Affiliation: Hasselt University
Vangansewinkel T, Lemmens S, Geurts N, Quanten K, Dooley D, Pejler G, et al
. Mouse mast cell protease 4 suppresses scar formation after traumatic spinal cord injury. Sci Rep. 2019;9:3715 pubmed publisher
..Therefore, we suggest a new mechanism via which endogenous mMCP4 can improve recovery after SCI. ..
Sommer D, Corstjens I, Sanchez S, Dooley D, Lemmens S, Van Broeckhoven J, et al
. ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury. Brain Behav Immun. 2019;: pubmed publisher
..These data indicate that ADAM17 expression on microglia cells (and not on macrophages or endothelial cells) plays a detrimental role in inflammation and functional recovery after SCI. ..
Geurts N, Vangansewinkel T, Lemmens S, Nelissen S, Geboes L, Schwartz C, et al
. Basophils are dispensable for the recovery of gross locomotion after spinal cord hemisection injury. J Leukoc Biol. 2016;99:579-82 pubmed publisher
Dooley D, Lemmens E, Ponsaerts P, Hendrix S. Interleukin-25 is detrimental for recovery after spinal cord injury in mice. J Neuroinflammation. 2016;13:101 pubmed publisher
..Our findings question the potential neuroprotective role of IL-25 following CNS trauma. ..
Lemmens S, Kusters L, Bronckaers A, Geurts N, Hendrix S. The ?2-Adrenoceptor Agonist Terbutaline Stimulates Angiogenesis via Akt and ERK Signaling. J Cell Physiol. 2017;232:298-308 pubmed publisher
..J. Cell. Physiol. 232: 298-308, 2017. © 2016 Wiley Periodicals, Inc. ..
Dooley D, Lemmens E, Vangansewinkel T, Le Blon D, Hoornaert C, Ponsaerts P, et al
. Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury. Stem Cell Reports. 2016;7:1099-1115 pubmed publisher
..Our data provide evidence that transplantation of MSC/IL-13 leads to improved functional and histopathological recovery in a mouse model of SCI. ..
Schönfeld L, Dooley D, Jahanshahi A, Temel Y, Hendrix S. Evaluating rodent motor functions: Which tests to choose?. Neurosci Biobehav Rev. 2017;83:298-312 pubmed publisher
..We also critically evaluate current methods and provide recommendations for choosing the best behavioral test for a new research line. ..
Hendrix S, Kramer P, Pehl D, Warnke K, Boato F, Nelissen S, et al
. Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4. FASEB J. 2013;27:920-9 pubmed publisher
..These data suggest that MCs exert protective functions after trauma, at least in part via mMCP-4, by suppressing exacerbated inflammation via their proteases. ..
Nelissen S, Vangansewinkel T, Geurts N, Geboes L, Lemmens E, Vidal P, et al
. Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4. Neurobiol Dis. 2014;62:260-72 pubmed publisher
..These data show for the first time that MCs may be protective after spinal cord injury and that they may reduce CNS damage by degrading inflammation-associated cytokines via the MC-specific chymase mMCP4. ..