Ellen Van Gulck

Summary

Affiliation: Institute of Tropical Medicine
Country: Belgium

Publications

  1. ncbi Efficient stimulation of HIV-1-specific T cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env proteins
    Ellen R A Van Gulck
    HIV and Retrovirology Research Unit, Department of Microbiology, Institute of Tropical Medicine of Antwerp, Nationalestraat 155, 2000 Antwerp, Belgium
    Blood 107:1818-27. 2006
  2. pmc Efficient in vitro expansion of human immunodeficiency virus (HIV)-specific T-cell responses by gag mRNA-electroporated dendritic cells from treated and untreated HIV type 1-infected individuals
    Ellen R Van Gulck
    Institute of Tropical Medicine of Antwerp, Department of Microbiology, Nationalestraat 155, Antwerp 2000, Belgium
    J Virol 82:3561-73. 2008
  3. ncbi Role of dendritic cells in HIV-immunotherapy
    Ellen Van Gulck
    Virology Unit, Departmentof Microbiology, Institute of Tropical Medicine ITMA, Antwerp, Belgium
    Curr HIV Res 8:310-22. 2010
  4. pmc Control of viral replication after cessation of HAART
    Ellen Van Gulck
    Virology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp ITMA, Antwerp, Belgium
    AIDS Res Ther 8:6. 2011
  5. pmc Interleukin-12p70 expression by dendritic cells of HIV-1-infected patients fails to stimulate gag-specific immune responses
    Ellen Van Gulck
    Virology Unit, Department of Microbiology, Institute of Tropical Medicine ITMA, 2000 Antwerp, Belgium
    Clin Dev Immunol 2012:184979. 2012
  6. doi Lipoplexes carrying mRNA encoding Gag protein modulate dendritic cells to stimulate HIV-specific immune responses
    Winni De Haes
    Institute of Tropical Medicine of Antwerp, Nationalestraat 155, Antwerp 2000, Belgium
    Nanomedicine (Lond) 8:77-87. 2013
  7. pmc Immune and viral correlates of "secondary viral control" after treatment interruption in chronically HIV-1 infected patients
    Ellen Van Gulck
    Virology Unit, Microbiology Group, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Antwerp, Belgium
    PLoS ONE 7:e37792. 2012
  8. pmc Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines
    Charlotte Pollard
    Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    Mol Ther 21:251-9. 2013
  9. doi mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients
    Ellen Van Gulck
    Department of Biomedical Sciences, Division of Microbiology, Virology Unit, Institute of Tropical Medicine, Antwerp, Belgium
    AIDS 26:F1-12. 2012
  10. pmc Can immunotherapy be useful as a "functional cure" for infection with Human Immunodeficiency Virus-1?
    Guido Vanham
    Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine of Antwerp, Nationalestraat 155, B 2000, Antwerpen, Belgium
    Retrovirology 9:72. 2012

Detail Information

Publications11

  1. ncbi Efficient stimulation of HIV-1-specific T cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env proteins
    Ellen R A Van Gulck
    HIV and Retrovirology Research Unit, Department of Microbiology, Institute of Tropical Medicine of Antwerp, Nationalestraat 155, 2000 Antwerp, Belgium
    Blood 107:1818-27. 2006
    ..These findings open a major perspective for the development of patient-specific immunotherapy for HIV-1 disease...
  2. pmc Efficient in vitro expansion of human immunodeficiency virus (HIV)-specific T-cell responses by gag mRNA-electroporated dendritic cells from treated and untreated HIV type 1-infected individuals
    Ellen R Van Gulck
    Institute of Tropical Medicine of Antwerp, Department of Microbiology, Nationalestraat 155, Antwerp 2000, Belgium
    J Virol 82:3561-73. 2008
    ..This paper shows that DC, loaded with consensus or autologous gag mRNA, expand HIV-specific T-cell responses in vitro...
  3. ncbi Role of dendritic cells in HIV-immunotherapy
    Ellen Van Gulck
    Virology Unit, Departmentof Microbiology, Institute of Tropical Medicine ITMA, Antwerp, Belgium
    Curr HIV Res 8:310-22. 2010
    ..Broad and potent immune response are needed to suppress the entire quasispecies, including the latent reservoir, and to prevent any escape...
  4. pmc Control of viral replication after cessation of HAART
    Ellen Van Gulck
    Virology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp ITMA, Antwerp, Belgium
    AIDS Res Ther 8:6. 2011
    ..We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual "secondary controller" status. But their viruses are clearly less fit compared to viruses from rebounders...
  5. pmc Interleukin-12p70 expression by dendritic cells of HIV-1-infected patients fails to stimulate gag-specific immune responses
    Ellen Van Gulck
    Virology Unit, Department of Microbiology, Institute of Tropical Medicine ITMA, 2000 Antwerp, Belgium
    Clin Dev Immunol 2012:184979. 2012
    ..This result which goes against expectation may lead to a re-evaluation of the need for IL-12 expression by DCs in order to improve T-cell responses in HIV-1-infected individuals...
  6. doi Lipoplexes carrying mRNA encoding Gag protein modulate dendritic cells to stimulate HIV-specific immune responses
    Winni De Haes
    Institute of Tropical Medicine of Antwerp, Nationalestraat 155, Antwerp 2000, Belgium
    Nanomedicine (Lond) 8:77-87. 2013
    ....
  7. pmc Immune and viral correlates of "secondary viral control" after treatment interruption in chronically HIV-1 infected patients
    Ellen Van Gulck
    Virology Unit, Microbiology Group, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Antwerp, Belgium
    PLoS ONE 7:e37792. 2012
    ..These data suggest that higher T cell proliferative responses and lower replication kinetics might be instrumental in secondary viral control in the absence of treatment...
  8. pmc Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines
    Charlotte Pollard
    Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    Mol Ther 21:251-9. 2013
    ..These results are of high relevance as they will stimulate the design and development of improved mRNA-based vaccination approaches...
  9. doi mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients
    Ellen Van Gulck
    Department of Biomedical Sciences, Division of Microbiology, Virology Unit, Institute of Tropical Medicine, Antwerp, Belgium
    AIDS 26:F1-12. 2012
    ..In an effort to raise protective antiviral immunity, dendritic cell immunotherapy was evaluated in six adults infected with human immunodeficiency virus (HIV)-1 and stable under highly active antiretroviral therapy (HAART)...
  10. pmc Can immunotherapy be useful as a "functional cure" for infection with Human Immunodeficiency Virus-1?
    Guido Vanham
    Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine of Antwerp, Nationalestraat 155, B 2000, Antwerpen, Belgium
    Retrovirology 9:72. 2012
    ..Finally, to achieve a long-lasting effect on viral control (i.e. a "functional cure") it is likely that these immune interventions should be combined with anti-latency drugs and/or gene therapy...
  11. pmc Polyelectrolyte capsules-containing HIV-1 p24 and poly I:C modulate dendritic cells to stimulate HIV-1-specific immune responses
    Winni De Haes
    Institute of Tropical Medicine of Antwerp, Department of Microbiology, Unit Virology, Antwerp, Belgium
    Mol Ther 18:1408-16. 2010
    ..Polyelectrolyte MCs could be useful for in vivo immunization in HIV-1 and other infections...