E Hermans

Summary

Country: Belgium

Publications

  1. ncbi Complex involvement of pertussis toxin-sensitive G proteins in the regulation of type 1alpha metabotropic glutamate receptor signaling in baby hamster kidney cells
    E Hermans
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom
    Mol Pharmacol 58:352-60. 2000
  2. pmc Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors
    E Hermans
    Laboratoire de Pharmacologie, Université catholique de Louvain 54 10, B 1200 Brussels, Belgium
    Biochem J 359:465-84. 2001
  3. ncbi Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors
    Emmanuel Hermans
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, FARL 54 10, Avenue Hippocrate 54, B 1200 Brussels, Belgium
    Pharmacol Ther 99:25-44. 2003
  4. ncbi Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor
    E Hermans
    Department of Cell Physiology and Pharmacology, University of Leicester, UK
    Neuropharmacology 37:1645-7. 1998
  5. ncbi Inhibition of N-linked glycosylation of the human type 1alpha metabotropic glutamate receptor by tunicamycin: effects on cell-surface receptor expression and function
    N Mody
    Department of Cell Physiology and Pharmacology, University of Leicester, UK
    Neuropharmacology 38:1485-92. 1999
  6. doi PICK1 expression in reactive astrocytes within the spinal cord of amyotrophic lateral sclerosis (ALS) rats
    M C Focant
    Group of Neuropharmacology, Institute of Neuroscience, Universite Catholique de Louvain, Brussels, Belgium
    Neuropathol Appl Neurobiol 39:231-42. 2013
  7. ncbi Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins
    Mustapha Najimi
    Laboratoire de Pharmacologie Exprimentale FARL, Département de Physiologie et de Pharmacologie, Université catholique de Louvain 54 10, Avenue Hippocrate 54, B 1200, Brussels, Belgium
    FEBS Lett 512:329-33. 2002
  8. ncbi Multiplicity and regulation of G-protein couplings
    E Hermans
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain
    Bull Mem Acad R Med Belg 164:255-62. 2009
  9. ncbi Down-regulation of neurotensin receptors after ligand-induced internalization in rat primary cultured neurons
    E Hermans
    Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium
    Neurochem Int 31:291-9. 1997
  10. ncbi Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1
    Mustapha Najimi
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Avenue Hippocrate 54, 1200, Brussels, Belgium
    FEBS Lett 523:224-8. 2002

Collaborators

  • N M Delzenne
  • G Page
  • D M Lambert
  • J V Selkirk
  • N Mody
  • M Najimi
  • Didier Pelaprat
  • Jean Marie Maloteaux
  • Barbara Bosier
  • Nicolas Vanhoutte
  • Stephanie Goursaud
  • Sébastien Tilleux
  • Céline Vermeiren
  • Anne Sophie Caumont
  • M C Focant
  • Isabelle de Hemptinne
  • S Goursaud
  • A O Dumont
  • J V Berger
  • Casim A Sarkar
  • B Bosier
  • Cédric Boucherie
  • Jean Noel Octave
  • Magali Peeters
  • Delphine Skrzydelski
  • C Boucherie
  • M Vergouts
  • A Sternotte
  • A G Calas
  • Jorge Abarca-Quinones
  • Bernard Gallez
  • Elena N Kozlova
  • Benedicte F Jordan
  • Stefan Dudli
  • Anja Mohr
  • Manca Kenig
  • Andreas Plückthun
  • Igor Dodevski
  • Isabelle Hemptinne
  • TSUNG PING SU
  • Pascal Romieu
  • Tangui Maurice
  • Anne Marie Lhiaubet
  • Antony Lebeau
  • Patricia Forgez
  • William Rostene
  • Misa Yamada

Detail Information

Publications39

  1. ncbi Complex involvement of pertussis toxin-sensitive G proteins in the regulation of type 1alpha metabotropic glutamate receptor signaling in baby hamster kidney cells
    E Hermans
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom
    Mol Pharmacol 58:352-60. 2000
    ..The latter are involved in the negative control of phospholipase C activity while also influencing the rate of desensitization of the mGlu1alpha receptor...
  2. pmc Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors
    E Hermans
    Laboratoire de Pharmacologie, Université catholique de Louvain 54 10, B 1200 Brussels, Belgium
    Biochem J 359:465-84. 2001
    ....
  3. ncbi Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors
    Emmanuel Hermans
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, FARL 54 10, Avenue Hippocrate 54, B 1200 Brussels, Belgium
    Pharmacol Ther 99:25-44. 2003
    ..This review aims at summarising the different studies that support the concept of multiplicity of G-protein coupling. The physiological and pharmacological relevance of this coupling promiscuity will be discussed...
  4. ncbi Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor
    E Hermans
    Department of Cell Physiology and Pharmacology, University of Leicester, UK
    Neuropharmacology 37:1645-7. 1998
    ..76+/-0.18; n=3). This suggests that CPCCOEt antagonizes type 1alpha metabotropic glutamate receptor activation by interacting with a site distinct from the agonist binding site...
  5. ncbi Inhibition of N-linked glycosylation of the human type 1alpha metabotropic glutamate receptor by tunicamycin: effects on cell-surface receptor expression and function
    N Mody
    Department of Cell Physiology and Pharmacology, University of Leicester, UK
    Neuropharmacology 38:1485-92. 1999
    ..Our data suggest that non-N-glycosylated human mGlu1alpha receptors can traffic to the cell surface and activate phospholipase C...
  6. doi PICK1 expression in reactive astrocytes within the spinal cord of amyotrophic lateral sclerosis (ALS) rats
    M C Focant
    Group of Neuropharmacology, Institute of Neuroscience, Universite Catholique de Louvain, Brussels, Belgium
    Neuropathol Appl Neurobiol 39:231-42. 2013
    ..In this study, we examined the expression of PICK1 in the spinal cord of transgenic rats expressing a mutated form of the human superoxide dismutase 1 (hSOD1(G93A) ) during the progression of the disease...
  7. ncbi Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins
    Mustapha Najimi
    Laboratoire de Pharmacologie Exprimentale FARL, Département de Physiologie et de Pharmacologie, Université catholique de Louvain 54 10, Avenue Hippocrate 54, B 1200, Brussels, Belgium
    FEBS Lett 512:329-33. 2002
    ..This region was also found to be involved in the control of receptor internalization. However, PTx failed to impair internalization, indicating that these two properties are not directly related...
  8. ncbi Multiplicity and regulation of G-protein couplings
    E Hermans
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain
    Bull Mem Acad R Med Belg 164:255-62. 2009
    ....
  9. ncbi Down-regulation of neurotensin receptors after ligand-induced internalization in rat primary cultured neurons
    E Hermans
    Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium
    Neurochem Int 31:291-9. 1997
    ..These results indicate that the neurotensin-induced receptor internalization in cultured neurons is irreversible and that it is followed by a down-regulation of the receptor through a degradative process...
  10. ncbi Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1
    Mustapha Najimi
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Avenue Hippocrate 54, 1200, Brussels, Belgium
    FEBS Lett 523:224-8. 2002
    ..Together, these results provide evidence for an acute regulation of EAAC1 trafficking after activation of a G protein-coupled receptor...
  11. ncbi Pertussis toxin-sensitive modulation of glutamate transport by endothelin-1 type A receptors in glioma cells
    Mustapha Najimi
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, 54 10, Avenue Hippocrate 54, 1200 Bruxelles, Belgium
    Biochim Biophys Acta 1668:195-202. 2005
    ....
  12. doi Enhanced expression of the high affinity glutamate transporter GLT-1 in C6 glioma cells delays tumour progression in rat
    Nicolas Vanhoutte
    Laboratory of Experimental Pharmacology, Universite Catholique de Louvain, 54 10, av Hippocrate 54, 1200 Brussels, Belgium
    Exp Neurol 218:56-63. 2009
    ....
  13. pmc Differential modulation of AP-1- and CRE-driven transcription by cannabinoid agonists emphasizes functional selectivity at the CB1 receptor
    B Bosier
    Unité de Chimie Pharmaceutique et de Radiopharmacie UCL 7340, Universite Catholique de Louvain, Brussels, Belgium
    Br J Pharmacol 155:24-33. 2008
    ..Herein, we characterized their influence on cAMP response element (CRE) and activator protein 1 (AP-1)-mediated regulation of gene transcription...
  14. ncbi Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors
    D M Lambert
    Unite de Chimie pharmaceutique et de Radiopharmacie, département des sciences pharmaceutiques, Universite Catholique de Louvain, UCL 7340, Avenue Mounier 73, B 1200, Brussels, Belgium
    Biochim Biophys Acta 1440:266-74. 1999
    ....
  15. ncbi Transcriptional regulation of the tyrosine hydroxylase gene by neurotensin in human neuroblastoma CHP212 cells
    M Najimi
    Laboratoire de Pharmacologie, Universite Catholique de Louvain, Brussels, Belgium
    Metab Brain Dis 16:165-74. 2001
    ....
  16. doi Glutamate-induced glioma cell proliferation is prevented by functional expression of the glutamate transporter GLT-1
    Nicolas Vanhoutte
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, 54 10, av Hippocrate 54, 1200 Brussels, Belgium
    FEBS Lett 582:1847-52. 2008
    ..This suggests that impaired glutamate uptake capacity in glioma cells indirectly contributes to their proliferation...
  17. ncbi Acute up-regulation of glutamate uptake mediated by mGluR5a in reactive astrocytes
    Céline Vermeiren
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Brussels, Belgium
    J Neurochem 94:405-16. 2005
    ..We conclude that mGluR5a contributes to a dynamic control of GLT-1 function in activated astrocytes, acting as a glial sensor of the extracellular glutamate concentration in order to acutely regulate the excitatory transmission...
  18. doi Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes
    J V Berger
    Institute of Neuroscience, Group of Neuropharmacology, Universite Catholique de Louvain, Avenue Hippocrate B1 54 10, B 1200 Brussels, Belgium
    Neuroscience 205:29-38. 2012
    ..As neuroinflammation commonly occurs in several nervous diseases, its influence on mGluR expression should be taken into account when considering these receptors as future drug targets...
  19. ncbi Increased dopamine uptake in striatal synaptosomes after treatment of rats with amantadine
    G Page
    Laboratoire de Pharmacologie, Université catholique de Louvain FARL 54 10, Avenue Hippocrate 54, B 1200, Brussels, Belgium
    Eur J Pharmacol 403:75-80. 2000
    ..An indirect mechanism would involve presynaptic dopamine receptors that control the activity of the DAT in response to the increased dopamine concentration in the synaptic cleft...
  20. doi Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression
    Barbara Bosier
    Unite de Chimie pharmaceutique et de Radiopharmacie, Universite Catholique de Louvain, Brussels, Belgium
    Biochem Pharmacol 77:216-27. 2009
    ..Together our results suggest that the physiological modulation of TH expression by cannabinoid agonists in dopaminergic neurons would be influenced by additional endogenous inputs...
  21. doi Cultured astrocytes derived from corpus callosum or cortical grey matter show distinct glutamate handling properties
    Stephanie Goursaud
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Brussels, Belgium
    J Neurochem 108:1442-52. 2009
    ..Moreover, the expression and activity of the astroglial components involved in the control of glutamatergic transmission are reinforced when these cells are maintained under conditions mimicking a gliotic environment...
  22. doi Activation of VIP/PACAP type 2 receptor by the peptide histidine isoleucine in astrocytes influences GLAST-mediated glutamate uptake
    Stephanie Goursaud
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Av Hippocrate 54 10, 1200 Brussels, Belgium
    J Neurochem 105:1165-75. 2008
    ..24 +/- 8.74 and 43.00 +/- 6.36%, when considering the 72 and 55 kDa immunoreactive proteins, respectively). Such cross-talk between PHI and glutamate transmission systems in glial cells opens attractive perspectives in neuropharmacology...
  23. ncbi Amantadine and memantine induce the expression of the glial cell line-derived neurotrophic factor in C6 glioma cells
    Anne Sophie Caumont
    Laboratoire de Pharmacologie Expérimentale FARL, Universite Catholique de Louvain, Avenue Hippocrate 54 10, 1200 Bruxelles, Belgium
    Neurosci Lett 394:196-201. 2006
    ..Together, these results demonstrate that the neuroprotective effect of amantadine and memantine could involve the regulation of GDNF production by glial cells...
  24. ncbi Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line
    Barbara Bosier
    Unité de Chimie Pharmaceutique et de Radiopharmacie UCL 7340, Universite Catholique de Louvain, Brussels, Belgium
    J Neurochem 102:1996-2007. 2007
    ....
  25. ncbi Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis
    Céline Vermeiren
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Brussels, Belgium
    J Neurochem 96:719-31. 2006
    ..The failure of activated mGluR5 to increase glutamate uptake in astrocytes derived from this animal model of ALS supports the theory of glutamate excitotoxicity in the pathogenesis of the disease...
  26. ncbi Induction of glial glutamate transporters in adult mesenchymal stem cells
    Isabelle de Hemptinne
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Brussels, Belgium
    J Neurochem 91:155-66. 2004
    ..Although the astrocytic nature of these cells remains to be confirmed, this observation gives support to the study of mesenchymal stem cells as a promising tool for the treatment of neurological diseases involving glutamate excitoxicity...
  27. ncbi Neuroinflammation and regulation of glial glutamate uptake in neurological disorders
    Sébastien Tilleux
    Laboratoire de Pharmacologie Expérimentale, Faculte de Medecine, Universite Catholique de Louvain, Brussels, Belgium
    J Neurosci Res 85:2059-70. 2007
    ..The aim of this review is to summarize and discuss the data showing an influence of inflammatory mediators and related free radicals on the expression and activity of glial glutamate transporters...
  28. ncbi Involvement of the sigma 1 receptor in the modulation of dopaminergic transmission by amantadine
    Magali Peeters
    Laboratoire de Pharmacologie Expérimentale FARL, Universite Catholique de Louvain, 54 10, Avenue Hippocrate 54, B 1200 Brussels, Belgium
    Eur J Neurosci 19:2212-20. 2004
    ..Together, these data demonstrate that aminoadamantanes behave as sigma1 receptor agonists, and confirm an involvement of this receptor in modulating dopamine receptors exerted by therapeutically relevant concentrations of amantadine...
  29. doi Selective up-regulation of GLT-1 in cultured astrocytes exposed to soluble mediators released by activated microglia
    Sébastien Tilleux
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Brussels, Belgium
    Neurochem Int 55:35-40. 2009
    ..Taken together, these results suggest that the GLT-1-dependent control of glutamate neurotransmission by either naive or chemically activated astrocytes is influenced by microglia-mediated inflammation...
  30. doi Distinct expression and regulation of the glutamate transporter isoforms GLT-1a and GLT-1b in cultured astrocytes from a rat model of amyotrophic lateral sclerosis (hSOD1G93A)
    Stephanie Goursaud
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Brussels, Belgium
    Neurochem Int 55:28-34. 2009
    ....
  31. ncbi In vitro differentiated neural stem cells express functional glial glutamate transporters
    Nicolas Vanhoutte
    Laboratoire de Pharmacologie Expérimentale FARL, Université catholique de Louvain 54 10, Avenue Hippocrate 54, B 1200 Brussels, Belgium
    Neurosci Lett 370:230-5. 2004
    ..Together, these results indicate that in vitro differentiation of cultured neural stem cells can give rise to distinct populations of astrocytes expressing functional glutamate transporters...
  32. doi Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells
    Barbara Bosier
    Unité de Chimie Pharmaceutique et de Radiopharmacie UCL 7340, Universite Catholique de Louvain, 73 40, Av E Mounier, B 1200 Brussels, Belgium
    FEBS Lett 582:3861-7. 2008
    ..These data indicate that complex interactions of the CB1 receptor with intracellular signalling partners controlling MAPK activities may explain the apparent disparities in cellular responses to functional selective agonists...
  33. doi In vitro evidence for impaired neuroprotective capacities of adult mesenchymal stem cells derived from a rat model of familial amyotrophic lateral sclerosis (hSOD1(G93A))
    Cédric Boucherie
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, 54 10, av Hippocrate 54, 1200 Brussels, Belgium
    Exp Neurol 212:557-61. 2008
    ....
  34. ncbi Molecular and functional characterisation of glutamate transporters in rat cortical astrocytes exposed to a defined combination of growth factors during in vitro differentiation
    Céline Vermeiren
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, av Hippocrate 54, 1200 Brussels, Belgium
    Neurochem Int 46:137-47. 2005
    ....
  35. ncbi Specific regulation of rat glial cell line-derived neurotrophic factor gene expression by riluzole in C6 glioma cells
    Anne Sophie Caumont
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, 54 10, Avenue Hippocrate 54, 1200 Bruxelles, Belgium
    J Neurochem 97:128-39. 2006
    ..This study suggests that the regulation of GDNF gene transcription in glial cells could contribute to the pharmacological properties of riluzole and possibly other neuroprotective drugs...
  36. ncbi Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevance
    Barbara Bosier
    Unité de Chimie Pharmaceutique et de Radiopharmacie UCL 7340, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Trends Pharmacol Sci 28:438-46. 2007
    ..Although such complexity should be regarded as an opportunity to gain pharmacological specificity, unraveling the physiological implications of these concepts is essential before their therapeutic relevance can be defined...
  37. pmc Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity
    Casim A Sarkar
    Biochemisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:14808-13. 2008
    ..These approaches may alleviate existing bottlenecks in structural studies of these targets by providing sufficient quantities of stable variants in defined conformational states...
  38. ncbi Generation of model cell lines expressing recombinant G-protein-coupled receptors
    Emmanuel Hermans
    Laboratory of Experimental Pharmacology, Catholic University of Louvain, Brussels, Belgium
    Methods Mol Biol 259:137-53. 2004
    ..This chapter gives a brief overview of the different techniques and provides methodology for the generation of transiently transfected cells and for selection, isolation and maintenance of stable transfected cell lines...
  39. ncbi Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus
    Delphine Skrzydelski
    Institut National de la Sante et de la Recherche Medicale, Unité 339, Hopital Saint Antoine, Paris, France
    Mol Pharmacol 64:421-9. 2003
    ..They also suggest that the differential involvement of these domains in coupling to G proteins might represent a molecular basis for agonist-selective responses through G protein-coupled receptors...