Research Topics
Species | Yves E HenrotinSummaryCountry: Belgium Publications
| Collaborators
|
Detail Information
Publications
[Guidelines for the management of knee and hip osteoarthritis: For whom? Why? To do what?]Yves Henrotin
Universite de Liege, CHU Sart Tilman, Institut de Pathologie, unité de recherche sur l os et cartilage UROC, 5, 4000 Liege, Belgique
Presse Med 39:1180-8. 2010..The barriers for the guidelines implementation are the lack of interest of the practitioners, the lack of scientific advances in the OA diagnosis and treatments and the low applicability of these guidelines in the daily practice...
Physiological effects of oral glucosamine on joint health: current status and consensus on future research prioritiesYves Henrotin
Bone and Cartilage Research Unit, University of Liege, Institute of Pathology, Level 5, CHU Sart Tilman, Liege, 4000, Belgium
BMC Res Notes 6:115. 2013..This paper summarizes the available evidence for beneficial effects of GlcN on joint health and proposes new insight into the design of future clinical trials aimed at identifying beneficial physiological effect of GlcN on joint tissues...- Early decrease of serum biomarkers of type II collagen degradation (Coll2-1) and joint inflammation (Coll2-1 NO2 ) by hyaluronic acid intra-articular injections in patients with knee osteoarthritis: A research study part of the Biovisco studyY Henrotin
Bone and Cartilage Research Unit, University of Liege, Institute of Pathology, Level 5, CHU Sart Tilman, 4000 Liege, Belgium
J Orthop Res 31:901-7. 2013..The serum level of Coll2-1 appeared to be a predictive factor for response to treatment. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 901-907, 2013... - Subchondral bone and osteoarthritis: biological and cellular aspectsY Henrotin
Bone and Cartilage Research Unit, University of Liege, 4000, Liege, Belgium
Osteoporos Int 23:S847-51. 2012..This narrative review describes these physiopathological mechanisms and identifies possible therapeutic targets for pharmacological modalities... - Intra-articular use of a medical device composed of hyaluronic acid and chondroitin sulfate (Structovial CS): effects on clinical, ultrasonographic and biological parametersYves Henrotin
Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Vivalia, Marche en Famenne, Bone and Cartilage Research Unit, University of Liège Institute of Pathology, Level 5, CHU Sart Tilman, 4000, Liege, Belgium
BMC Res Notes 5:407. 2012.... - Characterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfateCecile Lambert
Bone and Cartilage Research Unit, Institute of Pathology, CHU Sart Tilman, 4000 Liege, Belgium
Arthritis Res Ther 14:R58. 2012..The effects of interleukin (IL)-1β and chondroitin sulfate (CS) on the expression of pro- and anti-angiogenic factors by synovial fibroblasts cells (SFC) were also studied... - Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?Yves Henrotin
Bone and Cartilage Research Unit, University of Liege, Institute of Pathology, Level 5, CHU Sart Tilman, 4000 Liege, Belgium
Arthritis Res Ther 14:201. 2012..Finally, the importance of study design and criteria of evaluation are highlighted as new compounds represent new interesting options for the management of OA... - Fibulin 3 peptides Fib3-1 and Fib3-2 are potential biomarkers of osteoarthritisYves Henrotin
Bone and Cartilage Research Unit, University of Liege, Liege, Belgium
Arthritis Rheum 64:2260-7. 2012..This study was undertaken to identify new biomarkers of osteoarthritis (OA) by proteomics analysis and to develop specific immunoassays to detect and quantify them... - Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiativesY Henrotin
Bone and Cartilage Research Unit, University of Liege, Institute of Pathology, Level 5, CHU Sart Tilman, 4000 Liege, Belgium
Osteoarthritis Cartilage 20:215-7. 2012.... - Development and validation of a questionnaire assessing volitional competencies to enhance the performance of physical activities in chronic low back pain patientsCéline Mathy
Social Psychology Unit, Universite Libre de Bruxelles, Brussels, Belgium
BMC Musculoskelet Disord 12:111. 2011..However, there is at present no questionnaire allowing assessing the capacity of implementation intentions of physical activities in LBP patients... - Biological actions of curcumin on articular chondrocytesY Henrotin
University of Liege, Institute of Pathology, Sart Tilman, Liege, Belgium
Osteoarthritis Cartilage 18:141-9. 2010.... 
Biochemical biomarkers of oxidative collagen damageY Henrotin
Institute of Pathology, University of Liege, CHU Sart Tilman, 4000 Liege, Belgium
Adv Clin Chem 49:31-55. 2009..This chapter reviews the structural and biochemical changes to collagen induced by reactive oxygen and nitrogen species and discusses recent data on the use of collagen-derived biomarkers for measuring oxidative damage...- Type II collagen markers in osteoarthritis: what do they indicate?Yves Henrotin
Bone and Cartilage Research Unit, University of Liege, Institute of Pathology, Level 5, CHU Sart Tilman, Liege, Belgium
Curr Opin Rheumatol 19:444-50. 2007..Based on this analysis, we propose an update to the classification of the type II collagen biomarkers... - Subchondral bone in osteoarthritis physiopathology: state-of-the art and perspectivesY Henrotin
Bone and Cartilage Research Unit, Institute of Pathology, CHU Sart Tilman, University of Liege, Liege, Belgium
Biomed Mater Eng 19:311-6. 2009..In this paper, we propose a short review of the recent advances in the understanding of the role played by subchondral bone in OA... - Nutraceuticals: do they represent a new era in the management of osteoarthritis? - a narrative review from the lessons taken with five productsY Henrotin
Bone and Cartilage Research Unit, Institute of Pathology, Level 5, CHU Sart Tilman, 4000 Liege, Belgium
Osteoarthritis Cartilage 19:1-21. 2011..Evidences that can support health, physiological or functional benefit on osteoarthritis (OA) were gathered and the level of evidence relative to each of these ingredients was highlighted... - Study of the information delivery by general practitioners and rheumatologists to patients with acute low back painYves Henrotin
Belgian Back Society, Bone and Cartilage Research Unit, University of Liege, Institute of Pathology, CHU Sart Tilman, 4000, Liege, Belgium
Eur Spine J 20:720-30. 2011..This suggests that GP information campaign can modify the message that they deliver to LBP, and subsequently could change patient's beliefs on LBP... - Muscle: a source of progenitor cells for bone fracture healingYves Henrotin
Bone and Cartilage Research Unit, University of Liege, CHU Sart Tilman, 4000 Liege, Belgium
BMC Med 9:136. 2011..Please see related article: http://www.biomedcentral.com/1471-2474/12/288... - The role of reactive oxygen species in homeostasis and degradation of cartilageY E Henrotin
Bone and Cartilage Research Unit, Institute of Pathology, Level 5, CHU Sart Tilman, Liege, Belgium
Osteoarthritis Cartilage 11:747-55. 2003..ROS production has been found to increase in joint diseases, such as osteoarthritis and rheumatoid arthritis, but their role in joint diseases initiation and progression remains questionable... - Antioxidant to treat osteoarthritis: dream or reality?Y Henrotin
Bone and Cartilage Research Unit, University of Liege, Institute of Pathology, Level 5, CHU Sart Tilman, 4000 Liege, Belgium
Curr Drug Targets 8:347-57. 2007..However, until now, there is no consistent evidence that additional antioxidant supply is efficient to relieve OA symptoms or to prevent structural changes in OA cartilage... - Avocado/soybean unsaponifiables prevent the inhibitory effect of osteoarthritic subchondral osteoblasts on aggrecan and type II collagen synthesis by chondrocytesYves E Henrotin
Bone and Cartilage Metabolism Research Unit, Institute of Pathology B23, Liege, Belgium
J Rheumatol 33:1668-78. 2006..To determine the effects of avocado/soybean unsaponifiables (ASU) on osteoblast-induced dysregulation of chondrocyte metabolism... - Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytesYves E Henrotin
Bone and Cartilage Metabolism Research Unit, University Hospital, CHU Sart Tilman, Liege, Belgium
J Rheumatol 30:1825-34. 2003..To investigate the effects of avocado (A)/soybean (S) unsaponifiables on the metabolism of human osteoarthritic (OA) chondrocytes cultured in alginate beads over 12 days... - In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediatorsY Henrotin
Bone and Cartilage Metabolism Research Unit, Institute of Pathology, CHU Sart Tilman, Liege, Belgium
Inflamm Res 50:391-9. 2001.... - Type II collagen peptides for measuring cartilage degradationY Henrotin
Bone and Cartilage Research Unit, Institute of Pathology, CHU Sart Tilman, 4000 Liege, Belgium
Biorheology 41:543-7. 2004..In conclusion, these preliminary results indicate that Coll 2-1 could be a predictive marker of knee OA progression... - Oxygen and reactive oxygen species in cartilage degradation: friends or foes?Y Henrotin
Bone and Cartilage Research Unit, University of Liege, Institute of Pathology, Level 5, CHU Sart Tilman, 4000 Liege, Belgium
Osteoarthritis Cartilage 13:643-54. 2005..This review is focused on the influence of oxygen and derived reactive species on chondrocytes aging, metabolic function and chondrogenic phenotype... - Pharmaceutical and nutraceutical management of canine osteoarthritis: present and future perspectivesYves Henrotin
Bone and Cartilage Research Unit, Institute of Pathology, Level 5, CHU Sart Tilman, 4000 Liege, Belgium
Vet J 170:113-23. 2005..This paper provides an overview of recent discoveries in the pathophysiology and in the therapeutic management of osteoarthritis in dogs... - Effects of rhein on human articular chondrocytes in alginate beadsChristelle Sanchez
Bone and Cartilage Metabolism Research Unit, Institute of Pathology, CHU Sart-Tilman, , Belgium
Biochem Pharmacol 65:377-88. 2003..The COX-2 and iNOS mRNA levels and IL-8 production were not modified by rhein.Overall, these results contribute to explain the clinical efficiency of rhein and give new information on its mechanisms of action... - Metabolism of human articular chondrocytes cultured in alginate beads. Longterm effects of interleukin 1beta and nonsteroidal antiinflammatory drugsChristelle Sanchez
Bone and Cartilage Metabolism Research Unit, University Hospital, CHU Sart-Tilman, , Belgium
J Rheumatol 29:772-82. 2002..They fully blocked PGE2 production, inhibited IL-6 synthesis, and increased aggrecan synthesis. These effects appear advantageous for the longterm treatment of chronic joint diseases such as osteoarthritis... - Biochemical markers of bone and cartilage remodeling in prediction of longterm progression of knee osteoarthritisOlivier Bruyere
WHO Collaborating Center for Public Health Aspect of Osteoarticular Disorders (CCPHAOD, Liege, Belgium
J Rheumatol 30:1043-50. 2003..11 (0.83) mm in patients in the highest quartile (> +14.34 ng/ml) (p = 0.03). CONCLUSION: The 3-year radiological progression of knee OA could be predicted by a 1-year increase in OC or a 1-year decrease in HA levels... - Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral boneChristelle Sanchez
University of Liege, Sart Tilman, Liege, Belgium
Arthritis Rheum 58:442-55. 2008..To determine the phenotype of osteoblasts from the sclerotic zones of human osteoarthritic (OA) subchondral bone... - Differential regulation of chondrocyte metabolism by oncostatin M and interleukin-6Christelle Sanchez
Bone and Cartilage Metabolism Research Unit, Institute of Pathology B23, University Hospital, Sart-Tilman, , Belgium
Osteoarthritis Cartilage 12:801-10. 2004..CONCLUSIONS: OSM and IL-6, two glycoprotein 130 binding cytokines, show different activity profiles on OA chondrocytes, indicating that these cytokines could play different roles in the OA disease process... - Impact of the joint space width measurement method on the design of knee osteoarthritis studiesOlivier Bruyere
WHO Collaborating Center for Public Health Aspects of Osteoarticular Disorders, Liege, Belgium
Aging Clin Exp Res 15:136-41. 2003..The aim of this study was to assess the impact of the joint space width measurement method on sample size calculation in knee OA studies... - Radiologic features poorly predict clinical outcomes in knee osteoarthritisOlivier Bruyere
WHO Collaborating Center for Public Health Aspect of Osteoarticular Disorders, Liege, Belgium
Scand J Rheumatol 31:13-6. 2002..CONCLUSION: Radiographic and clinical progressions of the disease are significantly associated but the clinical relevance of the association is questionable... - Regulation of subchondral bone osteoblast metabolism by cyclic compressionChristelle Sanchez
University of Liege, Liege, Belgium
Arthritis Rheum 64:1193-203. 2012..This study was undertaken to evaluate the effects of cyclic compression on osteoblasts from OA subchondral bone... - Current concepts in the therapeutic management of osteoarthritis with glucosamineJean-Yves Reginster
WHO Collaborating Center for Public Health Aspects of Rheumatic Diseases, Liege, Belgium
Bull Hosp Jt Dis 63:31-6. 2005.... - New perspectives in the management of osteoarthritis. structure modification: facts or fantasy?Jean Yves Reginster
Bone and Cartilage Metabolism Research Unit, University of Liege, CHU Centre Ville, Policliniques L Brull, Liege, Belgium
J Rheumatol Suppl 67:14-20. 2003..An important issue is that all conclusive studies with such chemical entities resulted from the use of prescription medicines and not over-the-counter or nutriceutical supplements... - Naturocetic (glucosamine and chondroitin sulfate) compounds as structure-modifying drugs in the treatment of osteoarthritisJean Yves Reginster
Bone and Cartilage Metabolism Research Unit, University of Liege, Belgium
Curr Opin Rheumatol 15:651-5. 2003..Several entities have been investigated carefully for the symptomatic and structural management of osteoarthritis. This review reports recent findings suggesting that such compounds may delay the structural progression of osteoarthritis... - Relationship between biochemical markers and radiographic scores in the evaluation of the osteoarticular status of Warmblood stallionsDenis Verwilghen
Department of Clinical Sciences, Equine Clinic, Faculty of Veterinary Medicine of Liege, B 4000 Liege, Belgium
Res Vet Sci 87:319-28. 2009..A high percentage of horses with distal interphalangeal joint effusion was present in this study and was associated with decreased IGF-I and increased Coll2-1 levels... - High expression of PGE2 enzymatic pathways in cervical (pre)neoplastic lesions and functional consequences for antigen-presenting cellsMichael Herfs
Department of Pathology B23, GIGA Cancer, University of Liege, CHU Sart Tilman, 4000, Liege, Belgium
Cancer Immunol Immunother 58:603-14. 2009.... - Effects of glucocorticoids on the respiratory burst of Chlamydia-primed THP-1 cellsAnge Mouithys-Mickalad
Centre for Oxygen, Research and Development CORD, Institut de Chimie, B6a, University of Liege, Sart Tilman, 4000 Liege, Belgium
Biochem Biophys Res Commun 318:941-8. 2004..On the expression of p22(phox), a protein subunit of the NADPH oxidase, HCT had an increasing and MPL a decreasing effect. Glucocorticoids thus had unexpected effects on the inflammatory response of Chlamydia-primed monocytes... - New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritisMichelle Deberg
Bone and Cartilage Research Unit, , Sart Tilman, , Belgium
Osteoarthritis Cartilage 13:258-65. 2005..Further, these markers could be helpful for monitoring the effects of anti-inflammatory or antioxidant drugs on cartilage degradation... - The L1 major capsid protein of HPV16 differentially modulates APC trafficking according to the vaccination or natural infection contextLudivine Herman
Department of Experimental Pathology, University Hospital of Liege, CHU Sart Tilman, Liege, Belgium
Eur J Immunol 40:3075-84. 2010..Taken together, our data demonstrate that HPV16 VLP may differentially regulate the immune protective response according to their target cells... - Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysisFlorent Richy
Faculty of Medicine, Department of Public Health, Public Health and Epidemiology, , , Belgium
Arch Intern Med 163:1514-22. 2003.... - Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expressionVirginie Lamour
Metastasis Research Laboratory, Center of Experimental Cancer Research and Bone and Cartilage Metabolism Research Unit, University of Liege, 4000 Liege, Belgium
J Biol Chem 282:36240-9. 2007....