Albert Goldbeter

Summary

Country: Belgium

Publications

  1. ncbi request reprint A model for the dynamics of human weight cycling
    Albert Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, Brussels, Belgium
    J Biosci 31:129-36. 2006
  2. doi request reprint A model for the dynamics of bipolar disorders
    Albert Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, CP 231, B 1050 Brussels, Belgium
    Prog Biophys Mol Biol 105:119-27. 2011
  3. pmc From quiescence to proliferation: Cdk oscillations drive the mammalian cell cycle
    Claude Gérard
    Faculte des Sciences, Universite Libre de Bruxelles ULB, Campus Plaine Brussels, Belgium
    Front Physiol 3:413. 2012
  4. pmc Entrainment of the mammalian cell cycle by the circadian clock: modeling two coupled cellular rhythms
    Claude Gérard
    Faculte des Sciences, Universite Libre de Bruxelles ULB, Campus Plaine, CP 231, Brussels, Belgium
    PLoS Comput Biol 8:e1002516. 2012
  5. doi request reprint Oscillatory enzyme reactions and Michaelis-Menten kinetics
    Albert Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles ULB, Campus Plaine, CP 231, B 1050 Brussels, Belgium
    FEBS Lett 587:2778-84. 2013
  6. doi request reprint Origin of cyclicity in bipolar disorders: a computational approach
    A Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Brussels, Belgium
    Pharmacopsychiatry 46:S44-52. 2013
  7. doi request reprint Systems biology of cellular rhythms
    A Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles ULB, Campus Plaine, CP 231, B 1050 Brussels, Belgium
    FEBS Lett 586:2955-65. 2012
  8. doi request reprint Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways
    Albert Goldbeter
    Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    J Theor Biol 252:574-85. 2008
  9. ncbi request reprint Oscillations and waves of cyclic AMP in Dictyostelium: a prototype for spatio-temporal organization and pulsatile intercellular communication
    Albert Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050, Brussels, Belgium
    Bull Math Biol 68:1095-109. 2006
  10. ncbi request reprint Computational biology: a propagating wave of interest
    Albert Goldbeter
    Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    Curr Biol 14:R601-2. 2004

Detail Information

Publications41

  1. ncbi request reprint A model for the dynamics of human weight cycling
    Albert Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, Brussels, Belgium
    J Biosci 31:129-36. 2006
    ..Maintaining weight under a critical value should prevent weight cycling and allow body weight to stabilize below the oscillatory range...
  2. doi request reprint A model for the dynamics of bipolar disorders
    Albert Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, CP 231, B 1050 Brussels, Belgium
    Prog Biophys Mol Biol 105:119-27. 2011
    ..The model accounts for the clinical observation that antidepressants can trigger the transition to mania or increase the frequency of bipolar cycling...
  3. pmc From quiescence to proliferation: Cdk oscillations drive the mammalian cell cycle
    Claude Gérard
    Faculte des Sciences, Universite Libre de Bruxelles ULB, Campus Plaine Brussels, Belgium
    Front Physiol 3:413. 2012
    ..We compare the relative merits of the detailed and skeleton versions of the model for the Cdk network driving the mammalian cell cycle...
  4. pmc Entrainment of the mammalian cell cycle by the circadian clock: modeling two coupled cellular rhythms
    Claude Gérard
    Faculte des Sciences, Universite Libre de Bruxelles ULB, Campus Plaine, CP 231, Brussels, Belgium
    PLoS Comput Biol 8:e1002516. 2012
    ..The model predicts that the transition from entrainment to 24 h or 48 h might occur when the strength of coupling to the circadian clock or the level of growth factor decrease below critical values...
  5. doi request reprint Oscillatory enzyme reactions and Michaelis-Menten kinetics
    Albert Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles ULB, Campus Plaine, CP 231, B 1050 Brussels, Belgium
    FEBS Lett 587:2778-84. 2013
    ....
  6. doi request reprint Origin of cyclicity in bipolar disorders: a computational approach
    A Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Brussels, Belgium
    Pharmacopsychiatry 46:S44-52. 2013
    ....
  7. doi request reprint Systems biology of cellular rhythms
    A Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles ULB, Campus Plaine, CP 231, B 1050 Brussels, Belgium
    FEBS Lett 586:2955-65. 2012
    ..Finally we discuss the coupling between cellular rhythms and their robustness with respect to molecular noise...
  8. doi request reprint Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways
    Albert Goldbeter
    Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    J Theor Biol 252:574-85. 2008
    ..The model provides a framework for analyzing the dynamics of the segmentation clock in terms of a network of oscillating modules involving the Wnt, Notch and FGF signaling pathways...
  9. ncbi request reprint Oscillations and waves of cyclic AMP in Dictyostelium: a prototype for spatio-temporal organization and pulsatile intercellular communication
    Albert Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050, Brussels, Belgium
    Bull Math Biol 68:1095-109. 2006
    ....
  10. ncbi request reprint Computational biology: a propagating wave of interest
    Albert Goldbeter
    Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    Curr Biol 14:R601-2. 2004
  11. doi request reprint [Circadian rhythms and systems biology]
    Albert Goldbeter
    Unite de Chronobiologie theorique, Universite Libre de Bruxelles, Campus Plaine, CP 231, B 1050 Bruxelles, Belgique
    Med Sci (Paris) 26:49-56. 2010
    ..For circadian rhythms and the cell cycle, as for other recently observed cellular rhythms, periodic behavior represents an emergent property of biological systems related to their regulatory structure...
  12. ncbi request reprint Time-patterned drug administration: insights from a modeling approach
    Albert Goldbete
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Brussels, Belgium
    Chronobiol Int 19:157-75. 2002
    ..We discuss the implications of modeling studies to improve the temporal patterning of drug administration...
  13. ncbi request reprint Circadian rhythms and molecular noise
    Didier Gonze
    Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    Chaos 16:026110. 2006
    ..Intercellular coupling further increases the robustness of circadian oscillations...
  14. ncbi request reprint Stochastic models for circadian rhythms: effect of molecular noise on periodic and chaotic behaviour
    Didier Gonze
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, CP 231, B1050 Brussels, Belgium
    C R Biol 326:189-203. 2003
    ....
  15. pmc Toward a detailed computational model for the mammalian circadian clock
    Jean Christophe Leloup
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    Proc Natl Acad Sci U S A 100:7051-6. 2003
    ....
  16. doi request reprint Effect of positive feedback loops on the robustness of oscillations in the network of cyclin-dependent kinases driving the mammalian cell cycle
    Claude Gérard
    Faculte des Sciences, Universite Libre de Bruxelles ULB, Belgium
    FEBS J 279:3411-31. 2012
    ....
  17. doi request reprint Identifying mechanisms of chronotolerance and chronoefficacy for the anticancer drugs 5-fluorouracil and oxaliplatin by computational modeling
    Atilla Altinok
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, Brussels, Belgium
    Eur J Pharm Sci 36:20-38. 2009
    ..Corroborating experimental and clinical results, the simulations of the model account for the observation that the temporal profiles minimizing l-OHP cytotoxicity are in antiphase with those minimizing cytotoxicity for 5-FU...
  18. ncbi request reprint Sharp developmental thresholds defined through bistability by antagonistic gradients of retinoic acid and FGF signaling
    Albert Goldbeter
    Faculte des Sciences, Universite Libre de Bruxelles, U L B, Brussels, Belgium
    Dev Dyn 236:1495-508. 2007
    ..Given that mutually antagonistic signaling gradients are common in development, such bistable switches could represent an important principle underlying embryonic patterning...
  19. doi request reprint Dependence of the period on the rate of protein degradation in minimal models for circadian oscillations
    Claude Gérard
    Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, CP 231, B 1050 Brussels, Belgium
    Philos Trans A Math Phys Eng Sci 367:4665-83. 2009
    ..The analysis allows us to reconcile the contradictory predictions for the dependence of the period on the clock protein degradation rate in three minimal models used to describe circadian rhythms...
  20. doi request reprint Modeling the circadian clock: from molecular mechanism to physiological disorders
    Jean Christophe Leloup
    Faculte des Sciences, Universite Libre de Bruxelles, Belgium
    Bioessays 30:590-600. 2008
    ..It is important to clarify the conditions for entrainment and for its failure because dysfunctions of the circadian clock may lead to physiological disorders, which pertain not only to the sleep-wake cycle but also to mood and cancer...
  21. pmc Stochastic modelling of nucleocytoplasmic oscillations of the transcription factor Msn2 in yeast
    Didier Gonze
    Faculte des Sciences, Universite Libre de Bruxelles ULB, Campus Plaine, Brussels, Belgium
    J R Soc Interface 5:S95-109. 2008
    ....
  22. doi request reprint From simple to complex patterns of oscillatory behavior in a model for the mammalian cell cycle containing multiple oscillatory circuits
    Claude Gérard
    Faculté des Sciences, Université Libre de Bruxelles ULB, Campus Plaine, CP 231, B 1050 Brussels, Belgium
    Chaos 20:045109. 2010
    ....
  23. pmc Temporal self-organization of the cyclin/Cdk network driving the mammalian cell cycle
    Claude Gérard
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    Proc Natl Acad Sci U S A 106:21643-8. 2009
    ....
  24. ncbi request reprint Modeling the mammalian circadian clock: sensitivity analysis and multiplicity of oscillatory mechanisms
    Jean Christophe Leloup
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    J Theor Biol 230:541-62. 2004
    ..The results are discussed in relation to physiological disorders of the sleep-wake cycle linked to perturbations of the human circadian clock, such as the familial advanced sleep phase syndrome or the non-24h sleep-wake syndrome...
  25. ncbi request reprint A model for the enhancement of fitness in cyanobacteria based on resonance of a circadian oscillator with the external light-dark cycle
    Didier Gonze
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, Brussels, B 1050, Belgium
    J Theor Biol 214:577-97. 2002
    ..We also determine the effect of the photoperiod and extend the analysis to the case of a competition between three cyanobacterial strains...
  26. doi request reprint Selection of in-phase or out-of-phase synchronization in a model based on global coupling of cells undergoing metabolic oscillations
    Didier Gonze
    Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, CP 231, B 1050 Brussels, Belgium
    Chaos 18:037127. 2008
    ....
  27. ncbi request reprint Computational approaches to cellular rhythms
    Albert Goldbeter
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, CP 231, B 1050 Brussels, Belgium
    Nature 420:238-45. 2002
    ..Examples ranging from calcium oscillations to pulsatile intercellular communication and circadian rhythms illustrate how computational biology contributes to clarify the molecular and dynamical bases of cellular rhythms...
  28. pmc An automaton model for the cell cycle
    Atilla Altinok
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    Interface Focus 1:36-47. 2011
    ..A simple deterministic model leads to the same steady-state proportions of cells in the four phases of the cell cycle...
  29. ncbi request reprint A cell cycle automaton model for probing circadian patterns of anticancer drug delivery
    Atilla Altinok
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    Adv Drug Deliv Rev 59:1036-53. 2007
    ..m. These results fit well with experimental observations and illustrate how the modeling approach based on the cell cycle automaton may help to predict the cytotoxic effect of anticancer drugs affecting various phases of the cell cycle...
  30. doi request reprint Critical phase shifts slow down circadian clock recovery: implications for jet lag
    Jean Christophe Leloup
    Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, CP 231, B 1050 Brussels, Belgium
    J Theor Biol 333:47-57. 2013
    ..The marked increase in recovery times predicted near the threshold could be responsible for the most severe disturbances of the human circadian clock associated with jet lag. ..
  31. pmc A skeleton model for the network of cyclin-dependent kinases driving the mammalian cell cycle
    Claude Gérard
    Faculte des Sciences, Universite Libre de Bruxelles ULB, Campus Plaine, CP 231, 1050 Brussels, Belgium
    Interface Focus 1:24-35. 2011
    ..We compare the dynamical properties of the skeleton model with those of the more detailed model for the mammalian cell cycle...
  32. pmc Robustness of circadian rhythms with respect to molecular noise
    Didier Gonze
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    Proc Natl Acad Sci U S A 99:673-8. 2002
    ..Entrainment by light/dark cycles and cooperativity in repression enhance the robustness of circadian oscillations with respect to molecular noise...
  33. ncbi request reprint Segmentation clock: insights from computational models
    Olivier Pourquie
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA
    Curr Biol 13:R632-4. 2003
  34. pmc Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiae
    Michel Jacquet
    Laboratoire Information Génétique et Développement, Institut de Genetique et Microbiologie, Centre National de la Recherche Scientifique CNRS UPS UMR 8621, Universite Paris Sud, Orsay, France
    J Cell Biol 161:497-505. 2003
    ..We show that a computational model based on the possibility that Msn2 and Msn4 participate in autoregulatory loops controlling their subcellular localization can account for the oscillatory behavior of the two transcription factors...
  35. doi request reprint Implications of circadian clocks for the rhythmic delivery of cancer therapeutics
    Francis Levi
    INSERM, U776 Rythmes biologiques et cancers, Villejuif 94807, France
    Philos Trans A Math Phys Eng Sci 366:3575-98. 2008
    ..The models showed that additional therapeutic strategy further sets the constraints for the identification of the most effective chronomodulated schedules...
  36. pmc Zero-order switches and developmental thresholds
    Albert Goldbeter
    Mol Syst Biol 1:2005.0031. 2005
  37. pmc A biochemical oscillator explains several aspects of Myxococcus xanthus behavior during development
    Oleg A Igoshin
    Department of Physics, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 101:15760-5. 2004
    ..We also propose experiments to test the model...
  38. ncbi request reprint Nucleocytoplasmic oscillations of the yeast transcription factor Msn2: evidence for periodic PKA activation
    Cecilia Garmendia-Torres
    Universite de Paris Sud, Unite Mixte de Recherche 8621, Centre National de la Recherche Scientifique, Orsay, F 91405, France
    Curr Biol 17:1044-9. 2007
    ..The physiological significance of Msn2 oscillations is discussed in the light of the frequency encoding of cellular rhythms...
  39. pmc Biological switches and clocks
    John J Tyson
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J R Soc Interface 5:S1-8. 2008
    ..We review recent advances in modelling the gene-protein interaction networks that control circadian rhythms, cell cycle progression, signal processing and the design of synthetic gene networks...
  40. ncbi request reprint Development and validation of computational models for mammalian circadian oscillators
    Daniel B Forger
    Courant Institute, New York University, New York, New York, USA
    OMICS 7:387-400. 2003
    ..These studies have the potential to lead to new strategies for resetting the circadian clock. Manipulations of the circadian clock can be used to optimize performance by promoting alertness and physiological synchronization...
  41. ncbi request reprint Amplitude of circadian oscillations entrained by 24-h light-dark cycles
    Gen Kurosawa
    Aihara Complexity Modelling Project, ERATO, Japan Science and Technology Agency, Komaba Open Laboratory, The University of Tokyo, Tokyo, Japan
    J Theor Biol 242:478-88. 2006
    ..We discuss the physiological relevance of these results in regard to the setting of the free-running period of the circadian clock...