Research Topics

Jan Balzarini

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. Gondim A, Roberta da Silva S, Mathys L, Noppen S, Liekens S, Holanda Sampaio A, et al. Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity. Medchemcomm. 2019;10:390-398 pubmed publisher
    ..These novel findings indicate that lectins from the Brazilian flora may provide novel antiviral compounds with therapeutic potential. ..
  2. Thomas J, Jecic A, Vanstreels E, Van Berckelaer L, Romagnoli R, Dehaen W, et al. Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes. Eur J Med Chem. 2017;132:219-235 pubmed publisher
    ..These observations may be helpful to narrow down the intracellular localization and identification of the molecular target of the 5-substituted thiophene derivatives. ..
  3. Balzarini J, Menni M, Das K, Van Berckelaer L, Ford A, Maguire N, et al. Guanine ?-carboxy nucleoside phosphonate (G-?-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses. Biochem Pharmacol. 2017;136:51-61 pubmed publisher
    ..The unique properties of the ?-CNPs make this class of compounds, including G-?-CNP, direct acting inhibitors of multiple viral DNA polymerases. ..