Sven Hendrix


Affiliation: Hasselt University
Country: Belgium


  1. Vangansewinkel T, Lemmens S, Geurts N, Quanten K, Dooley D, Pejler G, et al. Mouse mast cell protease 4 suppresses scar formation after traumatic spinal cord injury. Sci Rep. 2019;9:3715 pubmed publisher
    ..Therefore, we suggest a new mechanism via which endogenous mMCP4 can improve recovery after SCI. ..
  2. Sommer D, Corstjens I, Sanchez S, Dooley D, Lemmens S, Van Broeckhoven J, et al. ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury. Brain Behav Immun. 2019;: pubmed publisher
    ..These data indicate that ADAM17 expression on microglia cells (and not on macrophages or endothelial cells) plays a detrimental role in inflammation and functional recovery after SCI. ..
  3. Geurts N, Vangansewinkel T, Lemmens S, Nelissen S, Geboes L, Schwartz C, et al. Basophils are dispensable for the recovery of gross locomotion after spinal cord hemisection injury. J Leukoc Biol. 2016;99:579-82 pubmed publisher
  4. Dooley D, Lemmens E, Ponsaerts P, Hendrix S. Interleukin-25 is detrimental for recovery after spinal cord injury in mice. J Neuroinflammation. 2016;13:101 pubmed publisher
    ..Our findings question the potential neuroprotective role of IL-25 following CNS trauma. ..
  5. Lemmens S, Kusters L, Bronckaers A, Geurts N, Hendrix S. The ?2-Adrenoceptor Agonist Terbutaline Stimulates Angiogenesis via Akt and ERK Signaling. J Cell Physiol. 2017;232:298-308 pubmed publisher
    ..J. Cell. Physiol. 232: 298-308, 2017. © 2016 Wiley Periodicals, Inc. ..
  6. Dooley D, Lemmens E, Vangansewinkel T, Le Blon D, Hoornaert C, Ponsaerts P, et al. Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury. Stem Cell Reports. 2016;7:1099-1115 pubmed publisher
    ..Our data provide evidence that transplantation of MSC/IL-13 leads to improved functional and histopathological recovery in a mouse model of SCI. ..
  7. Schönfeld L, Dooley D, Jahanshahi A, Temel Y, Hendrix S. Evaluating rodent motor functions: Which tests to choose?. Neurosci Biobehav Rev. 2017;83:298-312 pubmed publisher
    ..We also critically evaluate current methods and provide recommendations for choosing the best behavioral test for a new research line. ..
  8. Hendrix S, Kramer P, Pehl D, Warnke K, Boato F, Nelissen S, et al. Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4. FASEB J. 2013;27:920-9 pubmed publisher
    ..These data suggest that MCs exert protective functions after trauma, at least in part via mMCP-4, by suppressing exacerbated inflammation via their proteases. ..
  9. Nelissen S, Vangansewinkel T, Geurts N, Geboes L, Lemmens E, Vidal P, et al. Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4. Neurobiol Dis. 2014;62:260-72 pubmed publisher
    ..These data show for the first time that MCs may be protective after spinal cord injury and that they may reduce CNS damage by degrading inflammation-associated cytokines via the MC-specific chymase mMCP4. ..

More Information


  1. Vangansewinkel T, Geurts N, Quanten K, Nelissen S, Lemmens S, Geboes L, et al. Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6. FASEB J. 2016;30:2040-57 pubmed publisher
    ..Geurts, N., Quanten, K., Nelissen, S., Lemmens, S., Geboes, L., Dooley, D., Vidal, P. M., Pejler, G., Hendrix, S. Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6. ..