Damien Gruson

Summary

Country: Belgium

Publications

  1. ncbi request reprint Measurement of Galectin-3 with the ARCHITECT assay: Clinical validity and cost-effectiveness in patients with heart failure
    D Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium Department of laboratory medicine, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium Electronic address
    Clin Biochem 47:1006-9. 2014
  2. ncbi request reprint PTH: Potential role in management of heart failure
    D Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium Department of laboratory medicine, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium Electronic address
    Clin Chim Acta 433:290-6. 2014
  3. doi request reprint Galectin-3 testing: validity of a novel automated assay in heart failure patients with reduced ejection fraction
    D Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium Department of laboratory medicine, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium Electronic address
    Clin Chim Acta 429:189-93. 2014
  4. ncbi request reprint Value of proBNP1-108 testing for the risk stratification of patients with systolic heart failure
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium Department of laboratory medicine, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium Electronic address
    Peptides 50:125-8. 2013
  5. ncbi request reprint Comparison between intact and bioactive parathyroid hormone assays in patients with severe heart failure
    D Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Clin Biochem 46:391-4. 2013
  6. doi request reprint Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Peptides 33:351-3. 2012
  7. doi request reprint Increased circulating concentrations of bioactive PTH 1-84 in patients with heart failure
    D Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium
    J Endocrinol Invest 35:987-91. 2012
  8. doi request reprint Head-to-head comparison of the prohormone proBNP1-108 with BNP and Nt-proBNP in patients admitted to emergency department
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Clin Biochem 45:249-52. 2012
  9. ncbi request reprint Impact of growth hormone (GH) treatment on circulating Nt-proBNP concentrations and on cardiac function in adult GH-deficient patients
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Scand J Clin Lab Invest 72:387-94. 2012
  10. ncbi request reprint C-terminal FGF23 is a strong predictor of survival in systolic heart failure
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Peptides 37:258-62. 2012

Detail Information

Publications32

  1. ncbi request reprint Measurement of Galectin-3 with the ARCHITECT assay: Clinical validity and cost-effectiveness in patients with heart failure
    D Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium Department of laboratory medicine, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium Electronic address
    Clin Biochem 47:1006-9. 2014
    ..Our objectives were to determine the clinical validity and cost-effectiveness of the recently developed ARCHITECT Gal-3 automated immunoassay...
  2. ncbi request reprint PTH: Potential role in management of heart failure
    D Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium Department of laboratory medicine, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium Electronic address
    Clin Chim Acta 433:290-6. 2014
    ..As secondary hyperparathyroidism has been evidenced in HF patients, PTH testing might be relevant in HF patients for risk stratification and more personalized selection of treatment. ..
  3. doi request reprint Galectin-3 testing: validity of a novel automated assay in heart failure patients with reduced ejection fraction
    D Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium Department of laboratory medicine, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium Electronic address
    Clin Chim Acta 429:189-93. 2014
    ..Therefore, our data are also supporting the clinical validity of the Gal-3 automated assay...
  4. ncbi request reprint Value of proBNP1-108 testing for the risk stratification of patients with systolic heart failure
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium Department of laboratory medicine, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium Electronic address
    Peptides 50:125-8. 2013
    ..Our study therefore demonstrated that high levels of proBNP1-108, measured with an assay with enhanced analytical specificity, are related to the long-term risk of cardiovascular death in systolic heart failure. ..
  5. ncbi request reprint Comparison between intact and bioactive parathyroid hormone assays in patients with severe heart failure
    D Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Clin Biochem 46:391-4. 2013
    ..The aim of our study was to compare intact and bioactive PTH assays in patients with severe heart failure...
  6. doi request reprint Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Peptides 33:351-3. 2012
    ..This effect was associated with a twofold increase of Mstn gene expression. We have established for the first time that the two hypertrophic peptides UII and UCN stimulate the expression of Mstn...
  7. doi request reprint Increased circulating concentrations of bioactive PTH 1-84 in patients with heart failure
    D Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium
    J Endocrinol Invest 35:987-91. 2012
    ....
  8. doi request reprint Head-to-head comparison of the prohormone proBNP1-108 with BNP and Nt-proBNP in patients admitted to emergency department
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Clin Biochem 45:249-52. 2012
    ..We determined proBNP concentrations in patients admitted to ED and suspected of CHF...
  9. ncbi request reprint Impact of growth hormone (GH) treatment on circulating Nt-proBNP concentrations and on cardiac function in adult GH-deficient patients
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Scand J Clin Lab Invest 72:387-94. 2012
    ..These results suggest that Nt-proBNP may appear as a biomarker of GH status and GH treatment efficiency...
  10. ncbi request reprint C-terminal FGF23 is a strong predictor of survival in systolic heart failure
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Peptides 37:258-62. 2012
    ..In a multivariate analysis including age, EF, PTH, BNP, Ct-FGF23, calcium, phosphorus and eGFR levels, Ct-FGF23 is the strongest predictor of long term CV death...
  11. doi request reprint Galectins testing: new promises for the diagnosis and risk stratification of chronic diseases?
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Clin Biochem 45:719-26. 2012
    ....
  12. ncbi request reprint Biomarkers of inflammation and cardiac remodeling: the quest of relevant companions for the risk stratification of heart failure patients is still ongoing
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Biochem Med (Zagreb) 21:254-63. 2011
    ..However, before their potential translation to routine parameters several challenges ranging form the analytical validation to the cost-effectiveness estimation should be considered...
  13. doi request reprint Urocortin-induced cardiomyocytes hypertrophy is associated with regulation of the GSK-3β pathway
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Tour Claude Bernard, 54 Avenue Hippocrate, 1200 Brussels, Belgium
    Heart Vessels 27:202-7. 2012
    ..Furthermore, the pharmacological blockade of UCN receptors was able to prevent UCN-induced hypertrophy, which leads to inhibition of the Akt/GSK-3β pathway...
  14. doi request reprint Measurement of NT-proBNP with LOCI technology in heart failure patients
    D Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Clin Biochem 45:171-4. 2012
    ..The aim of our study was to determine NT-proBNP concentrations in heart failure (HF) patients with a luminescent oxygen channeling immunoassay (LOCI)...
  15. doi request reprint Diagnosing destabilized heart failure in the emergency setting: current and future biomarker tests
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Mol Diagn Ther 15:327-40. 2011
    ..The aim of this review article is to discuss and evaluate the clinical usefulness of both recognized and potential new biomarker tests for use in heart failure...
  16. doi request reprint Circulating levels of stress associated peptide Urocortin in heart failure patients
    D Gruson
    Unit of Diabetes and Nutrition, Cliniques Universitaires St Luc, Brussels, Belgium
    Peptides 31:354-6. 2010
    ..Our results demonstrate that plasma concentrations of UCN are significantly increased in patients with HF and that UCN may participate in the neurohumoral response of HF...
  17. ncbi request reprint Urotensin II induction of adult cardiomyocytes hypertrophy involves the Akt/GSK-3beta signaling pathway
    D Gruson
    Universite Catholique de Louvain, Unit of Diabetes and Nutrition, B 1200 Brussels, Belgium
    Peptides 31:1326-33. 2010
    ..All these effects are abolished by competitive inhibition of the UII receptor, consistent with new therapeutic perspectives for heart failure treatment...
  18. doi request reprint Raised plasma urotensin II in type 2 diabetes patients is associated with the metabolic syndrome phenotype
    Damien Gruson
    Endocrinology and Nutrition Unit, Universite Catholique de Louvain, Tour Claude Bernard, 54 Avenue Hippocrate, Brussels, Belgium
    J Clin Hypertens (Greenwich) 12:653-60. 2010
    ..02). UII plasma concentrations are significantly higher in T2DM patients presenting with MetS. Therefore, circulating UII may participate in the worsening course of some T2DM patients and may provide novel therapeutic perspectives...
  19. ncbi request reprint Automated immunoassay for reliable measurement of sex hormone binding globulin (SHBG)
    D Gruson
    Department of Laboratory Medicine, Cliniques Universitaires St Luc, 1200 Brussels, Belgium
    Clin Lab 57:87-90. 2011
    ..Sex hormone binding globulin (SHBG) is important for the transport and regulation of distribution of sex steroids...
  20. doi request reprint Increased plasma myostatin in heart failure
    Damien Gruson
    Department of Laboratory Medicine, Cliniques Universitaires St Luc, Tour Rosalyn Franklin, avenue E Mounier, Brussels, Belgium
    Eur J Heart Fail 13:734-6. 2011
    ..The aim of our study was to measure Mstn plasma concentrations in patients with congestive heart failure (CHF) and to evaluate their relationship with other neurohormones released in CHF...
  21. ncbi request reprint Laboratory medicine: the precursors strike back
    D Gruson
    Department of Laboratory Medicine, Cliniques Universitaires St Luc, Brussels, Belgium
    Acta Clin Belg 66:216-20. 2011
    ..The goal of this short review is to discuss some perspectives related to some analytes' precursors that have recently been evidenced to affect assay specificity or increase assay discriminatory power...
  22. doi request reprint Accuracy of N-terminal-pro-atrial natriuretic peptide in patients admitted to emergency department
    Damien Gruson
    Diabetes and Nutrition Unit, Cliniques Universitaires St Luc, Brussels, Belgium
    Scand J Clin Lab Invest 68:410-4. 2008
    ..The aim of our study was to determine the accuracy of N-terminal-pro-ANP (Nt-proANP) in such patients...
  23. doi request reprint Multimarker panel in patients admitted to emergency department: a comparison with reference methods
    Damien Gruson
    Department of Endocrinology and Nutrition, Unit of Diabetes and Nutrition, Cliniques Universitaires St Luc, Brussels, Belgium
    Clin Biochem 42:185-8. 2009
    ..Point of care testing and multimarker panels are rapidly expanding in emergency departments. We determined the reliability of Short-of-Breath SOB panel in patients admitted for acute dyspnea and/or chest pain...
  24. doi request reprint The impact of confounders on the test performance of natriuretic peptides for cardiac dysfunction in subjects aged 80 and older
    Bert Vaes
    Institut de Recherche Santé et Société, Universite Catholique de Louvain UCL, Brussels, Belgium
    Peptides 38:118-26. 2012
    ..Stratifying for individual confounders showed that different cut-off values could be used to optimize the diagnostic characteristics of natriuretic peptides...
  25. doi request reprint The prognostic value of pro-B-Type natriuretic peptide in acute pulmonary embolism
    Franck Verschuren
    Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Acute Medicine Departement, Accidents and Emergency Unit, Brussel, Belgium
    Thromb Res 131:e235-9. 2013
    ..To assess the clinical performance of pro-B-type natriuretic peptide 1-108 (proBNP) for the prognosis of acute pulmonary embolism...
  26. pmc Serum calcitonin estimation in medullary thyroid cancer: basal or stimulated levels?
    Chantal Daumerie
    Department of Endocrinology, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium
    Thyroid Res 6:S4. 2013
    ..As stimulated Ca test will eventually replace the pentagastrin test, there is a need to confirm or to modify the threshold identified for each assay individually...
  27. doi request reprint Reduction of miscarriages through universal screening and treatment of thyroid autoimmune diseases
    Thibault Lepoutre
    Department of Endocrinology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Gynecol Obstet Invest 74:265-73. 2012
    ..The aim of our study was to assess the rationale behind universal screening and propose thyroxine treatment in particular cases...
  28. ncbi request reprint TSH-assay interference: still with us
    Laurence Verdickt
    Department of Laboratory Medicine, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Clin Lab 58:1305-7. 2012
    ..Furthermore, the effective tracking of interferences with immunoassays is dependent on multidisciplinary collaboration and requires continuing cross-talk between physicians and laboratory staff...
  29. doi request reprint What are the characteristics of phenotypic type 2 diabetic patients with low-titer GAD65 antibodies?
    Yovan P Mahadeb
    Service d endocrinologie et nutrition, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Avenue Hippocrate UCL 54 74, 1200, Brussels, Belgium
    Acta Diabetol 51:103-11. 2014
    ....
  30. doi request reprint Quantification of serum free light chain kappa and lambda by the SPAPLUS analyser
    Diane Maisin
    Department of Clinical Chemistry, Cliniques Universitaires Saint Luc and Université catholique de Louvain, Brussels, Belgium
    Clin Biochem 46:622-6. 2013
    ..Clinical assessment of the SPAPLUS® system for the determination of the serum free light chains kappa (κ FLC) and lambda (λ FLC) compared to the BNII®...
  31. doi request reprint Is there a place for bone turnover markers in the assessment of osteoporosis and its treatment?
    Jean Pierre Devogelaer
    Division of Rheumatology and Rheumatology Unit, Department of Medicine, UCL 5390, Université Catholique de Louvain in Brussels, Saint Luc University Hospital, Avenue Hippocrate 10, B 1200 Brussels, Belgium
    Rheum Dis Clin North Am 37:365-86, v-vi. 2011
    ..Whether this behavior is cost-effective remains to be settled...
  32. ncbi request reprint Circulating urotensin II levels in moderate to severe congestive heart failure: its relations with myocardial function and well established neurohormonal markers
    D Gruson
    Unit of Diabetes and Nutrition, Catholic University of Louvain, Tour Claude Bernard, 54 Avenue Hippocrate, B 1200 Brussels, Belgium
    Peptides 27:1527-31. 2006
    ..42, p = 0.005) but poorly with Nt-proANP (r = 0.28, p = 0.07). Our results suggest that UII could play a role in worsening the course of congestive heart failure and is associated with established markers of cardiovascular dysfunction...