Karen Willard Gallo
Affiliation: Institut Jules Bordet
Solinas C, Marcoux D, Garaud S, Vitória J, Van den Eynden G, de Wind A, et al
. BRCA gene mutations do not shape the extent and organization of tumor infiltrating lymphocytes in triple negative breast cancer. Cancer Lett. 2019;: pubmed publisher
..While BRCA gene mutations may not directly drive immune infiltration, the greater number of TILpos tumors could signal greater immunogenicity in this group. ..
Porcu M, De Silva P, Solinas C, Battaglia A, Schena M, Scartozzi M, et al
. Immunotherapy Associated Pulmonary Toxicity: Biology Behind Clinical and Radiological Features. Cancers (Basel). 2019;11: pubmed publisher
De Silva P, Garaud S, Solinas C, de Wind A, Van den Eyden G, Jose V, et al
. FOXP1 negatively regulates tumor infiltrating lymphocyte migration in human breast cancer. EBioMedicine. 2019;39:226-238 pubmed publisher
..FUND: Belgian Fund for Scientific Research (FNRS 3.4513.12F) and Opération Télévie (7.4636.13F and 7.4609.15F), Fonds J.C. Heuson and Fonds Lambeau-Marteaux. ..
Solinas C, Porcu M, De Silva P, Musi M, Aspeslagh S, Scartozzi M, et al
. Cancer immunotherapy-associated hypophysitis. Semin Oncol. 2018;45:181-186 pubmed publisher
..A multidisciplinary team approach is merited to insure the correct diagnosis and management of immune-related hypophysitis. ..
Gu Trantien C, Garaud S, Migliori E, Solinas C, Lodewyckx J, Willard Gallo K. Quantifying Tertiary Lymphoid Structure-Associated Genes in Formalin-Fixed Paraffin-Embedded Breast Cancer Tissues. Methods Mol Biol. 2018;1845:139-157 pubmed publisher
..The protocols described are detailed to allow the user to quantify TLS-related gene expression on formalin-fixed paraffin-embedded human breast tumor tissues. ..
Garaud S, Gu Trantien C, Lodewyckx J, Boisson A, De Silva P, Buisseret L, et al
. A simple and rapid protocol to non-enzymatically dissociate fresh human tissues for the analysis of infiltrating lymphocytes. J Vis Exp. 2014;: pubmed publisher
..This protocol functions extremely well for human breast tissues and should be applicable to a wide variety of normal and abnormal tissues. ..
Noël G, Langouo Fontsa M, Willard Gallo K. The impact of tumor cell metabolism on T cell-mediated immune responses and immuno-metabolic biomarkers in cancer. Semin Cancer Biol. 2018;52:66-74 pubmed publisher
Solinas C, Ceppi M, Lambertini M, Scartozzi M, Buisseret L, Garaud S, et al
. Tumor-infiltrating lymphocytes in patients with HER2-positive breast cancer treated with neoadjuvant chemotherapy plus trastuzumab, lapatinib or their combination: A meta-analysis of randomized controlled trials. Cancer Treat Rev. 2017;57:8-15 pubmed publisher
..88 (95% CI 2.03-4.08; P<0.001). In HER2-positive breast cancer, high baseline TIL are associated with increased pCR probability irrespective of neoadjuvant anti-HER2 agent(s) and chemotherapy regimens used. ..
Gu Trantien C, Willard Gallo K. PD-1hiCXCR5-CD4+ TFH Cells Play Defense in Cancer and Offense in Arthritis. Trends Immunol. 2017;38:875-878 pubmed publisher
..T cells were recently identified in breast cancer (BC) and rheumatoid arthritis (RA) to have beneficial or detrimental roles, respectively, but are they inflammatory tissue effector TFH cells? ..