Christian Herens

Summary

Country: Belgium

Publications

  1. pmc Chromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas
    Federico E Turkheimer
    Department of Clinical Neuroscience, Division of Neuroscience, Imperial College London, UK
    BMC Bioinformatics 7:526. 2006
  2. ncbi request reprint Clonal chromosome aberrations in Philadelphia-negative cells from chronic myelocytic leukemia patients treated with imatinib mesylate: report of two cases
    Christian Herens
    Center for Human Genetics, University of Liege, Liege, Belgium
    Cancer Genet Cytogenet 147:78-80. 2003
  3. ncbi request reprint Deletion of the 5'-ABL region: a recurrent anomaly detected by fluorescence in situ hybridization in about 10% of Philadelphia-positive chronic myeloid leukaemia patients
    C Herens
    Departments of Human Genetics, Biological Haematology and Clinical Haematology, University of Liege, CHU, Sart Tilman, Liege, Belgium
    Br J Haematol 110:214-6. 2000
  4. ncbi request reprint Deletion (6)(p22p25) is a recurrent anomaly of thymoma: report of a second case and review of the literature
    Christian Herens
    Department of Human Genetics, University of Liege, Tour de Pathologie, B23 Sart Tilman, 4000 Liege, Belgium
    Cancer Genet Cytogenet 146:66-9. 2003
  5. ncbi request reprint Translocation (16;17)(q22;p13) is a recurrent anomaly of aneurysmal bone cysts
    C Herens
    Department of Human Genetics, University of Liege, CHU Sart Tilman, Liege, Belgium
    Cancer Genet Cytogenet 127:83-4. 2001
  6. ncbi request reprint Malignant solitary fibrous tumor of the pleura: report of a case with cytogenetic analysis
    Laurence de Leval
    Department of Pathology, C H U Sart Tilman, Tour de Pathologie, B23, 1, 4000, Liege, Belgium
    Virchows Arch 442:388-92. 2003
  7. doi request reprint Evidence for neo-generation of T cells by the thymus after non-myeloablative conditioning
    Emilie Castermans
    Department of Medicine, Division of Hematology, University of Liege, Liege, Belgium
    Haematologica 93:240-7. 2008
  8. ncbi request reprint Establishment and characterisation of two novel human KSHV- and EBV-negative Burkitt cell lines, GAL-01 and GAL-02, from a primary lymphomatous effusion
    Caroline Thielen
    Department of Pathology, C H U of Liège, Liege, Belgium
    Eur J Haematol 77:318-26. 2006
  9. ncbi request reprint Deletions of the 3'BCR and 5'ABL regions in patients with Philadelphia-positive chronic myeloid leukemia: a one-step process occurring in about 10% of the cases without any evidence of genetic instability in the target cells
    Mickaël Fournier
    Center for Human Genetics, University of Liege, CHU, Tour de Pathologie, B23, Sart Tilman, 4000 Liege, Belgium
    Cancer Genet Cytogenet 160:184-7. 2005
  10. ncbi request reprint Novel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (Type VIIC) and common polymorphisms in the ADAMTS2 gene
    Alain Colige
    Laboratory of Connective Tissues Biology, GIGA Research Center, University of Liege, Liege, Belgium
    J Invest Dermatol 123:656-63. 2004

Collaborators

Detail Information

Publications26

  1. pmc Chromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas
    Federico E Turkheimer
    Department of Clinical Neuroscience, Division of Neuroscience, Imperial College London, UK
    BMC Bioinformatics 7:526. 2006
    ....
  2. ncbi request reprint Clonal chromosome aberrations in Philadelphia-negative cells from chronic myelocytic leukemia patients treated with imatinib mesylate: report of two cases
    Christian Herens
    Center for Human Genetics, University of Liege, Liege, Belgium
    Cancer Genet Cytogenet 147:78-80. 2003
    ..The first patient presented with a duplication of chromosome 1, dup(1)(q21q42), and the second showed two new clonal aberrations consisting of inv(1)(q12q32) and del(7)(q22) in the same clone...
  3. ncbi request reprint Deletion of the 5'-ABL region: a recurrent anomaly detected by fluorescence in situ hybridization in about 10% of Philadelphia-positive chronic myeloid leukaemia patients
    C Herens
    Departments of Human Genetics, Biological Haematology and Clinical Haematology, University of Liege, CHU, Sart Tilman, Liege, Belgium
    Br J Haematol 110:214-6. 2000
    ..This anomaly was observed in 5/51 cases (9.8%). Cytological and clinical data suggest that the 5'-ABL deletion may be associated with dysplastic features of polymorphonuclear cells and metamyelocytes and a short chronic phase duration...
  4. ncbi request reprint Deletion (6)(p22p25) is a recurrent anomaly of thymoma: report of a second case and review of the literature
    Christian Herens
    Department of Human Genetics, University of Liege, Tour de Pathologie, B23 Sart Tilman, 4000 Liege, Belgium
    Cancer Genet Cytogenet 146:66-9. 2003
    ..Both patients presented with benign tumors. These data suggest that partial deletion of the short arm of chromosome 6 is a nonrandom change associated with benign thymomas...
  5. ncbi request reprint Translocation (16;17)(q22;p13) is a recurrent anomaly of aneurysmal bone cysts
    C Herens
    Department of Human Genetics, University of Liege, CHU Sart Tilman, Liege, Belgium
    Cancer Genet Cytogenet 127:83-4. 2001
    ..1999) reported 2 cases of aneurysmal bone cysts with a recurrent (16;17)(q22;p13) translocation. We present here two additional cases harboring the same translocation as well as additional chromosomal changes...
  6. ncbi request reprint Malignant solitary fibrous tumor of the pleura: report of a case with cytogenetic analysis
    Laurence de Leval
    Department of Pathology, C H U Sart Tilman, Tour de Pathologie, B23, 1, 4000, Liege, Belgium
    Virchows Arch 442:388-92. 2003
    ..Demonstration of a recurrent abnormal karyotype largely supports its relevance to the malignant clone and suggests a role of supernumerary chromosome(s) 8 in the determinism of malignant behavior in SFT...
  7. doi request reprint Evidence for neo-generation of T cells by the thymus after non-myeloablative conditioning
    Emilie Castermans
    Department of Medicine, Division of Hematology, University of Liege, Liege, Belgium
    Haematologica 93:240-7. 2008
    ..Background and objective. We investigated immune recovery in 50 patients given either unmanipulated or CD8-depleted allogeneic peripheral blood stem cells after non-myeloablative conditioning...
  8. ncbi request reprint Establishment and characterisation of two novel human KSHV- and EBV-negative Burkitt cell lines, GAL-01 and GAL-02, from a primary lymphomatous effusion
    Caroline Thielen
    Department of Pathology, C H U of Liège, Liege, Belgium
    Eur J Haematol 77:318-26. 2006
    ..The in vivo effusion occurred in a very peculiar clinical setting; the patient having a previous history of intestinal diffuse large B-cell lymphoma...
  9. ncbi request reprint Deletions of the 3'BCR and 5'ABL regions in patients with Philadelphia-positive chronic myeloid leukemia: a one-step process occurring in about 10% of the cases without any evidence of genetic instability in the target cells
    Mickaël Fournier
    Center for Human Genetics, University of Liege, CHU, Tour de Pathologie, B23, Sart Tilman, 4000 Liege, Belgium
    Cancer Genet Cytogenet 160:184-7. 2005
    ..Moreover, the different genetic events (Philadelphia chromosome formation; 5'ABL and 3'BCR deletions) occur simultaneously in a one-step process without any evidence for genetic instability in the target bone marrow cells...
  10. ncbi request reprint Novel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (Type VIIC) and common polymorphisms in the ADAMTS2 gene
    Alain Colige
    Laboratory of Connective Tissues Biology, GIGA Research Center, University of Liege, Liege, Belgium
    J Invest Dermatol 123:656-63. 2004
    ..The three other patients with a phenotype with some resemblance to EDS type VIIC only had silent and functionally neutral variations also frequently found in a normal population...
  11. ncbi request reprint Low T-cell chimerism is not followed by graft rejection after nonmyeloablative stem cell transplantation (NMSCT) with CD34-selected PBSC
    F Baron
    Department of Medicine, Division of Hematology, University of Liege, Liege, Belgium
    Bone Marrow Transplant 32:829-34. 2003
    ..Further studies are needed to confirm this encouraging preliminary report...
  12. ncbi request reprint Major decrease in the incidence of trisomy 21 at birth in south Belgium: mass impact of triple test?
    A Verloes
    Wallonia Centre for Human Genetics, Liege University, Liege, Belgium
    Eur J Hum Genet 9:1-4. 2001
    ....
  13. doi request reprint Systematic chromosomal aberrations found in murine bone marrow-derived mesenchymal stem cells
    Claire Josse
    Department of Human Genetics, Liege University, Liege, Belgium
    Stem Cells Dev 19:1167-73. 2010
    ..Therefore, we conclude that murine MSCs display high chromosomal instability and can generate tumors, and that care must be taken before using them for the evaluation of MSC therapeutic potential...
  14. pmc A case of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia with a rare FIP1L1 breakpoint
    Frederic Lambert
    Department of Human Genetics, Groupe Interdisciplinaire de Genoproteomique Appliquee, Centre Hospitalier Universitaire de Liege, University of Liege, Liege, Belgium
    J Mol Diagn 9:414-9. 2007
    ..As targeted therapy with tyrosine kinase inhibitors has dramatically changed the prognosis of FIP1L1-PDGFRA (+) CEL, false-negative results could hamper accurate diagnosis and treatment...
  15. ncbi request reprint T-cell/histiocyte-rich large B-cell lymphoma associated with a near-tetraploid karyotype and complex genetic abnormalities
    Laurence de Leval
    Department of Pathology, CHU Sart Tilman, Liege, Belgium
    APMIS 114:474-8. 2006
    ....
  16. doi request reprint Patterns of genomic aberrations suggest that Burkitt lymphomas with complex karyotype are distinct from other aggressive B-cell lymphomas with MYC rearrangement
    Violaine Havelange
    Center for Human Genetics, Cliniques Universitaires Saint Luc, de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Genes Chromosomes Cancer 52:81-92. 2013
    ..2012 Wiley Periodicals, Inc...
  17. ncbi request reprint Combination of nonmyeloablative stem cell transplantation and Imatinib in accelerated phase CML
    Frederic Baron
    Department of Medicine, Division of Hematology, University of Liege, Belgium
    Haematologica 87:ECR43. 2002
  18. pmc Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies
    Francois P Duhoux
    Center for Human Genetics, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 6:e26311. 2011
    ..It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis...
  19. ncbi request reprint Transmission of an undiagnosed sarcoma to recipients of kidney and liver grafts procured in a non-heart beating donor
    Olivier Detry
    Department of Abdominal Surgery, University of Liege, CHU Sart Tilman, Liege, Belgium
    Liver Transpl 11:696-9. 2005
    ..The management of liver graft recipients is very difficult in this setting, and long-term survival was very rarely reported...
  20. ncbi request reprint Peripheral T-cell lymphoma with t(6;14)(p25;q11.2) translocation presenting with massive splenomegaly
    Joan Somja
    Department of Pathology, B35, University of Liege, CHU Sart Tilman, Liege, Belgium
    Virchows Arch 464:735-41. 2014
    ..2) and supporting consideration of this translocation as a marker of biological aggressiveness. ..
  21. ncbi request reprint Abnormalities of the long arm of chromosome 21 in 107 patients with hematopoietic disorders: a collaborative retrospective study of the Groupe Français de Cytogénétique Hématologique
    Eric Jeandidier
    Laboratoire de Genetique, Centre Hospitalier de Mulhouse, 20 rue du Docteur Laennec, BP130, 68070, Mulhouse Cedex, France
    Cancer Genet Cytogenet 166:1-11. 2006
    ..The findings invite further investigation of the 21q abnormalities to detect their associated molecular rearrangements...
  22. ncbi request reprint Subtle trisomy 12q24.3 and subtle monosomy 22q13.3: three new cases and review
    Laura Rodriguez
    Estudio Colaborativo Español de Malformaciones Congénitas ECEMC del Centro de Investigación sobre Anomalías Congénitas CIAC, Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo, Madrid, Spain
    Am J Med Genet A 122:119-24. 2003
    ..A high resolution G-band karyotype also showed in Case II and III an abnormal chromosome 22, studied by FISH techniques which confirmed a der(22)t(12;22)(q24.3;q13.3) in both cases...
  23. ncbi request reprint Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH
    Heidi Van Limbergen
    Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Genes Chromosomes Cancer 33:60-72. 2002
    ....
  24. ncbi request reprint PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements
    Bruce Poppe
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Genes Chromosomes Cancer 44:218-23. 2005
    ..In addition, the recurrent incidence of this rearrangement in both HRTR-BCL (4 cases) and PTLD-DLBCL (2 cases) was previously unrecognized and is intriguing...
  25. ncbi request reprint High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by interphase FISH detection
    Esther Oliva
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 31:1277-84. 2007
    ..Our results indicate that the detection of this chromosomal abnormality can be used to diagnose ESTs with smooth muscle differentiation when the smooth muscle component is predominant...
  26. ncbi request reprint Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies
    Bruce Poppe
    Centre for Medical Genetics, University Hospital Ghent, Belgium
    Blood 103:229-35. 2004
    ..In addition, our results indicate that the transcriptional program associated with MLL rearrangements and MLL overexpression displays significant similarities...