David Dawson

Summary

Affiliation: ILSI Europe
Country: Belgium

Publications

  1. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: methyleugenol, CASRN: 93-15-2
    Benjamin Smith
    FIRMENICH S A, Switzerland
    Food Chem Toxicol 48:S89-97. 2010
  2. ncbi Evaluation of the Threshold of Toxicological Concern (TTC) - Challenges and approaches
    I Dewhurst
    Mammalian Toxicology, Chemicals Regulation, Directorate Health and Safety Executive, Mallard House, York YO1 7PX, UK Electronic address
    Regul Toxicol Pharmacol 65:168-77. 2013
  3. ncbi Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: benzene, CAS: 71-43-2
    Benjamin Smith
    FIRMENICH S A, Switzerland
    Food Chem Toxicol 48:S49-56. 2010
  4. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: (CAS No. 96-23-1) 1,3-dichloro-2-propanol (DCP)
    Gary Williams
    New York Medical College, USA
    Food Chem Toxicol 48:S57-62. 2010
  5. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: ethyl carbamate (CAS 51-79-6)
    Josef Schlatter
    Federal Office of Public Health, Switzerland
    Food Chem Toxicol 48:S63-8. 2010
  6. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: furan (CAS No. 110-00-9)
    Philip Carthew
    Unilever Research, UK
    Food Chem Toxicol 48:S69-74. 2010
  7. ncbi Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)
    Philip Carthew
    Unilever Research, UK
    Food Chem Toxicol 48:S98-105. 2010
  8. ncbi Evaluation of scientific criteria for identifying allergenic foods of public health importance
    J H M van Bilsen
    TNO Earth Environmental and Life Sciences, Zeist, The Netherlands
    Regul Toxicol Pharmacol 60:281-9. 2011
  9. ncbi EURRECA: development of tools to improve the alignment of micronutrient recommendations
    C Matthys
    ILSI Europe a i s b l, Brussels, Belgium
    Eur J Clin Nutr 64:S26-31. 2010
  10. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: aflatoxin B1 (AFB1)
    Diane Benford
    Food Standards Agency, UK
    Food Chem Toxicol 48:S34-41. 2010

Collaborators

Detail Information

Publications21

  1. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: methyleugenol, CASRN: 93-15-2
    Benjamin Smith
    FIRMENICH S A, Switzerland
    Food Chem Toxicol 48:S89-97. 2010
    ..9 mg/kg-bw/d following adjustment to daily average doses. The MoEs ranged from 100 to 800 depending on the assumptions used in the exposure estimation...
  2. ncbi Evaluation of the Threshold of Toxicological Concern (TTC) - Challenges and approaches
    I Dewhurst
    Mammalian Toxicology, Chemicals Regulation, Directorate Health and Safety Executive, Mallard House, York YO1 7PX, UK Electronic address
    Regul Toxicol Pharmacol 65:168-77. 2013
    ....
  3. ncbi Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: benzene, CAS: 71-43-2
    Benjamin Smith
    FIRMENICH S A, Switzerland
    Food Chem Toxicol 48:S49-56. 2010
    ..6 mg/kg-bw/d following adjustment to daily average doses. The MOEs ranged from 2 x 10(6) to 0.4 x 10(6) depending on the assumptions used in the exposure estimation...
  4. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: (CAS No. 96-23-1) 1,3-dichloro-2-propanol (DCP)
    Gary Williams
    New York Medical College, USA
    Food Chem Toxicol 48:S57-62. 2010
    ..62 mg/kg-body weight (bw)/day. The exposure of humans was estimated at an average of 0.00009 mg/kg-bw/day and a high exposure of 0.000136 mg/kg-bw/day. The MOEs for these exposures were 100,000 and 70,000, respectively...
  5. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: ethyl carbamate (CAS 51-79-6)
    Josef Schlatter
    Federal Office of Public Health, Switzerland
    Food Chem Toxicol 48:S63-8. 2010
    ..The corresponding calculated MOEs were 16600 and 3125, respectively...
  6. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: furan (CAS No. 110-00-9)
    Philip Carthew
    Unilever Research, UK
    Food Chem Toxicol 48:S69-74. 2010
    ..Dose-response modelling of the data for hepatocellular tumours gives a BMDL10 of 1.23 mg/kg/day, and MOEs of between 750 and 4300 for exposures of infants and adults...
  7. ncbi Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)
    Philip Carthew
    Unilever Research, UK
    Food Chem Toxicol 48:S98-105. 2010
    ..48 mg/kg/day for the prostate tumours, 0.74 mg/kg/day for mammary tumours and 2.71 mg/kg/day for colon tumours. The lowest MOEs for prostate, mammary and colon tumours were 20,000, 40,000 and 150,000, respectively...
  8. ncbi Evaluation of scientific criteria for identifying allergenic foods of public health importance
    J H M van Bilsen
    TNO Earth Environmental and Life Sciences, Zeist, The Netherlands
    Regul Toxicol Pharmacol 60:281-9. 2011
    ..The framework helps to identify gaps in knowledge and to uncover the level of heterogeneity of the evidence thus guiding research and providing a basis for sound risk management decisions...
  9. ncbi EURRECA: development of tools to improve the alignment of micronutrient recommendations
    C Matthys
    ILSI Europe a i s b l, Brussels, Belgium
    Eur J Clin Nutr 64:S26-31. 2010
    ..Therefore, EURRECA can contribute towards nutrition policy development and public health strategies...
  10. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: aflatoxin B1 (AFB1)
    Diane Benford
    Food Standards Agency, UK
    Food Chem Toxicol 48:S34-41. 2010
    ..Estimates of mean dietary exposure estimates were 0.4 ng/kg-bw/d and 2.6 ng/kg-bw/d, representing regions with low and high exposure, respectively. The MOEs for mean exposure therefore range from 100 to 600...
  11. ncbi Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: EXAMPLE: acrylamide (CAS No. 79-06-1)
    P Michael Bolger
    US Food and Drug Administration, USA
    Food Chem Toxicol 48:S25-33. 2010
    ..Acrylamide may be formed when foods, particularly those that are high in carbohydrates and low in protein, are subjected to high temperatures during cooking or other thermal processing...
  12. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: EXAMPLE 12: Sudan I (CAS No. 842-07-9)
    Myriam Coulet
    Nestle Research Centre, Switzerland
    Food Chem Toxicol 48:S106-11. 2010
    ..The great variability and uncertainties in the human exposure data which are country specific, depending on consumption patterns and methodology used, resulted in a large range of MOE values (from 30 to 2,000,000)...
  13. ncbi Recontamination as a source of pathogens in processed foods
    M W Reij
    Laboratory of Food Microbiology, Wageningen University, P O Box 8129, NL 6700 EV Wageningen, The Netherlands
    Int J Food Microbiol 91:1-11. 2004
    ..This paper advocates that an effort should be made to develop our knowledge and information on recontamination further and start using it systematically in the exposure assessment part of Microbiological Risk Assessment studies...
  14. ncbi Workshop on trichothecenes with a focus on DON: summary report
    John Christian Larsen
    Institute of Food Safety and Nutrition, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Toxicol Lett 153:1-22. 2004
    ..A number of recommendations were given under the headings: prevention, sampling and analytical methods, exposure assessment, and toxicology. Gaps in knowledge were also identified...
  15. ncbi A risk-based methodology for deriving quality standards for organic contaminants in sewage sludge for use in agriculture--Conceptual Framework
    D Schowanek
    Procter and Gamble European Technical Centre, Product Safety and Regulatory Affairs, Temselaan 100, 1853 Strombeek Bever, Belgium
    Regul Toxicol Pharmacol 40:227-51. 2004
    ..g., 100 years) needs to be assessed. The SQS may therefore vary with the (local) sludge application regime, and/or sludge pretreatment processes...
  16. ncbi Foodborne protozoan parasites
    David Dawson
    Campden and Chorleywood Food Research Association, Microbiology Department, Chipping Campden, Gloucestershire GL55 6LD, United Kingdom
    Int J Food Microbiol 103:207-27. 2005
    ..g., where water supplies may become contaminated)...
  17. ncbi Risk-benefit considerations of mitigation measures on acrylamide content of foods--a case study on potatoes, cereals and coffee
    C J Seal
    Newcastle University, School of Agriculture, Food and Rural Development, Newcastle upon Tyne, UK
    Br J Nutr 99:S1-S46. 2008
  18. ncbi Application of the margin of exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Example: leucomalachite green
    Andrew Renwick
    University of Southampton, UK
    Food Chem Toxicol 48:S75-80. 2010
    ..Human exposure estimates assumed that all consumed fish is contaminated with LMG. The calculated MoEs were 4,000,000 and 400,000 respectively for average and high exposure estimates...
  19. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic - example: 1-methylcyclopropene and its impurities (1-chloro-2-methylpropene and 3-chloro-2-methylpropene)
    Andrew Renwick
    University of Southampton, UK
    Food Chem Toxicol 48:S81-8. 2010
    ..No human exposure data are available and theoretical estimates had to be used to calculate the MoE. The MoEs ranged from 40,000 to 100,000,000 depending on the assumptions used in the exposure estimation...
  20. ncbi Application of the margin-of-exposure (MoE) approach to substances in food that are genotoxic and carcinogenic e.g.: benzo[a]pyrene and polycyclic aromatic hydrocarbons
    Diane Benford
    Food Standards Agency, UK
    Food Chem Toxicol 48:S42-8. 2010
    ..An average dietary exposure estimates of 0.008 microg BaP/kg-bw/day was identified from the range of national estimates. The calculated MoE was 15,000...
  21. ncbi Foodborne viruses: an emerging problem
    Marion Koopmans
    National Institute of Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan, 9, NL 3720 BA Bilthoven, The Netherlands
    Int J Food Microbiol 90:23-41. 2004
    ....