Kevin K Ariën

Summary

Affiliation: Institute of Tropical Medicine
Country: Belgium

Publications

  1. doi request reprint Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission
    Kevin K Ariën
    Department of Biomedical Sciences, Institute of Tropical Medicine, B 2000 Antwerp, Belgium
    J Antimicrob Chemother 68:2038-47. 2013
  2. ncbi request reprint Ex vivo models of HIV sexual transmission and microbicide development
    Kevin K Ariën
    Virology Unit, Division of Microbiology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    Curr HIV Res 10:73-8. 2012
  3. ncbi request reprint Replicative fitness of historical and recent HIV-1 isolates suggests HIV-1 attenuation over time
    Kevin K Ariën
    Department of Microbiology, HIV and Retrovirology Research Unit, Institute of Tropical Medicine, Antwerp, Belgium
    AIDS 19:1555-64. 2005
  4. ncbi request reprint Replicative fitness of CCR5-using and CXCR4-using human immunodeficiency virus type 1 biological clones
    Kevin K Ariën
    HIV and Retrovirology Research Unit, Department of Microbiology, Institute for Tropical Medicine, Nationalestraat 155, B 2000 Antwerpen, Belgium
    Virology 347:65-74. 2006
  5. pmc Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function
    Pieter J Meuwissen
    Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University, Ghent, B 9000, Belgium
    Retrovirology 9:34. 2012
  6. pmc Analysis of infectious virus clones from two HIV-1 superinfection cases suggests that the primary strains have lower fitness
    Antoinette C van der Kuyl
    Laboratory of Experimental Virology, Department of Medical Microbiology, Centre for Infection and Immunity Amsterdam CINIMA, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 7:60. 2010
  7. ncbi request reprint Survey of the temporal changes in HIV-1 replicative fitness in the Amsterdam Cohort
    Youssef Gali
    Department of Microbiology, Virology Unit, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    Virology 364:140-6. 2007
  8. pmc MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency
    Katrijn Grupping
    Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine of Antwerp, Antwerp, Belgium
    Retrovirology 9:36. 2012
  9. doi request reprint Development of an in vitro dual-chamber model of the female genital tract as a screening tool for epithelial toxicity
    Youssef Gali
    Virology Unit, Department of Microbiology, Institute of Tropical Medicine, B 2000 Antwerpen, Belgium
    J Virol Methods 165:186-97. 2010
  10. ncbi request reprint Is HIV-1 evolving to a less virulent form in humans?
    Kevin K Ariën
    HIV and Retrovirology Research Unit, Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, B2000 Antwerp, Belgium
    Nat Rev Microbiol 5:141-51. 2007

Collaborators

Detail Information

Publications17

  1. doi request reprint Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission
    Kevin K Ariën
    Department of Biomedical Sciences, Institute of Tropical Medicine, B 2000 Antwerp, Belgium
    J Antimicrob Chemother 68:2038-47. 2013
    ....
  2. ncbi request reprint Ex vivo models of HIV sexual transmission and microbicide development
    Kevin K Ariën
    Virology Unit, Division of Microbiology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    Curr HIV Res 10:73-8. 2012
    ..Here, we review the armamentarium on in vitro/ex vivo models of HIV sexual transmission and discuss how these models can be applied to study candidate microbicides...
  3. ncbi request reprint Replicative fitness of historical and recent HIV-1 isolates suggests HIV-1 attenuation over time
    Kevin K Ariën
    Department of Microbiology, HIV and Retrovirology Research Unit, Institute of Tropical Medicine, Antwerp, Belgium
    AIDS 19:1555-64. 2005
    ..Here we used primary human cells to study the replicative fitness of primary HIV-1 isolates from untreated patients, comparing historical (1986-1989) and recent samples (2002-2003)...
  4. ncbi request reprint Replicative fitness of CCR5-using and CXCR4-using human immunodeficiency virus type 1 biological clones
    Kevin K Ariën
    HIV and Retrovirology Research Unit, Department of Microbiology, Institute for Tropical Medicine, Nationalestraat 155, B 2000 Antwerpen, Belgium
    Virology 347:65-74. 2006
    ..These observations suggest that interaction between X4 viruses, DC and T cells might contribute to the preferential outgrowth of X4 viruses in AIDS patients...
  5. pmc Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function
    Pieter J Meuwissen
    Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University, Ghent, B 9000, Belgium
    Retrovirology 9:34. 2012
    ..In this study, we aimed to study the functional importance of this VGF region...
  6. pmc Analysis of infectious virus clones from two HIV-1 superinfection cases suggests that the primary strains have lower fitness
    Antoinette C van der Kuyl
    Laboratory of Experimental Virology, Department of Medical Microbiology, Centre for Infection and Immunity Amsterdam CINIMA, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 7:60. 2010
    ..The use of isolate-specific primer sets indicated that the primary and secondary strains co-exist in plasma at all time points after the moment of superinfection...
  7. ncbi request reprint Survey of the temporal changes in HIV-1 replicative fitness in the Amsterdam Cohort
    Youssef Gali
    Department of Microbiology, Virology Unit, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    Virology 364:140-6. 2007
    ..Apparently, the bottleneck, occurring with each transmission event, does not completely reset the fitness increase acquired during disease progression...
  8. pmc MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency
    Katrijn Grupping
    Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine of Antwerp, Antwerp, Belgium
    Retrovirology 9:36. 2012
    ..The miniCD4 proteins are a promising class of CD4bs inhibitors. Studying virus evolution under pressure of CD4bs inhibitors could provide insight on the gp120-CD4 interaction and viral entry...
  9. doi request reprint Development of an in vitro dual-chamber model of the female genital tract as a screening tool for epithelial toxicity
    Youssef Gali
    Virology Unit, Department of Microbiology, Institute of Tropical Medicine, B 2000 Antwerpen, Belgium
    J Virol Methods 165:186-97. 2010
    ..In conclusion, this model is a useful tool to (1) study HIV-1 transmission mechanisms and (2) evaluate epithelial toxicity of candidate microbicides...
  10. ncbi request reprint Is HIV-1 evolving to a less virulent form in humans?
    Kevin K Ariën
    HIV and Retrovirology Research Unit, Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, B2000 Antwerp, Belgium
    Nat Rev Microbiol 5:141-51. 2007
    ..Here, we explore whether HIV-1 has reached peak virulence or has already started the slow path to attenuation...
  11. doi request reprint A dual-chamber model of the female genital tract to evaluate epithelial toxicity of candidate anti-HIV microbicides
    Kevin K Ariën
    Virology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
    Curr Protoc Cell Biol . 2011
    ..Here we describe how this in vitro model can be used to assess the cellular toxicity and anti-HIV activity of antiretrovirals and formulations thereof that are intended to be used as microbicides...
  12. pmc The predominance of Human Immunodeficiency Virus type 1 (HIV-1) circulating recombinant form 02 (CRF02_AG) in West Central Africa may be related to its replicative fitness
    Harr F Njai
    HIV and Retrovirology Research Unit, Department of Microbiology, Institute of Tropical Medicine, 155 Nationalestraat, B 2000 Antwerp, Belgium
    Retrovirology 3:40. 2006
    ..Growth competition experiments were carried out at equal multiplicity of infection in activated T cells and monocyte-derived dendritic cells (MO-DC) in parallel...
  13. pmc Searching for lower female genital tract soluble and cellular biomarkers: defining levels and predictors in a cohort of healthy Caucasian women
    Jordan K Kyongo
    Virology Unit, Division of Microbiology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    PLoS ONE 7:e43951. 2012
    ....
  14. pmc In vitro evaluation of viability, integrity, and inflammation in genital epithelia upon exposure to pharmaceutical excipients and candidate microbicides
    Youssef Gali
    Department of Microbiology, Virology Unit, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    Antimicrob Agents Chemother 54:5105-14. 2010
    ..In conclusion, identification of safety issues concerning the use of pharmaceutical excipients could help to formulate less toxic vaginal microbicide preparations...
  15. pmc M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
    Philippe Selhorst
    Department of Biomedical Sciences, Unit of Virology, Institute of Tropical Medicine, Antwerp, B 2000, Belgium
    Retrovirology 10:12. 2013
    ..HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen...
  16. pmc In vitro activities of candidate microbicides against cell-associated HIV
    Philippe Selhorst
    Virology Unit, Institute of Tropical Medicine, Antwerp, Belgium
    Antimicrob Agents Chemother 56:805-15. 2012
    ..Overall, these results show that entry and protease inhibitors are eligible drug classes for inclusion in future combination microbicides...
  17. pmc Human immunodeficiency virus type 1 resistance or cross-resistance to nonnucleoside reverse transcriptase inhibitors currently under development as microbicides
    Philippe Selhorst
    Department of Microbiology, Virology Unit, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    Antimicrob Agents Chemother 55:1403-13. 2011
    ..Overall, these in vitro analyses demonstrate that due to potential cross-resistance, the large-scale introduction of single-NNRTI-based microbicides should be considered with caution...