W Jennes

Summary

Affiliation: Institute of Tropical Medicine
Country: Belgium

Publications

  1. ncbi Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands
    Wim Jennes
    Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
    J Immunol 177:6588-92. 2006
  2. doi Inhibitory KIR/HLA incompatibility between sexual partners confers protection against HIV-1 transmission
    Wim Jennes
    Laboratory of Immunology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    Blood 121:1157-64. 2013
  3. pmc Molecular epidemiology of HIV-1 transmission in a cohort of HIV-1 concordant heterosexual couples from Dakar, Senegal
    Wim Jennes
    Laboratory of Immunology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    PLoS ONE 7:e37402. 2012
  4. pmc The predominance of Human Immunodeficiency Virus type 1 (HIV-1) circulating recombinant form 02 (CRF02_AG) in West Central Africa may be related to its replicative fitness
    Harr F Njai
    HIV and Retrovirology Research Unit, Department of Microbiology, Institute of Tropical Medicine, 155 Nationalestraat, B 2000 Antwerp, Belgium
    Retrovirology 3:40. 2006
  5. pmc Low CD4+ T cell counts among African HIV-1 infected subjects with group B KIR haplotypes in the absence of specific inhibitory KIR ligands
    Wim Jennes
    Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
    PLoS ONE 6:e17043. 2011
  6. pmc Higher homologous and lower cross-reactive Gag-specific T-cell responses in human immunodeficiency virus type 2 (HIV-2) than in HIV-1 infection
    Wim Jennes
    Department of Microbiology, Laboratory of Immunology, Institute of Tropical Medicine, Antwerp, Belgium
    J Virol 82:8619-28. 2008
  7. pmc Suppressed cellular alloimmune responses in HIV-exposed seronegative female sex workers
    W Jennes
    Department of Microbiology, Laboratory of Immunology, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium
    Clin Exp Immunol 143:435-44. 2006
  8. ncbi Disturbed secretory capacity for macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta in progressive HIV infection
    Wim Jennes
    Department of Microbiology, Institute of Tropical Medicine, 2000 Antwerp, Belgium
    AIDS Res Hum Retroviruses 20:1087-91. 2004
  9. ncbi HIV-specific T helper responses and frequency of exposure among HIV-exposed seronegative female sex workers in Abidjan, Cote d'Ivoire
    Wim Jennes
    Department of Microbiology, Laboratory of Immunology, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium
    J Infect Dis 189:602-10. 2004
  10. ncbi Cellular human immunodeficiency virus (HIV)-protective factors: a comparison of HIV-exposed seronegative female sex workers and female blood donors in Abidjan, Côte d'Ivoire
    Wim Jennes
    Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
    J Infect Dis 187:206-14. 2003

Detail Information

Publications15

  1. ncbi Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands
    Wim Jennes
    Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
    J Immunol 177:6588-92. 2006
    ..In addition, exposed seronegatives more frequently possessed AB KIR genotypes, which contain more activating KIR. The data support an important role for NK cells and KIR/HLA interactions in antiviral immunity...
  2. doi Inhibitory KIR/HLA incompatibility between sexual partners confers protection against HIV-1 transmission
    Wim Jennes
    Laboratory of Immunology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    Blood 121:1157-64. 2013
    ..Our data suggest that KIR/HLA incompatibility between sexual partners confers protection against HIV-1 transmission and that this may be due to alloreactive NK cell killing of the HIV-1-infected partner's cells...
  3. pmc Molecular epidemiology of HIV-1 transmission in a cohort of HIV-1 concordant heterosexual couples from Dakar, Senegal
    Wim Jennes
    Laboratory of Immunology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    PLoS ONE 7:e37402. 2012
    ..A large number of HIV-1 infections in Africa occur in married couples. The predominant direction of intracouple transmission and the principal external origins of infection remain important issues of debate...
  4. pmc The predominance of Human Immunodeficiency Virus type 1 (HIV-1) circulating recombinant form 02 (CRF02_AG) in West Central Africa may be related to its replicative fitness
    Harr F Njai
    HIV and Retrovirology Research Unit, Department of Microbiology, Institute of Tropical Medicine, 155 Nationalestraat, B 2000 Antwerp, Belgium
    Retrovirology 3:40. 2006
    ..Growth competition experiments were carried out at equal multiplicity of infection in activated T cells and monocyte-derived dendritic cells (MO-DC) in parallel...
  5. pmc Low CD4+ T cell counts among African HIV-1 infected subjects with group B KIR haplotypes in the absence of specific inhibitory KIR ligands
    Wim Jennes
    Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
    PLoS ONE 6:e17043. 2011
    ..Our data suggest that group B KIR haplotypes and lack of specific inhibitory KIR ligand genes, genotypes considered to favor NK cell activation, are predictive of HIV-1 disease progression...
  6. pmc Higher homologous and lower cross-reactive Gag-specific T-cell responses in human immunodeficiency virus type 2 (HIV-2) than in HIV-1 infection
    Wim Jennes
    Department of Microbiology, Laboratory of Immunology, Institute of Tropical Medicine, Antwerp, Belgium
    J Virol 82:8619-28. 2008
    ..Understanding the nature of immune control of HIV-2 infection could be crucial for HIV vaccine design...
  7. pmc Suppressed cellular alloimmune responses in HIV-exposed seronegative female sex workers
    W Jennes
    Department of Microbiology, Laboratory of Immunology, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium
    Clin Exp Immunol 143:435-44. 2006
    ..Our data support the hypothesis that suppressed cellular alloimmune responses may play a role in protection against HIV infection...
  8. ncbi Disturbed secretory capacity for macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta in progressive HIV infection
    Wim Jennes
    Department of Microbiology, Institute of Tropical Medicine, 2000 Antwerp, Belgium
    AIDS Res Hum Retroviruses 20:1087-91. 2004
    ..Furthermore, we demonstrated that the detection of beta-chemokines in HIV patients by different methods may indeed result in contradictory findings...
  9. ncbi HIV-specific T helper responses and frequency of exposure among HIV-exposed seronegative female sex workers in Abidjan, Cote d'Ivoire
    Wim Jennes
    Department of Microbiology, Laboratory of Immunology, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium
    J Infect Dis 189:602-10. 2004
    ..The characteristics of human immunodeficiency virus (HIV) exposure that determine the induction of HIV-specific T cells and, in particular, T helper cells are not well understood...
  10. ncbi Cellular human immunodeficiency virus (HIV)-protective factors: a comparison of HIV-exposed seronegative female sex workers and female blood donors in Abidjan, Côte d'Ivoire
    Wim Jennes
    Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
    J Infect Dis 187:206-14. 2003
    ..These data indicate that ESN FSWs differ from HIV-seronegative female blood donors with respect to immunological factors that have no clear protective potential against HIV transmission...
  11. ncbi Enhanced ELISPOT detection of antigen-specific T cell responses from cryopreserved specimens with addition of both IL-7 and IL-15--the Amplispot assay
    Wim Jennes
    Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, CA, USA
    J Immunol Methods 270:99-108. 2002
    ..This method will be particularly useful for the assessment of antigen-stimulated cytokine production by T cells in cryopreserved biological specimens...
  12. ncbi Positive association between beta-chemokine-producing T cells and HIV type 1 viral load in HIV-infected subjects in Abidjan, Côte d'Ivoire
    Wim Jennes
    Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
    AIDS Res Hum Retroviruses 18:171-7. 2002
    ..05) in peripheral blood. These data indicate that increased percentages of beta-chemokine-producing T cells in HIV-1-infected subjects correlate with disease progression and are a sign of viremia-driven chronic T cell activation...
  13. ncbi Poorly soluble peptides can mimic authentic ELISPOT responses
    R Karl Karlsson
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141, USA
    J Immunol Methods 285:89-92. 2004
    ..Filtering the peptide prevented non-specific spot formation. These findings underscore the need for appropriate controls and proper peptide preparation in order to reduce the risk of false-positive ELISPOT responses...
  14. ncbi Dominant ex vivo cross-stimulation of CD8+ T-cells with whole soluble gag protein in HIV-infected subjects
    An Tavernier
    Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium
    J Acquir Immune Defic Syndr 41:548-56. 2006
    ..Soluble HIV proteins are often used to detect HIV-specific CD4+ T-helper cell responses in vitro. However, exogenous antigens can also indirectly stimulate CD8+ T-cells and thus complicate assessment of CD4+ T-cell responses...
  15. ncbi Unprotected sex and alloimmune activation
    Wim Jennes
    Lancet 363:1474; author reply 1474-5. 2004