Nathalie Meuleman

Summary

Affiliation: Institut Jules Bordet
Country: Belgium

Publications

  1. ncbi Mesenchymal stem cells derived from CD133-positive cells in mobilized peripheral blood and cord blood: proliferation, Oct4 expression, and plasticity
    Tatiana Tondreau
    Jules Bordet Institute, 121 Bd de Waterloo, 1000 Brussels, Belgium
    Stem Cells 23:1105-12. 2005
  2. ncbi Human marrow mesenchymal stem cell culture: serum-free medium allows better expansion than classical alpha-MEM medium
    Nathalie Meuleman
    Department of Experimental Hematology, Institut Jules Bordet, Centre des Tumeurs de l Universite Libre de Bruxelles, Brussels, Belgium
    Eur J Haematol 76:309-16. 2006
  3. ncbi [Pitfalls of monoclonal gammopathy]
    N Meuleman
    Service d Hematologie, Institut Jules Bordet, Bruxelles
    Rev Med Brux 34:335-8. 2013
  4. doi Infusion of mesenchymal stromal cells can aid hematopoietic recovery following allogeneic hematopoietic stem cell myeloablative transplant: a pilot study
    Nathalie Meuleman
    Department of Clinical and Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels 1000, Belgium
    Stem Cells Dev 18:1247-52. 2009
  5. ncbi Intrathecal donor lymphocyte infusion for the treatment of suspected refractory lymphomatous meningitis: a case report
    N Meuleman
    Department of Clinical and Expreimental Haematology, Institute Jules Bordet, Centre des Tumeurs de l Universite Libre de Bruxelles, Brussels, Belgium
    Eur J Haematol 77:523-6. 2006
  6. doi Reduced intensity conditioning haematopoietic stem cell transplantation with mesenchymal stromal cells infusion for the treatment of metachromatic leukodystrophy: a case report
    N Meuleman
    Department of Clinical and Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles ULB, Bruxelles, Belgium
    Haematologica 93:e11-3. 2008
  7. doi Modulated expression of adhesion molecules and galectin-1: role during mesenchymal stromal cell immunoregulatory functions
    Mehdi Najar
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Exp Hematol 38:922-32. 2010
  8. ncbi The source of human mesenchymal stromal cells influences their TLR profile as well as their functional properties
    Gordana Raicevic
    Laboratory of Clinical Cell Therapy, Universite Libre de Bruxelles, Brussels, Belgium
    Cell Immunol 270:207-16. 2011
  9. ncbi Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton's Jelly and bone marrow sources
    Mehdi Najar
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Cell Immunol 264:171-9. 2010
  10. doi A rapid, simple, and reproducible method for the isolation of mesenchymal stromal cells from Wharton's jelly without enzymatic treatment
    Cecile De Bruyn
    Service d Hématologie Expérimentale Laboratoire de Thérapie Cellulaire Clinique, Université Libre de Bruxelles Institut Jules Bordet, Bruxelles, Belgium
    Stem Cells Dev 20:547-57. 2011

Collaborators

Detail Information

Publications31

  1. ncbi Mesenchymal stem cells derived from CD133-positive cells in mobilized peripheral blood and cord blood: proliferation, Oct4 expression, and plasticity
    Tatiana Tondreau
    Jules Bordet Institute, 121 Bd de Waterloo, 1000 Brussels, Belgium
    Stem Cells 23:1105-12. 2005
    ..The selection of CD133-positive cells enabled us to obtain a homogeneous population of MSCs from UCB and MPB. These sources may have a major clinical importance thanks to their easy accessibility...
  2. ncbi Human marrow mesenchymal stem cell culture: serum-free medium allows better expansion than classical alpha-MEM medium
    Nathalie Meuleman
    Department of Experimental Hematology, Institut Jules Bordet, Centre des Tumeurs de l Universite Libre de Bruxelles, Brussels, Belgium
    Eur J Haematol 76:309-16. 2006
    ..This medium seems suitable for clinical scale expansion of MSC...
  3. ncbi [Pitfalls of monoclonal gammopathy]
    N Meuleman
    Service d Hematologie, Institut Jules Bordet, Bruxelles
    Rev Med Brux 34:335-8. 2013
    ..MGUS can also be associated with other diseases than malignant disorders such as Infections, autoimmune diseases. In some case it could reflect rare but severe disorders that will be crucial not to miss the diagnosis...
  4. doi Infusion of mesenchymal stromal cells can aid hematopoietic recovery following allogeneic hematopoietic stem cell myeloablative transplant: a pilot study
    Nathalie Meuleman
    Department of Clinical and Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels 1000, Belgium
    Stem Cells Dev 18:1247-52. 2009
    ..We found that infusion of MSCs without HSC co-infusion can restore medullary function in some patients with poor hematopoietic recovery. Our data suggest that patients with a less damaged stroma could benefit from this approach...
  5. ncbi Intrathecal donor lymphocyte infusion for the treatment of suspected refractory lymphomatous meningitis: a case report
    N Meuleman
    Department of Clinical and Expreimental Haematology, Institute Jules Bordet, Centre des Tumeurs de l Universite Libre de Bruxelles, Brussels, Belgium
    Eur J Haematol 77:523-6. 2006
    ..The patient died 13 months later from infectious complications with no evidence of progressive disease. To our knowledge, this is the first case report of IT DLI for possible refractory lymphomatous meningitis...
  6. doi Reduced intensity conditioning haematopoietic stem cell transplantation with mesenchymal stromal cells infusion for the treatment of metachromatic leukodystrophy: a case report
    N Meuleman
    Department of Clinical and Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles ULB, Bruxelles, Belgium
    Haematologica 93:e11-3. 2008
    ..This case report suggests the feasibility and the potential efficacy of reduced intensity conditioning (RIC) allogeneic HSCT combined with MSC infusion for patients with the adult form of MLD...
  7. doi Modulated expression of adhesion molecules and galectin-1: role during mesenchymal stromal cell immunoregulatory functions
    Mehdi Najar
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Exp Hematol 38:922-32. 2010
    ....
  8. ncbi The source of human mesenchymal stromal cells influences their TLR profile as well as their functional properties
    Gordana Raicevic
    Laboratory of Clinical Cell Therapy, Universite Libre de Bruxelles, Brussels, Belgium
    Cell Immunol 270:207-16. 2011
    ..This resistance was related to an overproduction of HGF. These data indicate that MSC source could be of importance while designing immunomodulating cell therapy in transplantation...
  9. ncbi Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton's Jelly and bone marrow sources
    Mehdi Najar
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Cell Immunol 264:171-9. 2010
    ..CD4(+) and CD8(+) T-lymphocytes were equally targeted by MSCs demonstrating that the immunomodulation was not restricted to a specific T-cell subpopulation...
  10. doi A rapid, simple, and reproducible method for the isolation of mesenchymal stromal cells from Wharton's jelly without enzymatic treatment
    Cecile De Bruyn
    Service d Hématologie Expérimentale Laboratoire de Thérapie Cellulaire Clinique, Université Libre de Bruxelles Institut Jules Bordet, Bruxelles, Belgium
    Stem Cells Dev 20:547-57. 2011
    ..In conclusion, we have established a simple, rapid, and reproducible protocol to isolate abundant MSCs from short segments of umbilical cords...
  11. pmc Gene expression profiling reveals differences in microenvironment interaction between patients with chronic lymphocytic leukemia expressing high versus low ZAP70 mRNA
    Basile Stamatopoulos
    Universite Libre de Bruxelles, Institut Jules Bordet, Laboratoire d Hematologie Experimentale, Bruxelles, Belgium
    Haematologica 94:790-9. 2009
    ..Zeta-associated protein 70 (ZAP70) is a widely recognized prognostic factor in chronic lymphocytic leukemia, but mechanisms by which its higher expression leads to a poor outcome must still be fully explained...
  12. pmc Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cells
    Thibaud André
    Laboratory of Clinical Cell Therapy, Universite Libre de Bruxelles ULB, Institut Jules Bordet, Brussels, Belgium
    PLoS ONE 8:e59756. 2013
    ..Previous studies have suggested that direct and indirect interactions between malignant cells and bone marrow mesenchymal stromal cells result in constitutive abnormalities in the bone marrow mesenchymal stromal cells...
  13. doi Characterization and functionality of the CD200-CD200R system during mesenchymal stromal cell interactions with T-lymphocytes
    Mehdi Najar
    Laboratory of Clinical Cell Therapy, Institut Jules Bordet, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Immunol Lett 146:50-6. 2012
    ..The findings presented here support bidirectional communication between MSCs and T-lymphocytes. Understanding the role of this ligand-receptor pair during co-culture will improve and increase the clinical use of MSCs...
  14. pmc Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells
    Tatiana Tondreau
    Institut Jules Bordet, Universite Libre de Bruxelles, Laboratory of Experimental Hematology, 121, Bd de Waterloo, 1000 Brussels, Belgium
    BMC Genomics 9:166. 2008
    ..Indeed, many studies have demonstrated that MSC can give rise to neuronal cells as well as many tissue-specific cell phenotypes...
  15. doi Preemptive management of Epstein-Barr virus reactivation after hematopoietic stem-cell transplantation
    Imran Ahmad
    Department of Clinical Hematology, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Transplantation 87:1240-5. 2009
    ..Because viral load after transplantation is correlated with PTLD occurrence, we developed a preemptive attitude based on polymerase chain reaction (PCR)-guided rituximab administration...
  16. doi Adipose-tissue-derived and Wharton's jelly-derived mesenchymal stromal cells suppress lymphocyte responses by secreting leukemia inhibitory factor
    Mehdi Najar
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Tissue Eng Part A 16:3537-46. 2010
    ..Further characterization of MSC physiological functions will increase the safety and efficacy of their use in clinical settings...
  17. ncbi In vitro study of matrix metalloproteinase/tissue inhibitor of metalloproteinase production by mesenchymal stromal cells in response to inflammatory cytokines: the role of their migration in injured tissues
    Tatiana Tondreau
    Laboratory of Experimental Hematology, Institut Jules Bordet ULB, Brussels, Belgium
    Cytotherapy 11:559-69. 2009
    ..We evaluated the effects of several inflammatory cytokines on the migration of BM MSC and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) production...
  18. pmc The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis, down-regulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells
    Basile Stamatopoulos
    Institut Jules Bordet, Universite Libre de Bruxelles ULB, Laboratoire d Hématologie Expérimentale Boulevard de Waterloo n 121 1000 Bruxelles, Belgium
    Haematologica 95:1136-43. 2010
    ..Stromal cell-derived factor-1 and its receptor, CXCR4, have been shown to play an important role in chronic lymphocytic leukemia cell trafficking and survival...
  19. pmc AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments
    Basile Stamatopoulos
    Universite Libre de Bruxelles, Institut Jules Bordet, Laboratoire de Thérapie Cellulaire Clinique LTCC, Boulevard de Waterloo 121, 1000 Bruxelles, Belgium
    Haematologica 97:608-15. 2012
    ..This protection is partially mediated by the chemokine SDF-1α (CXCL12) and its receptor CXCR4 (CD184) present on the chronic lymphocytic leukemia cell surface...
  20. ncbi Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: the importance of low cell ratio and role of interleukin-6
    Mehdi Najar
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Cytotherapy 11:570-83. 2009
    ..We addressed the importance of the MSC:T-cell ratio, requirement for cell contact and impact of soluble factors on the MSC-mediated effects. We also analyzed whether regulatory T cells could be modulated by MSC in co-cultures...
  21. pmc HDAC isoenzyme expression is deregulated in chronic lymphocytic leukemia B-cells and has a complex prognostic significance
    Michael Van Damme
    Laboratory of Clinical Cell Therapy, Faculty of Medicine, Institut Jules Bordet, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Epigenetics 7:1403-12. 2012
    ..38, p < 0.0001). However, we could not find statistical differences in HDAC expression after relapse. These results, validated by a 5-fold cross-validation, highlight the complex impact of HDAC expression in CLL clinical course...
  22. doi Inflammation and Toll-like receptor ligation differentially affect the osteogenic potential of human mesenchymal stromal cells depending on their tissue origin
    Gordana Raicevic
    Laboratory of Clinical Cell Therapy, Institut Jules Bordet ULB, 121 Boulevard de Waterloo, Brussels, Belgium
    Tissue Eng Part A 18:1410-8. 2012
    ....
  23. ncbi Quantification of ZAP70 mRNA in B cells by real-time PCR is a powerful prognostic factor in chronic lymphocytic leukemia
    Basile Stamatopoulos
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Clin Chem 53:1757-66. 2007
    ....
  24. doi microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification
    Basile Stamatopoulos
    Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Blood 113:5237-45. 2009
    ..69, P = .001). This score will help to identify, among the good and poor prognosis subgroups, patients who will need early therapy and thus will require a closer follow-up...
  25. doi In vivo production of mesenchymal stromal cells after injection of autologous platelet-rich plasma activated by recombinant human soluble tissue factor in the bone marrow of healthy volunteers
    Pierre Philippart
    1 Department of Stomatology and Maxillo Facial Surgery, HIS Site Bracops, Brussels, Belgium
    Tissue Eng Part A 20:160-70. 2014
    ..This self-stimulation system of BM seems thus to be a promising feasible process 3 days before clinical cell therapy applications. ..
  26. ncbi Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response
    Laurence Lagneaux
    Experimental Hematology, Bordet Institute, ULB, Brussels, Belgium
    Exp Hematol 35:1527-37. 2007
    ..The effects of valproic acid (VPA), an antiepileptic drug with histone deacetylase inhibitory activity, on mononuclear cells isolated from 40 CLL patients were evaluated...
  27. ncbi Zygomycosis in the immunocompromised patient: a case report
    Aspasia Georgala
    Infectious Disease Department, Jules Bordet Institute, Brussels, Belgium
    Acta Biomed 77:5-9. 2006
    ..We report a case of sinusitis due to Absidia corymbifera occurring during chemotherapy-induced bone marrow aplasia in a patient with acute leukaemia. The sinusitis was successfully treated with AmBisome, and surgical debridement...
  28. doi Radioembolization of the spleen: a revisited approach for the treatment of malignant lymphomatous splenomegaly
    Kristoff Muylle
    Department of Nuclear Medicine, Jules Bordet Institute, ULB, Héger Bordetstraat 1, 1000, Brussels, Belgium
    Cardiovasc Intervent Radiol 36:1155-60. 2013
    ..The advantages of radioembolization for the management of lymphomatous splenomegaly are discussed. ..
  29. ncbi Caspofungin salvage therapy in a neutropenic patient with probable invasive aspergillosis: a case report
    F S Taccone
    Intensive Care Unit ASTI, Institut Jules Bordet, Centre des Tumeurs de l Universite Libre de Bruxelles, Brussels, Belgium
    Support Care Cancer 11:742-4. 2003
    ..He had febrile neutropenia and probable invasive pulmonary aspergillosis (IA). Amphotericin B renal toxicity and clinical deterioration prompted a shift to caspofungin and resulted in a successful response...
  30. ncbi Long-term follow-up of autologous peripheral blood stem cell transplantation in the treatment of a patient with acute panmyelosis with myelofibrosis
    M C Ngirabacu
    Dept d Hématologie de l Institut J Bordet Université libre de Bruxelles, Brussels, Belgium
    Haematologica 91:ECR53. 2006
  31. ncbi Infusion of peripheral blood stem cells collected at diagnosis, with maintenance of the treatment, resulted in Ph-negative recovery in a chronic myeloid leukaemia patient in persisting aplasia on STI-571 therapy
    Philippe Lewalle
    Department of Haematology, Institut Bordet, University of Brussels, Belgium
    Br J Haematol 118:144-6. 2002
    ..Discontinuing an effective treatment because of persistent aplasia is a major concern; this method circumvents this problem inpatients who have undergone a stem cell harvest at diagnosis...