David Dawson

Summary

Affiliation: ILSI Europe
Country: Belgium

Publications

  1. doi request reprint Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: methyleugenol, CASRN: 93-15-2
    Benjamin Smith
    FIRMENICH S A, Switzerland
    Food Chem Toxicol 48:S89-97. 2010
  2. pmc Mapping low intake of micronutrients across Europe
    G B M Mensink
    Department of Epidemiology and Health Monitoring, Robert Koch Institute, General Pape Strasse 64, DE 12101 Berlin, Germany
    Br J Nutr 110:755-73. 2013
  3. pmc The role and requirements of digestible dietary carbohydrates in infants and toddlers
    A Stephen
    Elsie Widdowson Laboratory, MRC Human Nutrition Research, Cambridge, UK
    Eur J Clin Nutr 66:765-79. 2012
  4. pmc Impact of postprandial glycaemia on health and prevention of disease
    E E Blaak
    Department of Human Biology, School of Nutrition and Toxicology Research and Metabolism NUTRIM, Maastricht University, Maastricht, The Netherlands
    Obes Rev 13:923-84. 2012
  5. pmc Masked mycotoxins: a review
    Franz Berthiller
    Christian Doppler Laboratory for Mycotoxin Metabolism, Department for Agrobiotechnology IFA Tulln, University of Natural Resources and Life Sciences Vienna, Tulln, Austria
    Mol Nutr Food Res 57:165-86. 2013
  6. pmc Effect of type of TAG fatty acids on lutein and zeaxanthin bioavailability
    Béatrice Gleize
    INRA, UMR1260, Research Unit in Nutrition, Obesity and Risk of Thrombosis, Faculte de Medecine, 27 Boulevard Jean Moulin, F 13385 Marseille, Cedex 5, France
    Br J Nutr 110:1-10. 2013
  7. doi request reprint Evaluation of the Threshold of Toxicological Concern (TTC)--challenges and approaches
    I Dewhurst
    Mammalian Toxicology, Chemicals Regulation, Directorate Health and Safety Executive, Mallard House, York YO1 7PX, UK
    Regul Toxicol Pharmacol 65:168-77. 2013
  8. doi request reprint Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: furan (CAS No. 110-00-9)
    Philip Carthew
    Unilever Research, UK
    Food Chem Toxicol 48:S69-74. 2010
  9. doi request reprint Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)
    Philip Carthew
    Unilever Research, UK
    Food Chem Toxicol 48:S98-105. 2010
  10. doi request reprint Evaluation of scientific criteria for identifying allergenic foods of public health importance
    J H M van Bilsen
    TNO Earth Environmental and Life Sciences, Zeist, The Netherlands
    Regul Toxicol Pharmacol 60:281-9. 2011

Collaborators

Detail Information

Publications28

  1. doi request reprint Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: methyleugenol, CASRN: 93-15-2
    Benjamin Smith
    FIRMENICH S A, Switzerland
    Food Chem Toxicol 48:S89-97. 2010
    ..9 mg/kg-bw/d following adjustment to daily average doses. The MoEs ranged from 100 to 800 depending on the assumptions used in the exposure estimation...
  2. pmc Mapping low intake of micronutrients across Europe
    G B M Mensink
    Department of Epidemiology and Health Monitoring, Robert Koch Institute, General Pape Strasse 64, DE 12101 Berlin, Germany
    Br J Nutr 110:755-73. 2013
    ..In spite of the limitations of the data, the present study provides valuable new information about micronutrient intakes across Europe and the likelihood of inadequacy country by country...
  3. pmc The role and requirements of digestible dietary carbohydrates in infants and toddlers
    A Stephen
    Elsie Widdowson Laboratory, MRC Human Nutrition Research, Cambridge, UK
    Eur J Clin Nutr 66:765-79. 2012
    ..In infants, minimum carbohydrate (mainly lactose) intake should be 40% of total energy, gradually increasing to 55% energy by the age of 2 years...
  4. pmc Impact of postprandial glycaemia on health and prevention of disease
    E E Blaak
    Department of Human Biology, School of Nutrition and Toxicology Research and Metabolism NUTRIM, Maastricht University, Maastricht, The Netherlands
    Obes Rev 13:923-84. 2012
    ..Also of importance is the evaluation of the potential role of the time course of postprandial glycaemia...
  5. pmc Masked mycotoxins: a review
    Franz Berthiller
    Christian Doppler Laboratory for Mycotoxin Metabolism, Department for Agrobiotechnology IFA Tulln, University of Natural Resources and Life Sciences Vienna, Tulln, Austria
    Mol Nutr Food Res 57:165-86. 2013
    ..Dedicated chapters of this article address plant metabolism as well as the occurrence of masked mycotoxins in food, analytical aspects for their determination, toxicology and their impact on stakeholders...
  6. pmc Effect of type of TAG fatty acids on lutein and zeaxanthin bioavailability
    Béatrice Gleize
    INRA, UMR1260, Research Unit in Nutrition, Obesity and Risk of Thrombosis, Faculte de Medecine, 27 Boulevard Jean Moulin, F 13385 Marseille, Cedex 5, France
    Br J Nutr 110:1-10. 2013
    ..This is due partly to the higher bioaccessibility of these xanthophylls in the smaller mixed micelles produced when SFA are incorporated into mixed micelles...
  7. doi request reprint Evaluation of the Threshold of Toxicological Concern (TTC)--challenges and approaches
    I Dewhurst
    Mammalian Toxicology, Chemicals Regulation, Directorate Health and Safety Executive, Mallard House, York YO1 7PX, UK
    Regul Toxicol Pharmacol 65:168-77. 2013
    ....
  8. doi request reprint Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: furan (CAS No. 110-00-9)
    Philip Carthew
    Unilever Research, UK
    Food Chem Toxicol 48:S69-74. 2010
    ..Dose-response modelling of the data for hepatocellular tumours gives a BMDL10 of 1.23 mg/kg/day, and MOEs of between 750 and 4300 for exposures of infants and adults...
  9. doi request reprint Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)
    Philip Carthew
    Unilever Research, UK
    Food Chem Toxicol 48:S98-105. 2010
    ..48 mg/kg/day for the prostate tumours, 0.74 mg/kg/day for mammary tumours and 2.71 mg/kg/day for colon tumours. The lowest MOEs for prostate, mammary and colon tumours were 20,000, 40,000 and 150,000, respectively...
  10. doi request reprint Evaluation of scientific criteria for identifying allergenic foods of public health importance
    J H M van Bilsen
    TNO Earth Environmental and Life Sciences, Zeist, The Netherlands
    Regul Toxicol Pharmacol 60:281-9. 2011
    ..The framework helps to identify gaps in knowledge and to uncover the level of heterogeneity of the evidence thus guiding research and providing a basis for sound risk management decisions...
  11. doi request reprint EURRECA: development of tools to improve the alignment of micronutrient recommendations
    C Matthys
    ILSI Europe a i s b l, Brussels, Belgium
    Eur J Clin Nutr 64:S26-31. 2010
    ..Therefore, EURRECA can contribute towards nutrition policy development and public health strategies...
  12. doi request reprint Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: ethyl carbamate (CAS 51-79-6)
    Josef Schlatter
    Federal Office of Public Health, Switzerland
    Food Chem Toxicol 48:S63-8. 2010
    ..The corresponding calculated MOEs were 16600 and 3125, respectively...
  13. doi request reprint Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: (CAS No. 96-23-1) 1,3-dichloro-2-propanol (DCP)
    Gary Williams
    New York Medical College, USA
    Food Chem Toxicol 48:S57-62. 2010
    ..62 mg/kg-body weight (bw)/day. The exposure of humans was estimated at an average of 0.00009 mg/kg-bw/day and a high exposure of 0.000136 mg/kg-bw/day. The MOEs for these exposures were 100,000 and 70,000, respectively...
  14. doi request reprint Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: benzene, CAS: 71-43-2
    Benjamin Smith
    FIRMENICH S A, Switzerland
    Food Chem Toxicol 48:S49-56. 2010
    ..6 mg/kg-bw/d following adjustment to daily average doses. The MOEs ranged from 2 x 10(6) to 0.4 x 10(6) depending on the assumptions used in the exposure estimation...
  15. ncbi request reprint Recontamination as a source of pathogens in processed foods
    M W Reij
    Laboratory of Food Microbiology, Wageningen University, P O Box 8129, NL 6700 EV Wageningen, The Netherlands
    Int J Food Microbiol 91:1-11. 2004
    ..This paper advocates that an effort should be made to develop our knowledge and information on recontamination further and start using it systematically in the exposure assessment part of Microbiological Risk Assessment studies...
  16. ncbi request reprint Workshop on trichothecenes with a focus on DON: summary report
    John Christian Larsen
    Institute of Food Safety and Nutrition, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Toxicol Lett 153:1-22. 2004
    ..A number of recommendations were given under the headings: prevention, sampling and analytical methods, exposure assessment, and toxicology. Gaps in knowledge were also identified...
  17. ncbi request reprint A risk-based methodology for deriving quality standards for organic contaminants in sewage sludge for use in agriculture--Conceptual Framework
    D Schowanek
    Procter and Gamble European Technical Centre, Product Safety and Regulatory Affairs, Temselaan 100, 1853 Strombeek Bever, Belgium
    Regul Toxicol Pharmacol 40:227-51. 2004
    ..g., 100 years) needs to be assessed. The SQS may therefore vary with the (local) sludge application regime, and/or sludge pretreatment processes...
  18. ncbi request reprint Foodborne protozoan parasites
    David Dawson
    Campden and Chorleywood Food Research Association, Microbiology Department, Chipping Campden, Gloucestershire GL55 6LD, United Kingdom
    Int J Food Microbiol 103:207-27. 2005
    ..g., where water supplies may become contaminated)...
  19. doi request reprint Risk-benefit considerations of mitigation measures on acrylamide content of foods--a case study on potatoes, cereals and coffee
    C J Seal
    Newcastle University, School of Agriculture, Food and Rural Development, Newcastle upon Tyne, UK
    Br J Nutr 99:S1-S46. 2008
  20. doi request reprint Application of the margin of exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Example: leucomalachite green
    Andrew Renwick
    University of Southampton, UK
    Food Chem Toxicol 48:S75-80. 2010
    ..Human exposure estimates assumed that all consumed fish is contaminated with LMG. The calculated MoEs were 4,000,000 and 400,000 respectively for average and high exposure estimates...
  21. doi request reprint Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic - example: 1-methylcyclopropene and its impurities (1-chloro-2-methylpropene and 3-chloro-2-methylpropene)
    Andrew Renwick
    University of Southampton, UK
    Food Chem Toxicol 48:S81-8. 2010
    ..No human exposure data are available and theoretical estimates had to be used to calculate the MoE. The MoEs ranged from 40,000 to 100,000,000 depending on the assumptions used in the exposure estimation...
  22. doi request reprint Application of the margin-of-exposure (MoE) approach to substances in food that are genotoxic and carcinogenic e.g.: benzo[a]pyrene and polycyclic aromatic hydrocarbons
    Diane Benford
    Food Standards Agency, UK
    Food Chem Toxicol 48:S42-8. 2010
    ..An average dietary exposure estimates of 0.008 microg BaP/kg-bw/day was identified from the range of national estimates. The calculated MoE was 15,000...
  23. doi request reprint Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: EXAMPLE 12: Sudan I (CAS No. 842-07-9)
    Myriam Coulet
    Nestle Research Centre, Switzerland
    Food Chem Toxicol 48:S106-11. 2010
    ..The great variability and uncertainties in the human exposure data which are country specific, depending on consumption patterns and methodology used, resulted in a large range of MOE values (from 30 to 2,000,000)...
  24. doi request reprint Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: EXAMPLE: acrylamide (CAS No. 79-06-1)
    P Michael Bolger
    US Food and Drug Administration, USA
    Food Chem Toxicol 48:S25-33. 2010
    ..Acrylamide may be formed when foods, particularly those that are high in carbohydrates and low in protein, are subjected to high temperatures during cooking or other thermal processing...
  25. doi request reprint Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: aflatoxin B1 (AFB1)
    Diane Benford
    Food Standards Agency, UK
    Food Chem Toxicol 48:S34-41. 2010
    ..Estimates of mean dietary exposure estimates were 0.4 ng/kg-bw/d and 2.6 ng/kg-bw/d, representing regions with low and high exposure, respectively. The MOEs for mean exposure therefore range from 100 to 600...
  26. ncbi request reprint Foodborne viruses: an emerging problem
    Marion Koopmans
    National Institute of Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan, 9, NL 3720 BA Bilthoven, The Netherlands
    Int J Food Microbiol 90:23-41. 2004
    ....