Alfons Billiau

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. doi request reprint Collagen-induced arthritis and related animal models: how much of their pathogenesis is auto-immune, how much is auto-inflammatory?
    Alfons Billiau
    Laboratory of Immunobiology, Rega Institute University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Cytokine Growth Factor Rev 22:339-44. 2011
  2. ncbi request reprint Interferons: the pathways of discovery. II. Immunomodulatory, in vivo and applied aspects
    Alfons Billiau
    Rega Institute, University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    J Clin Virol 39:241-65. 2007
  3. doi request reprint A tale of two interferon bioassays: how frustration with discrepant results from slightly dissimilar methods can engender discovery
    Alfons Billiau
    Rega Institute for Medical Research, University of Leuven Katholieke Universiteit Leuven, Leuven, Belgium
    Methods Mol Biol 820:1-6. 2012
  4. doi request reprint Interferon-gamma: a historical perspective
    Alfons Billiau
    Rega Institute, University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    Cytokine Growth Factor Rev 20:97-113. 2009
  5. ncbi request reprint Interferon: the pathways of discovery I. Molecular and cellular aspects
    Alfons Billiau
    Rega Institute, University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    Cytokine Growth Factor Rev 17:381-409. 2006
  6. ncbi request reprint Anti-inflammatory properties of Type I interferons
    Alfons Billiau
    Rega Institute, University of Leuven, Minderbroedersstraat 10, BE 3000 Leuven, Belgium
    Antiviral Res 71:108-16. 2006
  7. ncbi request reprint Protective role of IFN-gamma in collagen-induced arthritis conferred by inhibition of mycobacteria-induced granulocyte chemotactic protein-2 production
    Hilde Kelchtermans
    Laboratory of Immunobiology, Rega Institute for Medical Research, University of Leuven, Minderbroederstraat 10, B 3000 Leuven, Belgium
    J Leukoc Biol 81:1044-53. 2007
  8. pmc Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis
    Bert De Klerck
    Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    Arthritis Res Ther 7:R1208-20. 2005
  9. pmc Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma
    Hilde Kelchtermans
    Laboratory of Immunobiology, Rega Institute for Medical Research, Katholieke Universiteit Leuven KULeuven, Leuven, Belgium
    Arthritis Res Ther 7:R402-15. 2005
  10. doi request reprint How interferon-gamma keeps autoimmune diseases in check
    Hilde Kelchtermans
    Laboratory of Immunobiology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Trends Immunol 29:479-86. 2008

Detail Information

Publications18

  1. doi request reprint Collagen-induced arthritis and related animal models: how much of their pathogenesis is auto-immune, how much is auto-inflammatory?
    Alfons Billiau
    Laboratory of Immunobiology, Rega Institute University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Cytokine Growth Factor Rev 22:339-44. 2011
    ..Superimposed on this, collagen-specific auto-immunity reinforces inflammatory reactivity in joints...
  2. ncbi request reprint Interferons: the pathways of discovery. II. Immunomodulatory, in vivo and applied aspects
    Alfons Billiau
    Rega Institute, University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    J Clin Virol 39:241-65. 2007
    ..Proof of principle for applications as they are established today has come from clinical trials performed quite independently of evidence from animal experiments...
  3. doi request reprint A tale of two interferon bioassays: how frustration with discrepant results from slightly dissimilar methods can engender discovery
    Alfons Billiau
    Rega Institute for Medical Research, University of Leuven Katholieke Universiteit Leuven, Leuven, Belgium
    Methods Mol Biol 820:1-6. 2012
    ..Superficially, the contaminant resembled IFN-β. However, further analysis showed that it was not an IFN at all but an IFN-inducing cytokine identifiable as interleukin-1...
  4. doi request reprint Interferon-gamma: a historical perspective
    Alfons Billiau
    Rega Institute, University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    Cytokine Growth Factor Rev 20:97-113. 2009
    ..Today IFN-gamma ranks among the most important endogenous regulators of immune responses...
  5. ncbi request reprint Interferon: the pathways of discovery I. Molecular and cellular aspects
    Alfons Billiau
    Rega Institute, University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    Cytokine Growth Factor Rev 17:381-409. 2006
    ..Lines of thought that linked each discovery to the next are expounded...
  6. ncbi request reprint Anti-inflammatory properties of Type I interferons
    Alfons Billiau
    Rega Institute, University of Leuven, Minderbroedersstraat 10, BE 3000 Leuven, Belgium
    Antiviral Res 71:108-16. 2006
    ..These observations deserve the attention of virologists for their potential role in the pathogenesis and clinical management of virus infections...
  7. ncbi request reprint Protective role of IFN-gamma in collagen-induced arthritis conferred by inhibition of mycobacteria-induced granulocyte chemotactic protein-2 production
    Hilde Kelchtermans
    Laboratory of Immunobiology, Rega Institute for Medical Research, University of Leuven, Minderbroederstraat 10, B 3000 Leuven, Belgium
    J Leukoc Biol 81:1044-53. 2007
    ..These results may also be applicable to other experimental models of autoimmunity that rely on the use of CFA...
  8. pmc Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis
    Bert De Klerck
    Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    Arthritis Res Ther 7:R1208-20. 2005
    ..Our observations indicate that CXCL12 acts as a pro-inflammatory factor in the pathogenesis of autoimmune arthritis by attracting inflammatory cells to joints and by stimulating the differentiation and activation of osteoclasts...
  9. pmc Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma
    Hilde Kelchtermans
    Laboratory of Immunobiology, Rega Institute for Medical Research, Katholieke Universiteit Leuven KULeuven, Leuven, Belgium
    Arthritis Res Ther 7:R402-15. 2005
    ..Our results demonstrate that the decrease in Treg cell activity in CIA is counter-regulated by endogenous IFN-gamma...
  10. doi request reprint How interferon-gamma keeps autoimmune diseases in check
    Hilde Kelchtermans
    Laboratory of Immunobiology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Trends Immunol 29:479-86. 2008
    ..We conclude that endogenous production of IFN-gamma during inflammatory and autoimmune diseases should be considered as a process with bidirectional immunoregulatory consequences, often resulting in moderation of pathology...
  11. doi request reprint Pulmonary inflammation in mice with collagen-induced arthritis is conditioned by complete Freund's adjuvant and regulated by endogenous IFN-γ
    Evelien Schurgers
    Laboratory of Immunobiology, Rega Institute, University of Leuven, Leuven, Belgium
    Eur J Immunol 42:3223-34. 2012
    ..We conclude that CIA in DBA/1 mice is accompanied by pulmonary inflammation. Although both disease processes are kept in check by endogenous IFN-γ, lack of strict parallelism indicates that overlap in their pathogeneses is partial...
  12. ncbi request reprint Biologic role of interferon beta in multiple sclerosis
    Alfons Billiau
    Rega Institute, University of Leuven, Leuven, Belgium
    J Neurol 251:II10-4. 2004
    ..The relative importance of each of these actions is presently unknown, and still other actions of IFNbeta may be at play. The possibility that therapeutic IFNbeta compensates for a lack of endogenous IFNbeta production is discussed...
  13. doi request reprint Myeloid cells are tunable by a polyanionic polysaccharide derivative and co-determine host rescue from lethal virus infection
    Sandra Li
    Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, Minderbroedersstraat 10, Leuven, Belgium
    J Leukoc Biol 88:1017-29. 2010
    ..These findings reinforce the role of neutrophils and macrophages as critical cells that can be manipulated toward antiviral defense...
  14. doi request reprint Collagen-induced arthritis as an animal model for rheumatoid arthritis: focus on interferon-γ
    Evelien Schurgers
    Laboratory of Immunobiology, Faculty of Medicine, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    J Interferon Cytokine Res 31:917-26. 2011
    ....
  15. ncbi request reprint Dependence on interferon-gamma for the spontaneous occurrence of arthritis in DBA/1 mice
    Patrick Matthys
    University of Leuven, Leuven, Belgium
    Arthritis Rheum 48:2983-8. 2003
    ..Male DBA/1 mice are known to spontaneously develop arthritis in the hind legs. The present study was undertaken to investigate the role of endogenous interferon-gamma (IFNgamma) in the pathogenesis of this ankylosing enthesopathy...
  16. pmc Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis
    Bert De Klerck
    Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    Arthritis Res Ther 6:R220-31. 2004
    ..They also provide a plausible explanation for the higher susceptibility of IFN-gammaR KO mice to CIA...
  17. ncbi request reprint New candidate loci for multiple sclerosis susceptibility revealed by a whole genome association screen in a Belgian population
    An Goris
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    J Neuroimmunol 143:65-9. 2003
    ..g. the integrin ligand EDIL3, the high-mobility group box protein TOX, neutral sphingomyelinase activating factor (NSMAF) and the B-cell specific transcription factor POU2AF1...
  18. ncbi request reprint The conserved helix C region in the superfamily of interferon-gamma /interleukin-10-related cytokines corresponds to a high-affinity binding site for the HSP70 chaperone DnaK
    Koen Vandenbroeck
    Biomolecular Sciences Research Group, McClay Research Centre for Pharmaceutical Sciences, Queen s University of Belfast, United Kingdom
    J Biol Chem 277:25668-76. 2002
    ....