Stijn Vansteelandt

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. pmc Make the most of your samples: Bayes factor estimators for high-dimensional models of sequence evolution
    Guy Baele
    Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium
    BMC Bioinformatics 14:85. 2013
  2. doi Natural direct and indirect effects on the exposed: effect decomposition under weaker assumptions
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Sciences, Ghent University, Krijgslaan 281 S9, 9000 Ghent, Belgium
    Biometrics 68:1019-27. 2012
  3. doi Causation and causal inference for genetic effects
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Science, Ghent University Krijgslaan, 281 S9, 9000 Ghent, Belgium
    Hum Genet 131:1665-76. 2012
  4. doi On model selection and model misspecification in causal inference
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Sciences, Ghent University, 281 S9 Krijgslaan, 9000 Ghent, Belgium
    Stat Methods Med Res 21:7-30. 2012
  5. pmc Age-disparity, sexual connectedness and HIV infection in disadvantaged communities around Cape Town, South Africa: a study protocol
    Wim Delva
    South African Centre for Epidemiological Modelling and Analysis, Stellenbosch University, 19 Jonkershoek Road, Stellenbosch 7600, South Africa
    BMC Public Health 11:616. 2011
  6. pmc Support vector machine versus logistic regression modeling for prediction of hospital mortality in critically ill patients with haematological malignancies
    T Verplancke
    Department of Intensive Care Medicine, Ghent University Hospital, Faculty of Medicine, Ghent University, Ghent, Belgium
    BMC Med Inform Decis Mak 8:56. 2008
  7. pmc Modelling the ancestral sequence distribution and model frequencies in context-dependent models for primate non-coding sequences
    Guy Baele
    Department of Plant Systems Biology, VIB, B 9052 Ghent, Belgium
    BMC Evol Biol 10:244. 2010
  8. ncbi Sense and sensitivity when correcting for observed exposures in randomized clinical trials
    S Vansteelandt
    Ghent University, Ghent, Belgium
    Stat Med 24:191-210. 2005
  9. ncbi Testing and estimating gene-environment interactions in family-based association studies
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281, S9, B 9000 Gent, Belgium
    Biometrics 64:458-67. 2008
  10. doi Estimating direct effects in cohort and case-control studies
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Sciences, Ghent University, Ghent, Belgium
    Epidemiology 20:851-60. 2009

Detail Information

Publications38

  1. pmc Make the most of your samples: Bayes factor estimators for high-dimensional models of sequence evolution
    Guy Baele
    Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium
    BMC Bioinformatics 14:85. 2013
    ..Most often, each model's marginal likelihood will be estimated individually, which leads the resulting Bayes factor to suffer from errors associated with each of these independent estimation processes...
  2. doi Natural direct and indirect effects on the exposed: effect decomposition under weaker assumptions
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Sciences, Ghent University, Krijgslaan 281 S9, 9000 Ghent, Belgium
    Biometrics 68:1019-27. 2012
    ....
  3. doi Causation and causal inference for genetic effects
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Science, Ghent University Krijgslaan, 281 S9, 9000 Ghent, Belgium
    Hum Genet 131:1665-76. 2012
    ..In this contribution, we will reflect on this and motivate, through illustrative examples, where insights from the causal inference literature may help to understand and correct for typical biases in genetic effect estimates...
  4. doi On model selection and model misspecification in causal inference
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Sciences, Ghent University, 281 S9 Krijgslaan, 9000 Ghent, Belgium
    Stat Methods Med Res 21:7-30. 2012
    ....
  5. pmc Age-disparity, sexual connectedness and HIV infection in disadvantaged communities around Cape Town, South Africa: a study protocol
    Wim Delva
    South African Centre for Epidemiological Modelling and Analysis, Stellenbosch University, 19 Jonkershoek Road, Stellenbosch 7600, South Africa
    BMC Public Health 11:616. 2011
    ....
  6. pmc Support vector machine versus logistic regression modeling for prediction of hospital mortality in critically ill patients with haematological malignancies
    T Verplancke
    Department of Intensive Care Medicine, Ghent University Hospital, Faculty of Medicine, Ghent University, Ghent, Belgium
    BMC Med Inform Decis Mak 8:56. 2008
    ....
  7. pmc Modelling the ancestral sequence distribution and model frequencies in context-dependent models for primate non-coding sequences
    Guy Baele
    Department of Plant Systems Biology, VIB, B 9052 Ghent, Belgium
    BMC Evol Biol 10:244. 2010
    ....
  8. ncbi Sense and sensitivity when correcting for observed exposures in randomized clinical trials
    S Vansteelandt
    Ghent University, Ghent, Belgium
    Stat Med 24:191-210. 2005
    ..We use the results to estimate the causal effect of observed exposure on successful blood pressure reduction in a randomized controlled clinical trial with partial non-compliance...
  9. ncbi Testing and estimating gene-environment interactions in family-based association studies
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281, S9, B 9000 Gent, Belgium
    Biometrics 64:458-67. 2008
    ..Simulation studies show that the proposed methodology is sufficiently powered for realistic sample sizes and that it provides valid tests and effect size estimators in the presence of admixture and stratification...
  10. doi Estimating direct effects in cohort and case-control studies
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Sciences, Ghent University, Ghent, Belgium
    Epidemiology 20:851-60. 2009
    ..In addition, I propose a powerful and easy-to-apply alternative that uses G-estimation in structural nested models to address these limitations both for cohort and case-control studies...
  11. doi Invited commentary: G-computation--lost in translation?
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281, Ghent, Belgium
    Am J Epidemiol 173:739-42. 2011
    ..They further propose a compromise approach, doubly robust standardization, that combines the benefits of both of these causal inference techniques and is not more difficult to implement...
  12. doi Marginal structural models for partial exposure regimes
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Science, Ghent University, Ghent, Belgium
    Biostatistics 10:46-59. 2009
    ..These describe the effect on the hazard of death of acquiring infection on a given day s, versus not acquiring infection "up to that day," had patients stayed in the ICU for at least s days...
  13. pmc A doubly robust test for gene-environment interaction in family-based studies of affected offspring
    Beatrijs Moerkerke
    Department of Data Analysis, Ghent University, Henri Dunantlaan 1, Ghent, Belgium
    Biostatistics 11:213-25. 2010
    ..It extends the FBAT-I to allow for missing parental mating types and families of arbitrary size. Simulation studies and the analysis of an Alzheimer's disease study confirm the adequate performance of the proposed test...
  14. doi Attributable mortality of ventilator-associated pneumonia: a reappraisal using causal analysis
    Maarten Bekaert
    Department of Applied Mathematics and Computer Sciences, Ghent University, Ghent, Belgium
    Am J Respir Crit Care Med 184:1133-9. 2011
    ..Measuring the attributable mortality of ventilator-associated pneumonia (VAP) is challenging and prone to different forms of bias. Studies addressing this issue have produced variable and controversial results...
  15. doi On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Sciences, Ghent University, Belgium
    Genet Epidemiol 33:394-405. 2009
    ..The principle is illustrated by an application to three genome-wide association analyses...
  16. ncbi Conditional generalized estimating equations for the analysis of clustered and longitudinal data
    Sylvie Goetgeluk
    Department of Applied Mathematics and Computer Sciences, Ghent University, Krijgslaan 281 S9, 9000 Ghent, Belgium
    Biometrics 64:772-80. 2008
    ..Under nonlinear models, this approach may yield inconsistent and inefficient estimators, though with little bias in most practical settings...
  17. doi Adjusting for time-varying confounding in the subdistribution analysis of a competing risk
    Maarten Bekaert
    Department of Applied Mathematics and Computer Science, Ghent University, Ghent, Belgium
    Lifetime Data Anal 16:45-70. 2010
    ..The methods are used to quantify the causal effect of nosocomial pneumonia on ICU mortality using data from the National Surveillance Study of Nosocomial Infections in ICU's (Belgium)...
  18. pmc Context-dependent codon partition models provide significant increases in model fit in atpB and rbcL protein-coding genes
    Guy Baele
    Department of Plant Systems Biology, Ghent, Belgium
    BMC Evol Biol 11:145. 2011
    ..Given that empirical research has provided indications of context-dependent substitution patterns at four-fold degenerate sites, we take those indications into account in this paper...
  19. doi A model-based approach to study nearest-neighbor influences reveals complex substitution patterns in non-coding sequences
    Guy Baele
    Department of Applied Mathematics and Computer Science, Ghent University, Ghent, Belgium
    Syst Biol 57:675-92. 2008
    ....
  20. pmc Preterm birth in twins after subfertility treatment: population based cohort study
    Hans Verstraelen
    Department of Obstetrics and Gynaecology, Ghent University Hospital 1P3, De Pintelaan, B 9000 Ghent, Belgium
    BMJ 331:1173. 2005
    ..To assess gestational length and prevalence of preterm birth among medically and naturally conceived twins; to establish the role of zygosity and chorionicity in assessing gestational length in twins born after subfertility treatment...
  21. ncbi Should we adjust for gestational age when analysing birth weights? The use of z-scores revisited
    Ilse Delbaere
    Department of Obstetrics and Gynaecology, Ghent University, De Pintelaan 185, B 9000 Ghent, Belgium
    Hum Reprod 22:2080-3. 2007
    ..g. single-embryo transfer (SET) versus double-embryo transfer (DET)] to birth weight, may induce bias, regardless of whether the adjustment happens via stratification, regression or through the use of z-scores...
  22. doi Psychological well-being and socio-economic hardship among AIDS orphans and other vulnerable children in Guinea
    Wim Delva
    International Centre for Reproductive Health, Ghent University, Ghent, Belgium
    AIDS Care 21:1490-8. 2009
    ..This situation calls for sustainable and holistic approaches to ensure the psychological and socio-economic stability of AIDS orphans and other vulnerable children...
  23. doi HIV testing and sexually transmitted infection care among sexually active youth in the Balkans
    Wim Delva
    International Centre for Reproductive Health, Ghent University, Ghent, Belgium
    AIDS Patient Care STDS 22:817-21. 2008
    ..Practical and psychological factors seem to challenge the accessibility of facilities for HIV testing and STI care...
  24. ncbi Sexual behaviour and contraceptive use among youth in the Balkans
    W Delva
    International Centre for Reproductive Health, University Hospital 2K3, De Pintelaan, 185, B 9000 Ghent, Belgium
    Eur J Contracept Reprod Health Care 12:309-16. 2007
    ..To assess sexual and health seeking behaviour related to contraception among high school students in Bosnia (Sarajevo), the FYR of Macedonia (Skopje), and Serbia and Montenegro (Belgrade and Podgorica)...
  25. doi Predictability of cerebral palsy in a high-risk NICU population
    E Himpens
    Ghent University, Belgium
    Early Hum Dev 86:413-7. 2010
    ..This study aims to create a predictive model for the assessment of the individual risk of developing cerebral palsy in a large cohort of selected high-risk infants...
  26. doi The decline of serum testosterone levels in community-dwelling men over 70 years of age: descriptive data and predictors of longitudinal changes
    B Lapauw
    Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
    Eur J Endocrinol 159:459-68. 2008
    ..This study was designed to assess longitudinal changes in serum testosterone levels, explore relationships with aging, genetic-, health-, and lifestyle-related factors, and investigate predictors of changes in healthy elderly men...
  27. doi Human chorionic gonadotropin levels in early IVF/ICSI pregnancies are higher in singletons after single embryo transfer compared with singletons after double embryo transfer
    I Delbaere
    Department of Obstetrics and Gynaecology, Ghent University, De Pintelaan 185 B 9000, Gent, Belgium
    Hum Reprod 23:2421-6. 2008
    ..The aim of this study is to assess differences in human chorionic gonadotropin (hCG) values between singleton IVF/ICSI pregnancies after elective single (eSET) versus double embryo transfer (DET)...
  28. doi Using non-reversible context-dependent evolutionary models to study substitution patterns in primate non-coding sequences
    Guy Baele
    Department of Plant Systems Biology, VIB, Ghent University, Technologiepark 927, 9052, Ghent, Belgium
    J Mol Evol 71:34-50. 2010
    ..Further, we show that further improvements are possible by clustering similar parameters across contexts...
  29. doi Serial measurements of mesothelioma serum biomarkers in asbestos-exposed individuals: a prospective longitudinal cohort study
    Kevin Hollevoet
    Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    J Thorac Oncol 6:889-95. 2011
    ..This study aims to examine the longitudinal behavior of SM and MPF in controls to gain insight in the optimal use of these biomarkers in screening...
  30. doi Effect decomposition in the presence of an exposure-induced mediator-outcome confounder
    Tyler J VanderWeele
    From the aDepartments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA and bDepartment of Applied Mathematics, Computer Science, and Statistics, University of Ghent, Ghent, Belgium
    Epidemiology 25:300-6. 2014
    ..The methods described here can shed insight into pathways and questions of mediation even when an exposure-induced mediator-outcome confounder is present. ..
  31. pmc Efficient context-dependent model building based on clustering posterior distributions for non-coding sequences
    Guy Baele
    Department of Applied Mathematics and Computer Science, Ghent University, Ghent, Belgium
    BMC Evol Biol 9:87. 2009
    ..An increased dimensionality leads to increases in numerical computations of the models, increased convergence times in Bayesian Markov chain Monte Carlo algorithms and even more tedious Bayes Factor calculations...
  32. doi The efficacy of the embryo transfer catheter in IVF and ICSI is operator-dependent: a randomized clinical trial
    Zhan Yao
    Department of Obstetrics and Gynaecology, Ghent University, De Pintelaan 185, B 9000 Gent, Belgium
    Hum Reprod 24:880-7. 2009
    ..Our aim was to perform a prospective randomized clinical trial comparing two catheters and to study interactions between catheters and operators...
  33. ncbi Accounting for correlation and compliance in cluster randomized trials
    T Loeys
    Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281, Building S9, 9000 Ghent, Belgium
    Stat Med 20:3753-67. 2001
    ..Our findings are illustrated with data from a vitamin A trial for the prevention of infant mortality in the rural plains of Nepal...
  34. ncbi Regression models for disease prevalence with diagnostic tests on pools of serum samples
    S Vansteelandt
    Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281, S9, 9000 Ghent, Belgium
    Biometrics 56:1126-33. 2000
    ..Compared to individual testing, age-homogeneous, optimal-sized pools of average size seven reduce cost to 44% of the original price with virtually no loss in precision...
  35. ncbi An improved statistical method for detecting heterotachy in nucleotide sequences
    Guy Baele
    Department of Applied Mathematics and Computer Science, Ghent University, Ghent, Belgium
    Mol Biol Evol 23:1397-405. 2006
    ..Using extensive testing, we show that this may not be due to heterotachy itself but merely due to the increased substitution rate at the detected heterotachous sites...
  36. ncbi Placental inflammation and perinatal transmission of HIV-1
    Fabian Mwanyumba
    International Centre for Reproductive Health, Ghent University, Ghent, Belgium
    J Acquir Immune Defic Syndr 29:262-9. 2002
    ..We suggest that further research on the role of antimicrobial treatment in the prevention of chorioamnionitis and the reduction of peripartum MTCT needs to be performed...
  37. ncbi Discussions
    James Robins
    Departments of Epidemiology, and Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts 02115, U S A
    Biometrics 63:650-3. 2007
  38. ncbi Both low and high activities of platelet monoamine oxidase increase the probability of becoming a smoker
    Jaanus Harro
    Department of Psychology, Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, EE 40510, Tartu, Estonia
    Eur Neuropsychopharmacol 14:65-9. 2004
    ..Furthermore, the possible association between above-average platelet MAO activity and behavioural phenotypes should be reexamined...