Karel Allegaert

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. doi request reprint Hepatic tolerance of repeated intravenous paracetamol administration in neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hosptials Leuven, Leuven, Belgium
    Paediatr Anaesth 18:388-92. 2008
  2. doi request reprint Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals, Campus Gasthuisberg, B 3000 Leuven, Belgium
    Pediatr Res 63:674-9. 2008
  3. doi request reprint Cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy
    Karel Allegaert
    Division of Woman and Child, University Hospitals Leuven, Leuven, Belgium
    Am J Obstet Gynecol 200:170.e1-7. 2009
  4. ncbi request reprint Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, Department of Paediatrics, University Hospital, Gasthuisberg, Leuven, Belgium
    Acta Paediatr 94:1273-9. 2005
  5. ncbi request reprint Dopamine is not an independent risk factor for reduced amikacin clearance in extremely low-birth-weight infants
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospital, Gasthuisberg Leuven, Belgium
    Pediatr Crit Care Med 7:143-6. 2006
  6. pmc Neonatal circulatory failure due to acute hypertensive crisis: clinical and echocardiographic clues
    Jacoba Louw
    Paediatric Cardiology, University Hospitals Leuven, Leuven, Belgium
    Cardiovasc J Afr 24:72-5. 2013
  7. doi request reprint In vivo glucuronidation activity of drugs in neonates: extensive interindividual variability despite their young age
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals Leuven, Belgium
    Ther Drug Monit 31:411-5. 2009
  8. pmc Pharmacokinetics of paracetamol and its metabolites in women at delivery and post-partum
    Aida Kulo
    Center for Clinical Pharmacology, University Hospitals Leuven, Leuven, Belgium
    Br J Clin Pharmacol 75:850-60. 2013
  9. doi request reprint Creatinine reference values in ELBW infants: impact of quantification by Jaffe or enzymatic method
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
    J Matern Fetal Neonatal Med 25:1678-81. 2012
  10. doi request reprint Continuous glucose monitoring and retinopathy of prematurity
    Sophie Vanhaesebrouck
    Neonatal Intensive Care Unit, University Hospital Leuven, Leuven, Belgium
    Eur J Ophthalmol 22:436-40. 2012

Collaborators

Detail Information

Publications82

  1. doi request reprint Hepatic tolerance of repeated intravenous paracetamol administration in neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hosptials Leuven, Leuven, Belgium
    Paediatr Anaesth 18:388-92. 2008
    ..An intravenous (i.v.) formulation of paracetamol is available, but reports on its hepatic tolerance in neonates are limited. We therefore assessed hepatic tolerance of i.v. paracetamol in neonates...
  2. doi request reprint Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals, Campus Gasthuisberg, B 3000 Leuven, Belgium
    Pediatr Res 63:674-9. 2008
    ..Besides compound-specific relevance, CYP2D6 iso-enzyme specific data on in vivo ontogeny of O-demethylation can contribute to safer and more effective administration of drugs metabolized by the same route in this population...
  3. doi request reprint Cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy
    Karel Allegaert
    Division of Woman and Child, University Hospitals Leuven, Leuven, Belgium
    Am J Obstet Gynecol 200:170.e1-7. 2009
    ..To study cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy...
  4. ncbi request reprint Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, Department of Paediatrics, University Hospital, Gasthuisberg, Leuven, Belgium
    Acta Paediatr 94:1273-9. 2005
    ..Since paracetamol provides a good substrate to study UGT (1A6) activity, urinary metabolites of propacetamol were determined in neonates in whom propacetamol was repeatedly administered...
  5. ncbi request reprint Dopamine is not an independent risk factor for reduced amikacin clearance in extremely low-birth-weight infants
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospital, Gasthuisberg Leuven, Belgium
    Pediatr Crit Care Med 7:143-6. 2006
    ..We therefore evaluated whether dopamine had an additional effect on amikacin clearance...
  6. pmc Neonatal circulatory failure due to acute hypertensive crisis: clinical and echocardiographic clues
    Jacoba Louw
    Paediatric Cardiology, University Hospitals Leuven, Leuven, Belgium
    Cardiovasc J Afr 24:72-5. 2013
    ..This study was undertaken to assess the clinical and echocardiographic manifestations of circulatory failure resulting from acute neonatal hypertensive crisis...
  7. doi request reprint In vivo glucuronidation activity of drugs in neonates: extensive interindividual variability despite their young age
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals Leuven, Belgium
    Ther Drug Monit 31:411-5. 2009
    ..A focused approach to unveil covariates of the interindividual range is needed to improve our knowledge on drug disposition in early life...
  8. pmc Pharmacokinetics of paracetamol and its metabolites in women at delivery and post-partum
    Aida Kulo
    Center for Clinical Pharmacology, University Hospitals Leuven, Leuven, Belgium
    Br J Clin Pharmacol 75:850-60. 2013
    ..To describe the paracetamol metabolic and elimination routes involved in this increase in clearance, we performed a population PK analysis in women at delivery and post-partum in which the different pathways were considered...
  9. doi request reprint Creatinine reference values in ELBW infants: impact of quantification by Jaffe or enzymatic method
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
    J Matern Fetal Neonatal Med 25:1678-81. 2012
    ..Serum creatinine (Scr) reflects to a certain extent glomerular filtration rate in neonates, but postnatal observations also depends on the technique used to quantify Scr (Jaffe colorimetry or enzymatic quantification)...
  10. doi request reprint Continuous glucose monitoring and retinopathy of prematurity
    Sophie Vanhaesebrouck
    Neonatal Intensive Care Unit, University Hospital Leuven, Leuven, Belgium
    Eur J Ophthalmol 22:436-40. 2012
    ....
  11. doi request reprint Prospective assessment of short-term propylene glycol tolerance in neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
    Arch Dis Child 95:1054-8. 2010
    ..Propylene glycol (PG) is an unintentional frequently administered solvent in neonates despite the fact that PG accumulation potentially results in hyperosmolarity, lactic acidosis and renal/hepatic toxicity...
  12. pmc Limited predictability of amikacin clearance in extreme premature neonates at birth
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Br J Clin Pharmacol 61:39-48. 2006
    ..Identify and quantify factors describing variability of amikacin clearance in preterm neonates at birth...
  13. doi request reprint The impact of pregnancy on urinary ketorolac metabolites after single intravenous bolus
    Aida Kulo
    Center for Clinical Pharmacology, University Hospitals Leuven, Leuven, Belgium
    Eur J Drug Metab Pharmacokinet 38:1-4. 2013
    ..031). The differences in urine metabolites suggest that the increased ketorolac clearance at delivery is in part explained by increased metabolic clearance to p-hydroxy-ketorolac, reflecting increased oxidation activity...
  14. doi request reprint Cefazolin plasma protein binding saturability during pregnancy
    Karel Allegaert
    Neonatal Intensive Care Unit, Division of Woman and Child, University Hospitals Leuven, Leuven, Belgium
    Methods Find Exp Clin Pharmacol 31:25-8. 2009
    ..4). The concept of saturability of CFZ plasma protein binding has been confirmed during pregnancy, but the free CFZ fraction is higher, likely explained by the lower albuminemia during pregnancy...
  15. ncbi request reprint Developmental pharmacokinetics of opioids in neonates
    Karel Allegaert
    Division of Woman and Child, University Hospital, Gasthuisberg, Leuven, Belgium
    J Opioid Manag 3:59-64. 2007
    ....
  16. ncbi request reprint Nonselective cyclo-oxygenase inhibitors and glomerular filtration rate in preterm neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, Department of Pediatrics, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Pediatr Nephrol 20:1557-61. 2005
    ..13-0.78 ml/kg/min, p<0.01) was demonstrated. Using amikacin clearance as marker, a significant and similar reduction in glomerular filtration rate was documented in preterm infants cotreated with ibuprofen or acetylsalicylic acid...
  17. doi request reprint The impact of ibuprofen or indomethacin on renal drug clearance in neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, Division of Woman and Child, University Hospitals Leuven, Leuven, Belgium
    J Matern Fetal Neonatal Med 22:88-91. 2009
    ..However, the magnitude of these effects and potential differences between ibuprofen or indomethacin remain unclear...
  18. doi request reprint Does intravenous paracetamol administration affect body temperature in neonates?
    Lynn Hopchet
    Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
    Arch Dis Child 96:301-4. 2011
    ..Intravenous paracetamol (acetaminophen) has recently been registered for treatment of pain in neonates but the pharmacodynamics, including effects on body temperature, have not been reported...
  19. doi request reprint Urinary metabolites after intravenous propofol bolus in neonates
    Anne Smits
    Division of Woman and Child, Neonatal Intensive Care Unit, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Drug Metab Pharmacokinet 38:97-103. 2013
    ..This confirms earlier documented propofol clearance studies. This is the first report of the modified quantification assay used to determine urinary propofol metabolites in neonates...
  20. ncbi request reprint Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, Department of Paediatrics, University Hospital, Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Clin Pharmacol 60:191-7. 2004
    ..Neonates had a median postnatal age of 1 day (range, 1-76 days). Median post-conceptual age (PCA) was 35 weeks (range, 27-42 weeks), and median weight was 2.4 kg (range, 0.51-4 kg)...
  21. ncbi request reprint Analgosedation in neonates: do we still need additional tools after 30 years of clinical research?
    Liesbeth Thewissen
    Neonatal Intensive Care Unit, Division of Woman and Child, University Hospital, Gasthuisberg, Herestraat, Leuven, Belgium
    Arch Dis Child Educ Pract Ed 96:112-8. 2011
    ..This review will focus on the limitations of the available assessment tools, newly emerging analgosedatives in neonates to illustrate how these compounds can be integrated into the changing concepts of neonatal care...
  22. doi request reprint Cross-sectional study of tracheomegaly in children after fetal tracheal occlusion for severe congenital diaphragmatic hernia
    Luc Breysem
    Department of Radiology, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
    Radiology 257:226-32. 2010
    ..To measure tracheal dimensions in children with congenital diaphragmatic hernia (CDH) who had undergone fetoscopic endoluminal tracheal occlusion (FETO) or were treated expectantly during gestation...
  23. ncbi request reprint The impact of ibuprofen on renal clearance in preterm infants is independent of the gestational age
    Karel Allegaert
    Neonatal Intensive Care Unit, Department of Paediatrics, University Hospital Gasthuisberg, Leuven, Belgium
    Pediatr Nephrol 20:740-3. 2005
    ..44+0.009x) with ibuprofen. Renal clearance, reflected by amikacin clearance, is decreased by ibuprofen in preterm infants of 24 to 34 weeks GA on respiratory support on the 1st day of life, independent of the GA...
  24. pmc Vancomycin pharmacokinetics in preterm neonates and the prediction of adult clearance
    Brian J Anderson
    Neonatal Intensive Care Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Br J Clin Pharmacol 63:75-84. 2007
    ..Size, standardized using allometric models, was the primary covariate used in our analysis...
  25. ncbi request reprint Determinants of drug metabolism in early neonatal life
    Karel Allegaert
    Neonatal Intensive Care Unit, Division Woman and Child, University Hospital, Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Curr Clin Pharmacol 2:23-9. 2007
    ..The implementation of multivariable models like non-linear mixed effects (NONMEM) models hereby provide us with the tools to disentangle the impact of various co-variables in this specific population...
  26. doi request reprint Cerebral and systemic hemodynamic effects of intravenous bolus administration of propofol in neonates
    Joke Vanderhaegen
    Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium joke vanderhaegen uz kuleuven ac be
    Neonatology 98:57-63. 2010
    ....
  27. ncbi request reprint Maturational pharmacokinetics of single intravenous bolus of propofol
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Paediatr Anaesth 17:1028-34. 2007
    ..Our aim was to document propofol pharmacokinetics in preterm and term neonates following a single intravenous bolus and compare these estimates with pharmacokinetics findings in toddlers and young children...
  28. doi request reprint Association between retinal neovascularization and serial weight measurements in murine and human newborns
    Sophie Vanhaesebrouck
    Neonatal Intensive Care Unit, University Hospital Leuven, Leuven, Belgium
    Eur J Ophthalmol 23:678-82. 2013
    ..Evidence is accumulating that one of the strongest predictors of ROP, in addition to oxygen use and low gestational age, is poor weight gain during the first postnatal weeks.
..
  29. ncbi request reprint Pharmacokinetics of drugs in neonates: pattern recognition beyond compound specific observations
    Anne Smits
    Neonatal Intensive Care Unit, University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Curr Pharm Des 18:3119-46. 2012
    ..Through improved predictability, such maturational models can serve to improve both the clinical care and feasibility and safety of clinical studies in neonates...
  30. doi request reprint Is indirect hyperbilirubinemia a useful biomarker of reduced propofol clearance in neonates?
    Anne Smits
    Neonatal Intensive Care Unit, University Hospitals Leuven, Belgium
    Biomark Med 6:283-9. 2012
    ..We aimed to document whether indirect bilirubin, instead of or in addition to PNA, could improve predictability of propofol clearance and serve as a useful biomarker of reduced propofol clearance in neonates...
  31. ncbi request reprint Contribution of glucuronidation to tramadol disposition in early neonatal life
    Karel Allegaert
    Neonatal Intensive Care Unit, Department of Pediatrics, University Hospital, Gathuisberg, Leuven, Belgium
    Basic Clin Pharmacol Toxicol 98:110-2. 2006
  32. doi request reprint Clinical practice: analgesia in neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, Division of Woman and Child, University Hospital, Leuven, Belgium
    Eur J Pediatr 168:765-70. 2009
    ..Finally, there is an extensive field of procedural techniques that need to be evaluated on their pain related response...
  33. doi request reprint The pharmacokinetics of intravenous paracetamol in neonates: size matters most
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospital, Herestraat 49, Leuven, Belgium
    Arch Dis Child 96:575-80. 2011
    ..The aim was to describe intravenous paracetamol pharmacokinetics, determine major covariates and suggest a dosing regimen for (pre)term neonates...
  34. doi request reprint The paracetamol concentration-effect relation in neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
    Paediatr Anaesth 23:45-50. 2013
    ....
  35. doi request reprint Pharmacological treatment of neonatal pain: in search of a new equipoise
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Semin Fetal Neonatal Med 18:42-7. 2013
    ..Since the available data are still incomplete, priorities for both clinical management and future research will be proposed...
  36. pmc Developmental pharmacokinetics of propylene glycol in preterm and term neonates
    Roosmarijn F W De Cock
    Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands
    Br J Clin Pharmacol 75:162-71. 2013
    ....
  37. doi request reprint Postnatal trends in creatinemia and its covariates in extremely low birth weight (ELBW) neonates
    Isabel George
    Department of Pediatric Nephrology, University Hospitals Leuven, Leuven, Belgium
    Pediatr Nephrol 26:1843-9. 2011
    ..ELBW neonates display trends similar to heavier neonates, but peak Scr is higher, and the subsequent decrease slower. Raised creatinemia in ELBW neonates reflects immaturity (GA) and morbidity (ventilation, Apgar)...
  38. ncbi request reprint Association of patent ductus arteriosus and severe hypothyroidism in term newborns: coincidence or causal?
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals, Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    J Matern Fetal Neonatal Med 16:339-41. 2004
    ..Based on our observation, hypothyroidism should be considered in term infants with PDA...
  39. doi request reprint Developmental pharmacology of tramadol during infancy: ontogeny, pharmacogenetics and elimination clearance
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals Leuven, Belgium
    Paediatr Anaesth 21:266-73. 2011
    ..To illustrate the complex interaction between ontogeny, i.e., age-dependent maturation, genetic polymorphisms and renal elimination clearance during infancy, based on developmental disposition of intravenous tramadol during infancy...
  40. ncbi request reprint Pharmacodynamics of chloral hydrate in former preterm infants
    Karel Allegaert
    Neonatal Intensive Care Unit, Department of Paediatrics, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 164:403-7. 2005
    ..Infants who displayed severe bradycardic (< 60/min) events ( n = 13) after administration of chloral hydrate had a lower gestational age at birth without difference in post-conception age at inclusion...
  41. ncbi request reprint Is propofol the perfect hypnotic agent for procedural sedation in neonates?
    Karel Allegaert
    Neonatal Intensive Care Unit, Division of Woman and Child, University Hospitals Leuven, Leuven, Belgium
    Curr Clin Pharmacol 4:84-6. 2009
    ..Propofol (2,6 di-isopropylphenol) is considered to be a short acting anaesthetic that is both rapid in onset and short in duration after cessation, but data on pharmacokinetics and metabolism in neonates were absent...
  42. doi request reprint Haemodynamics of intravenous paracetamol in neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Clin Pharmacol 66:855-8. 2010
    ..Reports on the haemodynamics of intravenous (iv) paracetamol in adult intensive care were recently published. We therefore wanted to explore the haemodynamics of iv paracetamol in neonates...
  43. ncbi request reprint Covariates of amikacin clearance in neonates: the impact of postnatal age on predictability
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals Leuven, Belgium
    Drug Metab Lett 2:286-9. 2008
    ..An exercise in the first month of life resulted in extended predictability (92%) with similar clearance estimates after the first postnatal days, reflecting the impact of postnatal age on clearance predictability...
  44. ncbi request reprint Structural and functional outcome in infants treated with cryotherapy for threshold retinopathy between 1989 and 1999
    Ingele Casteels
    Department of Ophthalmology, Neonatal Intensive Care Unit, University Hospitals, Leuven, Belgium
    J Pediatr Ophthalmol Strabismus 40:75-80. 2003
    ..To assess visual outcome, funduscopic appearance, and refraction for infants treated with cryotherapy for threshold retinopathy of prematurity (ROP) between 1989 and 1999...
  45. doi request reprint Ophthalmological findings in congenital cytomegalovirus infection: when to screen, when to treat?
    Sofie Ghekiere
    Departments of Ophthalmology, University of Leuven, Leuven, Belgium
    J Pediatr Ophthalmol Strabismus 49:274-82. 2012
    ..Further prospective studies are needed to set up guidelines for ophthalmological screening and treatment of infants with congenital CMV...
  46. doi request reprint The propylene glycol research project to illustrate the feasibility and difficulties to study toxicokinetics in neonates
    Aida Kulo
    Center for Clinical Pharmacology, University Hospitals Leuven, Leuven, Belgium
    Int J Pharm 435:112-4. 2012
    ....
  47. ncbi request reprint The clinical pharmacology of short acting analgo-sedatives in neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals Leuven, Belgium
    Curr Clin Pharmacol 6:222-6. 2011
    ..Based on the currently available information on predictability of disposition and the limited pharmacodynamic side effects (hemodynamics, neuro-apoptosis), it seems that remifentanil is the most promising compound for further evaluation...
  48. ncbi request reprint Perinatal growth characteristics and associated risk of developing threshold retinopathy of prematurity
    Karel Allegaert
    Neonatal Intensive Care Unit, Department of Pediatrics, University Hospitals, Leuven, Belgium
    J AAPOS 7:34-7. 2003
    ..To document perinatal growth characteristics in infants who developed threshold retinopathy of prematurity (ROP) in an attempt to describe prenatal and postnatal growth-related risk factors for threshold ROP...
  49. ncbi request reprint Variability in pain expression characteristics in former preterm infants
    Karel Allegaert
    Department of Pediatrics, University Hospital Gasthuisberg Leuven, Belgium
    J Perinat Med 33:442-8. 2005
    ..To document pain expression characteristics in former preterm infants in the first year of life in whom systematic evaluation and treatment of pain was provided...
  50. doi request reprint Mechanism based medicine in infancy: complex interplay between developmental pharmacology and pharmacogenetics
    Karel Allegaert
    Neonatal Intensive Care Unit, Division of Woman and Child, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Int J Clin Pharm 33:473-4. 2011
    ..To illustrate this, we further extended the tramadol example used by Wilffert et al. to illustrate the complex interplay between developmental pharmacology and pharmacogenetics...
  51. pmc Pharmacotherapy during neonatal extracorporeal membrane oxygenation: toward an evidence-based approach
    Maissa Rayyan
    Department of Woman and Child, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Crit Care 11:107. 2007
    ..The implementation of population pharmacokinetic models can further increase both the feasibility of such studies and the relevance of the results generated...
  52. ncbi request reprint Renal drug clearance in preterm neonates: relation to prenatal growth
    Karel Allegaert
    Department of Woman and Child, University of Leuven, Belgium
    Ther Drug Monit 29:284-91. 2007
    ..7%. Renal drug clearance is significantly lower in preterm neonates born SGA than in appropriate-for-gestational-age (AGA) controls. This reduced clearance was observed not only at birth but also up to the postnatal age of 4 weeks...
  53. doi request reprint Drug disposition and clinical practice in neonates: cross talk between developmental physiology and pharmacology
    Anne Smits
    Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
    Int J Pharm 452:8-13. 2013
    ..g. ontogeny renal or hepatic drug transporters): developmental pharmacology drives developmental pharmacology. ..
  54. doi request reprint Developmental pharmacokinetics in neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, Division of Woman and Child, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Expert Rev Clin Pharmacol 1:415-28. 2008
    ..The legal initiatives, including Paediatric Drug Regulation in the EU, and effective research tools, including population pharmacokinetics, are two important stimulants to boost further progress in this field. ..
  55. doi request reprint Educational paper: do we need neonatal clinical pharmacologists?
    Karel Allegaert
    Neonatal Intensive Care Unit, Division of Woman and Child, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 172:429-35. 2013
    ..e., the use of available data to improve current drug use and to predict pharmacokinetics/pharmacodynamics for similar compounds is needed. Development of clinical research networks is helpful to achieve these goals...
  56. doi request reprint Pharmacokinetics and pharmacodynamics of intravenous acetaminophen in neonates
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospitals Leuven, Belgium
    Expert Rev Clin Pharmacol 4:713-8. 2011
    ..Consequently, well designed and appropriately powered pharmacodynamic studies in neonates are urgently required, with specific emphasis on extreme preterm neonates...
  57. pmc Short-term use of parenteral nutrition with a lipid emulsion containing a mixture of soybean oil, olive oil, medium-chain triglycerides, and fish oil: a randomized double-blind study in preterm infants
    Maissa Rayyan
    Department of Neonatology, University Hospitals, Leuven, Belgium
    JPEN J Parenter Enteral Nutr 36:81S-94S. 2012
    ....
  58. doi request reprint Congenital heart defects in a novel recurrent 22q11.2 deletion harboring the genes CRKL and MAPK1
    Jeroen Breckpot
    Center for Human Genetics, University Hospitals Leuven, Herestraat, Leuven, Belgium
    Am J Med Genet A 158:574-80. 2012
    ..Computational gene prioritization methods and biological evidence denote the genes CRKL and MAPK1 as the highest ranking candidates for causing congenital heart disease within the deleted region...
  59. ncbi request reprint O-demethylation of tramadol in the first months of life
    Karel Allegaert
    Neonatal Intensive Care Unit, Department of Paediatrics, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Clin Pharmacol 61:837-42. 2005
    ..Assess in vivo O-demethylation activity in the first months of life...
  60. ncbi request reprint Systematic evaluation of pain in neonates: effect on the number of intravenous analgesics prescribed
    Karel Allegaert
    Department of Paediatrics, University Hospitals, Herestraat 49, Gasthuisberg, 3000, Leuven, Belgium
    Eur J Clin Pharmacol 59:87-90. 2003
    ..To document the effect of systematic evaluation of pain in neonates on prescription of intravenous analgesics in a level-III neonatal intensive care unit (NICU) as a marker of increased awareness of treating and preventing pain...
  61. doi request reprint Array comparative genomic hybridization as a diagnostic tool for syndromic heart defects
    Jeroen Breckpot
    Center of Human Genetics, University Hospitals Leuven, Leuven, Belgium
    J Pediatr 156:810-7, 817.e1-817.e4. 2010
    ..To investigate different aspects of the introduction of array comparative genomic hybridization (aCGH) in clinical practice...
  62. pmc Neonatal clinical pharmacology
    Karel Allegaert
    Department of Development and Regeneration, KU Leuven, Leuven, Belgium Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
    Paediatr Anaesth 24:30-8. 2014
    ..Consequently, pediatric anesthesiologists should consider to contribute to improved pharmacotherapy through clinical trial design and collaboration, as well as reporting on adverse effects of specific drugs. ..
  63. doi request reprint Paracetamol to induce ductus arteriosus closure: is it valid?
    Karel Allegaert
    Department of Development and Regeneration, KU Leuven, Leuven, Belgium
    Arch Dis Child 98:462-6. 2013
    ..Prospective comparative trials are reasonable and are urgently needed to establish both the effectiveness and safety data of paracetamol when used for this indication...
  64. doi request reprint Educational paper: Retinopathy of prematurity
    Ingele Casteels
    Department of Ophthalmology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Pediatr 171:887-93. 2012
    ..Conclusion: Retinopathy of prematurity is an important cause of ocular morbidity and blindness in children. With better understanding of the pathogenesis, screening and treatment guidelines have changed over time and are unit specific...
  65. doi request reprint Creatinaemia at birth is equal to maternal creatinaemia at delivery: does this paradigm still hold?
    Maike Kuppens
    Department of Woman and Child, University Hospitals, Leuven, Belgium
    J Matern Fetal Neonatal Med 25:978-80. 2012
    ..Paired maternal-neonatal creatinaemia samples in whom Jaffe in both or compensated Jaffe (maternal) and enzymatic quantification (neonate) were applied...
  66. doi request reprint Neonatal transient respiratory depression after maternal urapidil infusion for hypertension
    Sophie Vanhaesebrouck
    Neonatal Intensive Care Unit, Division Woman and Child, University Hospitals Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 168:221-3. 2009
    ..Infants of mothers who received urapidil should be carefully watched in the immediate postnatal phase as urapidil may still exert some significant effects on the neonate...
  67. ncbi request reprint Pseudo-Bartter syndrome in a neonate on prostaglandin infusion
    Sofie Vanhaesebrouck
    Neonatal Intensive Care Unit, Department of Paediatrics, University Hospitals Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 162:569-71. 2003
    ..v. PGE1 is a well-established pharmacological therapy in neonates with a ductus-dependent congenital cardiopathy to ensure ductus-dependent flow, we could only find one other report on pseudo-Bartter syndrome related to PGE1 infusion...
  68. ncbi request reprint Levetiracetam pharmacokinetics in neonates at birth
    Karel Allegaert
    Neonatal Intensive Care Unit, Division of Women and Child, University Hospital Gasthuisberg, Leuven, Belgium
    Epilepsia 47:1068-9. 2006
    ..Based on blood sampling in a formula-fed pair of twins, the estimated serum half-life of levetiracetam (LEV) at birth is 16-18 h...
  69. doi request reprint Evidence and patterns in lung response after fetal tracheal occlusion: clinical controlled study
    Mieke M Cannie
    Department of Radiology, University Hospital Gasthuisberg, Leuven, Belgium
    Radiology 252:526-33. 2009
    ....
  70. doi request reprint Pediatric clinical pharmacology: an introduction to a series of educational papers
    Karel Allegaert
    Department of Development and Regeneration, KU Leuven, Leuven, Belgium
    Eur J Pediatr 172:289-92. 2013
    ..We hope that many readers will reconsider their daily clinical practices and will be stimulated to collaborate to further improve pediatric drug therapy throughout Europe and beyond...
  71. doi request reprint Bladder catheter-induced obstructive bilateral hydroureteronephrosis in a newborn
    Karel Allegaert
    Neonatal Intensive Care Unit and Department of Radiology, University Hospitals Leuven, Herestraat, Leuven, Belgium
    Acta Paediatr 99:1747-9. 2010
    ..The normal findings at foetal ultrasound and the absence of muscular hypertrophy of the bladder hereby served as indicators of the iatrogenic nature of the initial abnormal ultrasound findings...
  72. doi request reprint Changing perspectives on the perinatal management of isolated congenital diaphragmatic hernia in Europe
    Jan A Deprest
    Woman and Child Division, Fetal Medicine Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Perinatol 36:329-47, ix. 2009
    ..Postnatal management has been standardized by European high-volume centers for the purpose of this and other trials...
  73. doi request reprint Determination of amikacin in cerebrospinal fluid by high-performance liquid chromatography with pulsed electrochemical detection
    Gordana Brajanoski
    Laboratorium voor Farmaceutische Analyse, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, O and N 2, PB 923, Herestraat 49, B 3000 Leuven, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 867:149-52. 2008
    ..Typical problems to be solved were the low amikacin concentrations and the limited sample volume of CSF...
  74. ncbi request reprint Not all intravenous paracetamol formulations are created equal
    Karel Allegaert
    Paediatr Anaesth 17:811-2. 2007
  75. ncbi request reprint Interindividual variability of aminoglycoside pharmacokinetics in preterm neonates at birth
    Karel Allegaert
    Eur J Clin Pharmacol 62:1011-2. 2006
  76. ncbi request reprint Population clinical pharmacology of children: modelling covariate effects
    Brian J Anderson
    Department of Anaesthesiology, University of Auckland, Auckland, New Zealand
    Eur J Pediatr 165:819-29. 2006
    ..Population modelling using mixed effects models provides a means to study variability in paediatric drug responses among individuals representative of those in whom the drug will be used clinically...
  77. ncbi request reprint The EPIBEL study: outcomes to discharge from hospital for extremely preterm infants in Belgium
    Piet Vanhaesebrouck
    Department of Neonatology, University Hospital Ghent, De Pintelaan 185 B 9000 Ghent, Belgium
    Pediatrics 114:663-75. 2004
    ..To determine mortality and morbidity at discharge from the hospital of a large population-based cohort of infants who were born at <or=26 weeks' gestation...
  78. ncbi request reprint Prophylactic ibuprofen in premature infants: a multicentre, randomised, double-blind, placebo-controlled trial
    Bart Van Overmeire
    Antwerp University Hospital, Edegem, Belgium
    Lancet 364:1945-9. 2004
    ....
  79. ncbi request reprint Pediatric intravenous paracetamol (propacetamol) pharmacokinetics: a population analysis
    Brian J Anderson
    Department of Anaesthesiology, University of Auckland, Auckland, New Zealand
    Paediatr Anaesth 15:282-92. 2005
    ..The aim of this study was to describe propacetamol pharmacokinetics in children in order to predict concentrations after a standard dosing regimen of propacetamol 30 mg x kg(-1) (15 mg x kg(-1) paracetamol) 6 h...
  80. ncbi request reprint Congenital diaphragmatic hernia and situs inversus totalis
    Coranne D Tesselaar
    Department of Pediatric Surgery, Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatrics 113:e256-8. 2004
  81. pmc Blunted inflammatory and faster clinical recovery following laser treatment compared to cryotherapy
    Karel Allegaert
    Arch Dis Child 92:655. 2007
  82. ncbi request reprint Population clinical pharmacology of children: general principles
    Brian J Anderson
    Department of Anaesthesiology, University of Auckland, Auckland, New Zealand
    Eur J Pediatr 165:741-6. 2006
    ..Population modelling using mixed-effects models provides a means to study variability in drug responses among individuals representative of those for whom the drug will be used clinically...