H Kadhim

Summary

Country: Belgium

Publications

  1. ncbi Cytokine immunoreactivity in cortical and subcortical neurons in periventricular leukomalacia: are cytokines implicated in neuronal dysfunction in cerebral palsy?
    Hazim Kadhim
    Laboratoire de Neurologie du Développement, Service de Neurologie Pediatrique, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain UCL, Avenue Mounier 52, 1200 Brussels, Belgium
    Acta Neuropathol 105:209-16. 2003
  2. ncbi Inflammatory cytokines in the pathogenesis of periventricular leukomalacia
    H Kadhim
    Service de Neurologie Pédiatrique et Laboratoire de Neurologie du Développement, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Neurology 56:1278-84. 2001
  3. ncbi Immune mechanisms in the pathogenesis of cerebral palsy: implication of proinflammatory cytokines and T lymphocytes
    Hazim Kadhim
    Laboratoire de Neurologie du Développement, Universite Catholique de Louvain, Belgium
    Eur J Paediatr Neurol 6:139-42. 2002
  4. ncbi Interleukin-2 in the pathogenesis of perinatal white matter damage
    H Kadhim
    Laboratoire de Neurologie du Développement, Universite Catholique de Louvain, Brussels, Belgium
    Neurology 58:1125-8. 2002
  5. ncbi Distinct cytokine profile in SIDS brain: a common denominator in a multifactorial syndrome?
    Hazim Kadhim
    Laboratoire de Neurologie du Développement, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Neurology 61:1256-9. 2003
  6. ncbi Molecular mechanisms of cell death in periventricular leukomalacia
    H Kadhim
    Neuropathology Unit, Brugmann University Hospital, Brussels, Belgium
    Neurology 67:293-9. 2006
  7. ncbi Polymicrogyria and motor neuropathy in Micro syndrome
    M C Nassogne
    Service de Neurologie Pediatrique, Cliniques Universitaires Saint Luc, Bruxelles, Belgium
    Neuropediatrics 31:218-21. 2000
  8. ncbi Efficacy of high dose steroid therapy in children with severe acute transverse myelitis
    P Defresne
    Service de Neurologie, Departement de Pediatrie, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, 1200 Bruxelles, Belgium
    J Neurol Neurosurg Psychiatry 71:272-4. 2001
  9. ncbi Serotonergic receptors in the midbrain correlated with physiological data on sleep apnea in SIDS victims
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University, School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S65-74. 2003
  10. ncbi The correlation between ubiquitin in the brainstem and sleep apnea in SIDS victims
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S75-86. 2003

Collaborators

Detail Information

Publications33

  1. ncbi Cytokine immunoreactivity in cortical and subcortical neurons in periventricular leukomalacia: are cytokines implicated in neuronal dysfunction in cerebral palsy?
    Hazim Kadhim
    Laboratoire de Neurologie du Développement, Service de Neurologie Pediatrique, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain UCL, Avenue Mounier 52, 1200 Brussels, Belgium
    Acta Neuropathol 105:209-16. 2003
    ..These findings might provide insights into the neuro-anatomical correlate for the intellectual deficits and the other cortical and deep gray neuronal dysfunctions associated with PVL...
  2. ncbi Inflammatory cytokines in the pathogenesis of periventricular leukomalacia
    H Kadhim
    Service de Neurologie Pédiatrique et Laboratoire de Neurologie du Développement, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Neurology 56:1278-84. 2001
    ..Periventricular leukomalacia (PVL) affects the developing white matter of neonatal brain. Inflammatory and infectious conditions are implicated in the cause of PVL...
  3. ncbi Immune mechanisms in the pathogenesis of cerebral palsy: implication of proinflammatory cytokines and T lymphocytes
    Hazim Kadhim
    Laboratoire de Neurologie du Développement, Universite Catholique de Louvain, Belgium
    Eur J Paediatr Neurol 6:139-42. 2002
    ..Additionally, markers of T-lymphocyte activation were upregulated. These findings provide new insight into mechanisms underlying neural cell death in this condition and might open new horizons for preventive and therapeutic strategies...
  4. ncbi Interleukin-2 in the pathogenesis of perinatal white matter damage
    H Kadhim
    Laboratoire de Neurologie du Développement, Universite Catholique de Louvain, Brussels, Belgium
    Neurology 58:1125-8. 2002
    ..These results suggest that interleukin-2, reported to be toxic to oligodendrocytes and myelin, could play a role in the molecular cascade leading to white matter damage in periventricular leukomalacia...
  5. ncbi Distinct cytokine profile in SIDS brain: a common denominator in a multifactorial syndrome?
    Hazim Kadhim
    Laboratoire de Neurologie du Développement, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Neurology 61:1256-9. 2003
    ..This IL-1 overexpression might contribute to molecular interactions in brainstem neurovegetative centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS...
  6. ncbi Molecular mechanisms of cell death in periventricular leukomalacia
    H Kadhim
    Neuropathology Unit, Brugmann University Hospital, Brussels, Belgium
    Neurology 67:293-9. 2006
    ..To investigate the cytokine-related molecular cascade leading to neural cell death in periventricular leukomalacia (PVL)...
  7. ncbi Polymicrogyria and motor neuropathy in Micro syndrome
    M C Nassogne
    Service de Neurologie Pediatrique, Cliniques Universitaires Saint Luc, Bruxelles, Belgium
    Neuropediatrics 31:218-21. 2000
    ..We report on polymicrogyria and motor neuropathy in a patient with Micro syndrome. These findings provide new insights into developmental defects underlying motor and mental disabilities...
  8. ncbi Efficacy of high dose steroid therapy in children with severe acute transverse myelitis
    P Defresne
    Service de Neurologie, Departement de Pediatrie, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, 1200 Bruxelles, Belgium
    J Neurol Neurosurg Psychiatry 71:272-4. 2001
    ..The treatment had a significant effect on the proportion of patients walking independently at 1 month and on the proportion with full recovery at 1 year, with no differences in the frequency of complications between the two groups...
  9. ncbi Serotonergic receptors in the midbrain correlated with physiological data on sleep apnea in SIDS victims
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University, School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S65-74. 2003
    ..To further explore this claim, the correlation between serotonin receptors in the brainstem and sleep apnea in SIDS victims was investigated...
  10. ncbi The correlation between ubiquitin in the brainstem and sleep apnea in SIDS victims
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S75-86. 2003
    ..One report claims an increased in ubiquitin in the liver of SIDS victims, ubiquitin being one of the heat-shock proteins. The correlation between ubiquitin in the brainstem and sleep apnea in SIDS was investigated here...
  11. ncbi Catecholaminergic neurons in the brain-stem and sleep apnea in SIDS victims
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S41-50. 2003
    ..Some reports have demonstrated a decrease of TH in the Sudden Infant Death Syndrome (SIDS) compared with controls. To further investigate this, the correlation between TH and sleep apnea was investigated here...
  12. ncbi The correlation between microtubule-associated protein 2 in the brainstem of SIDS victims and physiological data on sleep apnea
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S87-97. 2003
    ....
  13. ncbi The correlation between tau protein in the brainstem and sleep apnea in SIDS victims
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S99-107. 2003
    ..Tau protein may contribute to axonal development and neural plasticity; therefore, the correlation between tau protein in the brainstem and sleep apnea in SIDS was investigated here...
  14. ncbi The presence of TATA-binding protein in the brainstem, correlated with sleep apnea in SIDS victims
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S109-18. 2003
    ....
  15. ncbi Correlation between the Ki-67 antigen in the brainstem and physiological data on sleep apnea in SIDS victims
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S119-27. 2003
    ....
  16. ncbi The relationship between neuronal plasticity and serotonergic neurons in the brainstem of SIDS victims
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S139-46. 2003
    ..Therefore, the characteristics of GAP43-positive elements and their association with serotonergic neurons were here investigated in the brainstem of SIDS victims...
  17. ncbi The correlation between serotonergic neurons in the brainstem and sleep apnea in SIDS victims
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S31-40. 2003
    ..The correlation between serotonergic neurons or dendritic spines in the brainstem of SIDS and sleep apnea was investigated here...
  18. ncbi Investigation into the correlation in SIDS victims between Alzheimer precursor protein A4 in the brainstem and sleep apnea
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S21-30. 2003
    ..As chronic hypoxia is one of the favoured theories of causation in the sudden infant death syndrome (SIDS), the correlation between APP in the brainstem and sleep apnea in SIDS was investigated...
  19. ncbi In situ cytokine immune responses in acute disseminated encephalomyelitis: insights into pathophysiologic mechanisms
    Hazim Kadhim
    , Service d'Anatomopathologie, CHU Brugmann, , Brussels, Belgium
    Hum Pathol 34:293-7. 2003
    ..These observations might provide insights into molecular pathways involved in the immunopathogenesis of ADEM and might open new horizons in neuroimmunomodulation and anticytokine treatment...
  20. ncbi Neuroimaging of intraparenchymal lesions predicts outcome in shaken baby syndrome
    Christine Bonnier
    Service de Neurologie Pediatrique, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Pediatrics 112:808-14. 2003
    ..The aim of this study was to describe clinical and imaging features over time and to consider their value for predicting neurodevelopmental outcome...
  21. ncbi Clinicopathological correlation between brainstem gliosis using GFAP as a marker and sleep apnea in the sudden infant death syndrome
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S3-11. 2003
    ..Gliosis detected by immunohistochemistry of glial fibrillary acidic protein (GFAP) is a marker of apoptosis. The correlation between GFAP-positive reactive astrocytes in the brainstem and sleep apnea in SIDS was investigated...
  22. ncbi Pathological data on apoptosis in the brainstem and physiological data on sleep apnea in SIDS victims
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S13-20. 2003
    ..In this study, the correlation between apoptotic neurons or glias and sleep apnea in SIDS was investigated in the brainstem of SIDS victims...
  23. ncbi [Noxious effects of pro-inflammatory cytokines on perinatal brain development?]
    Guillaume Sebire
    Med Sci (Paris) 22:1015-6. 2006
  24. ncbi Polymicrogyria in chromosome 22q11 deletion syndrome
    Sophie Ghariani
    Department of Pediatric Neurology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Eur J Paediatr Neurol 6:73-7. 2002
    ....
  25. ncbi Aphasia owing to subcortical brain infarcts in childhood
    Ariel Gout
    Service de Neurologie, , , Paris, France
    J Child Neurol 20:1003-8. 2005
    ....
  26. ncbi Impact of early hemispherotomy in a case of Ohtahara syndrome with left parieto-occipital megalencephaly
    Ghassan Hmaimess
    Department of Pediatric Neurology, Saint Luc University Hospital, , Belgium
    Seizure 14:439-42. 2005
    ..It provides evidence that surgical intervention might provide promising results in selected cases, and that young age is not a contraindication for this type of surgery...
  27. ncbi Incongruent cerebral growth in sudden infant death syndrome
    Hazim Kadhim
    Anatomic Pathology Service, Brugmann University Hospital, Brussels, Belgium
    J Child Neurol 20:244-6. 2005
    ..In a previous study, we disclosed cytokine overexpression in the brains of these victims. Whether increased brain weight is linked to cytokine up-regulation remains, however, a moot case and merits further exploration...
  28. ncbi From epidemiology to physiology and pathology: apnea and arousal deficient theories in sudden infant death syndrome (SIDS)--with particular reference to hypoxic brainstem gliosis
    Toshiko Sawaguchi
    Department of Legal Medicine, School of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Forensic Sci Int 130:S21-9. 2002
    ..In conclusion, the present study sustains the possibility of an organic fragility within the arousal pathway in SIDS victims with repetitive sleep apneas...
  29. ncbi Association between sleep apnea and reactive astrocytes in brainstems of victims of SIDS and in control infants
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Forensic Sci Int 130:S30-6. 2002
    ....
  30. ncbi From physiology to pathology: arousal deficiency theory in sudden infant death syndrome (SIDS)--with reference to apoptosis and neuronal plasticity
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Forensic Sci Int 130:S37-43. 2002
    ..This autonomic response occurs within an acetylcholine afferent system and pedunculopontine tegmental nucleus (PPTN). The finding is, in future SIDS infants, associated with repetitive sleep apnea...
  31. ncbi Interaction between apnea, prone sleep position and gliosis in the brainstems of victims of SIDS
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Forensic Sci Int 130:S44-52. 2002
    ..The observed relation between prone sleep and the density of gliosis does not relate to epidemiological findings. Further studies are needed to investigate the unexpected statistical association...
  32. ncbi Substance P in the midbrains of SIDS victims and its correlation with sleep apnea
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S51-9. 2003
    ..Some reports claim an increase in SP in the brains of SIDS victims, so the correlation between SP and sleep apnea was investigated here...
  33. ncbi Lipopolysaccharide and hypoxia/ischemia induced IL-2 expression by microglia in neonatal brain
    Sylvie Girard
    Child Neurology Laboratory, Department of Pediatrics, Universite de Sherbrooke, Quebec, Canada
    Neuroreport 19:997-1002. 2008
    ..These results disclosed the ability of microglia to produce IL-2 and also suggest the implication of IL-2 in neural cell death triggered by perinatal lipopolysaccharide and hypoxia/ischemia exposures...