Affiliation: Institute of Tropical Medicine
Deborggraeve S, Laurent T, Espinosa D, Van der Auwera G, Mbuchi M, Wasunna M, et al
. A simplified and standardized polymerase chain reaction format for the diagnosis of leishmaniasis. J Infect Dis. 2008;198:1565-72 pubmed publisher
..The assay is a promising new tool for simplified and standardized molecular detection of Leishmania parasites. ..
Deborggraeve S, Büscher P. Molecular diagnostics for sleeping sickness: what is the benefit for the patient?. Lancet Infect Dis. 2010;10:433-9 pubmed publisher
..The current formats are not applicable to field conditions, and simplification, standardisation, and proper test evaluation in the target setting should be the main focus for future development. ..
Tehseen S, Jahan N, Qamar M, Desquesnes M, Shahzad M, Deborggraeve S, et al
. Parasitological, serological and molecular survey of Trypanosoma evansi infection in dromedary camels from Cholistan Desert, Pakistan. Parasit Vectors. 2015;8:415 pubmed publisher
..Our study supports using antibody detection tests, rather than parasitological and molecular examination, to assess surra prevalence in camels. It also calls for implementation of measures to control surra in the Cholistan Desert. ..
Kakabadze E, Makalatia K, Grdzelishvili N, Bakuradze N, Goderdzishvili M, Kusradze I, et al
. Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum ?-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo. Viruses. 2018;10: pubmed publisher
..We have selected bacteriophages that show strong lytic activity against this isolate and have potential for phage-based treatment of S. Typhi, and Salmonella in general. ..
Cuypers B, Lecordier L, Meehan C, Van den Broeck F, Imamura H, BÃ¼scher P, et al
. Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection. MBio. 2016;7:e02198-15 pubmed publisher
..Our data suggest that populations with high frequencies of the homozygous N264K ApoL1 variant may be at increased risk of contracting human African trypanosomiasis. ..
Deborggraeve S, Claes F, Laurent T, Mertens P, Leclipteux T, Dujardin J, et al
. Molecular dipstick test for diagnosis of sleeping sickness. J Clin Microbiol. 2006;44:2884-9 pubmed
..HAT-PCR-OC is a promising new tool for diagnosis of sleeping sickness in laboratory settings, and the diagnostic format described here may have wider application for other infectious diseases...
Deborggraeve S, Boelaert M, Rijal S, De Doncker S, Dujardin J, Herdewijn P, et al
. Diagnostic accuracy of a new Leishmania PCR for clinical visceral leishmaniasis in Nepal and its role in diagnosis of disease. Trop Med Int Health. 2008;13:1378-83 pubmed publisher
..3% (kappa-index 0.416, 95% CI: 0.30-0.53). Our findings indicate that PCR alone rather provides a marker for infection than a marker for disease and its role in VL diagnosis in endemic regions is discussed. ..