Sandrine Horman

Summary

Country: Belgium

Publications

  1. ncbi request reprint Evaluation of the role of AMP-activated protein kinase and its downstream targets in mammalian hibernation
    Sandrine Horman
    Hormone and Metabolic Research Unit, Christian de Duve Institute of Cellular Pathology and University of Louvain Medical School, Avenue Hippocrate, 75, B 1200 Brussels, Belgium
    Comp Biochem Physiol B Biochem Mol Biol 142:374-82. 2005
  2. ncbi request reprint Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491
    Sandrine Horman
    Hormone and Metabolic Research Unit, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    J Biol Chem 281:5335-40. 2006
  3. doi request reprint AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase
    Sandrine Horman
    Hormone and Metabolic Research Unit, de Duve Institute, Universite Catholique de Louvain, B 1200 Brussels
    J Biol Chem 283:18505-12. 2008
  4. ncbi request reprint Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2
    Sandrine Horman
    Hormone and Metabolic Research Unit, Christian de Duve Institute of Cellular Pathology, University of Louvain Medical School, Avenue Hippocrate 75, ICP UCL 7529, B 1200 Brussels, Belgium
    J Biol Chem 278:41970-6. 2003
  5. ncbi request reprint Stress-induced activation of the AMP-activated protein kinase in the freeze-tolerant frog Rana sylvatica
    Mark H Rider
    Hormone and Metabolic Research Unit, Christian de Duve Institute of Cellular Pathology, University of Louvain Medical School, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Cryobiology 53:297-309. 2006
  6. ncbi request reprint Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathways
    Louis Hue
    Hormone and Metabolic Research Unit, Christian de Duve International Institute of Cellular and Molecular Pathology, and University of Louvain Medical School, Avenue Hippocrate, 75, B 1200, Brussels, Belgium
    J Mol Cell Cardiol 34:1091-7. 2002
  7. ncbi request reprint Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle
    Lisa Miranda
    Hormone and Metabolic Research Unit, de Duve Institute, Universite Catholique de Louvain, Avenue Hippocrate, 75, 1200 Brussels, Belgium
    Pflugers Arch 455:1129-40. 2008
  8. ncbi request reprint Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia
    Elham Zarrinpashneh
    Division of Cardiology, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Am J Physiol Heart Circ Physiol 291:H2875-83. 2006
  9. ncbi request reprint Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis
    Sandrine Horman
    Hormone and Metabolic Research Unit, Christian de Duve International Institute of Cellular Pathology and Université Catholique de Louvain, Avenue Hippocrate, 75, B 1200, Brussels, Belgium
    Curr Biol 12:1419-23. 2002
  10. doi request reprint AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells
    Lisa Miranda
    de Duve Institute, Universite Catholique de Louvain, Avenue Hippocrate, B 1200 Brussels, Belgium
    Biochem Biophys Res Commun 396:656-61. 2010

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Evaluation of the role of AMP-activated protein kinase and its downstream targets in mammalian hibernation
    Sandrine Horman
    Hormone and Metabolic Research Unit, Christian de Duve Institute of Cellular Pathology and University of Louvain Medical School, Avenue Hippocrate, 75, B 1200 Brussels, Belgium
    Comp Biochem Physiol B Biochem Mol Biol 142:374-82. 2005
    ..In conclusion, AMPK does not appear to participate in the metabolic re-organization and/or the metabolic rate depression that occurs during ground squirrel hibernation...
  2. ncbi request reprint Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491
    Sandrine Horman
    Hormone and Metabolic Research Unit, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    J Biol Chem 281:5335-40. 2006
    ....
  3. doi request reprint AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase
    Sandrine Horman
    Hormone and Metabolic Research Unit, de Duve Institute, Universite Catholique de Louvain, B 1200 Brussels
    J Biol Chem 283:18505-12. 2008
    ..The findings suggest that AMPK attenuates contraction by phosphorylating and inactivating MLCK. This might contribute to reduced ATP turnover in the tonic phase of smooth muscle contraction...
  4. ncbi request reprint Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2
    Sandrine Horman
    Hormone and Metabolic Research Unit, Christian de Duve Institute of Cellular Pathology, University of Louvain Medical School, Avenue Hippocrate 75, ICP UCL 7529, B 1200 Brussels, Belgium
    J Biol Chem 278:41970-6. 2003
    ..eEF2K activity was unchanged by increasing the workload, suggesting that the decrease in eEF2 phosphorylation could result from the activation of an eEF2 phosphatase...
  5. ncbi request reprint Stress-induced activation of the AMP-activated protein kinase in the freeze-tolerant frog Rana sylvatica
    Mark H Rider
    Hormone and Metabolic Research Unit, Christian de Duve Institute of Cellular Pathology, University of Louvain Medical School, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Cryobiology 53:297-309. 2006
    ..The changes in phosphorylation state of translation factors are discussed in relation to the control of protein synthesis and stress-induced AMPK activation...
  6. ncbi request reprint Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathways
    Louis Hue
    Hormone and Metabolic Research Unit, Christian de Duve International Institute of Cellular and Molecular Pathology, and University of Louvain Medical School, Avenue Hippocrate, 75, B 1200, Brussels, Belgium
    J Mol Cell Cardiol 34:1091-7. 2002
    ..Intracellular acidosis induced by ischemia inhibited insulin signaling, whereas insulin pretreatment antagonized AMPK activation by ischemia...
  7. ncbi request reprint Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle
    Lisa Miranda
    Hormone and Metabolic Research Unit, de Duve Institute, Universite Catholique de Louvain, Avenue Hippocrate, 75, 1200 Brussels, Belgium
    Pflugers Arch 455:1129-40. 2008
    ....
  8. ncbi request reprint Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia
    Elham Zarrinpashneh
    Division of Cardiology, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Am J Physiol Heart Circ Physiol 291:H2875-83. 2006
    ..In conclusion, AMPKalpha(2) is required for the metabolic response of the heart to no-flow ischemia. The remaining AMPKalpha(1) cannot compensate for the absence of AMPKalpha(2)...
  9. ncbi request reprint Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis
    Sandrine Horman
    Hormone and Metabolic Research Unit, Christian de Duve International Institute of Cellular Pathology and Université Catholique de Louvain, Avenue Hippocrate, 75, B 1200, Brussels, Belgium
    Curr Biol 12:1419-23. 2002
    ..Therefore, the activation of eEF2 kinase by AMPK, resulting in the phosphorylation and inactivation of eEF2, provides a novel mechanism for the inhibition of protein synthesis...
  10. doi request reprint AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells
    Lisa Miranda
    de Duve Institute, Universite Catholique de Louvain, Avenue Hippocrate, B 1200 Brussels, Belgium
    Biochem Biophys Res Commun 396:656-61. 2010
    ..We suggest that AMPK links osmotic stress to the reorganization of the actin cytoskeleton...
  11. doi request reprint Insulin signalling in the heart
    Luc Bertrand
    CARD Unit, Division of Cardiology, Universite Catholique de Louvain, 55, Avenue Hippocrate, CARD5550, 1200 Brussels, Belgium
    Cardiovasc Res 79:238-48. 2008
    ..In this review, we will focus on the description of the molecular signalling elements involved in insulin action in the heart and vasculature under these different physiological, pathological, and therapeutical conditions...
  12. ncbi request reprint [Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases]
    Marc Foretz
    INSERM U567, CNRS URM8104, Université Paris5, Institut Cochin, Departement Endocrinologie, Métabolisme et Cancer, 24, rue du Faubourg Saint Jacques, 75014 Paris, France
    Med Sci (Paris) 22:381-8. 2006
    ..Thus, pharmacological AMPK activation may, through signaling, metabolic and gene expression effects, reduce the risk of Type 2 diabetes, metabolic syndrome and cardiac diseases...
  13. pmc Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders
    Benoit Viollet
    Institut Cochin, INSERM U567, Department of Endocrinology, Metabolism and Cancer, 24 rue du Faubourg Saint Jacques, Paris 75014, France
    J Physiol 574:41-53. 2006
    ....