoporotic postmenopausal women
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine, Department of Internal Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Kidney Int 74:641-8. 2008
    ..We found that transient changes in renal function can occur following an annual zoledronic acid infusion but, in the long term, renal function was not different from control patients...
  39. ncbi Sexual dimorphism in cortical bone size and strength but not density is determined by independent and time-specific actions of sex steroids and IGF-1: evidence from pubertal mouse models
    Filip Callewaert
    Center for Musculoskeletal Research, Leuven University Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    J Bone Miner Res 25:617-26. 2010
    ..In females, estrogens limit bone size during early puberty. These longitudinal findings in mice provide strong evidence that skeletal dimorphism is determined by independent and time-specific effects of sex steroids and IGF-1...
  40. ncbi Patient assessment using standardized bone mineral density values and a national reference database: implementing uniform thresholds for the reimbursement of osteoporosis treatments in Belgium
    S Boonen
    Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine, Katholieke Universiteit Leuven
    Osteoporos Int 14:110-5. 2003
    ..To this end, measures were taken to implement a uniform expression of BMD in Belgian patients, by converting each manufacturer's absolute BMD to standardized BMD (sBMD) values and by establishing a single national reference range...
  41. doi Musculoskeletal frailty: a geriatric syndrome at the core of fracture occurrence in older age
    E Gielen
    Gerontology and Geriatrics Section, Department of Experimental Medicine, KU Leuven, Leuven, Belgium
    Calcif Tissue Int 91:161-77. 2012
    ..As a result, operational definitions of frailty and therapeutic strategies in older patients tend to focus on the consequences of sarcopenia...
  42. ncbi Addressing the age-related needs of osteoporotic patients with strontium ranelate
    S Boonen
    Leuven University Centre for Metabolic Bone Diseases and Division of Geriatric Medicine, Leuven, Belgium
    Osteoporos Int 21:S415-23. 2010
    ..By implementing procedures to identify those at greatest risk and initiate safe and effective treatments, physicians can significantly improve patients' quality of life...
  43. ncbi Testosterone prevents orchidectomy-induced bone loss in estrogen receptor-alpha knockout mice
    L Vandenput
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Leuven, Belgium
    Biochem Biophys Res Commun 285:70-6. 2001
    ..In conclusion, although functional ERalpha may play a significant role during male skeletal development, this receptor does not seem essential for androgen-mediated skeletal maintenance in older male mice...
  44. doi Treatment with denosumab reduces the incidence of new vertebral and hip fractures in postmenopausal women at high risk
    S Boonen
    Leuven University Division of Geriatric Medicine, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 96:1727-36. 2011
    ..The FREEDOM (Fracture REduction Evaluation of Denosumab in Osteoporosis every 6 Months) trial showed denosumab significantly reduced the risk of fractures in postmenopausal women with osteoporosis...
  45. ncbi [Recurrent falling, osteoporosis and sarcopenia, three major problems, an integrated approach]
    E Dejaeger
    Afdeling Geriatrie, UZ Gasthuisberg K U Leuven
    Tijdschr Gerontol Geriatr 40:262-9. 2009
    ..Then some research projects related to prevention of falling will be dealt with briefly, whilst the final part discusses in greater detail the research programme 'Old age related osteoporosis and sarcopenia'...
  46. ncbi Skeletal effects of estrogen deficiency as induced by an aromatase inhibitor in an aged male rat model
    D Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Onderwijs en Navorsing, Gasthuisberg, Belgium
    Bone 27:611-7. 2000
    ..E(2) administration is able to prevent this trabecular bone loss in vorozole-treated animals...
  47. doi Physical activity in the androgen receptor knockout mouse: evidence for reversal of androgen deficiency on cancellous bone
    Jill Ophoff
    Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 378:139-44. 2009
    ..Thus, voluntary running in ARKO mice was able to reduce cancellous bone resorption, suggesting that sustained exercise may potentially compensate the effects of androgen disruption on cancellous bone...
  48. ncbi Reversing sex steroid deficiency and optimizing skeletal development in the adolescent with gonadal failure
    Dirk Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Endocr Dev 8:150-65. 2005
    ..Replacing sex steroids according to a biphasic pattern (starting at low doses and ending at high-normal doses) seems the safest approach to reach targeted height and to optimize bone development...
  49. ncbi Estrogens are essential for male pubertal periosteal bone expansion
    Roger Bouillon
    Division of Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Endocrinol Metab 89:6025-9. 2004
    ..These findings demonstrate that androgens alone are insufficient, whereas estrogens are essential for the process of pubertal periosteal bone expansion typically associated with the male bone phenotype...
  50. doi Differential regulation of bone and body composition in male mice with combined inactivation of androgen and estrogen receptor-alpha
    Filip Callewaert
    Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    FASEB J 23:232-40. 2009
    ..ERalpha activation alone is sufficient for the regulation of fat mass. Our findings clearly define the relative importance of AR and ERalpha signaling on trabecular and cortical bone mass as well as body composition in male mice...
  51. ncbi Androgens and bone
    Dirk Vanderschueren
    Bone Research Unit, Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Curr Opin Endocrinol Diabetes Obes 15:250-4. 2008
    ..Therefore, some of the most recent findings of skeletal estrogen action relevant for male skeletal physiology will also be discussed...
  52. ncbi Clinical Review: Sex steroids and the periosteum--reconsidering the roles of androgens and estrogens in periosteal expansion
    Dirk Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Gasthuisberg, Onderwijs and Navorsing, Herestraat 49, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 91:378-82. 2006
    ..However, recent data challenge this traditional concept...
  53. pmc Efficacy and safety of a once-yearly intravenous zoledronic acid 5 mg for fracture prevention in elderly postmenopausal women with osteoporosis aged 75 and older
    Steven Boonen
    Leuven University Centre for Metabolic Bone Diseases and Division of Geriatric Medicine, University of Leuven, Leuven, Belgium
    J Am Geriatr Soc 58:292-9. 2010
    ..To determine the efficacy of once-yearly intravenous zoledronic acid (ZOL) 5 mg in reducing risk of clinical vertebral, nonvertebral, and any clinical fractures in elderly osteoporotic postmenopausal women...
  54. ncbi [Falls among community-dwelling elderly: a pilot study of prevalence, circumstances and consequences in Flanders]
    Koen Milisen
    Centrum voor Ziekenhuis en Verplegingswetenschap, Katholieke Universiteit Leuven, Universitaire Ziekenhuizen Leuven
    Tijdschr Gerontol Geriatr 35:15-20. 2004
    ..We conclude that there is an urgent need to develop and implement preventive measures as well as multidisciplinary strategies to identify, assess and target high-risk persons for falling...
  55. ncbi Effect of 6-month whole body vibration training on hip density, muscle strength, and postural control in postmenopausal women: a randomized controlled pilot study
    Sabine M P Verschueren
    Laboratory of Motor Control, Department of Kinesiology, Faculteit Lichamelijke Opvoeding en Kinesitherapie, Katholieke Universiteit, Leuven, Belgium
    J Bone Miner Res 19:352-9. 2004
    ..Vibration training significantly increased BMD of the hip. These findings suggest that WBV training might be useful in the prevention of osteoporosis...
  56. ncbi Lack of association between osteoarthritis of the hip and gene polymorphisms of VDR, COL1A1, and COL2A1 in postmenopausal women
    J Aerssens
    Arthritis and Metabolic Bone Disease Research Unit, Leuven, Belgium
    Arthritis Rheum 41:1946-50. 1998
    ....
  57. ncbi Fracture protection in osteoporosis with risedronate
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    Hosp Med 65:535-40. 2004
  58. ncbi Identifying postmenopausal women with osteoporosis by calcaneal ultrasound, metacarpal digital X-ray radiogrammetry and phalangeal radiographic absorptiometry: a comparative study
    Steven Boonen
    Leuven University Center for Metabolic Bone Diseases, Universitaire Ziekenhuizen K U Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Osteoporos Int 16:93-100. 2005
    ..These data suggest that metacarpal DXR and phalangeal RA may be as effective as calcaneal QUS for targeting DXA testing in high-risk postmenopausal women...
  59. ncbi Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model
    Katrien Venken
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Bone Miner Res 21:576-85. 2006
    ..AR activation dominates normal trabecular bone development and cortical bone modeling in male mice. Moreover, optimal periosteal bone expansion is only observed in the presence of both AR and ER activation...
  60. ncbi Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model
    Liesbeth Vandenput
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
    J Bone Miner Res 19:1462-70. 2004
    ..These data show an essential role for androgen receptor-mediated androgen action in periosteal bone formation...
  61. doi Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice
    Filip Callewaert
    Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    J Bone Miner Res 25:124-31. 2010
    ..In conclusion, AR but not ERalpha activation limits the osteogenic response to loading in male mice possibly via an effect on WNT signaling...
  62. doi Sex steroids and the male skeleton: a tale of two hormones
    Filip Callewaert
    Department of Experimental Medicine, Katholieke Universiteit Leuven, Center for Musculoskeletal Research, Leuven University, Herestraat 49, B 3000 Belgium
    Trends Endocrinol Metab 21:89-95. 2010
    ..In fact, bone loss and fracture risk have been associated with estrogen exposure in elderly men. Overall, a compelling body of evidence suggests that both androgens and estrogens are crucial for male skeletal growth and maintenance...
  63. ncbi The transcription intermediary factor 1β coactivates the androgen receptor
    N Van Tilborgh
    Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg, Leuven, Belgium
    J Endocrinol Invest 36:699-706. 2013
    ..Moreover, since TIF1β is well expressed in prostate cancer cells, its functional interaction with androgen signalling could in the long run be a therapeutic target for this disease. ..
  64. ncbi Ergotamine-induced pleural and pericardial effusion successfully treated with colchicine
    V Helsen
    Division of Gerontology and Geriatrics, Katholieke Universiteit Leuven, Leuven, Belgium
    Acta Clin Belg 68:113-5. 2013
    ..This case highlights the importance of establishing an ergot alkaloid use registry in unexplained pleuropericardial effusions and supports the use of colchicine as a potential therapeutic approach...
  65. ncbi First-generation versus third-generation comprehensive geriatric assessment instruments in the acute hospital setting: a comparison of the Minimum Geriatric Screening Tools (MGST) and the interRAI Acute Care (interRAI AC)
    N I H Wellens
    Centre for Health Services and Nursing Research, Katholieke Universiteit Leuven, Belgium
    J Nutr Health Aging 15:638-44. 2011
    ..Comparison of the first-generation Minimum Geriatric Screening Tools (MGST) and the third-generation interRAI Acute Care (interRAI AC)...
  66. doi Osteoporosis and osteoporotic fracture occurrence and prevention in the elderly: a geriatric perspective
    Steven Boonen
    Leuven University Centre for Metabolic Bone Disease and Division of Geriatric Medicine, UZ Leuven Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Best Pract Res Clin Endocrinol Metab 22:765-85. 2008
    ..Falls prevention is an essential component of any strategy for decreasing fracture risk in old age. Currently, senile osteoporosis is under-diagnosed and under-treated, but age should not be a barrier to intervention...
  67. ncbi Growth without growth hormone receptor: estradiol is a major growth hormone-independent regulator of hepatic IGF-I synthesis
    Katrien Venken
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Belgium
    J Bone Miner Res 20:2138-49. 2005
    ..These data show that E(2) rescues pubertal growth during GH resistance through a novel mechanism of GHR-independent stimulation of hepatic IGF-I production...
  68. ncbi Bone and muscle protective potential of the prostate-sparing synthetic androgen 7alpha-methyl-19-nortestosterone: evidence from the aged orchidectomized male rat model
    Katrien Venken
    Laboratory for Experimental Medicine and Endocrinology, Onderwijs en Navorsing, Campus Gasthuisberg, Leuven, Belgium
    Bone 36:663-70. 2005
    ..Our findings support the need for human studies to explore the potential of MENT as an option for androgen replacement in aging men...
  69. ncbi Selecting an appropriate and reimbursed anti-osteoporotic treatment option: a practical tool in the Belgian setting
    V Grootaert
    Pharmacy Dept, University Hospitals Leuven, Leuven, Belgium
    Acta Clin Belg 67:13-8. 2012
    ..Two flowcharts, based on Belgian reimbursement criteria and literature review were developed. Both tools provide an overview of the reimbursed pharmacological agents in the management of osteoporosis in male and female subjects...
  70. doi Balloon kyphoplasty and vertebroplasty in the management of vertebral compression fractures
    S Boonen
    Division of Gerontology and Geriatrics and Center for Musculoskeletal Research, Department of Experimental Medicine, Leuven University, Leuven, Belgium
    Osteoporos Int 22:2915-34. 2011
    ..However, VP and BKP are not substitutes for appropriate evaluation and treatment of osteoporosis to reduce the risk of future fractures...
  71. ncbi Quantitative ultrasound and trabecular architecture in the human calcaneus
    P H Nicholson
    Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Bone Miner Res 16:1886-92. 2001
    ..Given the relative weakness and complexity of the emerging associations between QUS and architecture, it is prudent to regard QUS measurements in calcaneal bone primarily as an indicator of bone density...
  72. ncbi Fall prediction in inpatients by bedside nurses using the St. Thomas's Risk Assessment Tool in Falling Elderly Inpatients (STRATIFY) instrument: a multicenter study
    Koen Milisen
    Center for Health Services and Nursing Research, Department for Geriatric Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    J Am Geriatr Soc 55:725-33. 2007
    ..To assess the predictive value of the St. Thomas's Risk Assessment Tool in Falling Elderly Inpatients (STRATIFY) instrument, a simple fall-risk assessment tool, when administered at a patient's hospital bedside by nurses...
  73. doi Skeletal sexual dimorphism: relative contribution of sex steroids, GH-IGF1, and mechanical loading
    Filip Callewaert
    Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Endocrinol 207:127-34. 2010
    ....
  74. ncbi Translating fall incidence data into fall-preventive measures in geriatric wards--a survey in Belgian hospitals
    Joke Coussement
    Center for Health Services and Nursing Research, Katholieke Universiteit Leuven, Belgium
    Gerontology 55:398-404. 2009
    ..For this reason, the College of Geriatrics, a body funded by the Belgian Government to set up quality improvement initiatives in geriatric wards, selected 'Fall prevention in Belgian hospitals' as a quality project for the year 2006...
  75. ncbi Impact of androgens, growth hormone, and IGF-I on bone and muscle in male mice during puberty
    Katrien Venken
    Katholieke Universiteit Leuven, Belgium
    J Bone Miner Res 22:72-82. 2007
    ..GHR activation seems to be the main determinant of radial bone expansion, although GH and androgens are both necessary for optimal stimulation of periosteal growth during puberty...
  76. ncbi Impact of whole-body vibration training versus fitness training on muscle strength and muscle mass in older men: a 1-year randomized controlled trial
    An Bogaerts
    Division of Musculoskeletal Rehabilitation, Katholieke Universiteit Leuven, Tervuursevest 101, Leuven, Belgium
    J Gerontol A Biol Sci Med Sci 62:630-5. 2007
    ..This randomized controlled study investigated the effects of 1-year whole-body vibration (WBV) training on isometric and explosive muscle strength and muscle mass in community-dwelling men older than 60 years...
  77. ncbi Evidence-based guidelines for the treatment of postmenopausal osteoporosis: a consensus document of the Belgian Bone Club
    Steven Boonen
    Center for Metabolic Bone Diseases, Katholieke University Leuven, Leuven, Belgium
    Osteoporos Int 16:239-54. 2005
  78. doi The correlation between the SOS in trabecular bone and stiffness and density studied by finite-element analysis
    Liesbet Goossens
    Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, K U Leuven, Leuven, Belgium
    IEEE Trans Ultrason Ferroelectr Freq Control 55:1234-42. 2008
    ....
  79. pmc Tau levels do not influence human ALS or motor neuron degeneration in the SOD1G93A mouse
    I Taes
    Laboratory of Neurobiology and Department of Neurology, University Hospital Gasthuisberg, K U Leuven, Leuven, Belgium
    Neurology 74:1687-93. 2010
    ..However, the precise role of tau in motor neuron degeneration remains uncertain...
  80. ncbi Effects of whole body vibration training on postural control in older individuals: a 1 year randomized controlled trial
    An Bogaerts
    Division of Musculoskeletal Rehabilitation, Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, Tervuursevest 101, 3001 Leuven, Belgium
    Gait Posture 26:309-16. 2007
    ..The fitness group showed reduced falls frequency on the moving surface when vision was disturbed. Thus, whole body vibration training may improve some aspects of postural control in community dwelling older individuals...
  81. ncbi Musculoskeletal rehabilitation in osteoporosis: a review
    Michael Pfeifer
    Institute of Clinical Osteology, Clinic DER FURSTENHOF, Bad Pyrmont, Germany
    J Bone Miner Res 19:1208-14. 2004
    ..Further studies are needed to evaluate the effect of combined bone- and fall-directed strategies in patients with osteoporosis and an increased propensity to falls...
  82. ncbi Colles fracture, spine fracture, and subsequent risk of hip fracture in men and women. A meta-analysis
    Patrick Haentjens
    Department of Orthopaedics and Traumatology, Academisch Ziekenhuis, Vrije Universiteit Brussel, Brussels
    J Bone Joint Surg Am 85:1936-43. 2003
    ..We conducted a systematic review and meta-analysis of the literature to compare men and women with respect to the relative risk of hip fracture after a wrist or spine fracture...
  83. ncbi The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management
    Dieter Felsenberg
    Department of Radiology and Nuclear Medicine, Centre of Muscle and Bone Research, Charite Campus Benjamin Franklin, Free and Humboldt University, Berlin, Germany
    Clin Ther 27:1-11. 2005
    ..Clinical experience with patient follow-up strongly suggests that bone quality must also be taken into account...
  84. ncbi Evidence from data searches and life-table analyses for gender-related differences in absolute risk of hip fracture after Colles' or spine fracture: Colles' fracture as an early and sensitive marker of skeletal fragility in white men
    Patrick Haentjens
    Department of Orthopaedics and Traumatology, Vrije Universiteit Brussel, Brussels, Belgium
    J Bone Miner Res 19:1933-44. 2004
    ..These findings support the concept that forearm fracture is an early and sensitive marker of male skeletal fragility...
  85. ncbi The relationship among history of falls, osteoporosis, and fractures in postmenopausal women
    Piet Geusens
    Biomedical Research Institute, Limburgs Universitair Centrum, Diepenbeek, Belgium
    Arch Phys Med Rehabil 83:903-6. 2002
    ..To study the relative contribution of osteoporosis and falls to the occurrence of symptomatic fractures in postmenopausal women...
  86. ncbi Vertebral fracture risk reduction with risedronate in post-menopausal women with osteoporosis: a meta-analysis of individual patient data
    Jonathan D Adachi
    McMaster University, Hamilton, Ontario, Canada
    Aging Clin Exp Res 17:150-6. 2005
    ..These trials included two large vertebral fracture studies that used time-to-event methods to evaluate the effects of treatment on fracture risk, thereby allowing both the occurrence and the timing of fractures to be considered...
  87. ncbi Evidence-based guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis: a consensus document of the Belgian Bone Club
    Jean Pierre Devogelaer
    Rheumatology Unit, Saint Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium
    Osteoporos Int 17:8-19. 2006
    ..There is indeed no proof that the increased costs of combined treatments will translate into increased therapeutic efficacy...
  88. ncbi Safety and efficacy of risedronate in patients with age-related reduced renal function as estimated by the Cockcroft and Gault method: a pooled analysis of nine clinical trials
    Paul D Miller
    University of Colorado Health Science Center, Colorado Center for Bone Research, Lakewood, USA
    J Bone Miner Res 20:2105-15. 2005
    ..We studied the influence of renal function on the safety and efficacy of risedronate 5 mg daily in osteoporotic women. Risedronate was safe and effective in osteoporotic women with mild, moderate, or severe age-related renal impairment...
  89. doi Geographical variation in DXA bone mineral density in young European men and women. Results from the Network in Europe on Male Osteoporosis (NEMO) study
    Stephen Kaptoge
    Department of Medicine and Strangeways Research Laboratory, University of Cambridge, Wort s Causeway, Cambridge CB1 8RN, UK
    Bone 43:332-9. 2008
    ..Hip BMD mean values were lower in European women, but SD's differed little from the NHANES-III USA results in both sexes. It may be necessary to adjust NHANES-III based T-scores by adding/subtracting a country-specific adjustment factor...
  90. ncbi Osteoporosis management: translating research into optimal fracture protection II
    Andrea J Singer
    Georgetown University Medical Center, Washington, DC, USA
    Curr Med Res Opin 24:1789-96. 2008
    ..The challenges faced by physicians include identifying individuals at high risk of fracture, selecting the optimal treatment plan for each patient, and educating patients regarding their role in the effectiveness of therapy...
  91. pmc Assessment of non-vertebral fracture risk in postmenopausal women
    Christian Roux
    Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Hopital Cochin, Service de Rhumatologie, Paris 75014, France
    Ann Rheum Dis 66:931-5. 2007
    ..Non-vertebral (NV) fractures are responsible for a great amount of morbidity, mortality and cost attributable to osteoporosis...
  92. ncbi Teriparatide or alendronate in glucocorticoid-induced osteoporosis
    Kenneth G Saag
    University of Alabama at Birmingham, Birmingham 35294 3408, USA
    N Engl J Med 357:2028-39. 2007
    ..Studies of anabolic therapy in patients who are receiving long-term glucocorticoids and are at high risk for fracture are lacking...
  93. ncbi Efficacy and safety of risedronate 150 mg once a month in the treatment of postmenopausal osteoporosis
    Pierre D Delmas
    INSERM Research Unit 831 and University of Lyon, Lyon, France
    Bone 42:36-42. 2008
    ..This randomized, double-blind, multi-center study was designed to assess the efficacy and safety of a single 150 mg risedronate once-a-month oral dose compared with the 5 mg daily regimen...
  94. ncbi Effects of intravenous zoledronic acid once yearly on bone remodeling and bone structure
    Robert R Recker
    School of Medicine, Creighton University, Omaha, Nebraska 68131, USA
    J Bone Miner Res 23:6-16. 2008
    ..Zoledronic acid reduced bone turnover by 63% and preserved bone structure and volume, with evidence of ongoing bone remodeling in 99% of biopsies obtained...
  95. ncbi Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial
    Jean Yves Reginster
    University of Liege, Liege, Belgium
    Arthritis Rheum 58:1687-95. 2008
    ..This study was undertaken to assess the effect of strontium ranelate on nonvertebral and vertebral fractures in postmenopausal women with osteoporosis in a 5-year, double-blind, placebo-controlled trial...
  96. ncbi Zoledronic acid and clinical fractures and mortality after hip fracture
    Kenneth W Lyles
    Duke University Medical Center, Durham, NC, USA
    N Engl J Med 357:1799-809. 2007
    ..Mortality is increased after a hip fracture, and strategies that improve outcomes are needed...
  97. ncbi Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis
    Dennis M Black
    University of California, San Francisco, San Francisco, CA 94107, USA
    N Engl J Med 356:1809-22. 2007
    ..We assessed the effects of annual infusions of zoledronic acid on fracture risk during a 3-year period...
  98. ncbi Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older
    Ego Seeman
    Austin Hospital, University of Melbourne, Australia
    J Bone Miner Res 21:1113-20. 2006
    ..Strontium ranelate produces an early and sustained reduction of both vertebral and nonvertebral fractures in patients > or = 80 years of age...
  99. ncbi Review of comparative effectiveness of treatments to prevent fractures
    Dennis M Black
    Ann Intern Med 148:885-6; author reply 887. 2008
  100. ncbi Osteoporosis and the growth hormone-insulin-like growth factor axis
    Piet P M M Geusens
    Department of Rheumatology, University Hospital, Maastricht, The Netherlands
    Horm Res 58:49-55. 2002
    ..We will review the evidence of GH and IGF-I in the pathophysiology and treatment of osteoporosis...
  101. ncbi Dual energy x-ray absorptiometry-based assessment of male patients using standardized bone density values and a national reference database
    Stefan Goemaere
    Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Ghent, Belgium
    J Clin Densitom 10:25-33. 2007
    ..The current data provide a basis to implement a nation-wide, uniform expression of BMD in male patients and allow harmonization of the BMD-based diagnosis and treatment of osteoporosis in men...