- Optimization of a quantitative signal detection algorithm for spontaneous reports of adverse events post immunizationLionel Van Holle
Vaccine Safety Research Group, Vaccine Clinical Safety and Pharmacovigilance, GlaxoSmithKline Biologicals SA, Wavre, Belgium
Pharmacoepidemiol Drug Saf 22:477-87. 2013..To optimize the efficiency of signal detection by maximizing the proportion of true positive (TP) signals among signals detected by a disproportionality algorithm...
- Using time-to-onset for detecting safety signals in spontaneous reports of adverse events following immunization: a proof of concept studyLionel Van Holle
Safety and Observational Database Research, Epidemiology, GlaxoSmithKline Biologicals, Wavre, Belgium
Pharmacoepidemiol Drug Saf 21:603-10. 2012..In these analyses, time-to-onset (TTO; the time between vaccination and the onset of the adverse event) is rarely considered. Our objective is to assess the potential use of TTO to improve signal detection (SD)...
- Signal detection on spontaneous reports of adverse events following immunisation: a comparison of the performance of a disproportionality-based algorithm and a time-to-onset-based algorithmLionel Van Holle
Vaccine Safety Research Group VSRG, Vaccines Clinical Safety and Pharmacovigilance VCSP, GlaxoSmithKline Vaccines, Wavre, Belgium
Pharmacoepidemiol Drug Saf 23:178-85. 2014..Time-to-onset (TTO) methods measure how unexpected the TTO distribution of a vaccine-event pair is compared with what is expected from other vaccines and events. Our purpose is to compare the performance associated with each method...